WO1995021919A3 - Protein having tpo activity - Google Patents

Protein having tpo activity Download PDF

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Publication number
WO1995021919A3
WO1995021919A3 PCT/JP1995/000208 JP9500208W WO9521919A3 WO 1995021919 A3 WO1995021919 A3 WO 1995021919A3 JP 9500208 W JP9500208 W JP 9500208W WO 9521919 A3 WO9521919 A3 WO 9521919A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
tpo
protein
production
tpo activity
Prior art date
Application number
PCT/JP1995/000208
Other languages
French (fr)
Other versions
WO1995021919A2 (en
Inventor
Hiroshi Miyazaki
Takashi Kato
Kinya Ohgami
Akihiro Iwamatsu
Hiromichi Akahori
Ryota Kuroki
Toshiyuki Shimizu
Takanori Muto
Original Assignee
Kirin Brewery
Hiroshi Miyazaki
Takashi Kato
Kinya Ohgami
Akihiro Iwamatsu
Hiromichi Akahori
Ryota Kuroki
Toshiyuki Shimizu
Takanori Muto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX9504057A priority Critical patent/MX9504057A/en
Priority to KR1019950704474A priority patent/KR100237582B1/en
Priority to KR1019970702401A priority patent/KR100260272B1/en
Priority to JP7521122A priority patent/JP2996729B2/en
Application filed by Kirin Brewery, Hiroshi Miyazaki, Takashi Kato, Kinya Ohgami, Akihiro Iwamatsu, Hiromichi Akahori, Ryota Kuroki, Toshiyuki Shimizu, Takanori Muto filed Critical Kirin Brewery
Priority to AU16718/95A priority patent/AU702669B2/en
Priority to KR1019970702400A priority patent/KR100272867B1/en
Priority to BR9505781A priority patent/BR9505781A/en
Priority to PL95311885A priority patent/PL179884B1/en
Priority to NZ279555A priority patent/NZ279555A/en
Priority to RO95-01791A priority patent/RO118299B1/en
Priority to EP95908381A priority patent/EP0695355A1/en
Publication of WO1995021919A2 publication Critical patent/WO1995021919A2/en
Priority to NO19954058A priority patent/NO323195B1/en
Priority to FI954889A priority patent/FI954889A/en
Publication of WO1995021919A3 publication Critical patent/WO1995021919A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates to thrombopoietin (TPO) polypeptides having the biological activity of specifically stimulating or increasing platelet production comprising the amino acid sequence 1-332 of SEQ ID NO: 6 or a derivative thereof, DNA molecules encoding TPO polypeptides, processes for production of the polypeptides, antibodies specifically immunoreactive with the polypeptides, pharmaceutical compositions comprising the polypeptides, and methods for using the polypeptides in treatment of platelet disorders such as thrombocytopenia.
PCT/JP1995/000208 1994-02-14 1995-02-14 Protein having tpo activity WO1995021919A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
KR1019970702400A KR100272867B1 (en) 1994-02-14 1995-02-14 Protein having tpo activity
KR1019970702401A KR100260272B1 (en) 1994-02-14 1995-02-14 Dna comprising a base sequence encoding an amino acid sequence of a protein having tpo activity
JP7521122A JP2996729B2 (en) 1994-02-14 1995-02-14 Antibodies to TPO-active proteins
PL95311885A PL179884B1 (en) 1994-02-14 1995-02-14 Protein of tpo activity
AU16718/95A AU702669B2 (en) 1994-02-14 1995-02-14 Protein having TPO activity
KR1019950704474A KR100237582B1 (en) 1994-02-14 1995-02-14 Process for the preparation having tpo activity
BR9505781A BR9505781A (en) 1994-02-14 1995-02-14 Protein having TPO activity
MX9504057A MX9504057A (en) 1994-02-14 1995-02-14 Protein having tpo activity.
NZ279555A NZ279555A (en) 1994-02-14 1995-02-14 Thrombopoietin polypeptides their production and use
RO95-01791A RO118299B1 (en) 1994-02-14 1995-02-14 Thrompoietin polypeptide, dna sequence encoding for said protein, process for preparing the thrombopoietin process for preparing the thrombopoietin polypeptide and pharmaceutic composition comprising the same
EP95908381A EP0695355A1 (en) 1994-02-14 1995-02-14 Protein having tpo activity
NO19954058A NO323195B1 (en) 1994-02-14 1995-10-12 Protein having TPO activity, DNA coding for said protein, production methods, host cells, pharmaceutical compositions, uses and antibody
FI954889A FI954889A (en) 1994-02-14 1995-10-13 A protein with TPO activity

