WO1996001092A1 - Device for the release of an active agent - Google Patents
Device for the release of an active agent Download PDFInfo
- Publication number
- WO1996001092A1 WO1996001092A1 PCT/FI1995/000270 FI9500270W WO9601092A1 WO 1996001092 A1 WO1996001092 A1 WO 1996001092A1 FI 9500270 W FI9500270 W FI 9500270W WO 9601092 A1 WO9601092 A1 WO 9601092A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem
- active agent
- fastening means
- shaped body
- transverse part
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
Definitions
- the invention relates to an intrauterine device substantially in the shape of a T for releasing an active agent like a hormone.
- a widely used intrauterine contraceptive is a T-shaped body made of plastic comprising an elongated stem part one end of which is connected with a transverse part so that the stem and the transverse part together form a body substantially in the shape of a T.
- the stem is partly twisted by a copper wire which is capable of releasing copper ions.
- the device is inserted into the uterus by a separate insertion device. Attached to the device is a thread which is so long that it extends outside the uterine cervix when the device is in inserted position.
- T-shaped intrauterine devices releasing hormones and other active agents for contraception and treatment of hormonal disorders are also known in literature.
- US patent 3,935,860 describes a T-shaped body comprising a reservoir surrounded by a wall wherein the hormone is intermixed with the carrier.
- the wall is made of a substance which releases the active agent at a controlled rate.
- the carrier which is solid or liquid contains the active agent which is progestational or estrogenic hormone.
- US patent 4,014,988 describes also a T-shaped body which comprises a reservoir surrounded by a wall containing progestational hormone intermixed with a carrier.
- the wall is made of a material which releases the hormone at a controlled rate.
- US patent 4,180,064 discloses various intrauterine devices, a T-shaped device among others, wherein the progestational or estrogenic hormone is intermixed with a biodegradable polymer.
- T-shaped devices releasing hormone or other active agents are that both the stem and its transverse part together form one single piece. For this reason the device is complicated to manufacture and it is expensive and insertion of the device into the uterus is problematic.
- a commercially available levonorgestrel releasing contraceptive comprises a T-shaped device with a sheath- like polymer reservoir containing the hormone levonorgestrel, the reservoir being fitted around its vertical polyethylene stem.
- One way of fabricating it has been published in the international patent application PCT/FI93/00296.
- One aspect associated with this solution is that while the device is in inserted position in the uterus, release of the active agent takes place only in the lower part of the uterus. From the point of view of the results of treatment with active agents used for contraception as well as for other purposes, it is advantageous that their release takes place as high in the uterus as possible. This result can be achieved if the reservoir containing the active agent is placed higher in the T-piece than in the known levonorgestrel releasing contraceptive.
- the purpose of this invention is to eliminate the above drawbacks and to obtain a novel, essentially T-shaped intrauterine device containing an active agent which is the most effective possible from the point of view of the treatment and which is simple to manufacture and easy to insert into the uterus.
- a so-called bundle tie a fastening means widely used, for instance, in the field of packaging. It comprises a strip of flexible material, e.g. plastic, with a ring formed at its one end having grooves on its inner side. The other end of the strip is passed through the ring thus forming a loop.
- the strip is provided with ridges essentially over the entire length of the strip which fit into the grooves formed in the ring. The ridges and the grooves are so shaped that pulling of the strip to tighten up the loop is possible whereas pulling of the strip in opposite direction to loosen the loop is impossible.
- the object of the invention is therefore an intrauterine device essentially in the shape of a T for releasing an active agent comprising an elongated stem, to one end of which an elongated transverse part is joined so that this and the stem together form the body essentially in the shape of a T.
- the invention is characterized in that the transverse part comprises a polymer matrix reservoir containing the active agent and that the stem either comprises a polymer matrix reservoir containing the active agent or that it is a part which contains no active agent.
- the stem is secured to the transverse part by tightening a fastening means at the end of the stem partly or wholly around the transverse part.
- the reservoir containing the active agent may be surrounded by such a membrane which is capable of releasing the active agent at a predetermined rate.
- the active agent may be e.g. a hormone suitable for the treatment of menopausal symptoms or contraception, particularly estrogenic or progestational hormone.
