WO1996005770A1 - Blood collection, plasma separation, and high precision plasma dispensing device - Google Patents

Blood collection, plasma separation, and high precision plasma dispensing device Download PDF

Info

Publication number
WO1996005770A1
WO1996005770A1 PCT/SE1995/000952 SE9500952W WO9605770A1 WO 1996005770 A1 WO1996005770 A1 WO 1996005770A1 SE 9500952 W SE9500952 W SE 9500952W WO 9605770 A1 WO9605770 A1 WO 9605770A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
plunger
plasma
fluid
blood
Prior art date
Application number
PCT/SE1995/000952
Other languages
French (fr)
Inventor
Karl Erik Sundstrom
Lars Eric Sundstrom
Hans Olof Sundstrom
Original Assignee
Karl Erik Sundstrom
Lars Eric Sundstrom
Hans Olof Sundstrom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Erik Sundstrom, Lars Eric Sundstrom, Hans Olof Sundstrom filed Critical Karl Erik Sundstrom
Publication of WO1996005770A1 publication Critical patent/WO1996005770A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components

Definitions

  • Plasma separation Blood collection, plasma separation, and high precision plasma dispensing device.
  • This invention relates to an apparattis and a method for collecting a multiphase fluid such as blood and for separating and partitioning said fluid into a lighter phase and more partic ularly to blood collection in milliliter quantities , to plasma separation by centrifugation and to high precision plasma dispensings in microliter quantities, BACKGROUND
  • Specimen collection and specimen handling is an area of verv high cost, becautse it is very labour intensive. It is also prone to error. It subjects workers to biohazards from infectiuous agents which contami nate blood and is the area which at present is considered to be in greatest need of technological innovation and improvement.
  • the integral specimen collection, plasma separation and high precision plasma dispensing devise consists of a syringe with a p l unger designed as a cup and beeng provided with a ring shaped part with a self tapping screw working in the syringe when rotated, said cup is large enough to contain a plasma separating thixotropic gel and all the parts of the blood hea v i er then the plasma.
  • the ring shaped part on its bad side may have spoakes for engagement to turning devises.
  • the syringe is evacuated, and it is filled lite any other known evacuated specimen col l ect i on tube through a rubber stopper.
  • the plasma separation is performed by centrif ug n t ion or the syringe.
  • the heavier parts of the blood is trapped in the plunger behind the gel plug, which by force created by centrifugation has moved from the bottom of the cup towards its top, thus leaving the p l asma in front of the plunger free to be dispensed from the syringe when the plunger is advanced.
  • Flasma dispensing is done through dispensing device after penetrating the rubber stopper.
  • the size and the high precision of the volume dispensed may be controlled by the angu l ar movement of the plunger, which worts as an internal micrometer screw inside the syringe.
  • Fig 1 shows a cross section of the evacuated blood collection device empty except for a volume of thi xotropic gel at the bottom.
  • Fig 2 shows a cross section of the device equiped with a need l e and filled with blood.
  • Fig 3 shows a cross section of the device after centrifugation.
  • Fig 4 shows a cross section of the devise equipped with a delivery tip.
  • Fi g 5 shows the device of Fig 1 providec with a linearyl movable plungerrod 19.
  • the device consists of a plastic syringe 1 equi pped with a plunger 2 that is shaped lite a deep cup. This cup is pressfitted into an other plunger 3, which is equi pped with a self tapping scew thread 4 threading the syringe 1.
  • the plunger-cup 2 is partly filled with a gel-l i ke thi xothropic agent 5 of the type in common practise to separ ate the plasma from the rest of the blood.
  • the syringe is provided with a rubber stopper 6.
  • the plunger 3 is equipped with blade-life radially oriented spoakes 7 for eng agement to turning devices.
  • FIG. 1 shows the blood-collection device equipped with a hypodermic needle 8 fitted onto a valve containing adaptor 9 (eqiped with a needle 10) for multiple prelevment of a type used in common prax is by the profession.
  • the needle 10 is shown penetrating the rubberstooper 6.
  • the syringe is filled with blood 11.

Abstract

The device consists of a syringe (1) with a plunger designed as a cup (2) large enough to contain a plasma separating thixotropic gel (5) and all the heavier parts of the blood. By centrifugation the gel plug has moved to cover the heavier parts of the blood, which is trapped in the plunger (2), leaving the plasma free in front to be dispensed from the syringe by advancing the plunger (2).

