WO1997007812A1 - Production process of the ecological pharmaceutical compositions in the veterinary medical field - Google Patents

Production process of the ecological pharmaceutical compositions in the veterinary medical field Download PDF

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Publication number
WO1997007812A1
WO1997007812A1 PCT/MK1995/000001 MK9500001W WO9707812A1 WO 1997007812 A1 WO1997007812 A1 WO 1997007812A1 MK 9500001 W MK9500001 W MK 9500001W WO 9707812 A1 WO9707812 A1 WO 9707812A1
Authority
WO
WIPO (PCT)
Prior art keywords
procedure
obtaining
oils
ethers
mixing under
Prior art date
Application number
PCT/MK1995/000001
Other languages
French (fr)
Inventor
Jasna Mandic
Original Assignee
Jasna Mandic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jasna Mandic filed Critical Jasna Mandic
Priority to AU42725/96A priority Critical patent/AU4272596A/en
Publication of WO1997007812A1 publication Critical patent/WO1997007812A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)

Definitions

  • This request for patent is concerning of the production process i.e. the procedure for obtaining an ecological pharmaceutical com ⁇ positions applicated in veterinary medical field that means that this invention is 5 related with the field of medicine and pharmacology. Because of the fact that this invention is concerning of the applica ⁇ tion of the active substances from organic origins used during the process of production of this medicaments, according to " Interna ⁇ tional patent classification " , this invention could be classified in o the clss with classification number A6K31. Technical problems solved with this invention
  • the technical problem that is solved with this invention is the obtainment of various types of veterinary medicaments on the ba ⁇ sis of natural components, that successfully replace prior art prod- 5 ucts based on sulfonamides and antibiotics.
  • the application of the active substances according to the invention eliminates many un ⁇ wanted effects caused by the prior art sulfonamides and antibiot ⁇ ics, such as:
  • the medicaments based on the active components are ecological, and besides of that are not uretogenic and teratogenic and are in correlation with a new tendency in the 5 environmentprotection.
  • the primary component which is apphed in the pharmaceutical com ⁇ positions according to the invention is ethers oil obtained from any of the following plants: -ORIGANUM VULGARIS ( different variety )
  • the residue of the leaves and blossoms is used to extract tannin.
  • the substances which are used in the procedure for preparing the product are:
  • the three types of oils are mixed in the given percent ⁇ age.
  • the mixture is than blended together in a mixer with 30 % of the lactose at a speed of 200 rotations per minute for a period of 10 minutes.
  • the rest of the lactose is added and mixed again.
  • the mixture is then put in capsules.
  • the procedure for making the paste goes as follows: the vaselinum album is placed in the mixer together with 20 % of the total contents and heated up to a temperature of 50 °C . The heated mass is then added to the mixture of above-mentioned quantities of oil and the product is mixed together for 5 minutes at a speed of 100 rotations per minute. At the end the parafinum liquidum is added and the product is packed.
  • the substances which are used in the procedure for the prepa ⁇ ration ofthe product are:
  • the substance used in the procedure for preparing the product are:
  • the substances used in the procedure for preparing the prod ⁇ uct are: - MEDICAL POWDER 92-94 %

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The active substances are obtained from some varieties of plants: Origanum vulgaris, thymus vulgaris, salvia officialis, mentha piperita, where, by the distillation of dried parts of the plant, the ether oils, while by extraction, tanin is obtained. The ether oils and tannin are used in the procedure for obtaining several kinds of medicaments for curing different diseases in animals, as colibacillosis, coccidiosis, mastitis, wounds and others.