- the matrix reservoir containing the active agent and the surrounding membrane can be made of the same or different polymer or polymer mixture. It is essential that both the material of the matrix and the possible surrounding membrane is made of a flexible polymer. Silicon polymers are particularly suitable for this purpose.
- Fig. 1 shows a plan view of the T-shaped body according to the invention in which the stem is secured to the transverse part by tightening the fastening means formed at the end of the stem around the transverse part
- Fig. 2 shows a side view of the T-shaped body of Fig. 1
- Fig. 3 shows the T-shaped body fitted into an insertion tube
- Fig. 4 shows a cross-sectional view of the stem which together with the fastening means together with the stem form a uniform piece
- Fig. 5 shows the stem of Fig. 4 according to a second embodiment
- Fig. 6 shows the stem of Fig. 4 according to a third embodiment
- Fig. 7 shows the stem of Fig. 4 according to a fourth embodiment
- Fig. 8 shows the stem of Fig. 4 according to a fifth embodiment
- Fig. 9 shows the stem of Fig. 4 according to a sixth embodiment
- Fig. 10 shows the stem which is to be joined to the transverse part and in which the fastening means is a separate piece which can be secured to the stem
- Fig. 11 shows a T-shaped body where also the stem is a polymer matrix reservoir containing the active agent
- Fig. 12 shows a fastening means suitable for joining the stem of Fig. 11 and the transverse part together
- Fig. 13 shows the fastening means of Fig. 12 according to a second embodiment
- Fig. 14 shows a T-shaped body with two transverse parts joined to the stem
- Fig. 15 shows a stem suitable for joining two transverse parts.
- Fig. 1 shows a T-shaped body 10 according to the invention wherein the stem 20 is secured to a transverse part 40 by tightening the fastening means 22 formed at the end 21 of the stem around the transverse part 40 according to the so- called bundle tie technique. Securing to a ring 25 located at the end of the fastening means takes place in the way which is illustrated more clearly e.g. in Figs. 4 and 5.
- a pull-out thread 50 is attached to the opposite end 23 of the stem 20.
- Fig. 2 shows the T-shaped body of Fig. 1 seen from the side.
- the transverse part 40 comprises both a polymer matrix reservoir 41, which contains the active agent, and a covering membrane 42 surrounding the reservoir 41 which is capable of controlling the release rate of the active agent.
- the ends 43a, 43b (Fig. 1) of the transverse part 40 are preferably uncovered. Hence the release rate of the active agent at the ends is higher than from the area covered by the membrane 42 and this is an advantage from the point of view of the result
- Fig. 3 shows the T-shaped body seen from the front fitted into a cross-sectioned insertion tube 51.
- the size of the ring 25 of the fastening means 22 most preferably matches with the outer diameter of the insertion tube 51.
- Figure shows that the diameter of the fastening means tapers upwards .
- This shape is particularly suitable from the point of view of the insertion.
- the transverse part 40 is made of a very flexible polymer material and as the insertion device is introduced through the uterine cervix, the wings 44a, 44b of the body 40 on both sides of the fastening means 22 readily bend downwards so that they follow the insertion tube as indicated by the dashed lines upon penetrating the uterine cervix.
- the polymer material must be flexible enough so that the part 40 straightens again inside the uterus.
- Fig. 4 shows as a cross-section the stem 20 of the T-shaped body of Figs. 1-3 and one embodiment of the fastening element bent into a loop.
- the fastening means 22 which is of the same piece as the stem itself, comprises also the loop 25 formed at its end.
- the fastening means 22 is provided, at least within the part to be secured, with ridges 27 which lock with the grooves 26 formed on the inside of the ring 25.
- the ridges 27 and the grooves 26 are so shaped that tightening in the direction of the arrow is allowed but loosening in the opposite direction of the arrow is prevented.
- the stem 20 can be provided with ridges over the entire length in which case adjustment possibilities are not limited.
- the ridges 27 have been replaced by a single dovetail barb 27' which locks against the lower surface of the ring 25.
- Fig. 6 shows a third embodiment of the stem 20 and the fastening means.
- the fastening means is of the same piece as the stem itself and it comprises an annular ring 25 with a hole of exactly the right size to allow the spherical parts 28 fitted along the stem to be pulled through the hole by pulling hard enough in the direction of the arrow.
