WO1997013549A1 - Dispositif et procede de modulation des fonctions biologiques de structures biologiques - Google Patents

Dispositif et procede de modulation des fonctions biologiques de structures biologiques Download PDF

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Publication number
WO1997013549A1
WO1997013549A1 PCT/EP1996/004197 EP9604197W WO9713549A1 WO 1997013549 A1 WO1997013549 A1 WO 1997013549A1 EP 9604197 W EP9604197 W EP 9604197W WO 9713549 A1 WO9713549 A1 WO 9713549A1
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WO
WIPO (PCT)
Prior art keywords
generating
βaid
field
application area
electromagnetic
Prior art date
Application number
PCT/EP1996/004197
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English (en)
Inventor
Suleyman Seckiner Gorgun
Original Assignee
Suleyman Seckiner Gorgun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suleyman Seckiner Gorgun filed Critical Suleyman Seckiner Gorgun
Priority to AU72146/96A priority Critical patent/AU7214696A/en
Publication of WO1997013549A1 publication Critical patent/WO1997013549A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy

Definitions

  • the present invention relates to a device and process for the modulation of the biological functions of biological structures.
  • the object of the present invention is to provide a device and process for applying magnetic and/or electrical and/or electromagnetic fields and/or optical-frequency radiation and/or electromagnetic sound waves to biological structures, thereby producing effects of modulation of the biological functions.
  • the above object is achieved by the present invention in that it relates to a device and process of the type described in Claims 1 and 20 respectively for the treatment of biological structures.
  • Figure 1 shows schematically the simplified electrical circuit of a device for the treatment of biological structures, constructed according to the specifications of the present invention
  • Figure 2 is a logical diagram of the operation of the device shown in Figure 1;
  • Figure 3 shows the variation in time of some signals of the device shown in Figure 1;
  • Figure 4 shows, by means of an electrical circuit diagram, the principle of operation of a biological reaction.
  • the number 1 indicates as a whole a device for the treatment of biological structures according to the invention.
  • the device 1 comprises a first timer 5 and a second timer 7 connected to the timer 5 through a control line 9.
  • the first timer 5 is provided with a control input 10 (START/STOP) and a device 11 for manual regulation of the time-delay period Tl which can be provided by the timer 5.
  • the first timer 5 is also provided with an input 13 which can switch between automatic and manual operating modes of the timer 5; in the automatic operating mode, the output 5u of the timer 5 has a first logical value, for example a logical "1" , for a time Tl from the activation (START) of the control input 10, while in the manual operating mode the output 5u maintains the first logical value "1" between two successive activations (START/STOP) of the control input 10.
  • the second timer 7 is provided with a control input 15 (START/STOP) connected to the line 9 and with a device 17 for the manual regulation of the time-delay period T2 provided by the timer 7.
  • the second timer 7 is also provided with an input 19 which can switch between automatic and manual operating modes of the timer 7; in the automatic operating mode, the output 7u of the timer 7 has a first logical value, for example a logical w l", for a time T2 from the activation (START) of the control input 15, while in the manual operating mode the output 7u maintains the first logical value between two successive activations (START/STOP) of the control input 15.
  • a first logical value for example a logical w l"
  • the output 7u maintains the first logical value between two successive activations (START/STOP) of the control input 15.
  • the output 5u of the first timer 5 communicates with a control input 21a of a bistable circuit 21 which can generate a square-wave signal S at one of its outputs 21b when a logical M l" is applied to the input 21a.
  • the circuit 21 is provided with three regulating devices 24, 25 and 26 which can, respectively, set the frequency f_o of the signal S, the amplitude of the period (Ton) in which the signal S has a logical value of "1" and the amplitude of the period (Toff) in which the signal S has a value equal to a logical w 0" .