Description

PRODUCΠONPROCESSOFIΉE ECOLOGICAL
PHARMACEUTICAL COMPOSITIONS IN THE VETERINARY MEDICAL FIELD
Technical field concerning this invention
This request for patent is concerning of the production process i.e. the procedure for obtaining an ecological pharmaceutical com¬ positions applicated in veterinary medical field that means that this invention is 5 related with the field of medicine and pharmacology. Because of the fact that this invention is concerning of the applica¬ tion of the active substances from organic origins used during the process of production of this medicaments, according to " Interna¬ tional patent classification " , this invention could be classified in o the clss with classification number A6K31. Technical problems solved with this invention
The technical problem that is solved with this invention is the obtainment of various types of veterinary medicaments on the ba¬ sis of natural components, that successfully replace prior art prod- 5 ucts based on sulfonamides and antibiotics. The application of the active substances according to the invention eliminates many un¬ wanted effects caused by the prior art sulfonamides and antibiot¬ ics, such as:
1. the presence of biorecidives in the meat and milk of ani- 0 mals treated with such products; and
2. the acquirement of resistance of microorganisms-bacteria against the prior art products. The medicaments based on the active components are ecological, and besides of that are not uretogenic and teratogenic and are in correlation with a new tendency in the 5 environmentprotection.
Description ofthe prior art
In the prior arts were used veterinary medicaments based on antibiotics, 2 sulfonamides and even hormones for treating animal diseases such as cholera, different types of colibaciUosis, 0 dermatomycosis, inflammation of the udder, inflammation of the va¬ gina and uterus, various etiologies and coccidiosis. In order to avoid the unwanted consequences mentioned above, it is necessary to have ecologically healthy and unsuspected products.
More in particular a great deal of the bacteria that cause the 5 abovementioned diseases have developed a form of resistance against the prior art medicaments, so the products according to the inven¬ tion resolve the problems of treating the diseases hsted above, as well as various types of diarrhea, inflammation of the abdomen, gastritis, inflam¬ mation ofthe oral mucosa, inflammation ofthe ear, conjunctivitis, etc. Description ofthe solution ofthe technical problem
The primary component which is apphed in the pharmaceutical com¬ positions according to the invention is ethers oil obtained from any of the following plants: -ORIGANUM VULGARIS ( different variety )
-THYMUS VULGARIS (different variety) -SALVIA OFFICΓNALIS
-MENTHA PIPERITA
Besides these plants in the obtaining procedure for this com¬ positions can be use the other plants like : Saturea Hortensis, Saturea Montana, Saturea Subricata, Carum Coptimum Bent ( from India ), Thymus Zugus (from Spain ), Ocimum Gratisum ( from South France and Africa ), Moranda Pignata ( from Nord America ), Mosia Japanoica Maxinowist (from Japan) synthetic thymol having the chemical name isopropylcresol synthetic carvacrols could be used as well. The basic substances in the obtaining procedure for composi¬ tion are ethers oils obtained by destilation from one of these plants. Firstly the leaves and blossoms of the plants, which must be dry , are placed in a distiller. The ethers oil is obtained by the pro¬ cess of destilation by means of water vapor. In general the extracted oil contains a certain percentage of thymol and carvacrol: approx. 3% of tymol and 60-70% of carvacrol.
After the above described distillation, the residue of the leaves and blossoms is used to extract tannin.
Further we are going to explain the procedure for obtaining some varieties of the compositions, where the ethers oils, obtained by the above described process of destilation, are used.
1. The procedure for obtaining medicaments for the treat¬ ment of colibaciUosis in animals
1.1 Procedure for making a powder The substances which are used in the procedure for making a powder for the treatment of colibaciUosis are:
- CALCIUM CARBONATE 91-93 %
- ORIGANUM VULGARIS OLEUM 3-5 %
- OIL FROM THYMUS VULGARIS 1-3 % - OIL FROM MENTHA PIPERITA 0,5-1,5% - TANNIN 0,5-1,5%
30 % of the total quantity of calcium carbonate is put in a turbo vacuum mixer and the entire amount of ethers oils is gradually added. The total product is mixed together at a speed of 250 rota- tions per minute for 10 minutes. The ethers oils are mixed together directly before being poured in the mixer. After the mixing time of 10 minutes, the rest of the calcium carbonate is added and mixed at the above - mentioned speed for another 5 minutes. The powder is than ready to be packe 1.2 Procedure for making an emulsion
