WO1995033463A3 - Synergistic antibiotic compositions containing a perphyrin and an antibiotic - Google Patents

Synergistic antibiotic compositions containing a perphyrin and an antibiotic Download PDF

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Publication number
WO1995033463A3
WO1995033463A3 PCT/US1995/006998 US9506998W WO9533463A3 WO 1995033463 A3 WO1995033463 A3 WO 1995033463A3 US 9506998 W US9506998 W US 9506998W WO 9533463 A3 WO9533463 A3 WO 9533463A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibiotic
porphyrins
synergistic
composition
mixture
Prior art date
Application number
PCT/US1995/006998
Other languages
French (fr)
Other versions
WO1995033463A2 (en
Inventor
Zvi Malik
Yeshayahu Nitzan
Original Assignee
Univ Bar Ilan
Lichtenstein Joseph
Zvi Malik
Yeshayahu Nitzan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL10987494A external-priority patent/IL109874A0/en
Priority claimed from IL10987594A external-priority patent/IL109875A0/en
Priority claimed from IL10987694A external-priority patent/IL109876A0/en
Application filed by Univ Bar Ilan, Lichtenstein Joseph, Zvi Malik, Yeshayahu Nitzan filed Critical Univ Bar Ilan
Priority to EP95923690A priority Critical patent/EP0765161A2/en
Priority to AU28161/95A priority patent/AU2816195A/en
Publication of WO1995033463A2 publication Critical patent/WO1995033463A2/en
Publication of WO1995033463A3 publication Critical patent/WO1995033463A3/en
Priority to NO965109A priority patent/NO965109D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Porphyrins are used as antimicrobial agents in synergistic antibiotic composition, comprising as an antibiotic active ingredient a mixture of one or more porphyrins and at least one antibiotic compound. An antimicrobial composition, comprises as an active ingredient a porphyrin or a mixture of one or more porphyrins, alone or in admixture with conventional antibiotic materials and/or pharmaceutically acceptable or beneficial agents or additives, in a water-based cream composition. Also described is a sterilizing liquid composition, comprising as an active ingredient a porphyrin or a mixture of one or more porphyrins, in an aqueous solution, together with a surface-active agent.
PCT/US1995/006998 1994-06-02 1995-05-30 Synergistic antibiotic compositions containing a perphyrin and an antibiotic WO1995033463A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP95923690A EP0765161A2 (en) 1994-06-02 1995-05-30 Synergistic antibiotic compositions containing a perphyrin and an antibiotic
AU28161/95A AU2816195A (en) 1994-06-02 1995-05-30 Synergistic antibiotic compositions containing a perphyrin and an antibiotic
NO965109A NO965109D0 (en) 1994-06-02 1996-11-29 Antimicrobial compositions

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL109874 1994-06-02
IL10987494A IL109874A0 (en) 1994-06-02 1994-06-02 Synergistic antimicrobial compositions
IL109876 1994-06-02
IL10987594A IL109875A0 (en) 1994-06-02 1994-06-02 Antimicrobial cream compositions
IL10987694A IL109876A0 (en) 1994-06-02 1994-06-02 Antimicrobial liquid compositions
IL109875 1994-06-02

Publications (2)

Publication Number Publication Date
WO1995033463A2 WO1995033463A2 (en) 1995-12-14
WO1995033463A3 true WO1995033463A3 (en) 1996-05-17

Family

ID=27271659

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/006998 WO1995033463A2 (en) 1994-06-02 1995-05-30 Synergistic antibiotic compositions containing a perphyrin and an antibiotic

Country Status (5)