  • the output 21b of the circuit 21 is connected to a control line 28 communicating with the inputs II, 12, 13, 14, 15 of corresponding generator units Bl, B2, B3, B4 and B5.
  • the structures of the units Bl - B5 are completely identical, and consequently, for the sake of simplicity, only the unit Bl will be described and illustrated.
  • the unit Bl comprises a bistable circuit 36 having a control input 36a communicating with the control line 28.
  • the bistable circuit 36 can generate a square-wave signal T, with a frequency and duty cycle which can be regulated, when a logical "1" is applied to the input 36a.
  • the circuit 36 is provided with three regulating devices 38, 39 and 40 which can, respectively, set the frequency f_o of the signal T, the amplitude of the period (Ton) in which the signal T has a logical value of "1" and the amplitude of the period (Toff) in which the signal T has a value equal to a logical "0" .
  • the output 36b of the circuit 36 communicates, through an interposed switch 43, with a control input 46a of a transmitter 46 which can generate a radiofrequency signal W at the output on an antenna 48.
  • the antenna 48 may be of the rod, wire or parabolic type with the possibility of automatic aiming of the antenna 48.
  • the signal W is generated when a signal equivalent to a logical "1" is applied to the input 46a.
  • the circuit 46 is provided with three regulating devices 53, 54 and 55 which can, respectively, select the frequency f_o of the signal W, the amplitude of the period (Ton) in which the signal W has a "high” value and the amplitude of the period (Toff) in which the signal has a "low” value.
  • the circuit 46 is also provided with a control device 58 for the selection of the type of wave form (SQUARE, TRIANGULAR, SINUSOIDAL WAVE, etc.) of the radiofrequency signal W.
  • the signal W may also have, for example, a power which can be regulated from 0.1 to 500 watts and a frequency which can be regulated from 1 Hz to 1 terahertz.
  • a receiver-converter device (not illustrated) is provided to receive the radiofrequency signal W and convert it to a sound signal.
  • a signal amplifier may be provided at the output of the receiver-converter.
  • a sound transmitter may be used. The sound signal lies in an audible or inaudible frequency range.
  • a receiver-converter device (not illustrated) is provided to receive the radiofrequency signal and convert it into a light signal in a predetermined frequency range.
  • the unit Bl also comprises a static power supply circuit 61 which has a control unit 61a communicating with the output 36b through a relay 36c electrically connected to a 220 V alternating current line, and an output 61b communicating, through an interposed switch 64, with at least one metal sheet, for example a rectangular plate 66.
  • the said plate is made, for example, from platinum, gold, copper, aluminium, zinc, carbon or metal alloy, or from a core, of gold for example, covered by a coating, of copper for example.
  • the circuit 61 can generate at the output, when there is a logical "1" signal at the input, a constant voltage Vplate (lying for example between 10 and 200,000 volts) whose value can be regulated manually by means of a device 67.
  • the circuit 61 can also set its output 61b to a voltage of zero when a logical "0" is present at the input 61a.
  • the circuit 61 is also provided with an input 68 for the selection of the rise mode of the voltage Vplate; in a first operating mode (Cond-ON) , the voltage Vplate (of the rectangular pulse type with an amplitude proportional to the width of the period Ton) rises in a ramp with a slope which can be regulated, while in a second operating mode (Cond-off) the voltage Vplate rises in steps.
  • the voltage Vplate applied to the plate 66 can generate an electrical field E directed towards an application area 70 to which the radiofrequency signal W is also sent.
  • the device 1 also comprises a magnetic field generator 74 comprising a power supply circuit 76 and one or more coils, for example two, indicated by 78 and 79, supplied from the circuit 76.
  • the circuit 76 can supply to the coils 78, 79 a current Im having a predetermined wave form (for example rectangular, sinusoidal, triangular, etc.) and an intensity which can be regulated by means of a device 82.
