WO1996020648A1 - Fil de suture absorbable biocompatible et procede de fabrication - Google Patents

Fil de suture absorbable biocompatible et procede de fabrication Download PDF

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Publication number
WO1996020648A1
WO1996020648A1 PCT/US1995/016813 US9516813W WO9620648A1 WO 1996020648 A1 WO1996020648 A1 WO 1996020648A1 US 9516813 W US9516813 W US 9516813W WO 9620648 A1 WO9620648 A1 WO 9620648A1
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WO
WIPO (PCT)
Prior art keywords
filaments
yarn
suture
extruded
absorbable
Prior art date
Application number
PCT/US1995/016813
Other languages
English (en)
Inventor
Jeffrey D. Hutton
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Priority to EP95943967A priority Critical patent/EP0804125A4/fr
Priority to AU45290/96A priority patent/AU4529096A/en
Publication of WO1996020648A1 publication Critical patent/WO1996020648A1/fr

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Classifications

    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M23/00—Treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, characterised by the process
    • D06M23/10—Processes in which the treating agent is dissolved or dispersed in organic solvents; Processes for the recovery of organic solvents thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/12—Stretch-spinning methods
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
    • D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
    • D—TEXTILES; PAPER
    • D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
    • D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
    • D02J1/00—Modifying the structure or properties resulting from a particular structure; Modifying, retaining, or restoring the physical form or cross-sectional shape, e.g. by use of dies or squeeze rollers
    • D02J1/08—Interlacing constituent filaments without breakage thereof, e.g. by use of turbulent air streams
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M7/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made of other substances with subsequent freeing of the treated goods from the treating medium, e.g. swelling, e.g. polyolefins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M2200/00—Functionality of the treatment composition and/or properties imparted to the textile material
    • D06M2200/40—Reduced friction resistance, lubricant properties; Sizing compositions