- Fig. 7 shows a fourth embodiment of the stem and the fastening means.
- the fastening means 22, which together with the stem constitute one piece, is a loop whose ends 20 and 30 can be locked to one another by means of a dovetail barb 27' formed at the end 29 and a groove 26' shaped at the end 30.
- Fig. 8 shows a fifth embodiment of the stem and the fastening means.
- the end 29 of the fastening means 22 forming a loop is provided with ridges 27 and the loop can be locked by pushing the end 29 with the ridges to a desired depth into the opposite end 30 which is provided with such grooves 26 the pull-out of the end 29 out of the end 30 is prevented.
- the fastening means 22 forms an open loop whose ends 29, 30 need not be interlocked.
- the transverse part is pressed down between the flexible ends 29, 30. Due to the tension of the ends 29, 30 of the loop, the transverse part is held fast in the grip of loop.
- Fig. 10 shows a stem in which the fastening means 22 is separate loop which can be locked to the stem 20. It has barbs at both ends 29, 30 and locking takes place as the ends are placed against one another and are pushed into the groove 26 formed into the shaped end 21 of the stem.
- Fig. 11 shows a T-shaped body in which also the stem 20 is a polymer matrix reservoir containing the active agent.
- the stem 20 and the transverse part 40 are attached to each other with a separate fastening means 22 which is shown in more detail in Figs. 12 and 13.
- the principle of operation of the fastening means of Fig. 12 corresponds to the loop shown in Fig. 9.
- the loop 22 in the vertical plane holds the transverse part of the T-shaped body and the open loop 33 in the horizontal plane holds the end of the stem. Due to the tension of the ends 34, 35 of the loop 33, the end of the stem is held fast in the grip of the loop.
- Fig. 13 shows a solution which is an alternative to that of Fig. 12. Also in this solution the loop 22 in the vertical plane holds fast the transverse part of the T-shaped body and the loop 33 in the horizontal plane holds the end of the stem. The ends are interlocked according to the principle of the solution of Fig. 7.
- Fig. 14 shows a T-shaped body in which two transverse parts 40 and 40' are joined to the stem both of which comprise polymer matrix reservoirs containing the active agent.
- Fig. 15 shows a stem 20 suitable for joining two transverse parts.
- the lower fastening means 22' which functions according to the same fastening principle as the upper fastening means 22, opens to one or the other side and fastening of the lower transverse part 40' takes place by pushing it into the loop 22' from the side.
- the reservoirs can contain the same or different active agents.
- one reservoir may contain hormone and the other reservoir agent which prevents inflammation.
Landscapes
- Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX9606579A MX9606579A (en) | 1994-07-05 | 1995-05-19 | Device for the release of an active agent. |
EP95918627A EP0768850A1 (en) | 1994-07-05 | 1995-05-19 | Device for the release of an active agent |
AU24488/95A AU2448895A (en) | 1994-07-05 | 1995-05-19 | Device for the release of an active agent |
JP8503689A JPH10510168A (en) | 1994-07-05 | 1995-05-19 | Device for release of activator |
BR9507667A BR9507667A (en) | 1994-07-05 | 1995-05-19 | Intrauterine body essentially in the form of a t |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI943201A FI97944C (en) | 1994-07-05 | 1994-07-05 | Active substance delivery device |
FI943201 | 1994-07-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996001092A1 true WO1996001092A1 (en) | 1996-01-18 |
Family
