WO1995027396A1 - Antiseptic articles - Google Patents

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Publication number
WO1995027396A1
WO1995027396A1 PCT/FR1995/000371 FR9500371W WO9527396A1 WO 1995027396 A1 WO1995027396 A1 WO 1995027396A1 FR 9500371 W FR9500371 W FR 9500371W WO 9527396 A1 WO9527396 A1 WO 9527396A1
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WO
WIPO (PCT)
Prior art keywords
filaments
antiseptic
articles
articles according
cartridge
Prior art date
Application number
PCT/FR1995/000371
Other languages
French (fr)
Inventor
Jean-Pierre Lontrade
Original Assignee
Transphyto S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transphyto S.A. filed Critical Transphyto S.A.
Priority to AU21424/95A priority Critical patent/AU2142495A/en
Publication of WO1995027396A1 publication Critical patent/WO1995027396A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46D—MANUFACTURE OF BRUSHES
    • A46D1/00—Bristles; Selection of materials for bristles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
    • A46B11/001—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
    • A46B11/002—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs pressurised at moment of use manually or by powered means
    • A46B11/0041—Flexible or deformable reservoirs, e.g. resilient bulbs, compressible tubes

Definitions

  • the invention relates to the plastics industry and their applications in the fields of pharmaceutical, cosmetic, food packaging and sanitary or hygienic articles. It relates more particularly to articles in filiform plastic material with antiseptic properties.
  • the compound in C12 is generally present at 40% in the mixture and that in C14 at 20%.
  • the whole C12 + C14 constituting at least 70% of the mixture.
  • the object of the invention is in particular to overcome such drawbacks and to produce industrially antiseptic articles of constant and effective properties at low cost.
  • the subject of the invention is antiseptic articles, in particular for the packaging of pharmaceuticals, foodstuffs, cosmetics, and for sanitary or hygienic use, characterized in that they consist, at least in part, of an assembly. no occlusive of antiseptic filaments of a synthetic material of the group comprising nitrocellulose, poly ⁇ hexamethylene adipamide, and the linear polymer of ⁇ - caprolactam, superficially saturated with benzalkonium chloride, at least 50 percent in tetra ⁇ radical decyl not releasable under the conditions of use.
  • the antiseptic filaments can be assembled to form a braided, knitted, stranded or twisted wick, as well as a sheet formed by weaving, knitting, carding, juxtaposition / superposition or felting.
  • the filaments thus assembled advantageously have about 0.15 mm in diameter to ensure between them a rolling of the liquid suitable for good sterilization and filtration, with good mechanical strength. Finer filaments can be felted to form filter membranes.
  • the articles which are objects of the invention can in particular constitute filter cartridges for containers or conduits for sterile liquids formed from antiseptic filaments assembled in a permeable cylindrical mass surrounded by a tight cylindrical sheath open at its two ends. They find a particularly advantageous application in packages of sterile liquids comprising a receptacle with a flexible wall, the gou ⁇ lot of which is provided with a nozzle channeling the outlet of the liquid through a filter cartridge of anti-septic filaments.
  • Such a cartridge can be constituted by a bundle of braided, twisted, and / or stranded antiseptic filaments or by a stack of fibrous washers forming a cylindrical mass sheathed in plastic material which is overmolded in a dropper nozzle.
  • the end piece it is generally preferable for the end piece to be capped with a removable cap, the bottom of which is lined with a sheet of antiseptic filaments which is applied against the outlet opening of the end piece for 1 * seal between liquid distributions.
  • At least one ends of the cartridge of a bacteriological hydrophilic filter membrane with pores of about 0.2 ⁇ m opening In order to ensure asepsis inside a container, or upstream of a conduit, when the cartridge is not impregnated with liquid and therefore cannot fulfill its antiseptic role, at least one ends of the cartridge of a bacteriological hydrophilic filter membrane with pores of about 0.2 ⁇ m opening.
  • the elements of the nozzle other than the filaments, which are called to be exposed to the outside and in contact with the liquid during its distribution, will be made of a similar anti-septic material to that of the filaments, and saturated with antiseptic.
  • the antiseptic filaments can be assembled in tufts, the base of which is enclosed in a frame to form a brush, for example for dental use, or a brush, for example for the application of skin topicals.
  • the invention has multiple and diverse applications: there may be mentioned in particular brushes, combs and brushes for hygienic or cosmetic use, dressings, operating drapes, covers, gloves, masks respi ⁇ racks, podiatric insoles, sterile tissues, braided tubes for sterile liquid, various filters.
  • brushes, combs and brushes for hygienic or cosmetic use
  • dressings for operating drapes, covers, gloves, masks respi ⁇ racks
  • podiatric insoles podiatric insoles
  • sterile tissues braided tubes for sterile liquid
  • various filters various filters.
  • FIG. 1 is a view in elevation and in axial section of a bottle fitted with a sterile dispensing nozzle according to the invention
  • Figure 2 is a view similar to that of Figure 1, a variant of the nozzle
  • Figure 3 is a view similar to that of Figure 2, of another variant of the nozzle
  • Figure 5 is a side view of a swab brush according to the invention
  • Figure 6 is a view similar to that of Figure l of another variant.
  • the packaging shown in Figure 1 is particularly suitable for eye drops and other pharmaceutical products. It essentially comprises a bottle 1 with a flexible wall, for example made of polyethylene. In its neck is inserted in leaktight manner a nozzle 2, for example made of polyamide saturated with benzalkonium chloride predominantly of tetradecyl radical, terminated by a still mouthpiece 4 and capped with a cap 3, for example made of polyamide, the base is screwed onto a thread on the base of the nozzle.
  • a nozzle 2 for example made of polyamide saturated with benzalkonium chloride predominantly of tetradecyl radical
  • the bottom of the cap is lined with a pad 11 formed from an elastic sheet of antiseptic filaments entangled with poly ⁇ amide or nitrocellulose, saturated with benzalkium chloride predominantly of tetradecyl radical.
  • the axial channel of the nozzle is lined with a filter cartridge 5 formed of a bundle 6 of antiseptic filaments of polyamide or nitrocellulose saturated with ben ⁇ zalkonium chloride with preponderance of tetradecyl radical, assembled in a permeable cylindrical mass surrounded of a sealed cylindrical sheath 7, for example of polyethylene.
  • the bottom of the cap 3a has a conical stud 8a which comes to spur the cavity 3a of the still mouth of the nozzle 2a.
  • the upstream opening of the filter cartridge 5a is sealed by a bacteriological filter membrane 9a with pores of about 0.2 ⁇ m opening, welded or held by its periphery against an internal shoulder of the axial channel of the nozzle by a ring 10a, for example of polyamide saturated with benzalkonium chloride, predominantly of tetradecyl radical, crimped in the axial channel of the end piece.