  • the coils 78, 79 can generate a magnetic field H directed towards the application area 70.
  • the magnetic field H may have an intensity of, for example, between 1 and 30,000 gauss and may be continuous or pulsed with a frequency of between 0.1 Hz and 1 kHz.
  • block 100 the user selects (by acting on the input 10) an operating mode of the manual or automatic type. If the manual mode is selected, the block 100 is followed by a block 110; otherwise (with automatic mode selected) the block 100 is followed by a block 120.
  • the block 120 starts the timer 5 which sets its output to a voltage level equal to a logical "1" .
  • the block 120 is followed by a block 125 in which the circuit 21 is switched on to produce at the output the square-wave logic signal S having a frequency f_o and a duty cycle which can be regulated by means of the devices 24, 25 and 26.
  • Figure 3 shows, purely by way of example and without restriction, the logical state of the output 5u after a start of the device and the corresponding variation with time of the logic signal S.
  • the signal S is then sent to the circuit 36 which generates a square-wave logic signal T at its output 36b for all the time intervals in which the signal S has the value w l" .
  • the output 36b of the circuit 36 has a logical value of "0" for all the instants in which the signal S is equal to a logical "0" .
  • the signal T is thus sent by the 12 V d.c. line to the transmitter 46 and, through the relay 36c, by the 220 V a.c. line, for example, to the circuit 61; in particular, the transmitter 46 emits through the antenna 48 a pulse train having a wave form, frequency and duty cycle which can be regulated, for all the time intervals for which the signal T has the value M l" .
  • the transmitter 46 does not emit any signal for all the instants in which the signal T is equal to a logical « 0".
  • the circuit 61 also supplies the plate 66 which produces the field E, for all the time intervals in which the signal T is equal to "1" .
  • the circuit 61 does not supply the plate 66 in all instants in which the signal T is equal to a logical "0" .
  • the block 125 is followed by a block 130 which at the end of the time Tl is followed by a block 140 by means of which the user selects a manual or automatic operating mode for the second timer 7, by acting on the input 19. If the manual mode is selected, the block 140 is followed by a block 150; otherwise (with automatic mode selected) the block 140 is followed by a block 160.
  • the block 160 starts the timer 7 which sets its output 7u to a voltage level equal to a logical "1" .
  • the block 160 is followed by a block 165 in which the circuit 36 is switched on and produces a square-wave logic signal
  • the signal T is thus sent to the transmitter 46 and, through the relay 36c, to the circuit 61; in particular, the transmitter 46 emits through the antenna 48 a pulse train having a wave form, frequency and duty cycle which can be regulated, for all the time intervals for which the signal T has the value n l" .
  • the transmitter 46 does not emit any signal for all the instants in which the signal T is equal to a logical » 0".
  • the circuit 61 also supplies the plate 66 which produces the field E, for all the time intervals in which the signal T is equal to "1".
  • the circuit 61 does not supply the plate 66 for all the instants in which the signal T is equal to a logical "0" .
  • the block 165 is followed by a block 170 which at the end of the time T2 stops the operation of the device 1.
  • the circuit 46 is provided with a manual control for the transmission of the signal in continuous mode, also stopping operation after the block 170.
  • the block 110 in a similar way to block 125, switches on the circuit 21 which in turn controls the circuit 36 driving the transmitter 46 and the circuit 61.
  • the operations executed by the block 110 terminate (block 111) following a new activation (STOP) of the control input 10.
  • the block 150 switches on the circuit 36 which drives the transmitter 46 and the circuit 61.
  • the operations executed by the block 150 terminate (block 151) following a new activation (STOP) of the control input 19.
  • STOP new activation
  • a biological structure 70a to be treated is placed in the application area 70; this biological structure 70a may consist of a group of cells contained in a container (in vitro treatment) or may be a part of the body of a living organism (in vivo treatment) .