Description

Blood collection, plasma separation, and high precision plasma dispensing device.
FI ELD OF INVENTION
This invention relates to an apparattis and a method for collecting a multiphase fluid such as blood and for separating and partitioning said fluid into a lighter phase and more partic ularly to blood collection in milliliter quantities , to plasma separation by centrifugation and to high precision plasma dispensings in microliter quantities, BACKGROUND
Specimen collection and specimen handling is an area of verv high cost, becautse it is very labour intensive. It is also prone to error. It subjects workers to biohazards from infectiuous agents which contami nate blood and is the area which at present is considered to be in greatest need of technological innovation and improvement.
PRIOR ART
It is clear that the solutions to many of the problems associated with spec i men handling are robotisation and automation, however, presently used manual or robotic, automated or computer-controlled liquid hand l i ng and metr in g devi ces (pumps , p i pettors and di l utors ) are not ver y well adapted to robotic handling. Traditional automaticelly controlled liquid metering devices are heavy complex mechanisms, using reciprocating pistons in syringes connected to motor driven values. These valves are connected to liquid reservoirs via liquid carrying tubing and to sampling and delivery tips that are manipulated by robotic arms. The very high cost and complexity of such devices and the necessi t y for tubing carrying liquids. requi res that the same pump is usedfor many different liquids, bloodsamples, standards, diluents and reagents. This in turn leads to problems of carry-over and cross-contamination, further complicated by the necessity for washing (and wiping) sampling and dispensing tips before they can be introduced into any new liquid such as biood samples, standards or reagents. Rinsing and washing stations, rinsing liquids. tubing, pumps and collection reservoirs f or rincing liquids, all enlarage contaminated territorv , as well as adding to the size, cost and complexity of the structure. This also adds maintenance work on potentially contaminated material and increases operating costs and biohazards for the personnel. Often blood samples are received in the laboratory in tubes provided with a rubber stopper and identification marks. The liquid level of the plasma and the level of the heavier parts of the blood varies from tube to tube, for that reason traditional robotic liqid handling stations in the laboratory must be provided with expensive liquid level sensing devices for proper positionig of sampling tips. Removing the rubber stopper is the first step in 3 chain of mani pul at i ons which constitute bio-hazard risk . In many cases manual or robotic distribution of aliquots of sample are done into open containers or cups, that in turn are to be distributed to different analysis stations. In these and similar operations the direct identification with the original label on the recei ved sample tube is not always positively secured.
OBJECT OF THE INVENTION
It is the object of the present invention to provide an improved blood specimen collection, plasma separating and plasma dispensing device avoiding the aforementioned drawbacks.
It is a further object of the present invention to provide an an integral specimen collection and plasma dispensing device that easily and costeffectably can be handled by robotic manipulation, thus permitting and si mp l i f yi ng total automation of specimen handling.
It is a further object of the present invention to provide a plasma dispensing device that easily and safely can be handeled manuelly.
It is a further object of the present invention to provide an integral blood specimen collection, plasma separating and plasma dispensing device, that is low in cost and disposable.
It is a f urther object of the present invention to compleatly eliminate the transfer of the original sample from the original collection device for delivery of precisequant i t i es of plasma in the volume range required by clinical chemistry analysis, thereby eliminating many of the problems in prior art devices described earlier.
It is a further object of the present invention to compleatly eliminate the need for liquid level sensing devices in dedicated analytical instruments or robotic wortstations. It is a further object of this invention to provide a plasma d i spensi ng device that compleatly eliminates cross contamination.
It is a further object of this invention to guarantee positive identification of everv plasma dispensing performed, by the fact that the dispensing is done by the one and same original device as it was collected in.
It is a further object of this invention to reduce the bioharard to tersonnel in the laboratorv, bv the fact that the sample is kept in and man i pul ated and translocated in a closed container.
SUMMARY OF THE INVENTION
In accordance with these and other objects are accomp l i shed b y an apparatus as outlined in claim 1 a preffered embod yment of the invention the integral specimen collection, plasma separation and high precision plasma dispensing devise consists of a syringe with a p l unger designed as a cup and beeng provided with a ring shaped part with a self tapping screw working in the syringe when rotated, said cup is large enough to contain a plasma separating thixotropic gel and all the parts of the blood hea v i er then the plasma. The ring shaped part on its bad side may have spoakes for engagement to turning devises. The syringe is evacuated, and it is filled lite any other known evacuated specimen col l ect i on tube through a rubber stopper. The plasma separation is performed by centrif ug n t ion or the syringe. The heavier parts of the blood is trapped in the plunger behind the gel plug, which by force created by centrifugation has moved from the bottom of the cup towards its top, thus leaving the p l asma in front of the plunger free to be dispensed from the syringe when the plunger is advanced. Flasma dispensing is done through dispensing device after penetrating the rubber stopper. The size and the high precision of the volume dispensed may be controlled by the angu l ar movement of the plunger, which worts as an internal micrometer screw inside the syringe.
BR IEF DESCRIPTION OF THE DRAWINGS
Fig 1 shows a cross section of the evacuated blood collection device empty except for a volume of thi xotropic gel at the bottom.
Fig 2 shows a cross section of the device equiped with a need l e and filled with blood.
Fig 3 shows a cross section of the device after centrifugation.
Fig 4 shows a cross section of the devise equipped with a delivery tip.
Fi g 5 shows the device of Fig 1 providec with a linearyl movable plungerrod 19.
DETAILED DESCRIPTION OF THE DRAWINGS.
Refering to fig 1 of the drawings, that shows a cross section the blood-collection device unfilled, it will be seen that the device consists of a plastic syringe 1 equi pped with a plunger 2 that is shaped lite a deep cup. This cup is pressfitted into an other plunger 3, which is equi pped with a self tapping scew thread 4 threading the syringe 1. The plunger-cup 2 is partly filled with a gel-l i ke thi xothropic agent 5 of the type in common practise to separ ate the plasma from the rest of the blood. The syringe is provided with a rubber stopper 6. The plunger 3 is equipped with blade-life radially oriented spoakes 7 for eng agement to turning devices.
Refering to fig 2 of the drawings which showes the blood-collection device equipped with a hypodermic needle 8 fitted onto a valve containing adaptor 9 (eqiped with a needle 10) for multiple prelevment of a type used in common prax is by the profession. The needle 10 is shown penetrating the rubberstooper 6. The syringe is filled with blood 11.
Ref ering to fig 3 of the drawings which shows the syringe with the needle 3 and adaptor assembly 9 of fig 2 removed. It also snows the rearrangement of the content of the syringe after an appropr i ate time and speed of centrifugation. The gel-like agent 12 separates the plasma 13 free from the heavier parts of the blood 14 trapped inside the plunger cup 2 behind the gel plug which has moved from the bottom of the cup towards the top.
Retering to fig 4 of the drawings which shows the syri nge 1 equipped with with a plastic tip 15 f i tted onto a dispensing device 9 whose needle 10 penetrates the rubber-stopper 6. 16 indicates the thread tapped in the plastic body of the syringe 1 by the rotated part 3, which is shown advanced to a new position with reference to its position in fig 3.
Refering to fig 3 of the drawings, that shows the device offig 1 provided with a linearly movable plunger rod 19.