In one case the substances which are used in the procedure for preparing the product are:
- POLYETHYLENE GLYCOL 89,5-91,5 %
- ORIGANUM VULGARIS OIL 3-5 % - THYMUS VULGARIS OIL 1-3 %
- MENTHA PIPERITA OIL 0,5-1,5 %
- TANNTN 0,5-1,5 %
- GLYCEROL MONOSTEARATE 1-2 % and in the second case these substance are: - LAUREL OIL 91-93 %
- ORIGANUM VULGARIS OIL 3-5 %
- THYMUS VULGARIS OIL 1-3 %
- MENTHA PIPERITA OIL 0,5-1,5 %
- TANNTN 0,5-1,5 % The procedure is in both cases the same. Firstly, 30 % of the basic substance is placed in a turbo vacuum mixer (in the first case, the polyethylene glycol , and in the second case the laurel oil ) and the mixture of oils is added . Everything is mixed together for a period of 5 minutes at a speed of 200 rotations per minute. After this is done, the rest of the basic substance is added about 70 %. In the first case the glycerol monostearate is added as well. It is mixed for another 10 minutes with the same intensity. At the end it is packed in dark glass bottles.
13 Procedure for the production of capsules The substance which are used in the procedure for preparing the product are:
LACTOSE 91-93 %
ORIGANUM VULGARIS OIL 3-5 %
THYMUS VULGARIS OIL 1-3 % MENTHA PIPERITA OIL 0,5-1,5 % TANNTN 0,5-1,5 %
Firstly, the three types of oils are mixed in the given percent¬ age. The mixture is than blended together in a mixer with 30 % of the lactose at a speed of 200 rotations per minute for a period of 10 minutes. The rest of the lactose is added and mixed again. The mixture is then put in capsules.
1.4 Procedure for making a paste
The elements which are used in the procedure are:
- VASELINUM ALBUM 69-71 % - ORIGANUM VULGARIS OIL 3-5 %
- THYMUS VULGARIS OIL 1-3 % - MENTHA PIPERITA OJL 0,5-1,5 % - TANNTN 0,5-1,5 %
- PARAFTNUM LIQUIDUM 21-23 % The procedure for making the paste goes as follows: the vaselinum album is placed in the mixer together with 20 % of the total contents and heated up to a temperature of 50 °C . The heated mass is then added to the mixture of above-mentioned quantities of oil and the product is mixed together for 5 minutes at a speed of 100 rotations per minute. At the end the parafinum liquidum is added and the product is packed.
2. The procedure for obtaining product for the treatment and prevention of coccidiosis in animals
The substances which are used in the preparation of the prod- uct are:
- CALCIUM CARBONATE 92-94 % - OREGANO OIL 3-5 %
- THYMUS VULGARIS OIL 1-3 %
- MENTΗA PIPERITA OIL 0,5-1,5 % 20 % of the calcium carbonate is put in a turbo vacuum mixer and the total amount of oils is added after being mixed beforehand. The product is blended together for 10 minutes at 200 rotations per minute. Then the rest of the calcium carbonate is added and mixed again for another 10 minutes. Finally the product is packet. 3. The procedure for obtaining product for the treatment of mastitis
The substances which are used in the procedure for the prepa¬ ration ofthe product are:
- VASELINUM ALBUM 92-94 % - PARAFINUM LIQUIDUM 22-24 % - OREGANUM VULGARIS OIL 3-5 %
- THYMUS VULGARIS OIL 1-3 %
- MENTHA PIPERITA OIL 0,5-1,5%
20 % of the vaselinum album is put in a mixer that is previ- ously heated at 45°C. After the substance is melted the mixture of the given quantities of oils is added and mixed for 5 minutes at a speed of 200 rotations per minute. The rest of the vaselinum album and all of the parafinum liquidum are added as the product cools down. Then, the product is packed in appropriate syringes, 4.The procedure for obtaining product having anti-dermatitis properties
The substance used in the procedure for preparing the product are:
VASELINUM ALBUM 69-71 % - PARAFINUM LIQUIDUM 21-23 %
- OREGANUM VULGARIS OIL 3-5 %
- THYMUS VULGARIS OIL 2-4 %
- MENTHA PIPERITA OIL 0,5-1,5 % 20 % of the vaselinum album is put in a mixer which is previ- ously heated at 45 0 C. The oils are added and the product is mixed for 10 minutes at a speed of 50 rotations per minute. Then the rest of the vaselinum album and the parafinum liquidum are added. Finally the mass is cooled down and packed in appropriate tubes.
5. The procedure for obtaining products for the treatment of ani- mal wounds
The substances used in the procedure for preparing the prod¬ uct are: - MEDICAL POWDER 92-94 %
- OREGANUM VULGARIS OIL 4-6 % - THYMUS VULGARIS OIL 0,5-1,5 %
- MENTHA PIPERITA OIL 0,5-1,5 % the procedure for obtaining of this product is developing in the folowing phases:
20 % of the medical powder is put in a vacuum mixer and mixed together with the oils which are mixed beforehand. The mixture is blended together for 10 minutes at a speed of 200 rotations per minute. Then the rest of the medical powder is added and mixed another 5 minutes at a speed of 150 rotations per minute. Finally the powder is packed in bags or bottles under pressure.

