WO1996018736A3 - Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses - Google Patents
Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses Download PDFInfo
- Publication number
- WO1996018736A3 WO1996018736A3 PCT/US1995/015516 US9515516W WO9618736A3 WO 1996018736 A3 WO1996018736 A3 WO 1996018736A3 US 9515516 W US9515516 W US 9515516W WO 9618736 A3 WO9618736 A3 WO 9618736A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reversal
- induction
- reagent
- promoter
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24017—Stromelysin 1 (3.4.24.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU44120/96A AU4412096A (en) | 1994-12-13 | 1995-11-22 | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses |
JP51903596A JP2001526521A (en) | 1994-12-13 | 1995-11-22 | Methods and reagents for treating arthritic conditions, inducing graft tolerance and reversing the immune response |
MX9704440A MX9704440A (en) | 1994-12-13 | 1995-11-22 | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. |
EP95942944A EP0799313A2 (en) | 1994-12-13 | 1995-11-22 | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses |
US08/585,684 US5877021A (en) | 1995-07-07 | 1996-01-12 | B7-1 targeted ribozymes |
Applications Claiming Priority (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35492094A | 1994-12-13 | 1994-12-13 | |
US08/354,920 | 1994-12-13 | ||
US08/363,253 US5891683A (en) | 1993-09-02 | 1994-12-23 | Non-nucleotide containing enzymatic nucleic acid |
US08/363,253 | 1994-12-23 | ||
US08/363,254 US5891684A (en) | 1992-10-15 | 1994-12-23 | Base-modified enzymatic nucleic acid |
US08/363,254 | 1994-12-23 | ||
US08/390,850 US5612215A (en) | 1992-12-07 | 1995-02-17 | Stromelysin targeted ribozymes |
US08/390,850 | 1995-02-17 | ||
US08/426,124 US5716824A (en) | 1995-04-20 | 1995-04-20 | 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes) |
US08/426,124 | 1995-04-20 | ||
US08/432,874 | 1995-05-02 | ||
US08/432,874 US5627053A (en) | 1994-03-29 | 1995-05-02 | 2'deoxy-2'-alkylnucleotide containing nucleic acid |
US43450995A | 1995-05-04 | 1995-05-04 | |
US08/434,509 | 1995-05-04 | ||
US60/000,974 | 1995-07-07 | ||
US60/000,951 | 1995-07-07 | ||
US08/512,861 US6146886A (en) | 1994-08-19 | 1995-08-07 | RNA polymerase III-based expression of therapeutic RNAs |
US08/512,861 | 1995-08-07 | ||
US08/541,365 US5672501A (en) | 1994-12-23 | 1995-10-05 | Base-modified enzymatic nucleic acid |
US08/541,365 | 1995-10-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996018736A2 WO1996018736A2 (en) | 1996-06-20 |
WO1996018736A3 true WO1996018736A3 (en) | 1996-09-19 |
Family
ID=56289667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/015516 WO1996018736A2 (en) | 1994-12-13 | 1995-11-22 | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU4412096A (en) |
CA (1) | CA2207593A1 (en) |
WO (1) | WO1996018736A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8957198B2 (en) | 2003-02-03 | 2015-02-17 | Medtronic, Inc. | Compositions, devices and methods for treatment of Huntington's disease through intracranial delivery of sirna |
US9133517B2 (en) | 2005-06-28 | 2015-09-15 | Medtronics, Inc. | Methods and sequences to preferentially suppress expression of mutated huntingtin |
US9273356B2 (en) | 2006-05-24 | 2016-03-01 | Medtronic, Inc. | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
US9375440B2 (en) | 2006-11-03 | 2016-06-28 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69633272T2 (en) * | 1995-02-08 | 2005-09-08 | Takara Bio Inc., Otsu | Methods for cancer treatment and control |
US5807743A (en) * | 1996-12-03 | 1998-09-15 | Ribozyme Pharmaceuticals, Inc. | Interleukin-2 receptor gamma-chain ribozymes |
CA2275964A1 (en) * | 1996-12-24 | 1998-07-02 | Ribozyme Pharmaceuticals, Inc. | Synthesis of nucleosides and polynucleotides |