Definitions

  • This invention relates generally to a method of forming a suture yarn for use in medical sutures and to the formed suture yarn itself. More particularly, the invention relates to a method of making an absorbable, biocompatible suture yarn from a bioabsorbable polymer.
  • Sutures for use in the medical field are predominantly multi-filament structures formed by twisting together, braiding or otherwise combining a plurality of filaments.
  • a predetermined number of filaments are combined together to form a suture yarn, and a plurality of suture yarns are braided or twisted together to form the medical suture.
  • a core suture yarn is wrapped in sheath yarns to form the medical suture by either braiding or twisting.
  • the individual filaments are generally fabricated from a polymeric resin, and are optimally formed by extrusion from a polymer melt.
  • a highly desirable polymer for use in forming the individual filaments is poly (glycolic acid) (PGA) .
  • Filaments extruded from PGA are bioabsorbable and biocompatible, and therefore can safely be absorbed into the body after a relatively short time period, making it unnecessary for the sutures to be removed from the patient.
  • PGA poly (glycolic acid)
  • Producing multi-filament suture yarn is conventionally done using a two-step extrusion process.
  • the melted polymer is extruded using known melt-spinning techniques to produce yarns having low orientation. These yarns are subsequently draw-twisted in a second, off-line step whereby the fibers are drawn to strengthen the filaments and then the filaments are twisted to form a cohesive suture yarn.
  • U.S. Patent No. 5,102,419 shows one example of forming surgical sutures using this conventional two-step extrusion process.
  • U.S. Patent No. 5,232,648 forms multi-filament, bioabsorbable sutures using a two-step extrusion process and discloses data of the melt-spinning conditions for forming the fibers and drawing conditions for drawing the fibers into surgical filaments.
  • U.S. Patent No. 5,294,395 discloses an extrusion process and a redrawing process to form a thermoplastic onofilament suture.
  • monofilament sutures are drawn at much slower speeds than multi-filament sutures.
  • the extrusion process in U.S. Patent No. 5,294,395 uses a liquid quenching tank and heaters disposed between the drawing rolls. For at least these reasons, equipment for producing monofilament sutures is inappropriate for producing multi- filament suture yarns.
  • one object of the invention is to provide a high output method of producing surgical yarn made of a bioabsorbable polymer such as poly (glycolic acid) (PGA) .
  • PGA poly (glycolic acid)
  • a method of forming an absorbable biocompatible suture yarn comprises the steps of melt-extruding a bioabsorbable polymer to form a plurality of surgical filaments in a first step, drawing the extruded filaments in a second step, and combining the drawn filaments into a parallel contiguous arrangement to form a yarn.
  • the yarn is fed through an air jet entangler to entangle the filaments in the yarn.
  • surgical filaments used to form the surgical yarn are treated with a finishing solution having a lubricant and an anti-static agent in a non-aqueous-based carrier.
  • an absorbable, biocompatible suture yarn is formed by the step of melt-extruding a bioabsorbable polymer to form a plurality of surgical filaments in a first step, drawing th extruded filaments in a second step, and combining the draw filaments into a parallel contiguous arrangement to form a yarn.
  • the yarn is fed through an air jet entangler to entangle the filaments.
  • Figure l is a schematic diagram of a spin-draw extruder used in accordance with a first embodiment of the present invention
  • Figure 2 is a flow diagram of a method of forming PGA filaments in accordance with the first embodiment of the present invention
  • Figure 3 is a side elevational view of a jet entanglement apparatus for processing the suture filaments in accordance with the present invention
  • Figure 4 is a sectional plan view of part of the air jet entanglement apparatus in accordance with the present invention.
  • Figures 5A and 5B are perspective views of air jet entanglement chambers in accordance with the present invention.
  • Figure 6 is a flow diagram of a method of forming PGA filaments in accordance with a second embodiment of the present invention.
  • Figure 7 is a schematic diagram of a fiber extrusion system used in accordance with the second embodiment of the present invention.
  • Figure 8 is a schematic diagram of a draw-twister used in accordance with the second embodiment of the present invention.
  • the suture yarn produced by the disclosed method is formed from a bioabsorbable polymer .
  • a bioabsorbable polymer hile the embodiment disclosed below uses a poly (glycolic acid) (PGA) in forming the filaments, bioabsorbable polymers such as, for example, glycolide, lactide, caprolactone, p-dioxanone, trimethylene carbonate and other bioabsorbable poly (hydroxycarboxylic acid) and physical and chemical combinations thereof can be used without departing from the scope of the subject invention.