Claims

CLAIMS:
1. An apparatus for collecting a multiphase fluid such as blood and for separation and par titioning said fluid in to a lighter phase and a heavier phase, comprising
a syringe (1) being open at one end (17) and having an opening (18) at the other end for recieving a hypodermic needle (8) or a dispensing device respectivly , a plunger (2) being shaped lite a cup and being partly filled with gel-like thi xotropic soent (5),
2. The apparatus of claim 1, wherein said syringe (1) is evacuated and said opening (18) at said other end is provided with a rubber stopper (6).
3. The apparatus of claim 2, wherein means (3,4) are provided to prevent said plunger (2) from moving into said evacuated syringe (1).
4. The apparatus of claim 3, wherein said means consists of a ring shaped part (3), said part being pressfitted into said plunger (2) and being provided with a self-tapping screw (4).
5. The apparatus of claim 4, wherein said ring shaped part (3) is provided with engagement means (7) for rotating said part (3).
6. The apparatus of claim 5, wherein said ring shaped part (3) is provided with spokes (7) f or engaging motoric means.
7. The apparatus of claim 1, wherein means (19) is provided for moving said plunger (2).
8. The apparatus of claim 1, wherein said plunger (2) is prov ided with a sealing lip (20) around its open end.
9. A method for collecting a muliphase fluid such as blood and for separating and partitioning said fluid into a lighter phase and a heavier phase and for dispensing said lighter phase onto a sample means, such method comprising the steps of
sucking said fluid into a syringe according to claim 1, centrifugating said fluid in said syringe,
dispensing said l i ghter phase from said syringe onto said samp l e means.
10. The method of claim 9 , wherein said dispensing step is accomplished by motoric means.
PCT/SE1995/000952 1994-08-19 1995-08-18 Blood collection, plasma separation, and high precision plasma dispensing device WO1996005770A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9402812A SE9402812D0 (en) 1994-08-19 1994-08-19 Blood collection, plasma separation and high precision plasma dispensing device
SE9402812-3 1994-08-19

Publications (1)

Publication Number Publication Date
WO1996005770A1 true WO1996005770A1 (en) 1996-02-29

Family

ID=20394999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1995/000952 WO1996005770A1 (en) 1994-08-19 1995-08-18 Blood collection, plasma separation, and high precision plasma dispensing device

Country Status (2)

Country Link
SE (1) SE9402812D0 (en)
WO (1) WO1996005770A1 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT404317B (en) * 1996-08-02 1998-10-27 Greiner & Soehne C A LOCKING DEVICE, DISCONNECTING DEVICE AND RECEIVING CONTAINER FOR A RECEIVING DEVICE
EP1056490A1 (en) * 1998-02-27 2000-12-06 Cohesion Technologies, Inc. Cell separation device and metering syringe
AT409725B (en) * 1997-05-12 2002-10-25 Greiner & Soehne C A SEPARATOR
US7188734B2 (en) 2001-03-30 2007-03-13 Greiner Bio-One Gmbh Holding device, particularly for bodily fluids, comprising a separating device, and a separating device therefor
EP2277625A1 (en) 2004-01-23 2011-01-26 Greiner Bio-One GmbH Retaining device for blood, body fluids, tissue samples or tissue cultures
US7927563B1 (en) 2009-10-13 2011-04-19 Cytomedix, Inc. Kit for separation of biological fluids
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US8747781B2 (en) 2008-07-21 2014-06-10 Becton, Dickinson And Company Density phase separation device
US8794452B2 (en) 2009-05-15 2014-08-05 Becton, Dickinson And Company Density phase separation device
JP2014533142A (en) * 2012-03-05 2014-12-11 ドンクー バイオ アンド ファルマシーオー．， エルティーディー．Ｄｏｎｇｋｏｏ Ｂｉｏ ＆ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． Component separator
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886928A (en) * 1970-03-07 1975-06-03 Sarstedt W Device for the extraction of blood
EP0265876A2 (en) * 1986-10-27 1988-05-04 Habley Medical Technology Corporation Snap-on vernier syringe
WO1990002516A1 (en) * 1988-09-13 1990-03-22 Safe-Tec Clinical Products, Inc. Self-sealing fluid conduit and collection device
EP0363485A1 (en) * 1987-06-18 1990-04-18 Terumo Kabushiki Kaisha Method and apparatus for collecting blood sample
WO1991000114A1 (en) * 1989-06-23 1991-01-10 Ultradent Products, Inc. Syringe apparatus having improved plunger

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886928A (en) * 1970-03-07 1975-06-03 Sarstedt W Device for the extraction of blood
EP0265876A2 (en) * 1986-10-27 1988-05-04 Habley Medical Technology Corporation Snap-on vernier syringe
EP0363485A1 (en) * 1987-06-18 1990-04-18 Terumo Kabushiki Kaisha Method and apparatus for collecting blood sample
WO1990002516A1 (en) * 1988-09-13 1990-03-22 Safe-Tec Clinical Products, Inc. Self-sealing fluid conduit and collection device
WO1991000114A1 (en) * 1989-06-23 1991-01-10 Ultradent Products, Inc. Syringe apparatus having improved plunger