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
JP3909094 1994-02-14
JP6/39090 1994-02-14
US21216494A 1994-03-14 1994-03-14
JP6/79842 1994-03-25
JP7984294 1994-03-25
US22102094A 1994-04-01 1994-04-01
JP6/155126 1994-06-01
JP15512694 1994-06-01
JP16732894 1994-06-15
JP6/167328 1994-06-15
US27808394A 1994-07-20 1994-07-20
JP6/227159 1994-08-17
JP19316994 1994-08-17
JP22715994 1994-08-17
JP6/193169 1994-08-17
JP19391694 1994-08-18
JP6/193916 1994-08-18
US32030094A 1994-10-11 1994-10-11
JP30416794 1994-11-01
JP6/304167 1994-11-01
JP29866994 1994-12-01
JP6/298669 1994-12-01
US36181194A 1994-12-22 1994-12-22
JP34120094 1994-12-28
JP6/341200 1994-12-28

Publications (2)

Publication Number Publication Date
WO1995021919A2 WO1995021919A2 (en) 1995-08-17
WO1995021919A3 true WO1995021919A3 (en) 1995-12-07

Family

ID=27585306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1995/000208 WO1995021919A2 (en) 1994-02-14 1995-02-14 Protein having tpo activity

Country Status (1)

Country Link
WO (1) WO1995021919A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules
US9145450B2 (en) 1998-10-23 2015-09-29 Amgen Inc. Thrombopoietic compounds

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8192955B1 (en) 1994-01-03 2012-06-05 Genentech, Inc. Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US8147844B1 (en) 1994-01-03 2012-04-03 Genentech, Inc. Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
US8357513B1 (en) 1994-01-03 2013-01-22 Genentech, Inc. Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US8241900B1 (en) 1994-01-03 2012-08-14 Genentech, Inc. mpl ligand
US8278099B1 (en) 1994-02-15 2012-10-02 Genentech, Inc. Monoclonal antibody to human thrombopoietin
RO115788B1 (en) * 1994-03-31 2000-06-30 Amgen Inc. Mgdf polypeptide, mgdf polypeptide derivative, monopegylated mgdf polypeptide and process for preparing the same
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
EP1961760A3 (en) 1995-06-07 2008-09-03 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
PT1542714E (en) 2002-09-18 2014-06-23 Janssen Pharmaceuticals Inc Methods of increasing platelet and hematopoietic stem cell production
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
PL1675606T3 (en) 2003-08-28 2017-08-31 Janssen Pharmaceuticals, Inc. Peptides and compounds that bind to thrombopoietin receptors
WO2005033135A1 (en) 2003-10-09 2005-04-14 Daewoong Co., Ltd. Process for purifying human thrombopoietin with high content of sialic acid
PL1699915T3 (en) 2003-12-30 2010-11-30 Augustinus Bader Use of erythropoietin for liver tissue regeneration
EP1773400A2 (en) 2004-07-08 2007-04-18 Amgen Inc. Therapeutic peptides
ES2550055T3 (en) 2005-08-05 2015-11-04 Araim Pharmaceuticals, Inc. Protective tissue peptides and uses thereof
WO2007102946A2 (en) 2006-01-23 2007-09-13 Amgen Inc. Crystalline polypeptides
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
AU2008262490B2 (en) 2007-05-22 2011-11-17 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
US8853358B2 (en) 2008-01-22 2014-10-07 Araim Pharmaceuticals, Inc. Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARTLEY ET AL: "IDENTIFICATION AND CLONING OF A MEGAKARYOCYTE GROWTH AND DEVLOPMENT FACTOR THAT IS A LIGAND FOR THE CYTOKINE RECEPTOR MPL", CELL, vol. 77, 1 July 1994 (1994-07-01), pages 1117 - 1124 *
DE SAUVAGE ET AL: "STIMULATION OF MEGAKARYOCYTOPOIESIS AND THROMBOPOIESIS BY THE C-MPL LIGAND", NATURE, vol. 369, 16 June 1994 (1994-06-16), pages 533 - 538 *
MCDONALD: "THROMBOPOIETIN:ITS BIOLOGY,PURIFICATION,AND CHARACTERIZATION", EXPERIMENTAL HEMATOLOGY, vol. 16, no. 3, pages 201 - 205 *
SOHMA ET AL: "MOLECULAR CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN THROMBOPOIETIN GENE", FEBS LETTERS, vol. 353, no. 1, 10 October 1994 (1994-10-10), pages 57 - 61 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145450B2 (en) 1998-10-23 2015-09-29 Amgen Inc. Thrombopoietic compounds
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules

Also Published As

Publication number Publication date
WO1995021919A2 (en) 1995-08-17

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