  • FIG. 3 represents another variant of a tip adaptable to the bottle of FIG. 1 for the purified distribution of a liquid packaged with a preservative.
  • the cap 3b is not screwed but snapped onto the base of the nozzle 2b.
  • the axial channel of the endpiece is lined with a composite filter element formed by a downstream filter cartridge 5b containing antiseptic filaments, made of polyamide or nitro-cellulose saturated with benzalkonium chloride predominantly of tetradecyl radical, and of an upstream filtering cartridge 5′b containing sensor filaments of the preservative contained in the conditioned liquid, made of virgin polyamide or nitrocelluloses.
  • the downstream and upstream cartridges are separated by a bacteriological filter membrane 9b with pores of about 0.2 ⁇ m opening.
  • the fil ⁇ trante cartridge 5c is formed by a stack of permeable fibrous washers 12c welded at their periphery 13c and directly molded in a nozzle 2c whose base 14c is set in the neck 15c a container of blown plastic material, previously filled.
  • This structure is particularly suitable for sterile packaging installations with an integrated manufacturing-filling-sealing process for containers called "Blow Still Seal", such as those marketed under the brand “BOTTELPACK” by the Swiss company ROMMELAG, or under the brand “ ALP "by the company Automatic Liquid Packaging of the United States of America.
  • a screwed cap 3c the bottom of which is lined with an antiseptic buffer, protects the end piece, it is itself sheathed in an extension 16c of the neck of the bottle produced at the same time as the crimping, connected to the crimped part by a frangible zone 17c which breaks at the first unscrewing of the cap and thus constitutes a guarantee of prior non-use for the user.
  • Example 1 - Braiding a primary tubular braid of approximately 0.4 mm in diameter is first formed by braiding together 12 strands of wire of 15/100 mm in diameter. Then we braid together 12 primary braids to form a cylindrical braid of approximately 2.5 mm which is coated by peripheral annular extrusion of the same material to form a sheath of approximately 4 mm in diameter with a radial thickness of approximately 0 , 8 mm. Then cut into cylindrical sections to the desired length, for example about 20 mm for the filter cartridges 5, 5a of Figures 1 and 2 and about 10 mm for the cartridges 5b, 5'b of Figure 3.
  • Example 2 - Toronaqe first a cylindrical primary strand of about 0.84 mm in diameter is formed by twisting together 21 strands of wire of 14/100 mm in diameter. A primary strand is used as an axis to twist together 6 other primary strands to obtain a cylindrical strand of approximately 2.5 mm in diameter which is coated by extrusion of translucent low density polyethylene by forming a sheath of approximately 4 mm. diameter with a radial thickness of about 0.8 mm. Then cut into cylindrical sections to the desired length for the intended application.
  • Example 3 - Cardacre in a conventional machine of the "RANDO EBER" type, a nonwoven sheet is prepared by aerated carding of sections of polyamide filaments of approximately 15 to 30 mm in length and approximately 0.13 to 0.16 mm in diameter at least part of which is crimped. The monomer of the same polyamide is sprayed into the sheet to join the filaments together only at their points of intersection and polymerized to obtain a usable filter sheet, after saturation with benzalkonium chloride, for non-textile applications. antiseptic woven fabrics. The cutting of such a sheet into washers, for example by ultrasound with welding of the slices makes it possible to produce the pad 11 placed at the bottom of the cap 3 of the packaging of FIG. 1, and the washers 12c of the packaging of FIG. 6.
  • Example 4 Juxtaposition / Superposition: A sheet of contiguous parallel turns of polyamide fila ⁇ ments is deposited on a drum which is covered by depositing at least one analogous sheet of orientation not parallel to the previous one. A homogeneous sheet of crossed filaments is thus obtained which is cut into rounds which are stacked to form a fil ⁇ trante cartridge molded directly or after sheathing in a nozzle, such as that of FIG. 6.
  • Example 5 - Impregnation a benzalkonium chloride solution is used in the aqueous solvent of the liquid to be packaged.
  • a solution of benzalkonium chloride is prepared at a concentration of 100 ⁇ g / ml in an aqueous NaCl solution at 0.9 g% (pH 7.2).
  • the filaments or other articles to be saturated are soaked in this excess solution for approximately 2 hours at normal ambient temperature and pressure, then, after draining and drying, they are washed with an aqueous NaCl solution at 0.9 g% (pH 7.2) until the benzalkonium chloride disappears from the effluents. It is drained and dried at a temperature below about 110 ° C.
  • BAK fixed on filaments or other polyamide supports it is extracted three times by stirring at room temperature in a solvent mixture of 40 parts of ethanol and 60 of aqueous solution of anhydrous sodium acetate in 1 distilled water (8.5 g / l), adjusted to pH 5.0 with acetic acid for 30 minutes, with 2 ml of solvent per 100 mg of polyamide.
  • the washing solvents are then analyzed in a conventional manner with a high pressure liquid chromatograph, such as that "marketed under the name HEWLETT PACKARD 1050, with HELWETT PACKARD 3390 A recorder and WATERS column (3.9 x 150 mm) ⁇ Bondpak CN-10 ⁇ m-Ref 86688.
  • the calculations are carried out from the peak areas corresponding to BAK C12 and BAK C14, so that both the total amount of BAK fixed (C12 + C14) and the relative proportions of BAK C12 and BAK C14.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
  • Packages (AREA)

Abstract

Sanitary or hygienic antiseptic articles, in particular for packaging pharmaceuticals, foodstuffs and cosmetics, and at least partially consisting of a non-occlusive assembly of filaments made of synthetic material, particularly nitrocellulose, polyamide, especially polyhexamethylene adipamide, and epsilon-caprolactam polymer, and surface-saturated with benzalkonium chloride of which at least 50 % consists of a tetradecyl radical incapable of being released under the expected conditions of use.

Description

ARTICLES ANTISEPTIQUES ANTISEPTIC ARTICLES
L'invention concerne l'industrie des matières plastiques et leurs applications dans les domaines du conditionnement pharmaceutique, cosmétique, alimentaire et des articles sanitaires ou d'hygiène. Elle vise plus particulièrement des articles en matière plastique filiforme à propriétés antiseptiques.The invention relates to the plastics industry and their applications in the fields of pharmaceutical, cosmetic, food packaging and sanitary or hygienic articles. It relates more particularly to articles in filiform plastic material with antiseptic properties.
