WO1995021919A3 - Protein having tpo activity - Google Patents
Protein having tpo activity Download PDFInfo
- Publication number
- WO1995021919A3 WO1995021919A3 PCT/JP1995/000208 JP9500208W WO9521919A3 WO 1995021919 A3 WO1995021919 A3 WO 1995021919A3 JP 9500208 W JP9500208 W JP 9500208W WO 9521919 A3 WO9521919 A3 WO 9521919A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptides
- tpo
- protein
- production
- tpo activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019970702400A KR100272867B1 (en) | 1994-02-14 | 1995-02-14 | Protein having tpo activity |
KR1019970702401A KR100260272B1 (en) | 1994-02-14 | 1995-02-14 | Dna comprising a base sequence encoding an amino acid sequence of a protein having tpo activity |
JP7521122A JP2996729B2 (en) | 1994-02-14 | 1995-02-14 | Antibodies to TPO-active proteins |
PL95311885A PL179884B1 (en) | 1994-02-14 | 1995-02-14 | Protein of tpo activity |
AU16718/95A AU702669B2 (en) | 1994-02-14 | 1995-02-14 | Protein having TPO activity |
KR1019950704474A KR100237582B1 (en) | 1994-02-14 | 1995-02-14 | Process for the preparation having tpo activity |
BR9505781A BR9505781A (en) | 1994-02-14 | 1995-02-14 | Protein having TPO activity |
MX9504057A MX9504057A (en) | 1994-02-14 | 1995-02-14 | Protein having tpo activity. |
NZ279555A NZ279555A (en) | 1994-02-14 | 1995-02-14 | Thrombopoietin polypeptides their production and use |
RO95-01791A RO118299B1 (en) | 1994-02-14 | 1995-02-14 | Thrompoietin polypeptide, dna sequence encoding for said protein, process for preparing the thrombopoietin process for preparing the thrombopoietin polypeptide and pharmaceutic composition comprising the same |
EP95908381A EP0695355A1 (en) | 1994-02-14 | 1995-02-14 | Protein having tpo activity |
NO19954058A NO323195B1 (en) | 1994-02-14 | 1995-10-12 | Protein having TPO activity, DNA coding for said protein, production methods, host cells, pharmaceutical compositions, uses and antibody |
FI954889A FI954889A (en) | 1994-02-14 | 1995-10-13 | A protein with TPO activity |
Applications Claiming Priority (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3909094 | 1994-02-14 | ||
JP6/39090 | 1994-02-14 | ||
US21216494A | 1994-03-14 | 1994-03-14 | |
JP6/79842 | 1994-03-25 | ||
JP7984294 | 1994-03-25 | ||
US22102094A | 1994-04-01 | 1994-04-01 | |
JP6/155126 | 1994-06-01 | ||
JP15512694 | 1994-06-01 | ||
JP16732894 | 1994-06-15 | ||
JP6/167328 | 1994-06-15 | ||
US27808394A | 1994-07-20 | 1994-07-20 | |
JP6/227159 | 1994-08-17 | ||
JP19316994 | 1994-08-17 | ||
JP22715994 | 1994-08-17 | ||
JP6/193169 | 1994-08-17 | ||
JP19391694 | 1994-08-18 | ||
JP6/193916 | 1994-08-18 | ||
US32030094A | 1994-10-11 | 1994-10-11 | |
JP30416794 | 1994-11-01 | ||
JP6/304167 | 1994-11-01 | ||
JP29866994 | 1994-12-01 | ||
JP6/298669 | 1994-12-01 | ||
US36181194A | 1994-12-22 | 1994-12-22 | |
JP34120094 | 1994-12-28 | ||
JP6/341200 | 1994-12-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1995021919A2 WO1995021919A2 (en) | 1995-08-17 |
WO1995021919A3 true WO1995021919A3 (en) | 1995-12-07 |
Family
ID=27585306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1995/000208 WO1995021919A2 (en) | 1994-02-14 | 1995-02-14 | Protein having tpo activity |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1995021919A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9114175B2 (en) | 2005-08-12 | 2015-08-25 | Amgen Inc. | Modified Fc molecules |
US9145450B2 (en) | 1998-10-23 | 2015-09-29 | Amgen Inc. | Thrombopoietic compounds |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8192955B1 (en) | 1994-01-03 | 2012-06-05 | Genentech, Inc. | Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof |
US8147844B1 (en) | 1994-01-03 | 2012-04-03 | Genentech, Inc. | Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand |
US8357513B1 (en) | 1994-01-03 | 2013-01-22 | Genentech, Inc. | Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof |
US8241900B1 (en) | 1994-01-03 | 2012-08-14 | Genentech, Inc. | mpl ligand |
US8278099B1 (en) | 1994-02-15 | 2012-10-02 | Genentech, Inc. | Monoclonal antibody to human thrombopoietin |
RO115788B1 (en) * | 1994-03-31 | 2000-06-30 | Amgen Inc. | Mgdf polypeptide, mgdf polypeptide derivative, monopegylated mgdf polypeptide and process for preparing the same |
US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
US5986049A (en) * | 1994-12-30 | 1999-11-16 | Zymogenetics, Inc. | Purified thrombopoietin and method of making it |
US5696250A (en) * | 1995-02-15 | 1997-12-09 | Amgen Inc. | DNA encoding megakaryocyte growth and development factor analogs |
US5989538A (en) * | 1995-02-15 | 1999-11-23 | Amgen Inc. | Mpl ligand analogs |
TW434021B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions |
TW434020B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions |
EP1961760A3 (en) | 1995-06-07 | 2008-09-03 | Glaxo Group Limited | Peptides and compounds that bind to a thrombopoietin receptor |
US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
TW497972B (en) * | 1995-06-08 | 2002-08-11 | Kirin Brewery | Stable thrombopoietin (TPO)-containing lyophilized compositions |
US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
PT1542714E (en) | 2002-09-18 | 2014-06-23 | Janssen Pharmaceuticals Inc | Methods of increasing platelet and hematopoietic stem cell production |
US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
PL1675606T3 (en) | 2003-08-28 | 2017-08-31 | Janssen Pharmaceuticals, Inc. | Peptides and compounds that bind to thrombopoietin receptors |
WO2005033135A1 (en) | 2003-10-09 | 2005-04-14 | Daewoong Co., Ltd. | Process for purifying human thrombopoietin with high content of sialic acid |
PL1699915T3 (en) | 2003-12-30 | 2010-11-30 | Augustinus Bader | Use of erythropoietin for liver tissue regeneration |
EP1773400A2 (en) | 2004-07-08 | 2007-04-18 | Amgen Inc. | Therapeutic peptides |
ES2550055T3 (en) | 2005-08-05 | 2015-11-04 | Araim Pharmaceuticals, Inc. | Protective tissue peptides and uses thereof |
WO2007102946A2 (en) | 2006-01-23 | 2007-09-13 | Amgen Inc. | Crystalline polypeptides |
US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
AU2008262490B2 (en) | 2007-05-22 | 2011-11-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
US8853358B2 (en) | 2008-01-22 | 2014-10-07 | Araim Pharmaceuticals, Inc. | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
-
1995
- 1995-02-14 WO PCT/JP1995/000208 patent/WO1995021919A2/en not_active Application Discontinuation
Non-Patent Citations (4)
Title |
---|
BARTLEY ET AL: "IDENTIFICATION AND CLONING OF A MEGAKARYOCYTE GROWTH AND DEVLOPMENT FACTOR THAT IS A LIGAND FOR THE CYTOKINE RECEPTOR MPL", CELL, vol. 77, 1 July 1994 (1994-07-01), pages 1117 - 1124 * |
DE SAUVAGE ET AL: "STIMULATION OF MEGAKARYOCYTOPOIESIS AND THROMBOPOIESIS BY THE C-MPL LIGAND", NATURE, vol. 369, 16 June 1994 (1994-06-16), pages 533 - 538 * |
MCDONALD: "THROMBOPOIETIN:ITS BIOLOGY,PURIFICATION,AND CHARACTERIZATION", EXPERIMENTAL HEMATOLOGY, vol. 16, no. 3, pages 201 - 205 * |
SOHMA ET AL: "MOLECULAR CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN THROMBOPOIETIN GENE", FEBS LETTERS, vol. 353, no. 1, 10 October 1994 (1994-10-10), pages 57 - 61 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9145450B2 (en) | 1998-10-23 | 2015-09-29 | Amgen Inc. | Thrombopoietic compounds |