US6248878B1 (en) | 1996-12-24 | 2001-06-19 | Ribozyme Pharmaceuticals, Inc. | Nucleoside analogs |
US6319906B1 (en) * | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
WO1998050530A2 (en) * | 1997-05-09 | 1998-11-12 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids: synthesis, selection and use |
US6548657B1 (en) | 1997-06-09 | 2003-04-15 | Ribozyme Pharmaceuticals, Inc. | Method for screening nucleic acid catalysts |
US6280936B1 (en) | 1997-06-09 | 2001-08-28 | Ribozyme Pharmaceuticals, Inc. | Method for screening nucleic acid catalysts |
US6183959B1 (en) | 1997-07-03 | 2001-02-06 | Ribozyme Pharmaceuticals, Inc. | Method for target site selection and discovery |
US6316612B1 (en) | 1997-08-22 | 2001-11-13 | Ribozyme Pharmaceuticals, Inc. | Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides |
WO1999016871A2 (en) * | 1997-09-22 | 1999-04-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissensc | Nucleic acid catalysts with endonuclease activity |
US6656731B1 (en) | 1997-09-22 | 2003-12-02 | Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Nucleic acid catalysts with endonuclease activity |
US6127535A (en) * | 1997-11-05 | 2000-10-03 | Ribozyme Pharmaceuticals, Inc. | Nucleoside triphosphates and their incorporation into oligonucleotides |
US6617438B1 (en) | 1997-11-05 | 2003-09-09 | Sirna Therapeutics, Inc. | Oligoribonucleotides with enzymatic activity |
JP2003525017A (en) | 1998-04-20 | 2003-08-26 | リボザイム・ファーマシューティカルズ・インコーポレーテッド | Nucleic acid molecules with novel chemical composition that can regulate gene expression |
AU751480B2 (en) * | 1998-04-29 | 2002-08-15 | Ribozyme Pharmaceuticals, Inc. | Nucleoside triphosphates and their incorporation into ribozymes |
EP1493818A3 (en) * | 1998-04-29 | 2006-02-15 | Ribozyme Pharmaceuticals, Inc. | Nucleoside triphosphates and their incorporation into ribozymes |
EP1114827B1 (en) * | 1999-07-15 | 2010-11-17 | Japan Science and Technology Agency | Novel nucleic acid base pair |
US6831171B2 (en) | 2000-02-08 | 2004-12-14 | Yale University | Nucleic acid catalysts with endonuclease activity |
US7125660B2 (en) | 2000-09-13 | 2006-10-24 | Archemix Corp. | Nucleic acid sensor molecules and methods of using same |
US20050148530A1 (en) | 2002-02-20 | 2005-07-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US9994853B2 (en) | 2001-05-18 | 2018-06-12 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
US7132529B2 (en) * | 2001-07-30 | 2006-11-07 | Isis Pharmaceuticals, Inc. | Antisense modulation of stearoyl-CoA desaturase expression |
US20050043256A1 (en) | 2001-07-30 | 2005-02-24 | Isis Pharmaceuticals, Inc. | Antisense modulation of stearoyl-CoA desaturase expression |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
AU2003207708A1 (en) | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
EP2258847B2 (en) | 2002-08-05 | 2020-07-01 | Silence Therapeutics GmbH | Futher novel forms of interfering RNA molecules |
AU2012216354B2 (en) * | 2002-08-05 | 2016-01-14 | Silence Therapeutics Gmbh | Further novel forms of interfering RNA molecules |
US7829694B2 (en) | 2002-11-26 | 2010-11-09 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
US7605249B2 (en) | 2002-11-26 | 2009-10-20 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
US7618948B2 (en) | 2002-11-26 | 2009-11-17 | Medtronic, Inc. | Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA |
US7732591B2 (en) | 2003-11-25 | 2010-06-08 | Medtronic, Inc. | Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna |
US7960355B2 (en) | 2003-05-23 | 2011-06-14 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of the expression of B7 protein |
US7897582B2 (en) | 2003-05-23 | 2011-03-01 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
JP4682152B2 (en) | 2003-12-31 | 2011-05-11 | ザ・ペン・ステート・リサーチ・ファンデーション | Methods for predicting and overcoming resistance to chemotherapy for ovarian cancer and methods for predicting the occurrence of colon cancer |
US10508277B2 (en) | 2004-05-24 | 2019-12-17 | Sirna Therapeutics, Inc. | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference |
WO2006009575A1 (en) | 2004-06-22 | 2006-01-26 | The Board Of Trustees Of The University Of Illinois | METHODS OF INHIBITING TUMOR CELL PROLIFERATION WITH FOXM1 siRNA |
JP5192807B2 (en) * | 2005-06-24 | 2013-05-08 | ヤマサ醤油株式会社 | Stable crystals of protected pseudouridine |
DK2578685T3 (en) | 2005-08-23 | 2019-06-03 | Univ Pennsylvania | RNA CONTAINING MODIFIED NUCLEOSIDES AND METHODS OF USE THEREOF |
CN101321775B (en) | 2005-10-03 | 2012-05-23 | 大学健康网络 | ODCASE inhibitors for the treatment of malaria |
US8669345B2 (en) | 2006-01-27 | 2014-03-11 | Biogen Idec Ma Inc. | Nogo receptor antagonists |
US7741469B2 (en) | 2006-04-05 | 2010-06-22 | University Of Iowa Research Foundation | Compositions for treating hearing loss and methods of use thereof |
EP4082551A1 (en) | 2006-08-08 | 2022-11-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5' phosphate oligonucleotides |
EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
CN102439151A (en) | 2009-03-19 | 2012-05-02 | 默沙东公司 | Rna interference mediated inhibition of btb and cnc homology 1, basic leucine zipper transcription factor 1 (bach 1) gene expression using short interfering nucleic acid (sina) sequence listing |
US20120016011A1 (en) | 2009-03-19 | 2012-01-19 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
US20120035247A1 (en) | 2009-03-19 | 2012-02-09 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
EP2408915A2 (en) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GATA BINDING PROTEIN 3 (GATA3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
SG174581A1 (en) | 2009-03-27 | 2011-10-28 | Merck Sharp & Dohme | RNA INTERFERENCE MEDIATED INHIBITION OF THE INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1)GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
EP2411019A2 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
JP2012521764A (en) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | RNA interference-mediated inhibition of thymic stromal lymphocyte formation factor (TSLP) gene expression using small interfering nucleic acids (siNA) |
WO2010111464A1 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
WO2010111468A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
CA2781896C (en) | 2009-12-09 | 2021-03-30 | Nitto Denko Corporation | Modulation of hsp47 expression |
AU2011255203B2 (en) | 2010-05-21 | 2016-01-21 | Peptimed, Inc. | Reagents and methods for treating cancer |
SG186438A1 (en) | 2010-06-24 | 2013-01-30 | Quark Pharmaceuticals Inc | Double stranded rna compounds to rhoa and use thereof |
CN103068980B (en) | 2010-08-02 | 2017-04-05 | 瑟纳治疗公司 | Using short interfering nucleic acid(siNA)The connection albumen led of mediated rnai(Cadherin related protein matter), β 1(CTNNB1)The suppression of gene expression |
KR102072631B1 (en) | 2010-08-17 | 2020-02-03 | 시르나 쎄러퓨틱스 인코퍼레이티드 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
EP3372684B1 (en) | 2010-08-24 | 2020-10-07 | Sirna Therapeutics, Inc. | Single-stranded rnai agents containing an internal, non-nucleic acid spacer |
EP2609106A4 (en) | 2010-08-26 | 2014-03-19 | Merck Sharp & Dohme | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
EP3766975A1 (en) | 2010-10-29 | 2021-01-20 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina) |
KR20130103562A (en) | 2010-11-01 | 2013-09-23 | 펩타임드, 인코포레이티드 | Compositions of a peptide targeting system for treating cancer |
CA2828002A1 (en) | 2011-03-03 | 2012-09-07 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating lung disease and injury |
EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
TWI658830B (en) | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Retinoid-liposomes for enhancing modulation of hsp47 expression |
US10196637B2 (en) | 2011-06-08 | 2019-02-05 | Nitto Denko Corporation | Retinoid-lipid drug carrier |
CN104080912A (en) | 2012-01-12 | 2014-10-01 | 夸克制药公司 | Combination therapy for treating hearing and balance disorders |
DK2895608T3 (en) | 2012-09-12 | 2019-01-21 | Quark Pharmaceuticals Inc | DOUBLE-STRENGTHED OIGONUCLEOTIDE MOLECULES FOR P53 AND PROCEDURES FOR USING IT |
EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
WO2023097308A1 (en) | 2021-11-29 | 2023-06-01 | Hongene Biotech Corporation | Synthesis of 2' acetyl-ester protected nucleosides |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991010671A1 (en) * | 1990-01-11 | 1991-07-25 | Isis Pharmaceuticals, Inc. | Compositions and methods for detecting and modulating rna activity and gene expression |
EP0519463A1 (en) * | 1991-06-20 | 1992-12-23 | Europäisches Laboratorium Für Molekularbiologie (Embl) | Synthetic, catalytic oligonucleotides |
WO1993023569A1 (en) * | 1992-05-11 | 1993-11-25 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
WO1994002595A1 (en) * | 1992-07-17 | 1994-02-03 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of animal diseases |
WO1995004818A1 (en) * | 1993-08-06 | 1995-02-16 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting human immunodeficiency virus replication |
WO1995013380A2 (en) * | 1993-11-12 | 1995-05-18 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of arthritic conditions |
WO1995013378A1 (en) * | 1993-11-08 | 1995-05-18 | Ribozyme Pharmaceuticals, Inc. | Base-modified enzymatic nucleic acid |
WO1995023225A2 (en) * | 1994-02-23 | 1995-08-31 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting the expression of disease related genes |
-
1995
- 1995-11-22 AU AU44120/96A patent/AU4412096A/en not_active Abandoned
- 1995-11-22 WO PCT/US1995/015516 patent/WO1996018736A2/en not_active Application Discontinuation
- 1995-11-22 CA CA002207593A patent/CA2207593A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991010671A1 (en) * | 1990-01-11 | 1991-07-25 | Isis Pharmaceuticals, Inc. | Compositions and methods for detecting and modulating rna activity and gene expression |
EP0519463A1 (en) * | 1991-06-20 | 1992-12-23 | Europäisches Laboratorium Für Molekularbiologie (Embl) | Synthetic, catalytic oligonucleotides |
WO1993023569A1 (en) * | 1992-05-11 | 1993-11-25 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
WO1994002595A1 (en) * | 1992-07-17 | 1994-02-03 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of animal diseases |
WO1995004818A1 (en) * | 1993-08-06 | 1995-02-16 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting human immunodeficiency virus replication |
WO1995013378A1 (en) * | 1993-11-08 | 1995-05-18 | Ribozyme Pharmaceuticals, Inc. | Base-modified enzymatic nucleic acid |
WO1995013380A2 (en) * | 1993-11-12 | 1995-05-18 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of arthritic conditions |
WO1995023225A2 (en) * | 1994-02-23 | 1995-08-31 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting the expression of disease related genes |
Non-Patent Citations (7)
Title |
---|
BBA 1219 (1994),405-12 [ZP303] * |
J.EXP.MED. 180 (1994),631-40, XP000568831 * |
JBC 270 (1995), 25702-... * |
NAR 23 (1995),2677-84 * |
SYMONS R H: "RIBOZYMES", CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 4, no. 3, 1 June 1994 (1994-06-01), pages 322 - 330, XP000523747 * |
TAIRA, K. & NISHIKAWA, S.: "Construction of several kinds of ribozymes: their reactivities and utilities", ERICKSON, R. & IZANT, J. 'GENE REGULATION: BIOLOGY OF ANTISENSE RNA AND DNA';RAVEN PRESS, NEW YORK, US; 1992, pages 35 - 54, XP002002021 * |
