WO1994009379B1 - Real time magnetic resonance analysis with non-linear regression means - Google Patents
Real time magnetic resonance analysis with non-linear regression meansInfo
- Publication number
- WO1994009379B1 WO1994009379B1 PCT/US1993/009698 US9309698W WO9409379B1 WO 1994009379 B1 WO1994009379 B1 WO 1994009379B1 US 9309698 W US9309698 W US 9309698W WO 9409379 B1 WO9409379 B1 WO 9409379B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- free induction
- induction decay
- time
- digitized
- sample
- Prior art date
Links
- 238000004458 analytical method Methods 0.000 title claims 3
- 230000001939 inductive effect Effects 0.000 claims abstract 35
- 238000000034 method Methods 0.000 claims abstract 27
- 210000004940 Nucleus Anatomy 0.000 claims abstract 15
- 238000005481 NMR spectroscopy Methods 0.000 claims abstract 2
- 230000000875 corresponding Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000005284 excitation Effects 0.000 claims 2
Abstract
A pulsed NMR analysis system and process comprising sample throughput system (P, LI, V1, V2) and user system controls (104) to establish digitized free induction decay curves (C), from which components functions are determined using non-linear regression techniques to correlate the curve components to the target nuclei.
Claims
AMENDED CLAIMS
[received by the International Bureau on 21 March 1994 (21.03.94); original claims 8 and 16 cancelled; remaining claims amended (5 pages)]
1. In a time domain nuclear magnetic resonance analysis system, including means for accessing and removing successive samples of material from an industrial process, placing them in a sample measuring region and discarding successive samples from said region, means for applying a base magnetic field to said region to effect precession on sample nuclei therein and applying a local excitation pulse to said region to modify the precession, means defining receive antenna coil means and signal translating means interacting with the sample to effect a precession of nuclei to be measured and relaxation detected at the coil means as a free induction decay, said free induction decay defining a time equation, means for digitizing said free induction decay, means for decomposing the digitized free induction decay into component time equations and analyzing the derived coefficients of the component time equations corresponding to the type, property and quantity of target nuclei of interest, said analysis system improvement comprising:
means for forming a non-linear relationship between the derived coefficients of the component time equations representing the free induction decay curve and the true types, properties and quantities of the target nuclei of interest in the sample.
2. A system as defined in Claim 1 wherein said means for decomposing the free induction decay into component time equations comprises means utilizing an iteration technique for converting said digitized free induction decay into the time equation of said free induction decay and establishing the [said] zero
intercepts and the time characteristics of said component time equations .
3. A system as defined in claim 2 wherein said iteration technique comprises a Marquardt-
Levenberg technique for converting said digitized version of said free induction decay into the time equation of said free induction decay and establishing said zero intercepts and time characteristics of said equation.
4. A system as defined in claim 2 wherein said iteration technique comprises a Gauss-Newton technique for converting said digitized version of said free induction decay into the time equation of said free induction decay and establishing said zero intercepts and time characteristics of said equation.
5. A system as defined in claim 2 wherein said iteration technique comprises a Newton-Raphson technique for converting said digitized version of said free induction decay into the time equation of said free induction decay and establishing said zero intercepts and time characteristics of said equation.
6. A system as defined in claim 2 wherein said iteration technique comprises a steepest descent technique for converting said digitized version of said free induction decay into the time equation of said free induction decay and establishing said zero intercepts and time characteristics of said equation.
7. A system as defined in claim 1 wherein means for analyzing the free induction decay components corresponding to types, properties and quantities of target nuclei of the sample materials comprises: means for establishing calibration time
equations wherein the zero intercepts and time constant characteristics of said calibration time equations of standard samples are related in a non¬ linear regression function to the known physical types, properties and quantities of target nuclei in said standard samples, and means for comparing via said non-linear regression function said known sample zero intercepts and time characteristics to the zero intercepts and time characteristics of an unknown sample wherein said physical types, properties and quantities of nuclei of interest are read from the non-linear regression function.
9 A process for monitoring industrial processes utilizing magnetic resonance comprising: accessing and removing successive samples of material from said industrial process, placing said samples in a sample measuring region, applying a base magnetic field to said region to effect precession on sample nuclei therein, applying a local resonant excitation pulse to said region to modify the precession, receiving and translating [the] a free induction decay from the relaxation of the sample nuclei, said free induction decay defining a time function, digitizing the free induction decay and analyzing it to components [of the decay curve] corresponding in a non-linear fashion to quantities of target nuclei in the sample materials, said analyzing comprising: determining the time equation of said free induction decay components, establishing zero intercepts and time characteristics of said free induction decay components,
non-linearly relating said zero intercept and constants to the type property and quantity of target nuclei, and discarding said sample from said region.
10. A process as defined in claim 9 wherein the determining of the component equations derived from the digitized free induction decay comprises: applying an iteration technique to the digitized free induction decay wherein said digitized free induction decay is separated into a plurality of component equations.
11. A process as defined in claim 10 wherein the iteration technique comprises a Marquardt- Levenberg technique applied to the digitized free induction decay wherein said digitized free induction decay is separated into a plurality of component equations.
12. A process as defined in claim 10 wherein the iteration technique comprises a Gauss-Newton technique applied to the digitized free induction decay curve wherein said digitized free induction decay is separated into a plurality of component equations.
13. A process as defined in claim 10 wherein the iteration technique comprises a Newton-Raphson technique applied to the digitized free induction decay wherein said digitized free induction decay is separated into a plurality of component equations.
14. A process as defined in claim 10 wherein the iteration technique comprises a steepest descent technique applied to the digitized free induction
decay wherein said digitized free induction decay is separated into a plurality of component equations.
15. A process as defined in claim 9 wherein the component time equation zero intercepts and time characteristics are related to the quantity of target nuclei of the sample materials by the following steps comprising: generating non-linear regression functions relating the zero intercepts and time characteristics of the free induction decay components of standard samples to known quantities of target nuclei in said standard samples, and comparing said zero intercepts and time characteristics measured from an unknown sample to said non-linear regression function [curve] wherein said quantities of nuclei of interest contained in said unknown sample are calculated from the non¬ linear regression function.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU53279/94A AU672450B2 (en) | 1992-10-13 | 1993-10-12 | Real time magnetic resonance analysis with non-linear regression means |
| EP93923355A EP0665956A4 (en) | 1992-10-13 | 1993-10-12 | Real time magnetic resonance analysis with non-linear regression means. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/959,739 | 1992-10-13 | ||
| US07/959,739 US5319308A (en) | 1992-10-13 | 1992-10-13 | Real time magnetic resonance analysis with non-linear regression means |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1994009379A1 WO1994009379A1 (en) | 1994-04-28 |
| WO1994009379B1 true WO1994009379B1 (en) | 1994-05-26 |
Family
ID=25502347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1993/009698 WO1994009379A1 (en) | 1992-10-13 | 1993-10-12 | Real time magnetic resonance analysis with non-linear regression means |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5319308A (en) |
| EP (1) | EP0665956A4 (en) |
| AU (1) | AU672450B2 (en) |
| CA (1) | CA2153782A1 (en) |
| WO (1) | WO1994009379A1 (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5519319A (en) * | 1991-11-20 | 1996-05-21 | Auburn International, Inc. | Obtaining measurements of improved accuracy of one or more polymer properties with an on-line NMR system |
| US5675253A (en) * | 1991-11-20 | 1997-10-07 | Auburn International, Inc. | Partial least square regression techniques in obtaining measurements of one or more polymer properties with an on-line nmr system |
| US5650722A (en) * | 1991-11-20 | 1997-07-22 | Auburn International, Inc. | Using resin age factor to obtain measurements of improved accuracy of one or more polymer properties with an on-line NMR system |
| US5530350A (en) * | 1991-11-20 | 1996-06-25 | Auburn International, Inc. | Magnetic resonance analysis in real time, industrial usage mode |
| US5311131A (en) * | 1992-05-15 | 1994-05-10 | Board Of Regents Of The University Of Washington | Magnetic resonance imaging using pattern recognition |
| US5596275A (en) * | 1992-05-19 | 1997-01-21 | Auburn International, Inc. | NMR analysis of polypropylene in real time |
| US5420508A (en) * | 1993-09-24 | 1995-05-30 | Auburn International, Inc. | Measurement of material composition and properties |
| US5959044A (en) * | 1996-07-08 | 1999-09-28 | Villar; Juan Carlos | Method of controlling continuous ethylene-limited metallocene-catalyzed copolymerization systems |
| US5841891A (en) * | 1997-04-02 | 1998-11-24 | Eastman Kodak Company | Image analysis using the direct exponential curve resolution algorithm |
| US6298238B1 (en) | 1998-09-09 | 2001-10-02 | Qualcomm Incorporated | Fast user terminal position determination in a satellite communications system |
| US6438561B1 (en) * | 1998-11-19 | 2002-08-20 | Navigation Technologies Corp. | Method and system for using real-time traffic broadcasts with navigation systems |
| US6917882B2 (en) * | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US20030054390A1 (en) * | 1999-01-19 | 2003-03-20 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US7024312B1 (en) * | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| EP1108783A3 (en) | 1999-01-19 | 2001-09-05 | Maxygen, Inc. | Oligonucleotide-mediated nucleic acid recombination |
| US20070065838A1 (en) * | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
| US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
| US6477516B1 (en) * | 2000-05-16 | 2002-11-05 | Intevep, S.A. | System and method for predicting parameter of hydrocarbon with spectroscopy and neural networks |
| US6926355B2 (en) * | 2001-03-05 | 2005-08-09 | Kelsyus, Llc | Collapsible support and methods of using the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4641095A (en) * | 1985-05-15 | 1987-02-03 | Duke University Medical Center | Determination of T1 relaxation times used in automated nuclear magnetic resonance image synthesis |
| US5049819A (en) * | 1989-06-30 | 1991-09-17 | Auburn International, Inc. | Magnetic resonance analysis in real time, industrial usage mode |
| US5015954A (en) * | 1989-06-30 | 1991-05-14 | Auburn International, Inc. | Magnetic resonance analysis in real time, industrial usage mode |
| WO1992016851A1 (en) * | 1989-06-30 | 1992-10-01 | Auburn International, Inc. | Magnetic resonance analysis in real time, industrial usage mode |
| US5218299A (en) * | 1991-03-25 | 1993-06-08 | Reinhard Dunkel | Method for correcting spectral and imaging data and for using such corrected data in magnet shimming |
| JPH07501615A (en) * | 1991-11-20 | 1995-02-16 | オーバーン・インターナショナル・インコーポレーテッド | Improved magnetic resonance analysis in real-time industrial use mode |
| US5367260A (en) * | 1992-10-15 | 1994-11-22 | Auburn International, Inc. | Apparatus to obtain flow rates (melt index) in plastics via fixed frequency, pulsed NMR |
| US5408181A (en) * | 1993-08-30 | 1995-04-18 | Auburn International, Inc. | NMR system for measuring polymer properties |
| US5420508A (en) * | 1993-09-24 | 1995-05-30 | Auburn International, Inc. | Measurement of material composition and properties |
-
1992
- 1992-10-13 US US07/959,739 patent/US5319308A/en not_active Expired - Fee Related
-
1993
- 1993-10-12 EP EP93923355A patent/EP0665956A4/en not_active Withdrawn
- 1993-10-12 WO PCT/US1993/009698 patent/WO1994009379A1/en not_active Application Discontinuation
- 1993-10-12 AU AU53279/94A patent/AU672450B2/en not_active Ceased
- 1993-10-12 CA CA002153782A patent/CA2153782A1/en not_active Abandoned
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