WO1994013800A3 - Mk protein preparation and use in cell culture - Google Patents

Mk protein preparation and use in cell culture Download PDF

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Publication number
WO1994013800A3
WO1994013800A3 PCT/GB1993/002527 GB9302527W WO9413800A3 WO 1994013800 A3 WO1994013800 A3 WO 1994013800A3 GB 9302527 W GB9302527 W GB 9302527W WO 9413800 A3 WO9413800 A3 WO 9413800A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
cell culture
protein preparation
cells
seq
Prior art date
Application number
PCT/GB1993/002527
Other languages
French (fr)
Other versions
WO1994013800A2 (en
Inventor
John Kaye Heath
Original Assignee
Cancer Res Campaign Tech
John Kaye Heath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Res Campaign Tech, John Kaye Heath filed Critical Cancer Res Campaign Tech
Priority to AU56566/94A priority Critical patent/AU5656694A/en
Publication of WO1994013800A2 publication Critical patent/WO1994013800A2/en
Publication of WO1994013800A3 publication Critical patent/WO1994013800A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides a method of growing neurectodermal cells which comprises culturing said cells in vitro in the presence of MK protein. A suitable form of MK protein is the protein of Seq.ID No. 1. Cells grown in the presence of MK protein, or the protein itself, may be used to treat conditions in which damage to nerve cells has occurred.
PCT/GB1993/002527 1992-12-11 1993-12-10 Mk protein preparation and use in cell culture WO1994013800A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56566/94A AU5656694A (en) 1992-12-11 1993-12-10 Mk protein preparation and use in cell culture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9225928.2 1992-12-11
GB929225928A GB9225928D0 (en) 1992-12-11 1992-12-11 Growth factor

Publications (2)

Publication Number Publication Date
WO1994013800A2 WO1994013800A2 (en) 1994-06-23
WO1994013800A3 true WO1994013800A3 (en) 1994-09-29

Family

ID=10726489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/002527 WO1994013800A2 (en) 1992-12-11 1993-12-10 Mk protein preparation and use in cell culture

Country Status (3)

Country Link
AU (1) AU5656694A (en)
GB (1) GB9225928D0 (en)
WO (1) WO1994013800A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1486801A (en) * 1999-11-15 2001-05-30 Curagen Corporation Novel growth factor polypeptides and nucleic acids encoding same
WO2004085642A1 (en) * 2003-03-27 2004-10-07 Takashi Muramatsu Arthritis-associated gene and use thereof in examining arthritis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0476233A1 (en) * 1990-08-20 1992-03-25 American Cyanamid Company Human MK gene and protein sequence

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0476233A1 (en) * 1990-08-20 1992-03-25 American Cyanamid Company Human MK gene and protein sequence

Also Published As

Publication number Publication date
GB9225928D0 (en) 1993-02-03
AU5656694A (en) 1994-07-04
WO1994013800A2 (en) 1994-06-23

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