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277331B1 (en) 1996-08-02 2001-08-21 C. A. Greiner & Söhne Gesellschaft mbH Holding device for body fluids and tissues
AT404317B (en) * 1996-08-02 1998-10-27 Greiner & Soehne C A LOCKING DEVICE, DISCONNECTING DEVICE AND RECEIVING CONTAINER FOR A RECEIVING DEVICE
AT409725B (en) * 1997-05-12 2002-10-25 Greiner & Soehne C A SEPARATOR
EP1056490A1 (en) * 1998-02-27 2000-12-06 Cohesion Technologies, Inc. Cell separation device and metering syringe
EP1056490A4 (en) * 1998-02-27 2003-01-08 Cohesion Tech Inc Cell separation device and metering syringe
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US7188734B2 (en) 2001-03-30 2007-03-13 Greiner Bio-One Gmbh Holding device, particularly for bodily fluids, comprising a separating device, and a separating device therefor
US8448800B2 (en) 2004-01-23 2013-05-28 Greiner Bio-One Gmbh Method for the assembly of a cap with a receptacle
EP2277625A1 (en) 2004-01-23 2011-01-26 Greiner Bio-One GmbH Retaining device for blood, body fluids, tissue samples or tissue cultures
US9452427B2 (en) 2008-07-21 2016-09-27 Becton, Dickinson And Company Density phase separation device
US9714890B2 (en) 2008-07-21 2017-07-25 Becton, Dickinson And Company Density phase separation device
US10350591B2 (en) 2008-07-21 2019-07-16 Becton, Dickinson And Company Density phase separation device
US9933344B2 (en) 2008-07-21 2018-04-03 Becton, Dickinson And Company Density phase separation device
US8747781B2 (en) 2008-07-21 2014-06-10 Becton, Dickinson And Company Density phase separation device
US9700886B2 (en) 2008-07-21 2017-07-11 Becton, Dickinson And Company Density phase separation device
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US9339741B2 (en) 2008-07-21 2016-05-17 Becton, Dickinson And Company Density phase separation device
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US9919308B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US11786895B2 (en) 2009-05-15 2023-10-17 Becton, Dickinson And Company Density phase separation device
US9364828B2 (en) 2009-05-15 2016-06-14 Becton, Dickinson And Company Density phase separation device
US9079123B2 (en) 2009-05-15 2015-07-14 Becton, Dickinson And Company Density phase separation device
US8998000B2 (en) 2009-05-15 2015-04-07 Becton, Dickinson And Company Density phase separation device
US9731290B2 (en) 2009-05-15 2017-08-15 Becton, Dickinson And Company Density phase separation device
US9802189B2 (en) 2009-05-15 2017-10-31 Becton, Dickinson And Company Density phase separation device
US9919309B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US9919307B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US11351535B2 (en) 2009-05-15 2022-06-07 Becton, Dickinson And Company Density phase separation device
US10343157B2 (en) 2009-05-15 2019-07-09 Becton, Dickinson And Company Density phase separation device
US10807088B2 (en) 2009-05-15 2020-10-20 Becton, Dickinson And Company Density phase separation device
US8794452B2 (en) 2009-05-15 2014-08-05 Becton, Dickinson And Company Density phase separation device
US10376879B2 (en) 2009-05-15 2019-08-13 Becton, Dickinson And Company Density phase separation device
US10413898B2 (en) 2009-05-15 2019-09-17 Becton, Dickinson And Company Density phase separation device
US10456782B2 (en) 2009-05-15 2019-10-29 Becton, Dickinson And Company Density phase separation device
US7927563B1 (en) 2009-10-13 2011-04-19 Cytomedix, Inc. Kit for separation of biological fluids
JP2014533142A (en) * 2012-03-05 2014-12-11 ドンクー バイオ アンド ファルマシーオー．， エルティーディー．Ｄｏｎｇｋｏｏ Ｂｉｏ ＆ Ｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． Component separator
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid

Also Published As

Publication number Publication date
SE9402812D0 (en) 1994-08-19

Similar Documents

Publication Publication Date Title
WO1996005770A1 (en) Blood collection, plasma separation, and high precision plasma dispensing device
US5286453A (en) Device for dispensing a biological fluid from a sealed vacuum tube
EP1056490B1 (en) Cell separation device and metering syringe
US5211310A (en) Apparatus and method for dispensing phases of blood
US5163582A (en) Apparatus and method for aliquotting blood serum or blood plasma
US5251786A (en) Biological fluid collection and delivery apparatus and method
US4962044A (en) Test tube filter/dispenser apparatus and method
US5555920A (en) Method and apparatus for aliquotting blood serum or blood plasma
EP0901820A2 (en) Collection container assembly
EP1774342A2 (en) Automated fluid handling cartridge, fluid processing system, and methods
EP0650589A1 (en) Sample tube entry port for a chemical analyzer
US3926521A (en) Blood collecting and processing means
US5132232A (en) Method and apparatus for preparation of liquids for examination
US4119125A (en) Method and apparatus for handling liquid samples
US6302836B1 (en) Method for partitioning blood and delivering clean serum
EP0901817B1 (en) Collection container assembly
WO2019038714A1 (en) Piercing device and systems for liquid and gas handling
WO2014022653A1 (en) Biological liquid collection vessels, systems, and methods
US4930360A (en) Liquids sampler
US4974460A (en) Precision locating and supporting device
EP1092140B1 (en) Method and apparatus for extracting liquid samples from a closed container
US11480551B2 (en) Sample injector and sampling method, in particular for liquid chromatography
US3626762A (en) Method and apparatus for filling a capillary tube with liquid
EP3525932B1 (en) A device for collecting and/or handling a liquid sample and for separating said liquid sample into different components and a method for using the same
US4264204A (en) Method and apparatus for preparing fluid specimens

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase