WO1994016075A3 - Process for producing m-csf 223 - Google Patents
Process for producing m-csf 223 Download PDFInfo
- Publication number
- WO1994016075A3 WO1994016075A3 PCT/US1994/000658 US9400658W WO9416075A3 WO 1994016075 A3 WO1994016075 A3 WO 1994016075A3 US 9400658 W US9400658 W US 9400658W WO 9416075 A3 WO9416075 A3 WO 9416075A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- csf
- amino acid
- wild
- type
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
DNA molecules which encode a 255 amino acid polypeptide, comprising the 32 amino acid M-CSF leader sequence and the 223 amino acid mature M-CSF polypeptide, and lack the coding sequence for the carboxy-terminal propeptide sequence present in wild-type M-CSF DNA, result in highly efficient production of M-CSF, which displays similar post-translational modifications as wild-type M-CSF and is unaffected in biological properties.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6516370A JPH08505534A (en) | 1993-01-13 | 1994-01-12 | Method for manufacturing M-CSF223 |
AU61252/94A AU6125294A (en) | 1993-01-13 | 1994-01-12 | Process for producing m-csf 223 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US414193A | 1993-01-13 | 1993-01-13 | |
US08/004,141 | 1993-01-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994016075A2 WO1994016075A2 (en) | 1994-07-21 |
WO1994016075A3 true WO1994016075A3 (en) | 1994-12-22 |
Family
ID=21709373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/000658 WO1994016075A2 (en) | 1993-01-13 | 1994-01-12 | Process for producing m-csf 223 |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPH08505534A (en) |
AU (1) | AU6125294A (en) |
WO (1) | WO1994016075A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2746412B1 (en) * | 1996-03-21 | 1998-06-12 | Rhone Poulenc Rorer Sa | PURIFICATION OF PLASMID DNA OF PHARMACEUTICAL QUALITY |
US6136536A (en) * | 1997-10-29 | 2000-10-24 | Genetics Institute, Inc. | Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins |
EP1721986A1 (en) * | 1997-10-29 | 2006-11-15 | Genetics Institute, LLC | Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987006954A1 (en) * | 1986-05-06 | 1987-11-19 | Genetics Institute, Inc. | Production of m-csf |
EP0261592A1 (en) * | 1986-09-17 | 1988-03-30 | Otsuka Pharmaceutical Co., Ltd. | Gene coding for human colony-stimulating factors |
WO1988003173A2 (en) * | 1986-10-24 | 1988-05-05 | Cetus Corporation | New forms of colony stimulating factor-1 |
US4868119A (en) * | 1986-12-11 | 1989-09-19 | Genetics Institute, Inc. | Hematopoietic growth factors |
US4879227A (en) * | 1986-05-06 | 1989-11-07 | Genetics Institute, Inc. | Production of a recombinant human colony stimulating factor |
FR2667612A1 (en) * | 1990-10-09 | 1992-04-10 | Toyo Jozo Kk | STABLE PRODUCTION OF M-CSF ACTIVE POLYPEPTIDE |
-
1994
- 1994-01-12 WO PCT/US1994/000658 patent/WO1994016075A2/en active Application Filing
- 1994-01-12 JP JP6516370A patent/JPH08505534A/en active Pending
- 1994-01-12 AU AU61252/94A patent/AU6125294A/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987006954A1 (en) * | 1986-05-06 | 1987-11-19 | Genetics Institute, Inc. | Production of m-csf |
US4879227A (en) * | 1986-05-06 | 1989-11-07 | Genetics Institute, Inc. | Production of a recombinant human colony stimulating factor |
EP0261592A1 (en) * | 1986-09-17 | 1988-03-30 | Otsuka Pharmaceutical Co., Ltd. | Gene coding for human colony-stimulating factors |
WO1988003173A2 (en) * | 1986-10-24 | 1988-05-05 | Cetus Corporation | New forms of colony stimulating factor-1 |
US4868119A (en) * | 1986-12-11 | 1989-09-19 | Genetics Institute, Inc. | Hematopoietic growth factors |
FR2667612A1 (en) * | 1990-10-09 | 1992-04-10 | Toyo Jozo Kk | STABLE PRODUCTION OF M-CSF ACTIVE POLYPEPTIDE |
GB2249100A (en) * | 1990-10-09 | 1992-04-29 | Toyo Jozo Kk | Expression of M-CSF deletion mutant polypeptides |
Non-Patent Citations (2)
Title |
---|
MASAYUKI TAKAHASHI ET AL: "Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity : Molecular clonig and expression of carboxyl-terminal deletion mutants of human M-CSF", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 161, no. 2, 15 June 1989 (1989-06-15), DULUTH, MINNESOTA US, pages 892 - 900 * |
S.C. CLARK ET AL: "The human hematopoietic colony-stimulating-factors", SCIENCE, vol. 236, June 1987 (1987-06-01), LANCASTER, PA US, pages 12229 - 1237 * |
Also Published As
Publication number | Publication date |
---|---|
AU6125294A (en) | 1994-08-15 |
JPH08505534A (en) | 1996-06-18 |
WO1994016075A2 (en) | 1994-07-21 |
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