  • optical-frequency radiation and/or electromagnetic sound waves are applied by directing the radiation and/or waves preferentially towards the receptor organs present in the biological structure.
  • the type of effect which may be obtained on the biological structures depends on the type of cells used in the treatment and on the intensity, the orientation and the frequency of the electrical and/or magnetic and/or electromagnetic fields and/or of the optical- frequency radiation and/or electromagnetic sound waves used.
  • the electrical field E and the magnetic field H are, for example, disposed with versors of propagation parallel to each other and the electromagnetic field W is normally transverse with respect to the magnetic and electrical field.
  • One observed effect of the action of one or more of the three fields and/or of the optical-frequency radiation and/or electromagnetic sound waves, in suitable conditions, is the induction of cellular necrosis.
  • necrosis has been produced in vitro with an electromagnetic field W having a frequency within the range 1 Hz - 50 MHz, a power up to 60 watts and a wave form of the sinusoidal or square type.
  • a voltage of the order of 200-380 volts is applied to the plate 66 and the magnetic field used has an intensity of up to 40 gauss and is of the pulsed or continuous type.
  • necrosis indicated above has been produced in vivo with an electromagnetic field W having a frequency within the range 1 Hz - 8 MHz, a power up to 60 watts and a wave form of the sinusoidal or square type.
  • a voltage of the order of 100-380 volts is applied to the plate 66 and the magnetic field used has an intensity of up to 40 gauss and is of the pulsed or continuous type.
  • the biological mechanism producing the cellular necrosis is based on an effect of the said signals on the energy metabolism of the cell. More precisely, it is suggested that the chromosomes, after signals have been received as a result of the variation of potential of the cytoplasm membrane, cause genes, by an electromechanical effect, to emit signals which regulate the cell dynamics for normal cell functions and for mitochondrial activity for the production of ATP.
  • a model of the operation of the mitochondrion is assumed to be provided by the circuit in Figure 4, in which the Zener diode D 2 (of the frequency type) represents the on-off operation as a function of the frequency, the impedance Z represents the impedance of the glycoprotein sensors present in the mitochondrial membrane, and the transistor represents the ATP activation process.
  • the means used are considered to cause cellular necrosis by producing the elongation of the carbohydrate chains of the mitochondrial glycoprotein sensors with a consequent increase in their impedance and therefore a decrease in ATP production. It is therefore the decreased availability of ATP which is believed to result, beyond a certain threshold, in cell necrosis. It has also been hypothesized that superconducting junctions of the Josephson type are formed between adjacent cells during the aforesaid process of necrosis.
  • the Josephson effect discovered in 1962, is found when two superconductors are brought close enough together that they are separated only by a thin dielectric layer (Josephson junction) . The presence of such regions between adjacent cells has not yet been demonstrated, but it may be supposed that the currents of positive ions which pass through the cell membranes and are propagated along the cellular structure may be considered to be "supercurrents" .
  • the device 1 by virtue of the action of one or more of the three fields E, H and W, and/or of optical-frequency radiation and/or electromagnetic sound waves mentioned above, is capable of producing effects of modulation on the biological functions of biological structures.
  • the device 1 may advantageously be used to modulate molecular activity during biological and biochemical reactions and interactions.
  • the process of necrosis described above may advantageously be used to control (and reduce) the growth and reproduction of pathological cells, for example neoplastic cells; alternatively it is possible to accelerate the process of regeneration of normal cells, for example by rapid scar formation at surgical incisions.
  • pathological cells for example neoplastic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Magnetic Treatment Devices (AREA)

