WO1995032292A3 - Detection of viral antigens coded by reverse-reading frames - Google Patents

Detection of viral antigens coded by reverse-reading frames Download PDF

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Publication number
WO1995032292A3
WO1995032292A3 PCT/US1995/006266 US9506266W WO9532292A3 WO 1995032292 A3 WO1995032292 A3 WO 1995032292A3 US 9506266 W US9506266 W US 9506266W WO 9532292 A3 WO9532292 A3 WO 9532292A3
Authority
WO
WIPO (PCT)
Prior art keywords
reading frames
polypeptide antigens
reverse
coded
detection
Prior art date
Application number
PCT/US1995/006266
Other languages
French (fr)
Other versions
WO1995032292A2 (en
Inventor
Kirk E Fry
Jungsuh P Kim
Frederick A Murphy
Jeffrey M Linnen
Original Assignee
Genelabs Tech Inc
Kirk E Fry
Jungsuh P Kim
Frederick A Murphy
Jeffrey M Linnen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genelabs Tech Inc, Kirk E Fry, Jungsuh P Kim, Frederick A Murphy, Jeffrey M Linnen filed Critical Genelabs Tech Inc
Priority to AU25941/95A priority Critical patent/AU2594195A/en
Publication of WO1995032292A2 publication Critical patent/WO1995032292A2/en
Publication of WO1995032292A3 publication Critical patent/WO1995032292A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

The present invention describes a novel method to determine whether a test subject is infected with a selected virus, where the virus has an RNA genome. The method includes the identification of polypeptide antigens coded by reverse open reading frames, that is, reading frames coded in the opposite direction to the major known viral reading frames. Further, the invention includes the reverse frame polypeptide antigens, methods of identifying and producing such polypeptide antigens, and antibodies that are specifically immunoreactive with said polypeptide antigens. These polypeptide antigens and antibodies are useful in diagnostic and therapeutic applications.
PCT/US1995/006266 1994-05-20 1995-05-17 Detection of viral antigens coded by reverse-reading frames WO1995032292A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU25941/95A AU2594195A (en) 1994-05-20 1995-05-17 Detection of viral antigens coded by reverse-reading frames

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US24698594A 1994-05-20 1994-05-20
US08/246,985 1994-05-20
US28556194A 1994-08-03 1994-08-03
US08/285,561 1994-08-03
US32972994A 1994-10-26 1994-10-26
US08/329,729 1994-10-26
US34427194A 1994-11-23 1994-11-23
US08/344,271 1994-11-23
US35750994A 1994-12-16 1994-12-16
US08/357,509 1994-12-16
US38988695A 1995-02-15 1995-02-15
US08/389,886 1995-02-15

Publications (2)

Publication Number Publication Date
WO1995032292A2 WO1995032292A2 (en) 1995-11-30
WO1995032292A3 true WO1995032292A3 (en) 1996-01-25

Family

ID=27559345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/006266 WO1995032292A2 (en) 1994-05-20 1995-05-17 Detection of viral antigens coded by reverse-reading frames

Country Status (2)

Country Link
AU (1) AU2594195A (en)
WO (1) WO1995032292A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720166B2 (en) 1994-02-14 2004-04-13 Abbott Laboratories Non-a, non-b, non-c, non-c, non-d, non-e hepatitis reagents and methods for their use
US6051374A (en) * 1994-02-14 2000-04-18 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US6558898B1 (en) 1994-02-14 2003-05-06 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US6156495A (en) * 1994-02-14 2000-12-05 Abbott Laboratories Hepatitis GB virus recombinant proteins and uses thereof
US6451578B1 (en) 1994-02-14 2002-09-17 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US5981172A (en) * 1994-02-14 1999-11-09 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E Hepatitis reagents and methods for their use
US5843450A (en) * 1994-02-14 1998-12-01 Abbott Laboratories Hepatitis GB Virus synthetic peptides and uses thereof
US6586568B1 (en) 1994-02-14 2003-07-01 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US5709997A (en) * 1995-08-14 1998-01-20 Abbott Laboratories Nucleic acid detection of hepatitis GB virus
US5955318A (en) * 1995-08-14 1999-09-21 Abbott Laboratories Reagents and methods useful for controlling the translation of hepatitis GBV proteins
US5807670A (en) * 1995-08-14 1998-09-15 Abbott Laboratories Detection of hepatitis GB virus genotypes
IT1284630B1 (en) * 1996-04-17 1998-05-21 Sorin Biomedica Diagnostics Sp SPECIFIC EPITOPES OF VIRUSES ASSOCIATED WITH NON"A"-NON"E HEPATITIS, COMPOSITIONS AND METHOD FOR DETECTING ANTIBODY OF THESE EPITOPES.
US6020195A (en) * 1996-09-18 2000-02-01 Roche Diagnostics Gmbh Antibodies against hepatitis G virus and their use for the diagnostic detection of HGV and as a therapeutic agent
CN1058751C (en) * 1998-06-15 2000-11-22 中国人民解放军第二军医大学 Full length CDNA clone of hepatitis virus G genome and its construction method

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A. MARRIOT ET AL.: "The S segment of sandfly fever Sicilian virus: evidence for an ambisense genome", VIROLOGY, vol. 169, pages 341 - 345 *
C. GIORGIO ET AL.: "Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever and Uukuniemi viruses", VIROLOGY, vol. 180, pages 738 - 753 *
D. AUPERIN ET AL.: "Sequencing studies of Pichinde arenavirus S RNA indicate a novel coding strategy, an ambisense viral S RNA", J. VIROL., vol. 52, no. 2, pages 897 - 904 *
G. SCHLAUDER ET AL.: "Molecular and serological analysis in the transmission of the GB hepatitis agents", J. MED. VIROL., vol. 46, pages 81 - 90 *
H. OVERTON ET AL.: "Identification of the N ans NSS proteins coded by the ambisense S RNA of Punta Toro phlebovirus using monospecific antisera raised to baculovirus expressed N and NSs proteins", VIROLOGY, vol. 157, pages 338 - 350 *
J. SALUZZO ET AL.: "Antigenic and biological properties of Rift Valley fever virus isolated during the 1987 Mauritanian apidemic", RES. VIROL., vol. 140, pages 155 - 164 *
J. SIMONS ET AL.: "Identification of two flavivirus-like genomes in the GB agent", PROC. NATL. ACAD. SCI. USA, vol. 92, pages 3401 - 3405 *
J. SIMONS ET AL.: "Uukuniemivirus S segment RNA", J. VIROL., vol. 64, no. 1, pages 247 - 255 *
J. STRUTHERS ET AL.: "Identification of a major non-structural protein in the nuclei of Rift Valley Fever virus infected cells", J. GEN. VIROL., vol. 60, pages 381 - 384 *

Also Published As

Publication number Publication date
AU2594195A (en) 1995-12-18
WO1995032292A2 (en) 1995-11-30

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