US9114175B2 (en) | 2005-08-12 | 2015-08-25 | Amgen Inc. | Modified Fc molecules |
Also Published As
Publication number | Publication date |
---|---|
WO1995021919A2 (en) | 1995-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1995021919A3 (en) | Protein having tpo activity | |
CA2263889A1 (en) | P-selectin ligand proteins | |
AU704515C (en) | Novel protein and process for producing the same | |
EP1439230A3 (en) | Human transmembrane protein TMP-2 gene | |
ES2170755T3 (en) | CONJUGADOS OF ANIMAL PHARMACO ESCINDIBLES BY LISOSOMAL ENZYMES. | |
EP0921818A4 (en) | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids | |
WO1997044356A3 (en) | Ret ligand (retl) for stimulating neural and renal growth | |
CA2006322A1 (en) | Recombinant dna molecules, hosts, processes and human somatomedin carrier protein-like polypeptides | |
EP1396542A3 (en) | P-Selectin Ligand Protein | |
WO1997011179A3 (en) | VARIANTS OF HUMAN RECOMBINANT INTERFERON-η (RHU-IFN-η) HAVING INCREASED HEAT-STABILITY | |
EP2017343A3 (en) | Protein A based binding domains with desirable activities | |
WO1995030001A3 (en) | Novel p-selectin ligand protein | |
AU7791398A (en) | Antimicrobial peptides derived from ubiquicidine | |
DE69837265D1 (en) | POLYPEPTIDES FOR REGENERATING THE NERVOUS SYSTEM | |
DE59410423D1 (en) | SERIN-THREONINE-KINASE CONTAINING TUMOR THERAPY AND TUMOR DIAGNOSIS | |
MX9504057A (en) | Protein having tpo activity. | |
YU8395A (en) | PROTEIN WITH TPO ACTIVITY | |
CA2163805A1 (en) | Novel activating factor of leukocytes | |
WO2004042043A3 (en) | Crystal structures of bacterial ribulose-phosphate 3-epimerases | |
WO2003097789A3 (en) | Farnesyl diphosphate synthase from pseudomonas aeruginosa | |
WO2004058811A3 (en) | Crystal structures of yhhf polypeptides | |
DE69528575D1 (en) | ANTIFUNGAL PROTEINS, CODING DNA, AND THESE HOSTING CELL | |
WO2003027274A3 (en) | Purified polypeptides from pseudomonas aeruginosa | |
WO1999043834A3 (en) | P-selectin ligand protein, including tetrameric fusion proteins | |
WO2005005469A3 (en) | Novel purified polypeptides from staphylococcus aureus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 95190305.5 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU JP KE KG KR KZ LK LR LT LU LV MD MG MN MW MX NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA US US US US US US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): KE MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 279555 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2160591 Country of ref document: CA Ref document number: 954889 Country of ref document: FI |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1995908381 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 1996 535025 Country of ref document: US Date of ref document: 19960102 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 1995908381 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1019970702401 Country of ref document: KR Ref document number: 1019970702400 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 1019970702400 Country of ref document: KR Ref document number: 1019970702401 Country of ref document: KR |
|
WWG | Wipo information: grant in national office |
Ref document number: 1019970702401 Country of ref document: KR |
|
WWG | Wipo information: grant in national office |
Ref document number: 1019970702400 Country of ref document: KR |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1995908381 Country of ref document: EP |