WO1997029075A1 - Substituted amide derivatives - Google Patents

Substituted amide derivatives Download PDF

Info

Publication number
WO1997029075A1
WO1997029075A1 PCT/JP1997/000306 JP9700306W WO9729075A1 WO 1997029075 A1 WO1997029075 A1 WO 1997029075A1 JP 9700306 W JP9700306 W JP 9700306W WO 9729075 A1 WO9729075 A1 WO 9729075A1
Authority
WO
WIPO (PCT)
Prior art keywords
group represented
halogeno
hydroxy
lower alkyl
ethynylene
Prior art date
Application number
PCT/JP1997/000306
Other languages
French (fr)
Japanese (ja)
Inventor
Yoshikazu Iwasawa
Tetsuya Aoyama
Kumiko Kawakami
Sachie Arai
Toshihiko Satoh
Yoshiaki Monden
Original Assignee
Banyu Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharmaceutical Co., Ltd. filed Critical Banyu Pharmaceutical Co., Ltd.
Priority to AU16194/97A priority Critical patent/AU1619497A/en
Publication of WO1997029075A1 publication Critical patent/WO1997029075A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Abstract

Compounds represented by general formula (I), pharmacologically acceptable salts or esters thereof, and antitumor agents comprising these as the active ingredients, wherein Ar1, Ar2, and Ar3 each represents aryl or heteroaryl; A1 represents C¿2-6? hydrocarbyl or a group represented by -A?1a-W1-A1b¿- (where W1 represents oxygen, sulfur, ethynylene, cyclopropylene, or a group represented by -NRw-); A2 represents C¿2-8? hydrocarbyl; Q represents a group represented by -(CH2)m- or -(CH2)n-W?2-(CH¿2)p- (where W2 represents oxygen, sulfur, vinylene, ethynylene, or a group represented by -NHCOCH=CH-); R1 represents hydrogen, halogeno, hydroxy, lower alkyl, lower alkoxy, aryl, or heteroaryl group; R?2, R6, and R7¿ each represents hydrogen, halogeno, hydroxy, lower alkyl, lower alkenyl, or lower alkoxy; R?3 and R4¿ each represents hydrogen, halogeno, hydroxy, amino, nitro, cyano, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkyl, lower hydroxyalkyl, lower fluoroalkyl, or lower alkoxy; and R5 represents lower alkyl.
PCT/JP1997/000306 1996-02-07 1997-02-07 Substituted amide derivatives WO1997029075A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16194/97A AU1619497A (en) 1996-02-07 1997-02-07 Substituted amide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8/45504 1996-02-07
JP4550496 1996-02-07

Publications (1)

Publication Number Publication Date
WO1997029075A1 true WO1997029075A1 (en) 1997-08-14

Family

ID=12721247

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/000306 WO1997029075A1 (en) 1996-02-07 1997-02-07 Substituted amide derivatives

Country Status (2)

Country Link
AU (1) AU1619497A (en)
WO (1) WO1997029075A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007201276B2 (en) * 2002-03-12 2009-11-05 Merck Sharp & Dohme Corp. Substituted amides
US9394287B2 (en) 2010-11-05 2016-07-19 Senomyx, Inc. Compounds useful as modulators of TRPM8
US9732071B2 (en) 2015-10-01 2017-08-15 Senomyx, Inc. Compounds useful as modulators of TRPM8

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138214A (en) * 1993-02-12 1995-05-30 Banyu Pharmaceut Co Ltd Substituted amic acid derivative
WO1996005168A1 (en) * 1994-08-11 1996-02-22 Banyu Pharmaceutical Co., Ltd. Substituted amide derivative
WO1996005169A1 (en) * 1994-08-12 1996-02-22 Banyu Pharmaceutical Co., Ltd. N,n-disubstituted amic acid derivative
WO1997001275A1 (en) * 1995-06-29 1997-01-16 Merck & Co., Inc. Combinations of inhibitors of farnesyl-protein transferase

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138214A (en) * 1993-02-12 1995-05-30 Banyu Pharmaceut Co Ltd Substituted amic acid derivative
WO1996005168A1 (en) * 1994-08-11 1996-02-22 Banyu Pharmaceutical Co., Ltd. Substituted amide derivative
WO1996005169A1 (en) * 1994-08-12 1996-02-22 Banyu Pharmaceutical Co., Ltd. N,n-disubstituted amic acid derivative
WO1997001275A1 (en) * 1995-06-29 1997-01-16 Merck & Co., Inc. Combinations of inhibitors of farnesyl-protein transferase

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007201276B2 (en) * 2002-03-12 2009-11-05 Merck Sharp & Dohme Corp. Substituted amides
US9394287B2 (en) 2010-11-05 2016-07-19 Senomyx, Inc. Compounds useful as modulators of TRPM8
US10016418B2 (en) 2010-11-05 2018-07-10 Seaomyx, Inc. Compounds useful as modulators of TRPM8
US10953007B2 (en) 2010-11-05 2021-03-23 Firmenich Incorporated Compounds useful as modulators of TRPM8
US9732071B2 (en) 2015-10-01 2017-08-15 Senomyx, Inc. Compounds useful as modulators of TRPM8

Also Published As

Publication number Publication date
AU1619497A (en) 1997-08-28

Similar Documents

Publication Publication Date Title
WO1996005168A1 (en) Substituted amide derivative
EP0805154A4 (en)
EP0992239A4 (en) Neuropeptide y receptor antagonist
DK1162980T3 (en) Pyridoxine compounds for the treatment of cardiovascular disease pathologies
CA2311742A1 (en) 6-amino-9-benzyl-8-hydroxypurine derivatives
EP1156045A4 (en) Amide derivatives and drug compositions
CA2272291A1 (en) Crf antagonistic quino- and quinazolines
EP1400518A4 (en) Heterocyclic compound derivatives and medicines
PT981330E (en) TOP COMPOSITIONS
GEP20022654B (en) Indazole Amide Compounds As Serotoninergic Agents
AU641952B2 (en) Substituted N-(imidazolyl)alkyl alanine derivatives
WO2000039083A3 (en) Pyrazole compounds and uses thereof
EP1243268A4 (en) Medicinal composition
EP1284272A4 (en) Estra-1,3,5(10)-triene derivatives
WO1997029075A1 (en) Substituted amide derivatives
IT1273790B (en) DIAZOTATED HETEROCYCLIC DERIVATIVES WITH ACTIVITIES TO THE ANTAGONIST
WO1997029073A1 (en) Substituted amide derivatives
EP0889034A4 (en) Aminopyridine derivatives
WO1997029074A1 (en) N,n-disubstituted amic acid derivatives
EP1062949A4 (en) IgE ANTIBODY PRODUCTION INHIBITORS AND AUTOIMMUNE DISEASES INHIBITORS
EP0995437A4 (en) 2,3-dihydrobenzofuran derivatives
WO1997029077A1 (en) Substituted amide derivatives
EP0882699A4 (en) Amino compounds and angiotensin iv receptor agonists
EP0755928A4 (en) 5-aminoflavone derivatives
RS50449B (en) Substituted bisindolylmaleimides for the inhibition of cell proliferation

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN YU AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase