WO1994012220A3 - Water soluble non-immunogenic polyamide cross-linking agents - Google Patents

Water soluble non-immunogenic polyamide cross-linking agents Download PDF

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Publication number
WO1994012220A3
WO1994012220A3 PCT/US1993/011470 US9311470W WO9412220A3 WO 1994012220 A3 WO1994012220 A3 WO 1994012220A3 US 9311470 W US9311470 W US 9311470W WO 9412220 A3 WO9412220 A3 WO 9412220A3
Authority
WO
WIPO (PCT)
Prior art keywords
linking agents
cross
immunogenic
water soluble
soluble non
Prior art date
Application number
PCT/US1993/011470
Other languages
French (fr)
Other versions
WO1994012220A2 (en
Inventor
Ton T Hai
Deanna J Nelson
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Priority to EP94903302A priority Critical patent/EP0624099A1/en
Priority to AU57295/94A priority patent/AU675686B2/en
Priority to JP6513389A priority patent/JPH07502784A/en
Publication of WO1994012220A2 publication Critical patent/WO1994012220A2/en
Priority to NO942749A priority patent/NO942749L/en
Publication of WO1994012220A3 publication Critical patent/WO1994012220A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polyamides (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to water-soluble nonimmunogenic polyamide cross-linking agents and their use to cross-link, polymerize, decorate, and conjugate proteins, polynucleotides and other biological substrates to form substantially nonimmunogenic water-soluble products. The present invention also relates to proteins, polynucleotides and other biological substrates which are cross-linked, conjugated, polymerized or decorated with water-soluble polyamides to form substantially nonimmunogenic products.
PCT/US1993/011470 1992-11-25 1993-11-24 Water soluble non-immunogenic polyamide cross-linking agents WO1994012220A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP94903302A EP0624099A1 (en) 1992-11-25 1993-11-24 Water soluble non-immunogenic polyamide cross-linking agents
AU57295/94A AU675686B2 (en) 1992-11-25 1993-11-24 Water soluble non-immunogenic polyamide cross-linking agents
JP6513389A JPH07502784A (en) 1992-11-25 1993-11-24 Water-soluble non-immunogenic polyamide crosslinker
NO942749A NO942749L (en) 1992-11-25 1994-07-22 Water-soluble, non-immunogenic polyamide crosslinking agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98144792A 1992-11-25 1992-11-25
US07/981,447 1992-11-25

Publications (2)

Publication Number Publication Date
WO1994012220A2 WO1994012220A2 (en) 1994-06-09
WO1994012220A3 true WO1994012220A3 (en) 1994-09-29

Family

ID=25528372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/011470 WO1994012220A2 (en) 1992-11-25 1993-11-24 Water soluble non-immunogenic polyamide cross-linking agents

Country Status (7)

Country Link
EP (1) EP0624099A1 (en)
JP (1) JPH07502784A (en)
AU (1) AU675686B2 (en)
CA (1) CA2135880A1 (en)
IL (1) IL107715A0 (en)
NO (1) NO942749L (en)
WO (1) WO1994012220A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019240A1 (en) * 1994-12-21 1996-06-27 Novartis Ag Oligonucleotide-dendrimer conjugates
ES2170042T3 (en) * 1998-08-28 2004-10-01 Gryphon Therapeutics, Inc. PROCEDURE FOR THE PREPARATION OF POLYAMIDE CHAINS OF PRECISE LENGTH AND ITS CONJUGATES WITH PROTEINS.
EP1400551B1 (en) * 1998-08-28 2007-06-13 Amylin Pharmaceuticals, Inc. Polyamide chains of precise length and their conjugates with proteins
TWI391456B (en) * 2007-04-03 2013-04-01 羅門哈斯電子材料有限公司 Metal plating compositions and methods

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53121899A (en) * 1977-04-01 1978-10-24 Sumitomo Chem Co Ltd Preparation of novel water-soluble polyamide
EP0121091A1 (en) * 1983-03-03 1984-10-10 Henkel Kommanditgesellschaft auf Aktien Multifunctional quaternary ammonium compounds with up to 4 quaternary ammonium groups at the chain ends, their production and use in cosmetic preparations, particularly for treating the hair
US4593073A (en) * 1985-04-23 1986-06-03 The Royal Institution For The Advancement Of Learing (Mcgill Univ.) Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids
EP0245840A2 (en) * 1986-05-15 1987-11-19 Hoechst Aktiengesellschaft Biodegradable polymers for retarding preparations with controlled release
EP0314127A2 (en) * 1987-10-30 1989-05-03 Abbott Laboratories Heterobifunctional coupling agents
EP0345789A2 (en) * 1988-06-10 1989-12-13 Keith E. Taylor Method and device for attachement of biologically useful materials to a solid phase
WO1992012960A2 (en) * 1991-01-29 1992-08-06 Pinaroo Ltd. Derivatives of dicarboxylic acids having six to twelve carbon atoms and use of these derivatives and dicarboxylic acids alone in the preparation of pharmaceutical compositions for enteral and parenteral nutrition

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53121899A (en) * 1977-04-01 1978-10-24 Sumitomo Chem Co Ltd Preparation of novel water-soluble polyamide
EP0121091A1 (en) * 1983-03-03 1984-10-10 Henkel Kommanditgesellschaft auf Aktien Multifunctional quaternary ammonium compounds with up to 4 quaternary ammonium groups at the chain ends, their production and use in cosmetic preparations, particularly for treating the hair
US4593073A (en) * 1985-04-23 1986-06-03 The Royal Institution For The Advancement Of Learing (Mcgill Univ.) Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids
EP0245840A2 (en) * 1986-05-15 1987-11-19 Hoechst Aktiengesellschaft Biodegradable polymers for retarding preparations with controlled release
EP0314127A2 (en) * 1987-10-30 1989-05-03 Abbott Laboratories Heterobifunctional coupling agents
EP0345789A2 (en) * 1988-06-10 1989-12-13 Keith E. Taylor Method and device for attachement of biologically useful materials to a solid phase
WO1992012960A2 (en) * 1991-01-29 1992-08-06 Pinaroo Ltd. Derivatives of dicarboxylic acids having six to twelve carbon atoms and use of these derivatives and dicarboxylic acids alone in the preparation of pharmaceutical compositions for enteral and parenteral nutrition

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ABRAHAM A. ET AL: "Folate analogues. 33. Synthesis of folate and antifolate poly-gamma-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cells.", J MED CHEM, vol. 33, no. 2, February 1990 (1990-02-01), US, pages 711 - 717, XP002418703, DOI: doi:10.1021/jm00164a038 *
DATABASE WPI Week 7848, Derwent World Patents Index; AN 78-86786A *
HARALAMBIDIS J. ET AL: "The preparation of polyamide-oligonucleotide probes comtaining multiple non-radioactive labels", NUCLEIC ACIDS RESEARCH, vol. 18, no. 3, 11 February 1990 (1990-02-11), ARLINGTON, VIRGINIA, US, pages 501 - 505, XP001156484 *
HARALAMBIDIS J. ET AL: "The synthesis of polyamide-oligonucleotide conjugate molecules.", NUCLEIC ACIDS RES, vol. 18, no. 3, 11 February 1990 (1990-02-11), pages 493 - 499, XP008047194 *
KANDA P. ET AL: "Synthesis of polyamide supports for use in peptide synthesis and as peptide-resin conjugates for antibody production", INT. J. PEPT. PROTEIN RES., vol. 38, no. 4, 1991, DK, pages 385 - 391, XP000229212 *
OGATA, NAOYA ET AL: "Solution polycondensation of diesters and diamines having hetero atom groups in polar solvents", POLYM. J., VOL. 11, NO. 10, PAGE(S) 827-33,, 1979 *
SANUI K. ET AL: "Room-temperature polycondensation of beta-amino acid derivatives. V. Synthesis of hydrophilic polyamide by the polycondensation of beta-amino acid derivatives.", J POLYM SCI UA1], vol. 7, no. 3, March 1969 (1969-03-01), US, pages 889 - 898 *
SATO, HISAYA ET AL: "Preparation of regularly sequenced polyamides containing definite numbers of oxyethylene units", MAKROMOL. CHEM., VOL. 182, NO. 3, PAGE(S) 755-62,, 1981 *
VERSCHOOR J.A. ET AL: "Haptenated nylon-coated polystyrene plates as a solid phase for ELISA", J. IMMUNOL. METHODS, vol. 127, no. 1, 1990, NETHERLANDS, pages 43 - 49, XP023974690, DOI: doi:10.1016/0022-1759(90)90339-W *

Also Published As

Publication number Publication date
JPH07502784A (en) 1995-03-23
AU675686B2 (en) 1997-02-13
WO1994012220A2 (en) 1994-06-09
CA2135880A1 (en) 1994-06-09
IL107715A0 (en) 1994-02-27
AU5729594A (en) 1994-06-22
EP0624099A1 (en) 1994-11-17
NO942749D0 (en) 1994-07-22
NO942749L (en) 1994-09-23

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