ID=8541056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FI1995/000270 WO1996001092A1 (en) | 1994-07-05 | 1995-05-19 | Device for the release of an active agent |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0768850A1 (en) |
JP (1) | JPH10510168A (en) |
CN (1) | CN1151686A (en) |
AU (1) | AU2448895A (en) |
BR (1) | BR9507667A (en) |
CA (1) | CA2189870A1 (en) |
FI (1) | FI97944C (en) |
MX (1) | MX9606579A (en) |
WO (1) | WO1996001092A1 (en) |
ZA (1) | ZA954368B (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999018884A1 (en) * | 1997-10-10 | 1999-04-22 | Duirs Nz Limited | Drug delivery system |
WO2002062415A1 (en) * | 2001-02-09 | 2002-08-15 | Interag | Geometry retainable devices for body cavities |
WO2003068117A1 (en) * | 2002-02-12 | 2003-08-21 | Dirk Wildemeersch | T-shaped intra-uterine device and method for the production thereof |
US6759393B1 (en) | 1999-04-12 | 2004-07-06 | Pfizer Inc. | Growth hormone and growth hormone releasing hormone compositions |
WO2009060077A2 (en) | 2007-11-07 | 2009-05-14 | N.V. Organon | Intrauterine deposit |
US7829112B2 (en) | 2003-04-29 | 2010-11-09 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
WO2012063262A3 (en) * | 2010-11-08 | 2012-07-05 | Hll Lifecare Limited | Intrauterine device with controlled copper release |
US8568374B2 (en) | 2009-05-04 | 2013-10-29 | Merck Sharp & Dohme B.V. | Intrauterine system |
WO2015189853A1 (en) * | 2014-06-13 | 2015-12-17 | Meril Endo Surgery Private Limited | An intrauterine device |
US9907691B2 (en) | 2013-03-13 | 2018-03-06 | Hologic, Inc. | Intrauterine contraceptive devices |
US9999592B2 (en) | 2008-07-03 | 2018-06-19 | Bayer Oy | Intrauterine delivery system for contraception |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1400258A1 (en) * | 2002-09-18 | 2004-03-24 | Schering Oy | Pharmaceutical composition delivery device and its manufacturing process |
CN105726103B (en) * | 2016-02-05 | 2018-08-10 | 复旦大学附属肿瘤医院 | A kind of uterine neck pore prevents adhesion device |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845761A (en) * | 1970-06-02 | 1974-11-05 | Alza Corp | Intrauterine contraceptive anti-fertility device for the management of reproduction |
US4014988A (en) * | 1975-10-31 | 1977-03-29 | Alza Corporation | Method for treating hypermenorrhea with uterine therapeutic system |
US4180064A (en) * | 1972-12-27 | 1979-12-25 | Alza Corporation | System for delivering agent to environment of use over prolonged time |
US4198966A (en) * | 1978-06-29 | 1980-04-22 | Seppo Kaivola | Intrauterine contraceptive and method of manufacturing the same |
US4326511A (en) * | 1979-10-05 | 1982-04-27 | Zimerman Clota E | Intrauterine contraceptive device |
CH638397A5 (en) * | 1977-12-27 | 1983-09-30 | Alza Corp | DIFFERENTIAL DELIVERY DEVICE WITH AN ACTIVE SUBSTANCE RESERVOIR. |
US4582052A (en) * | 1982-03-23 | 1986-04-15 | Repromed, Inc. | Povidone-iodine dispensing fiber |
WO1991007934A1 (en) * | 1989-11-23 | 1991-06-13 | Metallicom A.G. | Process for the manufacture of a carrier or iud provided with a pulling element, and a carrier or iud provided with a pulling element |
-
1994
- 1994-07-05 FI FI943201A patent/FI97944C/en not_active IP Right Cessation
-
1995
- 1995-05-19 MX MX9606579A patent/MX9606579A/en unknown
- 1995-05-19 WO PCT/FI1995/000270 patent/WO1996001092A1/en not_active Application Discontinuation
- 1995-05-19 CN CN95193910A patent/CN1151686A/en active Pending
- 1995-05-19 EP EP95918627A patent/EP0768850A1/en not_active Withdrawn
- 1995-05-19 JP JP8503689A patent/JPH10510168A/en active Pending
- 1995-05-19 AU AU24488/95A patent/AU2448895A/en not_active Abandoned
- 1995-05-19 BR BR9507667A patent/BR9507667A/en not_active Application Discontinuation
- 1995-05-19 CA CA002189870A patent/CA2189870A1/en not_active Abandoned