On connaît les propriétés de certaines matières plastiques à fixer superficiellement des substances anti¬ septiques. C'est notamment le cas des polyamides avec le chlorure de benzalkonium. Mais on a constaté que la capa¬ cité de rétention et, par suite, l'efficacité antisep¬ tique des polyamides traités variait suivant les types de polyamide et de chlorure de benzalkonium et leur degré de saturation. Cette variabilité des propriétés est incompa¬ tible avec la commercialisation de produits industriels de qualité et propriétés constantes.We know the properties of certain plastics to surface-fix anti-septic substances. This is particularly the case of polyamides with benzalkonium chloride. However, it has been found that the retention capacity and, consequently, the antiseptic efficacy of the polyamides treated varied according to the types of polyamide and of benzalkonium chloride and their degree of saturation. This variability in properties is incompatible with the marketing of industrial products of constant quality and properties.
Le chlorure de benzalkonium du commerce le plus utilisé comme antiseptique, notamment dans les collyres, est un mélange de chlorures d'alkylbenzyldiméthylammonium de formule générale :The most widely used commercial benzalkonium chloride as an antiseptic, in particular in eye drops, is a mixture of alkylbenzyldimethylammonium chlorides of general formula:
Figure imgf000003_0001
Figure imgf000003_0001
où R désigne un radical alkyle de structure cnH2n+l où n est un nombre pair compris entre 8 et 18, les valeurs n = 12 et 14 étant prédominantes. Le composé en C12 est généralement présent à 40 % dans le mélange et celui en C14 à 20 %. L'ensemble C12+ C14 constituant 70 % au moins du mélange.where R denotes an alkyl radical of structure c n H 2n + l where n is an even number between 8 and 18, the values n = 12 and 14 being predominant. The compound in C12 is generally present at 40% in the mixture and that in C14 at 20%. The whole C12 + C14 constituting at least 70% of the mixture.
Or des études comparatives ont révélé que c'est le composé avec n = 14 (radical tetradecyl C^r^g) qui présente la meilleure activité antiseptique.However, comparative studies have revealed that it is the compound with n = 14 (tetradecyl radical C ^ r ^ g) which exhibits the best antiseptic activity.
Activité bactéricide du BAKBAK bactericidal activity
Longueur de Concentration minimale bactéricide en μg/ l chaîne R S. Aurens S. Typhosa AeruginosaLength of minimum bactericidal concentration in μg / l chain R S. Aurens S. Typhosa Aeruginosa
C12 45 40 120C12 45 40 120
C14 15 12 40C14 15 12 40
D'autres études comparatives ont révélé que parmi les matériaux synthétiques du commerce aptes à fixer superficiellement le chlorure de benzalkonium, les plus performants chimiquement et mécaniquement sont la nitro- cellulose, le polyhexamethylene adipamide, commercialisé sous la dénomination "Nylon 6-6", et le polymère linéaire d'ε-caprolactam commercialisé notamment sous l'appel¬ lation "Nylon 6".Other comparative studies have revealed that among the commercially available synthetic materials capable of fixing benzalkonium chloride on the surface, the most chemically and mechanically efficient are nitro-cellulose, polyhexamethylene adipamide, sold under the name "Nylon 6-6", and the linear polymer of ε-caprolactam sold in particular under the name "Nylon 6".
Par ailleurs, des études comparatives complémen- taires ont démontré que, parmi les diverses formes struc¬ turelles réalisables industriellement, c'est sous la for¬ me de filaments saturés superficiellement de chlorure de benzalkonium que l'on obtient la meilleure efficacité antiseptique dans les applications pratiques. La quantité de chlorure de benzalkonium fixée pour une même masse de matériau est d'autant plus grande que les filaments sont plus fins. En fait, la capacité de rétention augmente avec la surface spécifique du matériau support, et dépend aussi de sa forme. Ainsi, on a constaté que l'on pouvait fixer envi¬ ron 188 g de BAK pour 100 g de membranes filtrantes "SARTOLON 0,45 μ" en Nylon 6 de la société allemande SARTORIUS contre environ 221 mg pour 100 g de membranes filtrantes "BYODINE C 0,45 μ" en Nylon 6-6 de la société dite PALL, et environ 544 mg pour 100 g de membrane filtrante "SM 11 307-050 0,45 μ" en nitrocellulose de la société allemande SARTORIUS. Ces membranes sont formées par feutrage de filaments d'environ 0,10 mm de diamètre. Pour des fils d'environ 0,14 mm de diamètre, le BAK fixé est d'environ 37 mg pour 100 g de fils en Nylon 6, et d'environ 55 mg pour 100 g de fils en Nylon 6-6. Les fils de Nylon 6 fixent environ 44 mg pour 100 g en 0,4 mm de diamètre, 61 mg en 0,2 mm de diamètre et 61 mg en 0,14 mm de diamètre.Furthermore, additional comparative studies have shown that, among the various industrially feasible structural forms, it is in the form of filaments saturated superficially with benzalkonium chloride that the best antiseptic efficacy is obtained in practical applications. The thinner the filaments of benzalkonium chloride fixed for the same mass of material. In fact, the retention capacity increases with the specific surface of the support material, and also depends on its shape. Thus, it was found that it was possible to fix approximately 188 g of BAK per 100 g of filter membranes. "SARTOLON 0.45 μ" in Nylon 6 from the German company SARTORIUS against approximately 221 mg per 100 g of filter membranes "BYODINE C 0.45 μ" in Nylon 6-6 from the company called PALL, and approximately 544 mg for 100 g of filter membrane "SM 11 307-050 0.45 μ" made of nitrocellulose from the German company SARTORIUS. These membranes are formed by felting filaments of about 0.10 mm in diameter. For wires about 0.14 mm in diameter, the fixed BAK is about 37 mg per 100 g of nylon 6 son, and about 55 mg per 100 g of nylon 6-6 son. The nylon 6 threads fix around 44 mg per 100 g in 0.4 mm in diameter, 61 mg in 0.2 mm in diameter and 61 mg in 0.14 mm in diameter.
Dans certains pays, notamment en France, les règlements pharmaceutiques imposent l'addition d'un con¬ servateur, tel que le chlorure de benzalkonium, dans les solutions conditionnées dans des récipients à prélève¬ ments répétitifs. Ces conservateurs présentent cependant des risques d'effets indésirables secondaires, notamment dans les collyres. On a donc proposé de capter le conser¬ vateur au passage d'un filtre afin de distribuer ainsi une solution stérile épurée, mais la portion de celle-ci restant dans le filtre et l'embout distributeur reste exposée à la pollution entre deux distributions. Il en est de même pour la face aval de membranes filtrantes bactériologiques.In some countries, notably in France, pharmaceutical regulations require the addition of a preservative, such as benzalkonium chloride, in solutions packaged in containers with repetitive samples. These preservatives, however, present risks of undesirable side effects, in particular in eye drops. It has therefore been proposed to capture the conservator when passing a filter in order to thus distribute a purified sterile solution, but the portion of the latter remaining in the filter and the dispensing nozzle remains exposed to pollution between two distributions. It is the same for the downstream face of bacteriological filter membranes.