  • PGA poly (glycolic acid)
  • bioabsorbable polymers such as, for example, glycolide, lactide, caprolactone, p-dioxanone, trimethylene carbonate and other bioabsorbable poly (hydroxycarboxylic acid) and physical and chemical combinations thereof can be used without departing from the scope of the subject invention.
  • Extruded PGA polymer yields an absorbable, biocompatible filament ideally suited for use as a suture yarn.
  • the PGA suture safely breaks down in the patient's body after a tim period sufficient for the sutured tissue (for example) to heal .
  • the PGA polymer is used in a spin drawing process and preferably has an inherent viscosity at 30°C of between 0.9 dl/g and 1.2 dl/g as measured in a solvent of hexafluoroacetone sesquihydrate, with a concentration of polymer in the solvent of 0.5% w/v.
  • the moisture content of the polymer prior to extrusion is less than 50 ppm.
  • the method for forming the suture yarn from the PGA polymer in accordance with the first embodiment features three primary processing steps, namely:
  • FIG. 1 shows a spin draw extrusion apparatus for forming the PGA filaments.
  • a dry PGA polymer preferably having a moisture content no greater than 50 ppm, is fed into a hopper 10, extruded through a melt extruder 12 and formed into filaments by a spin head 14 containing filtration media and a spinneret.
  • a 3/4" (an approximately .29 centimeter) diameter, 20:1 1/d extruder is used to form the individual filaments, and is operated at a temperature of 250°C.
  • the formed filaments are then passed through a hot collar 16 and are quenched in air as they drop from the hot collar .
  • the number of filaments used to form a yarn depends on the overall denier of the suture yarn and whether the yarn is to be incorporated into a sheath or core.
  • the finish applicator applies a spin finish solution to the filaments to assist in subsequent processing.
  • the spin finish solution comprises a lubricating agent, e.g., mineral oil, an anti-static agent, such as sorbitan monolaurate, and a solvent, e.g., xylene.
  • Xylene is a non-aqueous carrier and thus will not break down the PGA filaments.
  • the spin finish is washed and rinsed or otherwise removed from the suture yarns after processing is complete.
  • the filaments are combined in a parallel contiguous arrangement to form a yarn 21.
  • a tension is applied to the yarn as it passes over the godets to draw th yarn to the desired draw ratio.
  • godet 20 takes up 2000 feet/minute (fp ) (approximately 60.95 decameters/minute (dpm))of yarn and is not heated
  • godet 22 is heated to 58°C and operated to take up 2005 feet (approximately 61.10 decameters) of yarn per minute
  • godet 24 is heated to 110°C and takes up 9000 fpm (approximately 274.30 decameters) of yarn (per minute) .
  • a draw ratio of approximately 4.5X is achieved by operating the godets at these speeds, although the preferred range of draw ratio can be from 3 to 5X.
  • Filaments extruded for use in sheath or core construction preferably have a denier of between 0.2 to 6.0 denier, more preferably between 1.5 to 3.0 denier and ideally 2.2 denier.
  • Sheath filaments desirably have a low denier to maintain smooth surface characteristics.
  • Core filaments may have a higher denier, especially for suture with a high overall denier .
  • the resulting yarn suitable for use to manufacture PGA braid preferably has a tenacity of at least 6.0 gpd and a breaking elongation between 15% and 40%.
  • a fluid is forced at elevated pressure into a chamber through which the multi-filament yarn is passed.
  • the fluid is preferably air or some other gas.
  • the turbulence of the gas causes the filament to entangle or intermingle in the area impinged by the jet.
  • the movement of the yarn and the size of the chamber interact to create turbulent pulsations which entangle the filaments together . Therefore, even with a constant pressure air supply, the yarn can exit the chamber with discrete regularly spaced apart areas of entanglement alternating with non-entangled areas. The entangled portions are retained by the yarn through subsequent processing steps.
  • jet entanglement of the yarn achieves many of the same features of twisting the yarn but at a much higher speed and with a simpler process, thus reducing the costs associated with combining the individual filaments.
  • the air jet entanglement apparatus 30 comprises a slub catcher 32, eyelets 34, 36 and 38, support frame 40, and quick release connector 42.
  • the entangler also includes an air supply line 44 and a mounting plate 46 for supporting the entanglement device.
  • the mounting plate includes an adjustment slot 48 with adjustment wing nut 50, support box 52, roller 54 and entanglement body 56.
  • the entanglement body 56 is preferably fabricated as an integral single piece from a hard, durable material such as tungsten carbide, ceramic coated steel, or solid ceramic. As best seen in Figures 5A and 5B, the entanglement body is formed to have a chamber 58 extending lengthwise along the moving path of the threadline in which the entanglement takes place, and a threading slot 60 to facilitate easy threading of the suture yarn within the chamber .
  • the chamber 58 can be triangular or rectangular in cross-sectio to facilitate turbulence.
  • the height H of the triangular chamber 58 in Figure 5A i.e., the distance from the base to the apex of the triangular cross-section, is preferably from about 2.0 millimeters to about 5.0 millimeters, and more preferably between 2.3 and 4.3 millimeters.
  • the rectangular chamber 5 in Figure 5B preferably has a height H of approximately 3.1 millimeters and a width W of approximately 1.1 millimeter.
  • the preferred length of the chamber shown in Figure 5B is approximately 25 millimeters.
  • Air or other suitable gas is introduced into the chamber through an orifice 62, which may be oriented at an angle y from a line perpendicular to the longitudinal path of the threadline. Angle y can be from about 0° to about 15°.
  • the diameter of the orifice can range from about 1 to 3 millimeters, and more preferably from about 1 to 1.5 millimeters.
  • the air is introduced into the chamber at a preferred pressure of about 80 to 100 psi (5.6 to 7.0 kilograms per square centimeter), although a range of about 10 to 100 psi (.70 to 7.0 kilograms per square centimeter) is acceptable.
  • the entanglement body 56 is secured to the support frame 40 by a locking plate 64 and locking screw 66.
  • Quick release connector 42 for the air supply line 44 is secured to the support block 52 and, in turn, supports the support frame 40 and allows for consistent and precise positioning of the entanglement body between eyelets 36 and 38.
  • the entanglement body can be of any of the various configurations and dimensions suitable for the suture entangling process of the present invention.
  • suture yarn 21 passes over godet 24, it is then passed through eyelet 34, slot 33 in the slub catcher 32, through eyelet 36 and into chamber 56 at a preferred speed of up to about 9000 fpm (274.31 decameters per minute) .
  • Air is injected from orifice 62 at approximately 80 to 100 psi (5.6 to 7.0 kilograms per square centimete ) and preferably at an angle y of about 5°.
  • the turbulence is characterized by pulsations, i.e., discrete impingements of air, on the suture yarn to produce impingements about, for example, every l cm to 4 cm.
  • a slight tension of between .05 to .10 grams per denier (gpd) is applied to the yarn as it is draw through the entangler. After exiting from chamber 56, the entangled yarn passes through eyelet 38, around roller 54, and onto a take-up spool 68 on winder 69 (see Figure 1) .
  • Subsequent processing of the entangled yarn may entail combining it with other entangled yarns and then twisting o braiding the combined yarns.
  • Sutures can be formed with yarns comprising a separately constructed core around which sheath yarns are braided.
  • 3 to 7 air entangled yarns are individually fed into a center of a structure as it is being braided to compose the core.
  • the to 7 yarns can also be plied or twisted in a separate operation to form a core yarn.
  • the need to ply multiple yarns can be eliminated by spinning large denier yarns having hundreds of filaments.
  • the large denie yarns on the order of from about 100 to about 1000 denier, are jet entangled in accordance with the invention.
  • sheath yarns do not need to be plied.
  • about 4 to 36 sheath yarns may be braided around a constructed core to form the finished suture.
  • the finished suture may be braided with sheath yarns only and thus without a core.
  • spin drawing a PGA polymer to form surgical filaments and subsequently processing the filament yarn using an air entangler offers many advantages over conventional medical suture forming methods.
  • spin drawing a PGA polymer significantly increases production over the conventional two-step extrusion method of forming suture filaments.
  • using a jet entangler to entangle the yarn eliminates the need for a twisting operation of the individual filaments and the accompanying capital costs of twisting equipment and facilities, resulting in lower production costs.
  • Another advantage of jet entanglement is that yarn processability is improved and breakage of filaments is reduced. Even if the filament breaks it can only strip back as far as the next closest impingement or entangled area, which is generally no more than about 1 to 4 centimeters.
  • air entanglement tends to imbed broken ends of filaments within the suture yarn, reducing the likelihood that the broken filaments will accumulate during further processing. These results are especially important when the individual filaments possess a low denier, e.g., a denier less than 2. Therefore, another related advantage of employing jet entanglement is that it enables the suture to be made from filaments of low denier at a low defect rate. Use of lower denier filaments, as discussed above, is desirable because lower denier filaments result in a smoother suture.
  • PGA polymer is used in a two step lag-drawing process that includes two primary processing steps, namely:
  • the PGA polymer used in the lag- drawing process preferably has an inherent viscosity at 30° of between 0.9 dl/g and 1.2 dl/g as measured in a solvent o hexafluoroacetone sesquihydrate, with a concentration of polymer in solvent of 0.5% w/v.
  • the moisture content of th polymer prior to extrusion is less than 50 ppm.
  • Figure 6 is a flow diagram of a method of forming PGA filaments in accordance with the second embodiment of the present invention.
  • Multi-filament yarns fabricated from the PGA polymer resin are melt extruded using an extrusion system a shown in Figure 7.
  • the step is substantially similar to ho the individual filaments are formed in step 1 of the first embodiment, except that two spin heads 14 are used.
  • a dry PGA polymer preferably having a moisture content no greater than 50 ppm, is fed into a hopper 10, extruded to a melt extruder 12 and formed into filaments by spin heads 14 containing filtration media and a spinneret.
  • a 3/4" (an approximately .29 centimeter) diameter, 20:1 1/d extruder is used to form the individual filaments, and is operated at a temperature of 250°C.
  • the formed filaments are then passed through hot collar 16 and are quenched in air as they drop from the hot collar. After quenching, the individual filaments are passed through a finish applicator 18 and then over a multitude of godets 26 which are rotated at substantially the same speed of, for example, 1800 fpm (54.86 decameter per minute) and used to direct the as-spun filaments to low speed winders 80.
  • the finish applicator applies a spin finish solution to the filaments to assist in subsequent processing.
  • the spin finish solution comprises a lubricating agent, e.g., mineral oil, an anti-static agent, such as sorbitan monolaurate, and a solvent, e.g., xylene.
  • Xylene is a non-aqueous carrier and thus will not break down the PGA filaments.
  • the spin finish is washed and rinsed or otherwise removed from the suture yarns after processing is complete.
  • the lubricating agent is chosen to have certain characteristics such that it is biocompatible with mammals, has sufficient lubricity to minimize filament to filament friction and filament breakage, is liquid at the temperature of application, is hydrophobic, and has a viscosity at the temperature of application of between l and 100 cp.
  • the desired lubricant is also essentially free of water or moisture so as to be chemically and physically nonreactive with the filament composition.
  • each draw twisting apparatus includes a feed roll 86, draw roll 88 and a heat set roll 90 for drawing the multi-filament yarn.
  • a take-up spindle 92 is used to wind the drawn filaments and, at the same time, impart a twisting motion to the filaments to provide about, for example, 1 to 2 twists per inch (approximately 2.564 centimeters) to the drawn filaments.
  • the draw ratio of the yarn as it is processed by the draw twisting apparatus can be, for example, in the range of 2 to 20, and more preferably in the range of 4 to 5.
  • the draw-twisted yarn is tested and then used for subsequent processing, suc as braiding, to form sutures as discussed above with respec to the first embodiment.
  • both first and second embodiments use a lubricant and a finishing solution that is, among other characteristics, hydrophobic. In this manner, the PG filaments formed in the suture will not be broken down prematurely.
  • the drawing step can be performed a relatively long period of time after the filaments are spun for example, a day or two later.
  • the subject invention also contemplates performing the drawing step substantially immediately after the filaments are spun and lubricated to prevent aging of the filaments.
  • the second embodiment also contemplates using an air jet entangler, as disclosed above with respect to the first embodiment, to entangle the multi -filament yarn produced in the spinning process of step 1.
  • the air jet entangler would replace the draw-twisting apparatus.
  • the as-spun filaments are subsequently drawn over a series of godets rotating at sequentially increasing speeds to be drawn at a ratio in, for example, the range of 2 and 20, and more preferably in the range of 4 to 5.
  • the drawing step can be performed a relatively long period of time after the filaments are spun, for example, a day or two later.
  • the modified process also contemplates performing the drawing step substantially immediately after the filaments are spun and lubricated to prevent aging of the filaments.
  • the filaments which are combined in a parallel contiguous arrangement to form a yarn, are sent through the air jet entangler to be entangled as discussed above in step 3 of the first embodiment.
  • the entangled filaments are then wound up conventionally, i.e., without twisting.

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  • Engineering & Computer Science (AREA)
  • Textile Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Procédé de fabrication d'un fil de suture médicale absorbable et biocompatible (21) consistant en l'étape de pultrusion d'un polymère bioabsorbable, afin d'obtenir des filaments de suture (19). On applique aux filaments (19) une finition au moyen d'un support à base non aqueuse pendant le traitement et on réalise une étape d'embrouillement sous l'effet d'air après la combinaison des filaments (19) en fil de suture (21).
PCT/US1995/016813 1995-01-03 1995-12-22 Fil de suture absorbable biocompatible et procede de fabrication WO1996020648A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP95943967A EP0804125A4 (fr) 1995-01-03 1995-12-22 Fil de suture absorbable biocompatible et procede de fabrication
AU45290/96A AU4529096A (en) 1995-01-03 1995-12-22 Absorbable biocompatible suture and method of manufacture

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US36788095A 1995-01-03 1995-01-03
US36760695A 1995-01-03 1995-01-03
US08/367,606 1995-01-03
US08/367,880 1995-01-03
US39095295A 1995-02-21 1995-02-21
US08/390,952 1995-02-21

Publications (1)

Publication Number Publication Date
WO1996020648A1 true WO1996020648A1 (fr) 1996-07-11

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PCT/US1995/016813 WO1996020648A1 (fr) 1995-01-03 1995-12-22 Fil de suture absorbable biocompatible et procede de fabrication

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EP (1) EP0804125A4 (fr)
AU (1) AU4529096A (fr)
WO (1) WO1996020648A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130226236A1 (en) * 2010-11-02 2013-08-29 Intuitive Medi Corp Inc. Suture manufactured using poly octyl cyanoacrylate and manufacturing method therefor
EP2642002A1 (fr) * 2010-11-15 2013-09-25 Kureha Corporation Fil non-tiré en résine d'acide polyglycolique, fil tiré en résine d'acide polyglycolique utilisant ledit fil non tiré, et procédé de production de chaque fil
US9517062B2 (en) 2014-12-03 2016-12-13 Smith & Nephew, Inc. Closed loop suture for anchoring tissue grafts
US10925716B2 (en) 2015-02-25 2021-02-23 Smith & Nephew, Inc. Closed loop suture for anchoring tissue grafts

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US4621638A (en) * 1984-07-30 1986-11-11 Pfizer Hospital Products Group, Inc. Hard elastic sutures
US5232648A (en) * 1991-07-19 1993-08-03 United States Surgical Corporation Bioabsorbable melt spun fiber based on glycolide-containing copolymer
US5292328A (en) * 1991-10-18 1994-03-08 United States Surgical Corporation Polypropylene multifilament warp knitted mesh and its use in surgery

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US5275618A (en) * 1991-11-13 1994-01-04 United States Surgical Corporation Jet entangled suture yarn and method for making same
US5288516A (en) * 1993-02-11 1994-02-22 E. I. Du Pont De Nemours And Company Process of producing bioabsorbable filaments

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US4621638A (en) * 1984-07-30 1986-11-11 Pfizer Hospital Products Group, Inc. Hard elastic sutures
US5232648A (en) * 1991-07-19 1993-08-03 United States Surgical Corporation Bioabsorbable melt spun fiber based on glycolide-containing copolymer
US5292328A (en) * 1991-10-18 1994-03-08 United States Surgical Corporation Polypropylene multifilament warp knitted mesh and its use in surgery

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* Cited by examiner, † Cited by third party
Title
See also references of EP0804125A4 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130226236A1 (en) * 2010-11-02 2013-08-29 Intuitive Medi Corp Inc. Suture manufactured using poly octyl cyanoacrylate and manufacturing method therefor
EP2642002A1 (fr) * 2010-11-15 2013-09-25 Kureha Corporation Fil non-tiré en résine d'acide polyglycolique, fil tiré en résine d'acide polyglycolique utilisant ledit fil non tiré, et procédé de production de chaque fil
EP2642002A4 (fr) * 2010-11-15 2014-04-30 Kureha Corp Fil non-tiré en résine d'acide polyglycolique, fil tiré en résine d'acide polyglycolique utilisant ledit fil non tiré, et procédé de production de chaque fil
JP5735536B2 (ja) * 2010-11-15 2015-06-17 株式会社クレハ ポリグリコール酸系樹脂未延伸糸、それを用いたポリグリコール酸系樹脂延伸糸、およびそれらの製造方法
US9493891B2 (en) 2010-11-15 2016-11-15 Kureha Corporation Method for producing polyglycolic acid resin yarn
US9517062B2 (en) 2014-12-03 2016-12-13 Smith & Nephew, Inc. Closed loop suture for anchoring tissue grafts
US10925716B2 (en) 2015-02-25 2021-02-23 Smith & Nephew, Inc. Closed loop suture for anchoring tissue grafts

Also Published As

Publication number Publication date
EP0804125A4 (fr) 1999-05-26
EP0804125A1 (fr) 1997-11-05
AU4529096A (en) 1996-07-24

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