- 1995-05-29 ZA ZA954368A patent/ZA954368B/en unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845761A (en) * | 1970-06-02 | 1974-11-05 | Alza Corp | Intrauterine contraceptive anti-fertility device for the management of reproduction |
US4180064A (en) * | 1972-12-27 | 1979-12-25 | Alza Corporation | System for delivering agent to environment of use over prolonged time |
US4014988A (en) * | 1975-10-31 | 1977-03-29 | Alza Corporation | Method for treating hypermenorrhea with uterine therapeutic system |
CH638397A5 (en) * | 1977-12-27 | 1983-09-30 | Alza Corp | DIFFERENTIAL DELIVERY DEVICE WITH AN ACTIVE SUBSTANCE RESERVOIR. |
US4198966A (en) * | 1978-06-29 | 1980-04-22 | Seppo Kaivola | Intrauterine contraceptive and method of manufacturing the same |
US4326511A (en) * | 1979-10-05 | 1982-04-27 | Zimerman Clota E | Intrauterine contraceptive device |
US4582052A (en) * | 1982-03-23 | 1986-04-15 | Repromed, Inc. | Povidone-iodine dispensing fiber |
WO1991007934A1 (en) * | 1989-11-23 | 1991-06-13 | Metallicom A.G. | Process for the manufacture of a carrier or iud provided with a pulling element, and a carrier or iud provided with a pulling element |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999018884A1 (en) * | 1997-10-10 | 1999-04-22 | Duirs Nz Limited | Drug delivery system |
AU734838B2 (en) * | 1997-10-10 | 2001-06-21 | Vetoquinol Usa, Inc. | Drug delivery system |
US6759393B1 (en) | 1999-04-12 | 2004-07-06 | Pfizer Inc. | Growth hormone and growth hormone releasing hormone compositions |
WO2002062415A1 (en) * | 2001-02-09 | 2002-08-15 | Interag | Geometry retainable devices for body cavities |
AU2002235050B2 (en) * | 2001-02-09 | 2007-02-15 | Interag | Geometry retainable devices for body cavities |
WO2003068117A1 (en) * | 2002-02-12 | 2003-08-21 | Dirk Wildemeersch | T-shaped intra-uterine device and method for the production thereof |
BE1014635A3 (en) * | 2002-02-12 | 2004-02-03 | Wildemeersch Dirk | |
US7838024B2 (en) | 2003-04-29 | 2010-11-23 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
US7883718B2 (en) | 2003-04-29 | 2011-02-08 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
US7833545B2 (en) | 2003-04-29 | 2010-11-16 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
US7829112B2 (en) | 2003-04-29 | 2010-11-09 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
US8291910B2 (en) | 2007-11-07 | 2012-10-23 | Msd Oss B.V. | Intrauterine deposit |
WO2009060077A2 (en) | 2007-11-07 | 2009-05-14 | N.V. Organon | Intrauterine deposit |
EP2942040A1 (en) | 2007-11-07 | 2015-11-11 | Merck Sharp & Dohme B.V. | Intrauterine deposit |
US9999592B2 (en) | 2008-07-03 | 2018-06-19 | Bayer Oy | Intrauterine delivery system for contraception |
US10532025B2 (en) | 2008-07-03 | 2020-01-14 | Bayer Oy | Intrauterine delivery system for contraception |
US8568374B2 (en) | 2009-05-04 | 2013-10-29 | Merck Sharp & Dohme B.V. | Intrauterine system |
WO2012063262A3 (en) * | 2010-11-08 | 2012-07-05 | Hll Lifecare Limited | Intrauterine device with controlled copper release |
US9907691B2 (en) | 2013-03-13 | 2018-03-06 | Hologic, Inc. | Intrauterine contraceptive devices |
WO2015189853A1 (en) * | 2014-06-13 | 2015-12-17 | Meril Endo Surgery Private Limited | An intrauterine device |
Also Published As
Publication number | Publication date |
---|---|
AU2448895A (en) | 1996-01-25 |
EP0768850A1 (en) | 1997-04-23 |
FI97944B (en) | 1996-12-13 |
ZA954368B (en) | 1996-03-07 |
BR9507667A (en) | 1997-10-07 |
CN1151686A (en) | 1997-06-11 |
CA2189870A1 (en) | 1996-01-18 |
JPH10510168A (en) | 1998-10-06 |
FI97944C (en) | 1997-03-25 |
FI943201A0 (en) | 1994-07-05 |
MX9606579A (en) | 1997-06-28 |
FI943201A (en) | 1996-01-06 |
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