L'invention a notamment pour but de pallier de tels inconvénients et de réaliser industriellement des articles antiseptiques de propriétés constantes et per- formantes à faible coût.The object of the invention is in particular to overcome such drawbacks and to produce industrially antiseptic articles of constant and effective properties at low cost.
L'invention a pour objet des articles antisep¬ tiques, notamment pour le conditionnement de produits pharmaceutiques, alimentaires, cosmétiques, et à usage sanitaire ou d'hygiène, caractérisés en ce qu'ils sont constitués, au moins en partie, par un assemblage non occlusif de filaments antiseptiques d'une matière syn¬ thétique du groupe comprenant la nitrocellulose, le poly¬ hexamethylene adipamide, et le polymère linéaire d'ε- caprolactam, superficiellement saturés de chlorure de benzalkonium, au moins à 50 pour cent en radical tetra¬ decyl non libérable dans les conditions prévues d'utilisation.The subject of the invention is antiseptic articles, in particular for the packaging of pharmaceuticals, foodstuffs, cosmetics, and for sanitary or hygienic use, characterized in that they consist, at least in part, of an assembly. no occlusive of antiseptic filaments of a synthetic material of the group comprising nitrocellulose, poly¬ hexamethylene adipamide, and the linear polymer of ε- caprolactam, superficially saturated with benzalkonium chloride, at least 50 percent in tetra¬ radical decyl not releasable under the conditions of use.
Les filaments antiseptiques peuvent être assem¬ blés pour constituer une mèche tressée, tricotée, toronée ou torsadée, aussi bien qu'une nappe formée par tissage, tricotage, cardage, juxtaposition/superposition ou feutrage.The antiseptic filaments can be assembled to form a braided, knitted, stranded or twisted wick, as well as a sheet formed by weaving, knitting, carding, juxtaposition / superposition or felting.
Les filaments ainsi assemblés ont avantageusement environ 0,15 mm de diamètre pour assurer entre eux un laminage du liquide propre à une bonne stérilisation et filtration, avec une bonne tenue mécanique. Des filaments plus fins peuvent être feutrés pour former des membranes filtrantes.The filaments thus assembled advantageously have about 0.15 mm in diameter to ensure between them a rolling of the liquid suitable for good sterilization and filtration, with good mechanical strength. Finer filaments can be felted to form filter membranes.
Les articles, objets de l'invention peuvent cons- tituer notamment des cartouches filtrantes pour réci¬ pients ou conduits de liquides stériles formées de fila¬ ments antiseptiques assemblés en une masse cylindrique perméable entourée d'une gaine cylindrique étanche ouverte à ses deux extrémités. Ils trouvent une application particulièrement intéressante dans des conditionnements de liquides sté¬ riles comprenant un récipient à paroi souple dont le gou¬ lot est muni d'un embout canalisant la sortie du liquide à travers une cartouche filtrante de filaments anti-, septiques.The articles which are objects of the invention can in particular constitute filter cartridges for containers or conduits for sterile liquids formed from antiseptic filaments assembled in a permeable cylindrical mass surrounded by a tight cylindrical sheath open at its two ends. They find a particularly advantageous application in packages of sterile liquids comprising a receptacle with a flexible wall, the gou¬ lot of which is provided with a nozzle channeling the outlet of the liquid through a filter cartridge of anti-septic filaments.
Une telle cartouche peut être constituée par un faisceau de filaments antiseptiques tressés, torsadés, et/ou toronés ou par un empilage de rondelles fibreuses formant une masse cylindrique gainée de matière plastique qui est surmoulée dans un embout stilligoutte. Dans de tels conditionnements, il est générale¬ ment préférable que l'embout soit coiffé d'un capuchon amovible dont le fond est garni d'une nappe de filaments antiseptiques qui s'applique contre l'ouverture de sortie de l'embout pour 1*obturer entre les distributions de liquide.Such a cartridge can be constituted by a bundle of braided, twisted, and / or stranded antiseptic filaments or by a stack of fibrous washers forming a cylindrical mass sheathed in plastic material which is overmolded in a dropper nozzle. In such packaging, it is generally preferable for the end piece to be capped with a removable cap, the bottom of which is lined with a sheet of antiseptic filaments which is applied against the outlet opening of the end piece for 1 * seal between liquid distributions.
Afin d'assurer l'asepsie à l'intérieur d'un réci¬ pient, ou en amont d'un conduit, lorsque la cartouche n'est pas imprégnée de liquide et ne peut donc remplir son rôle antiseptique, on munira au moins une des extré¬ mités de la cartouche d'une membrane filtrante hydrophile bactériologique à pores d'environ 0,2 μm d'ouverture.In order to ensure asepsis inside a container, or upstream of a conduit, when the cartridge is not impregnated with liquid and therefore cannot fulfill its antiseptic role, at least one ends of the cartridge of a bacteriological hydrophilic filter membrane with pores of about 0.2 μm opening.
Lorsqu'on désire distribuer pur un liquide ren¬ fermant un antiseptique, plus particulièrement du chlo- rure de benzalkonium, on peut utiliser les propriétés de captation de cet antiseptique par les matières synthé¬ tiques visées par l'invention tout en protégeant de la pollution le liquide purifié résiduel dans l'embout de distribution. Pour cela, suivant l'invention, on peut équiper l'embout d'un élément filtrant composite dont la partie amont renferme des filaments non saturés de chlo¬ rure de benzalkonium, et la partie aval renferme des filaments antiseptiques saturés de chlorure de benzalkonium. Afin d'assurer le maximum de protection, les élé¬ ments de l'embout, autres que les filaments, appelés à être exposés à l'extérieur et au contact du liquide lors de sa distribution, seront réalisés en un matériau anti¬ septique analogue à celui des filaments, et saturés d'antiseptique.When it is desired to distribute pure a liquid containing an antiseptic, more particularly benzalkonium chloride, it is possible to use the properties of capture of this antiseptic by the synthetic materials targeted by the invention while protecting from pollution the residual purified liquid in the dispensing nozzle. For this, according to the invention, it is possible to equip the endpiece with a composite filtering element, the upstream part of which contains unsaturated filaments of benzalkonium chloride, and the downstream part contains antiseptic filaments saturated with benzalkonium chloride. In order to ensure maximum protection, the elements of the nozzle, other than the filaments, which are called to be exposed to the outside and in contact with the liquid during its distribution, will be made of a similar anti-septic material to that of the filaments, and saturated with antiseptic.
Pour d'autres applications pratiques de l'inven¬ tion, les filaments antiseptiques peuvent être assemblés en touffes dont la base est enserrée dans une monture pour former une brosse, par exemple à usage dentaire, ou un pinceau, par exemple pour l'application de topiques cutanés.For other practical applications of the invention, the antiseptic filaments can be assembled in tufts, the base of which is enclosed in a frame to form a brush, for example for dental use, or a brush, for example for the application of skin topicals.
En plus du conditionnement stérile de liquides, l'invention comporte des applications multiples et diver- ses : on peut citer notamment les brosses, peignes et pinceaux à usage hygiénique ou cosmétique, les panse¬ ments, champs opératoires, housses, gants, masques respi¬ ratoires, semelles podologiques, tissus stériles, tubes tressés de conduite de liquide stérile, filtres divers. L'invention pourra être plus clairement comprise par quelques exemples, ainsi que par l'examen et la des¬ cription détaillée des dessins annexés, qui concernent des modes de réalisation pratique choisis simplement à titre d'illustration parmi les nombreuses formes d'exécu- tion, adaptations et variantes de l'invention concevables par un technicien averti.In addition to the sterile packaging of liquids, the invention has multiple and diverse applications: there may be mentioned in particular brushes, combs and brushes for hygienic or cosmetic use, dressings, operating drapes, covers, gloves, masks respi ¬ racks, podiatric insoles, sterile tissues, braided tubes for sterile liquid, various filters. The invention may be more clearly understood by a few examples, as well as by examining and describing the detailed description of the appended drawings, which relate to practical embodiments chosen simply by way of illustration from the numerous forms of execution. tion, adaptations and variants of the invention conceivable by an experienced technician.
Sur ces dessins : la figure 1 est une vue en élévation et en coupe axiale d'un flacon équipé d'un embout distributeur stérile suivant l'invention ; la figure 2 est une vue analogue à celle de la figure 1, d'une variante d'embout ; la figure 3 est une vue analogue à celle de la figure 2, d'une autre variante d'embout ; la figure 4 et une vue de côté d'une brosse à dent suivant l'invention ; la figure 5 est une vue de côté d'une brosse écouvillon suivant l'invention ; et, la figure 6 est une vue analogue à celle de la figure l d'une autre variante.In these drawings: FIG. 1 is a view in elevation and in axial section of a bottle fitted with a sterile dispensing nozzle according to the invention; Figure 2 is a view similar to that of Figure 1, a variant of the nozzle; Figure 3 is a view similar to that of Figure 2, of another variant of the nozzle; Figure 4 and a side view of a toothbrush according to the invention; Figure 5 is a side view of a swab brush according to the invention; and, Figure 6 is a view similar to that of Figure l of another variant.
Sur ces figures, les éléments correspondants sont désignés par les mêmes références numériques, éventuel¬ lement affectées d'un indice. Les dimensions et les pro¬ portions respectives de ces éléments peuvent ne pas être respectées pour une meilleure clarté des dessins. Le conditionnement représenté sur la figure 1 convient tout particulièrement pour les collyres et autres produits pharmaceutiques. Il comprend essentielle¬ ment un flacon 1 à paroi souple, par exemple en poly- éthylène. Dans son goulot est inséré de façon étanche un embout 2, par exemple en polyamide saturé de chlorure de benzalkonium à prépondérance de radical tetradecyl, ter¬ miné par une embouchure stilligoutte 4 et coiffé d'un capuchon 3, par exemple en polyamide, dont la base est vissée sur un filetage de la base de l'embout. Le fond du capuchon est garni d'un tampon 11 formé d'une nappe élastique de filaments antiseptiques enchevêtrés de poly¬ amide ou nitrocellulose, saturés de chlorure de benzal¬ konium à prépondérance de radical tetradecyl. Le canal axial de l'embout est garni d'une cartouche filtrante 5 formée d'un faisceau 6 de filaments antiseptiques de polyamide ou nitrocellulose saturés de chlorure de ben¬ zalkonium à prépondérance de radical tetradecyl, assem¬ blés en une masse cylindrique perméable entourée d'une gaine cylindrique étanche 7, par exemple en polyéthylène.In these figures, the corresponding elements are designated by the same reference numerals, possibly assigned an index. The dimensions and the respective pro¬ portions of these elements may not be respected for better clarity of the drawings. The packaging shown in Figure 1 is particularly suitable for eye drops and other pharmaceutical products. It essentially comprises a bottle 1 with a flexible wall, for example made of polyethylene. In its neck is inserted in leaktight manner a nozzle 2, for example made of polyamide saturated with benzalkonium chloride predominantly of tetradecyl radical, terminated by a still mouthpiece 4 and capped with a cap 3, for example made of polyamide, the base is screwed onto a thread on the base of the nozzle. The bottom of the cap is lined with a pad 11 formed from an elastic sheet of antiseptic filaments entangled with poly¬ amide or nitrocellulose, saturated with benzalkium chloride predominantly of tetradecyl radical. The axial channel of the nozzle is lined with a filter cartridge 5 formed of a bundle 6 of antiseptic filaments of polyamide or nitrocellulose saturated with ben¬ zalkonium chloride with preponderance of tetradecyl radical, assembled in a permeable cylindrical mass surrounded of a sealed cylindrical sheath 7, for example of polyethylene.
Dans la variante de la figure 2, le fond du capuchon 3a présente un téton conique 8a qui vient épou¬ ser la cavité 3a de l'embouchure stilligoutte de l'embout 2a. L'ouverture amont de la cartouche filtrante 5a est operculée par une membrane filtrante bactériologique 9a à pores d'environ 0,2 μm d'ouverture, soudée ou maintenue par sa périphérie contre un épaulement interne du canal axial de l'embout par une bague 10a, par exemple en polyamide saturé de chlorure de benzalkonium à prépondé- rance de radical tetradecyl, sertie dans le canal axial de 1•embout.In the variant of FIG. 2, the bottom of the cap 3a has a conical stud 8a which comes to spur the cavity 3a of the still mouth of the nozzle 2a. The upstream opening of the filter cartridge 5a is sealed by a bacteriological filter membrane 9a with pores of about 0.2 μm opening, welded or held by its periphery against an internal shoulder of the axial channel of the nozzle by a ring 10a, for example of polyamide saturated with benzalkonium chloride, predominantly of tetradecyl radical, crimped in the axial channel of the end piece.