USMAN, N. ET AL.: "Chemical modification of hammerhead ribozymes: activity and nuclease resistance", NUCL.ACIDS SYMP.SER. 31 (09/11-11-94);163-4, XP002002020 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8957198B2 (en) | 2003-02-03 | 2015-02-17 | Medtronic, Inc. | Compositions, devices and methods for treatment of Huntington's disease through intracranial delivery of sirna |
US9133517B2 (en) | 2005-06-28 | 2015-09-15 | Medtronics, Inc. | Methods and sequences to preferentially suppress expression of mutated huntingtin |
US9273356B2 (en) | 2006-05-24 | 2016-03-01 | Medtronic, Inc. | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
US9375440B2 (en) | 2006-11-03 | 2016-06-28 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
Also Published As
Publication number | Publication date |
---|---|
AU4412096A (en) | 1996-07-03 |
WO1996018736A2 (en) | 1996-06-20 |
CA2207593A1 (en) | 1996-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1996018736A3 (en) | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses | |
EP0654077A4 (en) | Method and reagent for treatment of animal diseases. | |
EP2361923A3 (en) | Oligoribonucleotides and ribonucleases for cleaving RNA | |
WO2001025488A3 (en) | Method for enrichment of natural antisense messenger rna | |
CA2162361A1 (en) | Antisense oligonucleotides which combat aberrant splicing and methods of using the same | |
ZA981762B (en) | Nucleic acid molecules encoding enzymes having fructosyl polymerase activity. | |
WO1994025612A3 (en) | Nucleotide sequences for the control of the expression of dna sequences in a cellular host | |
EP1700915A3 (en) | Enzymatic DNA molecules | |
WO1995031541A3 (en) | Methods and compositions for treatment of restenosis and cancer using ribozymes | |
DE69736598D1 (en) | Ribonucleic acid RNA preparation and its use | |
AU5982996A (en) | Method for the specific coupling of the cap of the 5' end of an mRNA fragment and preparation of mRNA and of complete cDNA | |
WO2003046173A1 (en) | siRNA EXPRESSION SYSTEM AND PROCESS FOR PRODUCING FUNCTIONAL GENE-KNOCKDOWN CELLS AND THE LIKE USING THE SAME | |
WO1995006731A3 (en) | Non-nucleotide containing enzymatic nucleic acid | |
CA2177732A1 (en) | Antisense oligonucleotides having tumorigenicity-inhibiting activity | |
GR3024597T3 (en) | 7-deazapurine modified oligonucleotides | |
PT1053313E (en) | OLIGONUCLEOTIDOS '' ANTISENSE '' OPTIMIZED COMPLEMENTARY SEQUENCES OF DNA METHYLTRANSFERASE | |
NO951364D0 (en) | DNA compounds comprising sequences encoding mannuronan C-5 epimerase | |
EP0656070A4 (en) | Nucleic acid probes for bacteria of the genus legionella. | |
WO1998032846A3 (en) | Enzymatic nucleic acid treatment of diseases or conditions related to levels of c-fos | |
EP1118667A4 (en) | Novel enzyme compositions, process for producing the same and utilization of the same | |
MX9704440A (en) | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. | |
EP0794256A3 (en) | Method for culturing microorganisms having methanol metabolic pathway | |
WO2001088124A3 (en) | Method and reagent for the inhibition of erg | |
WO1997035960A8 (en) | Purified proteins, recombinant dna sequences and processes for producing caffeine free beverages | |
AU1981295A (en) | Novel protein-kinase, nucleic acid sequences encoding the same and methods related thereto |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AU CA JP MX |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AU CA JP MX |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
ENP | Entry into the national phase |
Ref document number: 2207593 Country of ref document: CA Ref country code: CA Ref document number: 2207593 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1995942944 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1995942944 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1995942944 Country of ref document: EP |