Country Link
EP (1) EP0765161A2 (en)
AU (1) AU2816195A (en)
CA (1) CA2191627A1 (en)
NO (1) NO965109D0 (en)
WO (1) WO1995033463A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620805B1 (en) 1996-03-14 2003-09-16 Yale University Delivery of nucleic acids by porphyrins
NL1020336C2 (en) * 2002-04-09 2003-10-13 Photobiochem Leiden N V Use of a compound for the preparation of a pharmaceutical preparation for treating burns, and a method for treating burns.
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
CN113425850B (en) * 2021-06-04 2022-10-11 江南大学 Photosensitive antibacterial modified porphyrin metal organic framework material and preparation method thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU721442A1 (en) * 1977-09-12 1980-03-15 Московский Ордена Трудового Красного Знамени Институт Тонкой Химической Технологии Им. М.В. Ломоносова Method of preparing beta-unsubstituted porphyrins
JPS58981A (en) * 1981-06-26 1983-01-06 Tama Seikagaku Kk Water-soluble porphyrin derivative
JPS61189284A (en) * 1985-02-18 1986-08-22 Tama Seikagaku Kk Water-soluble porphyrin derivative metal chelate compound
WO1988004174A1 (en) * 1986-12-08 1988-06-16 The Rockefeller University Use of tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US4753958A (en) * 1985-02-07 1988-06-28 University Of Cal Photochemotherapy of epithelial diseases with derivatives of hematoporphyrins
EP0350036A2 (en) * 1988-07-06 1990-01-10 Long Island Jewish Medical Center Topical hematoporphyrin
US5109016A (en) * 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
WO1993010153A1 (en) * 1991-11-15 1993-05-27 Institut National De La Recherche Agronomique Bactericidal product, pharmaceutical composition containing same and food additive
WO1993021992A1 (en) * 1992-04-30 1993-11-11 Institute Of Dental Surgery Laser treatment
WO1995017893A1 (en) * 1993-12-28 1995-07-06 New York Blood Center Methods for preventing or treating hiv-1 or hiv-2 infection

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU721442A1 (en) * 1977-09-12 1980-03-15 Московский Ордена Трудового Красного Знамени Институт Тонкой Химической Технологии Им. М.В. Ломоносова Method of preparing beta-unsubstituted porphyrins
JPS58981A (en) * 1981-06-26 1983-01-06 Tama Seikagaku Kk Water-soluble porphyrin derivative
US4753958A (en) * 1985-02-07 1988-06-28 University Of Cal Photochemotherapy of epithelial diseases with derivatives of hematoporphyrins
JPS61189284A (en) * 1985-02-18 1986-08-22 Tama Seikagaku Kk Water-soluble porphyrin derivative metal chelate compound
WO1988004174A1 (en) * 1986-12-08 1988-06-16 The Rockefeller University Use of tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US5109016A (en) * 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
EP0350036A2 (en) * 1988-07-06 1990-01-10 Long Island Jewish Medical Center Topical hematoporphyrin
WO1993010153A1 (en) * 1991-11-15 1993-05-27 Institut National De La Recherche Agronomique Bactericidal product, pharmaceutical composition containing same and food additive
WO1993021992A1 (en) * 1992-04-30 1993-11-11 Institute Of Dental Surgery Laser treatment
WO1995017893A1 (en) * 1993-12-28 1995-07-06 New York Blood Center Methods for preventing or treating hiv-1 or hiv-2 infection

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8043, Derwent World Patents Index; Class B02, AN 80-76663C *
DATABASE WPI Section Ch Week 8307, Derwent World Patents Index; Class B02, AN 83-15782K *
DATABASE WPI Section Ch Week 8640, Derwent World Patents Index; Class B02, AN 86-261537 *
FRANK R. VENZIO ET AL.: "Bactericidal effects of photoradiation therapy with hematoporphyrin derivative", J.INFECT.DIS., vol. 151, no. 1, pages 166 - 169 *
GIUSEPPE TOFFOLI ET AL.: "In K562 leukemia cells treated with doxorubicin and hemin, a decrease in c-myc mRNA expression correlates with loss of self-renewal capability but not with erythroid differentiation", LEUK. RES., vol. 13, no. 4, pages 279 - 287 *
YESHAYAHU NITZAN ET AL.: "Inactivation of gram-negative bacteria by photosensitized porphyrins", PHOTOCHEMISTRY ANS PHOTOBIOLOGY, vol. 55, no. 1, pages 89 - 96 *
ZVI MALIK ET AL.: "Effects of photoactivated haematoporphyrin derivative on bacteria and antibiotic resistance", MICROBIOS LETTERS, vol. 21, no. 83-84, pages 103 - 112 *

Also Published As

Publication number Publication date
EP0765161A2 (en) 1997-04-02
AU2816195A (en) 1996-01-04
NO965109D0 (en) 1996-11-29
WO1995033463A2 (en) 1995-12-14
CA2191627A1 (en) 1995-12-14

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