WO1996013586A3 - Histiocyte-secreted factor (hsf) - Google Patents

Histiocyte-secreted factor (hsf) Download PDF

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Publication number
WO1996013586A3
WO1996013586A3 PCT/JP1995/002200 JP9502200W WO9613586A3 WO 1996013586 A3 WO1996013586 A3 WO 1996013586A3 JP 9502200 W JP9502200 W JP 9502200W WO 9613586 A3 WO9613586 A3 WO 9613586A3
Authority
WO
WIPO (PCT)
Prior art keywords
hsf
nucleotide sequences
histiocyte
secreted factor
antibodies
Prior art date
Application number
PCT/JP1995/002200
Other languages
French (fr)
Other versions
WO1996013586A2 (en
Inventor
Nobuko Satomi
Original Assignee
Nobuko Satomi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobuko Satomi filed Critical Nobuko Satomi
Publication of WO1996013586A2 publication Critical patent/WO1996013586A2/en
Publication of WO1996013586A3 publication Critical patent/WO1996013586A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides isolated nucleotide sequences encoding histiocyte-secreted factor (HSF) or an HSF analog and the complements of these sequences. Also provided are isolated nucleotide sequences comprising a portion of an HSF genomic sequence, which can consist of coding regions, non-coding regions, or both. The invention includes nucleotide sequences suitable for use as hybridization probes and amplification primers and for insertion into vectors for propagation and expression. The invention also provides isolated HSF polypeptides and analogs, along with anti-HSF antibodies. These polypeptides and antibodies are useful in cancer chemotherapy and as tools in the study of tumor regression.
PCT/JP1995/002200 1994-10-26 1995-10-26 Histiocyte-secreted factor (hsf) WO1996013586A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29778094 1994-10-26
JP6/297780 1994-10-26

Publications (2)

Publication Number Publication Date
WO1996013586A2 WO1996013586A2 (en) 1996-05-09
WO1996013586A3 true WO1996013586A3 (en) 1996-08-01

Family

ID=17851088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1995/002200 WO1996013586A2 (en) 1994-10-26 1995-10-26 Histiocyte-secreted factor (hsf)

Country Status (1)

Country Link
WO (1) WO1996013586A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149751A2 (en) * 1983-11-21 1985-07-31 Kyorin Pharmaceutical Co., Ltd. Proteinaceous substance showing antitumorous action and method for its manufacture
EP0159276A2 (en) * 1984-04-20 1985-10-23 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Substantially purified tumor growth inhibitory factor (tif)
EP0161384A2 (en) * 1984-05-17 1985-11-21 Yamanouchi Pharmaceutical Co., Ltd. Human endogenous cancer regulatory factors, method of preparing the same, and pharmaceutical compositions containing the same
JPS61280431A (en) * 1985-05-29 1986-12-11 Suntory Ltd Novel polypeptide containing antitumor activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149751A2 (en) * 1983-11-21 1985-07-31 Kyorin Pharmaceutical Co., Ltd. Proteinaceous substance showing antitumorous action and method for its manufacture
EP0159276A2 (en) * 1984-04-20 1985-10-23 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Substantially purified tumor growth inhibitory factor (tif)
EP0161384A2 (en) * 1984-05-17 1985-11-21 Yamanouchi Pharmaceutical Co., Ltd. Human endogenous cancer regulatory factors, method of preparing the same, and pharmaceutical compositions containing the same
JPS61280431A (en) * 1985-05-29 1986-12-11 Suntory Ltd Novel polypeptide containing antitumor activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A.M. WANG ET AL: "Molecular cloning of the complementary DNA for human Tumor Necrosis Factor", SCIENCE, vol. 228, 12 April 1985 (1985-04-12), LANCASTER, PA US, pages 149 - 154, XP002000373 *
CHEMICAL ABSTRACTS, vol. 106, no. 23, 8 June 1987, Columbus, Ohio, US; abstract no. 194775g, NISHIHARA TATSURO ET AL: "Novel antitumor polypeptide production by human macrophage-like cells" page 605; column l; XP002000375 *
K. HARANAKA ET AL: "Purification and partial amino acid sequence of rabbit Tumor Necrosis Factor", INTERNATIONAL JOURNAL OF CANCER, vol. 36, 1985, pages 395 - 400, XP002000372 *
KATSUYUKI HARANAKA ET AL: "Establishment and characterization of human myelomonocytic (TYS) and histiocytic (TYH) cell lines", INTERNATIONAL JOURNAL OF CANCER, vol. 36, 1985, pages 313 - 319, XP002000374 *

Also Published As

Publication number Publication date
WO1996013586A2 (en) 1996-05-09

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