La figure 3 représente une autre variante d'em¬ bout adaptable au flacon de la figure 1 pour la distri¬ bution épurée d'un liquide conditionné avec un conser- vateur. Dans cette variante, le capuchon 3b n'est pas vissé mais encliqueté sur la base de l'embout 2b. Le canal axial de l'embout est garni d'un élément filtrant composite formé d'une cartouche filtrante aval 5b renfer¬ mant des filaments antiseptiques, en polyamide ou nitro- cellulose saturés de chlorure de benzalkonium à prépon¬ dérance de radical tetradecyl, et d'une cartouche fil¬ trante amont 5'b renfermant des filaments capteurs du conservateur contenu dans le liquide conditionné, en polyamide ou nitrocelluloses vierges. Les cartouches aval et amont sont séparées par une membrane filtrante bacté¬ riologique 9b à pores d'environ 0,2 μm d'ouverture.FIG. 3 represents another variant of a tip adaptable to the bottle of FIG. 1 for the purified distribution of a liquid packaged with a preservative. In this variant, the cap 3b is not screwed but snapped onto the base of the nozzle 2b. The axial channel of the endpiece is lined with a composite filter element formed by a downstream filter cartridge 5b containing antiseptic filaments, made of polyamide or nitro-cellulose saturated with benzalkonium chloride predominantly of tetradecyl radical, and of an upstream filtering cartridge 5′b containing sensor filaments of the preservative contained in the conditioned liquid, made of virgin polyamide or nitrocelluloses. The downstream and upstream cartridges are separated by a bacteriological filter membrane 9b with pores of about 0.2 μm opening.
Pour les variantes des figures 2 et 3 on peut utiliser, notamment, les membranes filtrantes bactériolo¬ giques "BYODINE" ou "SARTOLON" du commerce. Dans l'embout de la figure 6, la cartouche fil¬ trante 5c est formée d'un empilage de rondelles fibreuses 12c perméables soudées à leur périphérie 13c et direc¬ tement surmoulées dans un embout 2c dont la base 14c est sertie dans le col 15c d'un récipient le en matière plas- tique soufflée, préalablement rempli. Cette structure convient tout particulièrement aux installations de con¬ ditionnement stérile à processus intégré de fabrication- remplissage-scellage de récipients dit "Blow Still Seal", tel ceux commercialisés sous la marque "BOTTELPACK" par la société suisse ROMMELAG, ou sous la marque "ALP" par la société Automatic Liquid Packaging des Etats-Unis d'Amérique. Une coiffe 3c, vissée, dont le fond est garni d'un tampon antiseptique lie, protège l'embout, elle est elle-même gainée dans un prolongement 16c du col du flacon réalisé en même temps que le sertissage, relié à la partie sertie par une zone frangible 17c qui se rompt au premier dévissage de la coiffe et constitue ainsi une garantie de non-utilisation préalable pour l'utilisateur.For the variants of FIGS. 2 and 3, it is possible to use, in particular, the commercial "BYODINE" or "SARTOLON" bacteriological filter membranes. In the nozzle of FIG. 6, the fil¬ trante cartridge 5c is formed by a stack of permeable fibrous washers 12c welded at their periphery 13c and directly molded in a nozzle 2c whose base 14c is set in the neck 15c a container of blown plastic material, previously filled. This structure is particularly suitable for sterile packaging installations with an integrated manufacturing-filling-sealing process for containers called "Blow Still Seal", such as those marketed under the brand "BOTTELPACK" by the Swiss company ROMMELAG, or under the brand " ALP "by the company Automatic Liquid Packaging of the United States of America. A screwed cap 3c, the bottom of which is lined with an antiseptic buffer, protects the end piece, it is itself sheathed in an extension 16c of the neck of the bottle produced at the same time as the crimping, connected to the crimped part by a frangible zone 17c which breaks at the first unscrewing of the cap and thus constitutes a guarantee of prior non-use for the user.
On pourra réaliser des cartouches filtrantes et autres articles antiseptiques objets de l'invention avec les techniques classiques de travail de fils, notamment comme décrit dans les exemples suivants :We can make filter cartridges and other antiseptic articles of the invention with conventional yarn working techniques, in particular as described in the following examples:
Exemple 1 - Tressage : on forme d'abord une tresse tubulaire primaire d'environ 0,4 mm de diamètre en tressant ensemble 12 brins de fil de 15/100 de mm de diamètre. Puis on tresse ensemble 12 tresses primaires pour former une tresse cylindrique d'environ 2,5 mm que l'on enrobe par extrusion annulaire périphérique de même matériau pour former une gaine d'environ 4 mm de diamètre avec une épaisseur radiale d'environ 0,8 mm. On découpe ensuite en tronçons cylindriques à la longueur désirée, par exemple environ 20 mm pour les cartouches filtrantes 5, 5a des figures 1 et 2 et environ 10 mm pour les cartouches 5b, 5'b de la figure 3. Exemple 2 - Toronaqe : on forme d'abord un toron primaire cylindrique d'environ 0,84 mm de diamètre en torsadant ensemble 21 brins de fil de 14/100 de mm de diamètre. On utilise un toron primaire comme axe pour torsader ensemble 6 autres torons primaires pour obtenir un toron cylindrique d'environ 2,5 mm de diamètre que l'on enrobe par extrusion de polyéthylène basse densité translucide en formant une gaine d'environ 4 mm de diamètre avec une épaisseur radiale d'environ 0,8 mm. On découpe ensuite en tronçons cylindriques à la longueur désirée pour l'application envisagée.Example 1 - Braiding: a primary tubular braid of approximately 0.4 mm in diameter is first formed by braiding together 12 strands of wire of 15/100 mm in diameter. Then we braid together 12 primary braids to form a cylindrical braid of approximately 2.5 mm which is coated by peripheral annular extrusion of the same material to form a sheath of approximately 4 mm in diameter with a radial thickness of approximately 0 , 8 mm. Then cut into cylindrical sections to the desired length, for example about 20 mm for the filter cartridges 5, 5a of Figures 1 and 2 and about 10 mm for the cartridges 5b, 5'b of Figure 3. Example 2 - Toronaqe: first a cylindrical primary strand of about 0.84 mm in diameter is formed by twisting together 21 strands of wire of 14/100 mm in diameter. A primary strand is used as an axis to twist together 6 other primary strands to obtain a cylindrical strand of approximately 2.5 mm in diameter which is coated by extrusion of translucent low density polyethylene by forming a sheath of approximately 4 mm. diameter with a radial thickness of about 0.8 mm. Then cut into cylindrical sections to the desired length for the intended application.