Abstract

Ce dispositif de modulation de fonctions biologiques, selon l'invention, comprend: des moyens de production d'un champ (46) électromagnétique capable de produire, lorsqu'ils sont activés, un signal (W) de fréquence radioélectrique qui peut être dirigé vers une zone (70) d'application, et/ou des moyens de production d'un champ (61) électrique, pouvant appliquer, lorsqu'ils sont activés, un champ (E) électrique sur ladite zone (70), et/ou des moyens de production d'un champ (74) magnétique, pouvant appliquer, lorsqu'ils sont excités, un champ (H) magnétique sur ladite zone (70), et/ou des moyens de production d'un rayonnement à des fréquences optiques, pouvant diriger, lorsqu'ils sont activés, le rayonnement sur ladite zone, et/ou des moyens de production d'ondes sonores électromagnétiques, pouvant diriger, lorsqu'ils sont activés, ces ondes sur ladite zone d'application.
PCT/EP1996/004197 1995-10-10 1996-09-26 Dispositif et procede de modulation des fonctions biologiques de structures biologiques WO1997013549A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU72146/96A AU7214696A (en) 1995-10-10 1996-09-26 Device and process for the modulation of the biological functions of biological structures

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITTO95A000809 1995-10-10
IT95TO000809A IT1280961B1 (it) 1995-10-10 1995-10-10 Dispositivo e metodo per la modulazione delle funzioni biologiche.

Publications (1)

Publication Number Publication Date
WO1997013549A1 true WO1997013549A1 (fr) 1997-04-17

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PCT/EP1996/004197 WO1997013549A1 (fr) 1995-10-10 1996-09-26 Dispositif et procede de modulation des fonctions biologiques de structures biologiques

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AU (1) AU7214696A (fr)
IT (1) IT1280961B1 (fr)
WO (1) WO1997013549A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005020869A1 (fr) * 2003-08-29 2005-03-10 Achim Von Othegraven Appareil de traitement therapeutique
WO2008056414A1 (fr) 2006-11-08 2008-05-15 Medical Appliance Co., Ltd. Appareil accélérant la production de facteur neurotrophique
GB2486853B (en) * 2011-04-18 2013-06-05 Freewave Ltd Therapeutic apparatus for irradiating biological cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007468A1 (fr) * 1988-02-09 1989-08-24 Fellner Donald G Procede d'elimination de tissu adipeux du corps
US5186171A (en) * 1991-02-19 1993-02-16 Kuhry Anthony B Electrotherapy device and process
WO1995007729A1 (fr) * 1993-09-13 1995-03-23 Theta Electronics S.A. Dispositifs de stimulation des defenses naturelles d'un individu ou de tout systeme cellulaire
WO1995033514A1 (fr) * 1994-06-09 1995-12-14 Magnetic Resonance Therapeutics, Inc. Procede d'electrotherapie

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007468A1 (fr) * 1988-02-09 1989-08-24 Fellner Donald G Procede d'elimination de tissu adipeux du corps
US5186171A (en) * 1991-02-19 1993-02-16 Kuhry Anthony B Electrotherapy device and process
WO1995007729A1 (fr) * 1993-09-13 1995-03-23 Theta Electronics S.A. Dispositifs de stimulation des defenses naturelles d'un individu ou de tout systeme cellulaire
WO1995033514A1 (fr) * 1994-06-09 1995-12-14 Magnetic Resonance Therapeutics, Inc. Procede d'electrotherapie

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005020869A1 (fr) * 2003-08-29 2005-03-10 Achim Von Othegraven Appareil de traitement therapeutique
WO2008056414A1 (fr) 2006-11-08 2008-05-15 Medical Appliance Co., Ltd. Appareil accélérant la production de facteur neurotrophique
EP2081645A1 (fr) * 2006-11-08 2009-07-29 Medical Appliance Co., Ltd. Appareil accélérant la production de facteur neurotrophique
EP2081645A4 (fr) * 2006-11-08 2011-09-21 Mind Co Ltd P Appareil accélérant la production de facteur neurotrophique
US8562506B2 (en) 2006-11-08 2013-10-22 P-Mind Co., Ltd. Neurotrophic factor production promoting device
US8951183B2 (en) 2006-11-08 2015-02-10 P-Mind Co., Ltd. Neurotrophic factor production promoting device
GB2486853B (en) * 2011-04-18 2013-06-05 Freewave Ltd Therapeutic apparatus for irradiating biological cells

Also Published As

Publication number Publication date
AU7214696A (en) 1997-04-30
IT1280961B1 (it) 1998-02-11
ITTO950809A1 (it) 1997-04-10
ITTO950809A0 (it) 1995-10-10

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