Claims

1. The procedure for obtaining an ecological, pharmaceutical medicaments in the veterinary medicine different than the up to now known synthetic chemical medicaments is characterized by the application of active substances from organic origin obtained from several varieties plants from which the most exploited are: ORIG¬ ANUM VULGARE, THYMUS VULGARIS , SALVIA OFFICIALIS, MENTHA PIPERITA , where phases are developed :
- obtaining of the ethers oils by destilation of dried parts of the plant and - obtaining of the tannin by the extraction.
2. The procedure for obtaining of medicaments for the treat¬ ment of cβlibacillosis in animals is characterized by the application of determined percentage composition of ethers oils and tannin and calcium carbonate and their appropriate mixing under determined conditions, there are optained : powder, emulsion, capsules and paste.
3. The procedure for obtaining products for the treatment and prevention of coccidiosis in animals is characterized by applica¬ tion of the determined percentage composition of ethers oils and calcium carbonate and their appropriate mixing under determined conditions.
4. The procedure for obtaining product for the treatment of mastitis is characterized by the apphcation of determined percentage of ethers oils, vaselinum album and parafinum liquidum, and there appropriate mixing under determinate conditions.
5. The procedure for obtaining product having anti-dermatitis properties is characterized by the determined percentage composi¬ tion of eteric oils, vaselinum album and parafinum liquidum and ap¬ propriate mixing under determined conditions.
6. The procedure for obtaining products for the treatment of animal wounds is characterized by the application of deteimined percentage com¬ position of eteric oils and medical powder and their appropriate mixing under deteπnined conditions where can be obtained: powder and spray depending of the way of packing.
PCT/MK1995/000001 1995-08-25 1995-12-14 Production process of the ecological pharmaceutical compositions in the veterinary medical field WO1997007812A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU42725/96A AU4272596A (en) 1995-08-25 1995-12-14 Production process of the ecological pharmaceutical compositions in the veterinary medical field

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MK7695 1995-08-25
MK950076 1995-08-25

Publications (1)

Publication Number Publication Date
WO1997007812A1 true WO1997007812A1 (en) 1997-03-06

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PCT/MK1995/000001 WO1997007812A1 (en) 1995-08-25 1995-12-14 Production process of the ecological pharmaceutical compositions in the veterinary medical field

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AU (1) AU4272596A (en)
WO (1) WO1997007812A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794024A1 (en) * 1999-05-28 2000-12-01 Ecopsi TANNIN-BASED PREPARATION FOR THE TREATMENT OF COCCIDIOSIS
EP4011385A1 (en) * 2020-12-07 2022-06-15 Diko Holger Becker Active substance for the treatment of mastitis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424534A1 (en) * 1989-04-28 1991-05-02 DERYABIN, Alexandr Mikhailovich Pharmaceutical preparation for treatment of mastitis in animals and humans
JPH06166626A (en) * 1992-05-12 1994-06-14 Taiyo Kagaku Co Ltd Live bacterium powder
JPH06256180A (en) * 1993-03-04 1994-09-13 Taiyo Kagaku Co Ltd Enteric environment-improving composition
FR2706770A1 (en) * 1993-06-21 1994-12-30 Pelletier Jacques Formula for the treatment of tuberculosis.
JPH07305089A (en) * 1994-05-10 1995-11-21 Pola Chem Ind Inc Conception promoter

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424534A1 (en) * 1989-04-28 1991-05-02 DERYABIN, Alexandr Mikhailovich Pharmaceutical preparation for treatment of mastitis in animals and humans
JPH06166626A (en) * 1992-05-12 1994-06-14 Taiyo Kagaku Co Ltd Live bacterium powder
JPH06256180A (en) * 1993-03-04 1994-09-13 Taiyo Kagaku Co Ltd Enteric environment-improving composition
FR2706770A1 (en) * 1993-06-21 1994-12-30 Pelletier Jacques Formula for the treatment of tuberculosis.
JPH07305089A (en) * 1994-05-10 1995-11-21 Pola Chem Ind Inc Conception promoter

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9428, Derwent World Patents Index; Class B04, AN 94-230621, XP002006855 *
DATABASE WPI Section Ch Week 9441, Derwent World Patents Index; Class B04, AN 94-329918, XP002006854 *
DATABASE WPI Section Ch Week 9604, Derwent World Patents Index; Class B04, AN 96-036108, XP002006030 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794024A1 (en) * 1999-05-28 2000-12-01 Ecopsi TANNIN-BASED PREPARATION FOR THE TREATMENT OF COCCIDIOSIS
WO2000072858A1 (en) * 1999-05-28 2000-12-07 Ecopsi Food additive composition for preventive treatment of coccidiosis
EP4011385A1 (en) * 2020-12-07 2022-06-15 Diko Holger Becker Active substance for the treatment of mastitis

Also Published As

Publication number Publication date
AU4272596A (en) 1997-03-19

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