Exemple 3 - Cardacre : dans une machine classique du type "RANDO EBER" on prépare une nappe non tissée par cardage aéré de tronçons de filaments de polyamide d'en¬ viron 15 à 30 mm de longueur et environ 0,13 à 0,16 mm de diamètre dont au moins une partie sont frisés. On pulvé¬ rise du monomère du même polyamide dans la nappe pour réunir les filaments entre eux seulement à leurs points d'intersection et on polymérise pour obtenir une nappe filtrante utilisable, après saturation au chlorure de benzalkonium, pour les applications de textiles non- tissés antiseptiques. Le découpage d'une telle nappe en rondelles, par exemple par ultrasons avec soudure des tranches permet de réaliser le tampon 11 disposé au fond du capuchon 3 du conditionnement de la figure 1, et les rondelles 12c du conditionnement de la figure 6.Example 3 - Cardacre: in a conventional machine of the "RANDO EBER" type, a nonwoven sheet is prepared by aerated carding of sections of polyamide filaments of approximately 15 to 30 mm in length and approximately 0.13 to 0.16 mm in diameter at least part of which is crimped. The monomer of the same polyamide is sprayed into the sheet to join the filaments together only at their points of intersection and polymerized to obtain a usable filter sheet, after saturation with benzalkonium chloride, for non-textile applications. antiseptic woven fabrics. The cutting of such a sheet into washers, for example by ultrasound with welding of the slices makes it possible to produce the pad 11 placed at the bottom of the cap 3 of the packaging of FIG. 1, and the washers 12c of the packaging of FIG. 6.
Exemple 4 - Juxtaposition/Superposition : On dépose une nappe de spires contiguës parallèles de fila¬ ments de polyamide sur un tambour que l'on recouvre par dépôt d'au moins une nappe analogue d'orientation non parallèle à la précédente. On obtient ainsi une nappe homogène de filaments croisés que l'on découpe en ron¬ delles que l'on empile pour former une cartouche fil¬ trante surmoulée directement ou après gainage dans un embout, tel celui de la figure 6. Exemple 5 - Imprégnation : on utilise une solu¬ tion de chlorure de benzalkonium dans le solvant aqueux du liquide à conditionner. Ainsi, pour des collyres, on prépare une solution de chlorure de benzalkonium à la concentration de 100 μg/ml dans une solution aqueuse de NaCl à 0,9 g % (pH 7,2). On fait tremper les filaments ou autres articles à saturer dans cette solution en excès pendant environ 2 heures à température et pressions ambiantes normales, puis, après égouttage et séchage, on les lave avec une solution aqueuse de NaCl à 0,9 g% (pH 7,2) jusqu'à disparition du chlorure de benzalkonium dans les effluents. On égoutte et sèche à température inférieure à 110°C environ.Example 4 - Juxtaposition / Superposition: A sheet of contiguous parallel turns of polyamide fila¬ ments is deposited on a drum which is covered by depositing at least one analogous sheet of orientation not parallel to the previous one. A homogeneous sheet of crossed filaments is thus obtained which is cut into rounds which are stacked to form a fil¬ trante cartridge molded directly or after sheathing in a nozzle, such as that of FIG. 6. Example 5 - Impregnation : a benzalkonium chloride solution is used in the aqueous solvent of the liquid to be packaged. Thus, for eye drops, a solution of benzalkonium chloride is prepared at a concentration of 100 μg / ml in an aqueous NaCl solution at 0.9 g% (pH 7.2). The filaments or other articles to be saturated are soaked in this excess solution for approximately 2 hours at normal ambient temperature and pressure, then, after draining and drying, they are washed with an aqueous NaCl solution at 0.9 g% (pH 7.2) until the benzalkonium chloride disappears from the effluents. It is drained and dried at a temperature below about 110 ° C.
Lorsqu'on utilise une solution de chlorure de benzalkonium (BAK) classique 60/40 à 60 % de radical duodécyl (BAK C12) et 40 % de radical tetradecyl (BAK C14) on constate dans le BAK fixé sur du polyamide des proportions de BAK C12 et BAK C14 variant de 50/50 à 40/60 ce qui révèle une affinité plus importante des polyamides pour le BAK C14, d'autant plus intéressante que le BAK C14 a une activité bactéricide plus élevée que le BAK C12.When using a conventional benzalkonium chloride solution (BAK) 60/40 with 60% of duodecyl radical (BAK C12) and 40% of tetradecyl radical (BAK C14) we find in the BAK fixed on polyamide the proportions of BAK C12 and BAK C14 varying from 50/50 to 40/60 which reveals a greater affinity of polyamides for BAK C14, all the more interesting that BAK C14 has a higher bactericidal activity than BAK C12.
Pour déterminer la quantité de BAK fixé sur des filaments ou autres supports en polyamide, on l'extrait à trois reprises par agitation à température ambiante dans un mélange solvant de 40 parties de éthanol et 60 de solution aqueuse d'acétate de sodium anhydre dans l'eau distillée (8,5 g/1), ajustée à pH 5,0 avec de l'acide acétique pendant 30 minutes, avec 2 ml de solvant pour 100 mg de polyamide. On analyse ensuite de façon clas¬ sique les solvants de lavage avec un chromatographe liquide à haute pression, tel celui "commercialisé sous la dénomination HEWLETT PACKARD 1050, avec enregistreur HELWETT PACKARD 3390 A et colonne WATERS (3,9 x 150 mm)μ Bondpak CN-lOμm-Réf. 86688. Après étalonnage, on effectue les calculs à partir des aires de pics correspondants au BAK C12 et au BAK C14. On peut ainsi contrôler à la fois la quantité totale de BAK fixée (C12 + C14) et les proportions relatives de BAK C12 et BAK C14. To determine the quantity of BAK fixed on filaments or other polyamide supports, it is extracted three times by stirring at room temperature in a solvent mixture of 40 parts of ethanol and 60 of aqueous solution of anhydrous sodium acetate in 1 distilled water (8.5 g / l), adjusted to pH 5.0 with acetic acid for 30 minutes, with 2 ml of solvent per 100 mg of polyamide. The washing solvents are then analyzed in a conventional manner with a high pressure liquid chromatograph, such as that "marketed under the name HEWLETT PACKARD 1050, with HELWETT PACKARD 3390 A recorder and WATERS column (3.9 x 150 mm) μ Bondpak CN-10μm-Ref 86688. After calibration, the calculations are carried out from the peak areas corresponding to BAK C12 and BAK C14, so that both the total amount of BAK fixed (C12 + C14) and the relative proportions of BAK C12 and BAK C14.

