WO1996015242A3 - Methods for inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor - Google Patents

Methods for inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor Download PDF

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Publication number
WO1996015242A3
WO1996015242A3 PCT/US1995/015000 US9515000W WO9615242A3 WO 1996015242 A3 WO1996015242 A3 WO 1996015242A3 US 9515000 W US9515000 W US 9515000W WO 9615242 A3 WO9615242 A3 WO 9615242A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibiting
methods
cell proliferation
inhibitory factor
mitogenic activity
Prior art date
Application number
PCT/US1995/015000
Other languages
French (fr)
Other versions
WO1996015242A2 (en
Inventor
Graeme J Wistow
Vishwas Paralkar
Original Assignee
Us Health
Graeme J Wistow
Vishwas Paralkar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Graeme J Wistow, Vishwas Paralkar filed Critical Us Health
Priority to AU43657/96A priority Critical patent/AU4365796A/en
Publication of WO1996015242A2 publication Critical patent/WO1996015242A2/en
Publication of WO1996015242A3 publication Critical patent/WO1996015242A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

This invention is directed to methods of inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor ('MIF'). Inhibitory nucleic acids directed against MIF inhibit cell growth in both cells induced by growth factors and transformed (malignant) cells that express oncogenes.
PCT/US1995/015000 1994-11-16 1995-11-16 Methods for inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor WO1996015242A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43657/96A AU4365796A (en) 1994-11-16 1995-11-16 Methods for inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34082694A 1994-11-16 1994-11-16
US08/340,826 1994-11-16

Publications (2)

Publication Number Publication Date
WO1996015242A2 WO1996015242A2 (en) 1996-05-23
WO1996015242A3 true WO1996015242A3 (en) 1996-08-08

Family

ID=23335092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/015000 WO1996015242A2 (en) 1994-11-16 1995-11-16 Methods for inhibiting cell proliferation by inhibiting the mitogenic activity of macrophage migration inhibitory factor

Country Status (2)

Country Link
AU (1) AU4365796A (en)
WO (1) WO1996015242A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774227B1 (en) * 1993-05-17 2004-08-10 Cytokine Pharmasciences, Inc. Therapeutic uses of factors which inhibit or neutralize MIF activity
CA2318811A1 (en) * 1998-01-30 1999-08-26 Cold Spring Harbor Laboratory Modulation of cell proliferation, methods and reagents
AU5322699A (en) * 1998-07-27 2000-02-21 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Conversion of naturally-occurring quinones to quinone derivatives by macrophage migration inhibition factor and uses thereof
US6268151B1 (en) * 2000-01-20 2001-07-31 Isis Pharmaceuticals, Inc. Antisense modulation of macrophage migration inhibitory factor expression
UY27304A1 (en) 2001-05-24 2002-12-31 Avanir Pharmaceuticals INHIBITORS OF THE INHIBITOR FACTOR OF MIGRATION OF MACROPHAGES AND METHODS FOR IDENTIFICATION
TW200418829A (en) 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
CA2600175A1 (en) 2005-03-24 2006-03-20 Avanir Pharmaceuticals Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors
JP2014530360A (en) 2011-10-07 2014-11-17 バクスター・ヘルスケヤー・ソシエテ・アノニムＢａｘｔｅｒ Ｈｅａｌｔｈｃａｒｅ ＳＡ OxMIF as a diagnostic marker

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026307A1 (en) * 1993-05-17 1994-11-24 The Picower Institute For Medical Research Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026307A1 (en) * 1993-05-17 1994-11-24 The Picower Institute For Medical Research Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PARALKAR, V. ET AL.: "Cloning the human gene for macrophage migration inhibitory factor ( MIF ).", GENOMICS, (1994 JAN 1) 19 (1) 48-51, XP000569580 *
PARALKAR, V. ET AL.: "MIF: An essential intermediate for growth factor induced mitogenesis.", ANNUAL MEETING OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, SAN FRANCISCO, CALIFORNIA, USA, MAY 21-25, 1995. & FASEB JOURNAL 9 (6). 1995. A1332, XP002002563 *

Also Published As

Publication number Publication date
AU4365796A (en) 1996-06-06
WO1996015242A2 (en) 1996-05-23

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