Claims

REVENDICATIONS
1. Articles antiseptiques, notamment pour le con¬ ditionnement de produits pharmaceutiques, alimentaires, cosmétiques, et à usage sanitaire ou d'hygiène, consti¬ tués, au moins en partie, par un assemblage non occlusif de filaments antiseptiques d'une matière synthétique, superficiellement saturés de chlorure de benzalkonium, non libérable dans les conditions prévues d'utilisation, caractérisés en ce qu'au moins 50 pour cent du chlorure de benzalkonium est à radical tetradecyl, et en ce que les filaments sont en une matière synthétique du groupe comprenant la nitrocellulose, le polyhexamethylene adipamide et le polymère linéaire d'ε-caprolactam.1. Antiseptic articles, in particular for the packaging of pharmaceuticals, foodstuffs, cosmetics, and for sanitary or hygienic use, constituted, at least in part, by a non-occlusive assembly of antiseptic filaments of a synthetic material , superficially saturated with benzalkonium chloride, not releasable under the conditions of use, characterized in that at least 50 percent of the benzalkonium chloride is of tetradecyl radical, and in that the filaments are made of a synthetic material from the group comprising nitrocellulose, polyhexamethylene adipamide and the linear polymer of ε-caprolactam.
2. Articles, suivant la revendication 1, caracté¬ risés en ce que les filaments antiseptiques constituent une nappe formée par tissage, tricotage, cardage, juxtaposition/superposition, ou feutrage.2. Articles according to claim 1, caracté¬ ized in that the antiseptic filaments constitute a sheet formed by weaving, knitting, carding, juxtaposition / superposition, or felting.
3. Articles, suivant la revendication 1, caracté¬ risés en ce que les filaments antiseptiques sont assem¬ blés en mèche tressée, tricotée, toronée ou torsadée.3. Articles according to claim 1, caracté¬ ized in that the antiseptic filaments are assem¬ blown braided woven, knitted, stranded or twisted.
4. Articles, suivant l'une des revendications 1 à 3, notamment cartouches filtrantes pour récipients ou conduits de liquides stériles, caractérisés en ce qu'ils sont constitués de filaments antiseptiques, assemblés en une masse cylindrique perméable longitudinalement entou¬ rée d'une gaine cylindrique étanche ouverte à ses deux extrémités.4. Articles according to one of claims 1 to 3, in particular filter cartridges for containers or conduits of sterile liquids, characterized in that they consist of antiseptic filaments, assembled in a longitudinally permeable cylindrical mass surrounded by a sealed cylindrical sheath open at both ends.
5. Articles, suivant l'une des revendications 1 à 4, notamment conditionnements de liquides stériles, caractérisés en ce qu'ils comprennent un récipient (1) à paroi souple dont le goulot est muni d'un embout (2) canalisant la sortie du liquide à travers une cartouche filtrante (5) de filaments antiseptiques (6) .5. Articles according to one of claims 1 to 4, in particular packaging for sterile liquids, characterized in that they comprise a container (1) with a flexible wall, the neck of which is provided with a nozzle (2). channeling the outlet of the liquid through a filter cartridge (5) of antiseptic filaments (6).
6. Articles, suivant l'une des revendications 4 et 5, caractérisés en ce que la cartouche (5) est cons- tituée par un faisceau de filaments antiseptiques (6) tressés et/ou torsadés formant une masse cylindrique gainée de matière plastique qui est surmoulée dans un embout stilligoutte (2) .6. Articles according to one of claims 4 and 5, characterized in that the cartridge (5) is constituted by a bundle of antiseptic filaments (6) braided and / or twisted forming a cylindrical mass sheathed with plastic which is overmolded in a dropper tip (2).
7. Articles, suivant la revendication 6, carac- térisés en ce que les filaments ont environ 0,15 mm de diamètre.7. Articles according to claim 6, characterized in that the filaments are about 0.15 mm in diameter.
8. Articles, suivant l'une des revendications 4 et 5, caractérisés en ce que la cartouche est constituée par un empilage de rondelles fibreuses perméables 12c, gainé tubulairement de matière plastique surmoulée dans un embout stilligoutte.8. Articles, according to one of claims 4 and 5, characterized in that the cartridge is constituted by a stack of permeable fibrous washers 12c, sheathed tubularly with plastic material overmolded in a dropper nozzle.
9. Articles, suivant l'une des revendications 6 à 8, caractérisés en ce que l'embout est coiffé d'un capu¬ chon (3) amovible dont le fond est garni d'une nappe (11) de filaments antiseptiques qui s'applique contre l'ouver¬ ture (4) de sortie de l'embout (2) pour l'obturer entre les distributions de liquide.9. Articles according to one of claims 6 to 8, characterized in that the endpiece is topped with a removable capu¬ (3) whose bottom is lined with a sheet (11) of antiseptic filaments which s 'applies against the opening (4) outlet of the nozzle (2) to close it between the liquid distributions.
10. Articles, suivant l'une des revendications 4 à 8, caractérisés en ce qu'au moins une des extrémités de la cartouche (5) est garnie d'une membrane filtrante (9a) hydrophile bactériologique à pores d'environ 0,2 μ d'ouverture.10. Articles according to one of claims 4 to 8, characterized in that at least one of the ends of the cartridge (5) is provided with a bacteriological hydrophilic filter membrane (9a) with pores of about 0.2 μ of opening.
11. Articles, suivant l'une des revendications 4 à 10, caractérisés en ce que la cartouche renferme un élément filtrant composite dont la partie amont (5*b) est formée de filaments non saturés de chlorure de benzal¬ konium et la partie aval (5b) de filaments saturés de chlorure de benzalkonium.11. Articles according to one of claims 4 to 10, characterized in that the cartridge contains a composite filter element the upstream part (5 * b) of which is formed of unsaturated filaments of benzal¬ konium chloride and the downstream part (5b) of saturated benzalkonium chloride filaments.
12. Articles, suivant l'une des revendications 5 à 11, caractérisés en ce que les éléments de l'embout, autres que les filaments, appelés à être exposés à l'ex¬ térieur et au contact du liquide lors de sa distribution sont réalisés en un matériau antiseptique analogue à celui des filaments.12. Articles, according to one of claims 5 to 11, characterized in that the elements of the end piece, other than the filaments, which are called to be exposed to the outside and in contact with the liquid during its distribution, are made of an antiseptic material similar to that of the filaments.
13. Articles, suivant l'une des revendications 1 et 3, caractérisés en ce que les filaments antiseptiques sont assemblés en touffes dont la base est enserrée dans une monture pour former une brosse ou un pinceau. 13. Articles, according to one of claims 1 and 3, characterized in that the antiseptic filaments are assembled in tufts, the base of which is clamped in a frame to form a brush or a paintbrush.
PCT/FR1995/000371 1994-04-07 1995-03-24 Antiseptic articles WO1995027396A1 (en)

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FR9404103A FR2718330B1 (en) 1994-04-07 1994-04-07 Antiseptic items.

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999035911A1 (en) * 1998-01-13 1999-07-22 Unilever Plc Antimicrobial toothbrush

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AU2142495A (en) 1995-10-30
FR2718330B1 (en) 1998-10-02
FR2718330A1 (en) 1995-10-13

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