WO1994006447A3 - Morphogenese induite par la proteine 60a - Google Patents

Morphogenese induite par la proteine 60a Download PDF

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Publication number
WO1994006447A3
WO1994006447A3 PCT/US1993/008741 US9308741W WO9406447A3 WO 1994006447 A3 WO1994006447 A3 WO 1994006447A3 US 9308741 W US9308741 W US 9308741W WO 9406447 A3 WO9406447 A3 WO 9406447A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
vivo
protein
tissue
morphogenesis
Prior art date
Application number
PCT/US1993/008741
Other languages
English (en)
Other versions
WO1994006447A2 (fr
Inventor
Thangavel Kuberasampath
Roy H L Pang
Hermann Oppermann
David C Rueger
Charles M Cohen
Original Assignee
Creative Biomolecules Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creative Biomolecules Inc filed Critical Creative Biomolecules Inc
Priority to AU51292/93A priority Critical patent/AU5129293A/en
Publication of WO1994006447A2 publication Critical patent/WO1994006447A2/fr
Publication of WO1994006447A3 publication Critical patent/WO1994006447A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention se rapporte à des procédés d'utilisation d'un fragment morphogéniquement actif de la protéine 60A pour induire la morphogénèse tissulaire, ainsi qu'à des procédés d'accroissement de la population des cellules souches chez un mammifère, à des procédés de stimulation des cellules souches pour différencier et maintenir leur phénotype différencié in vivo ou in vitro, à des procédés d'induction de la croissance spécifique des tissus in vivo, et à des procédés de remplacement des tissus malades ou endommagés in vivo.
PCT/US1993/008741 1992-09-15 1993-09-15 Morphogenese induite par la proteine 60a WO1994006447A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU51292/93A AU5129293A (en) 1992-09-15 1993-09-15 60a protein-induced morphogenesis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US94529292A 1992-09-15 1992-09-15
US945,292 1992-09-15
US2933593A 1993-03-04 1993-03-04
US029,335 1993-03-04
US4051093A 1993-03-31 1993-03-31
US040,510 1993-03-31

Publications (2)

Publication Number Publication Date
WO1994006447A2 WO1994006447A2 (fr) 1994-03-31
WO1994006447A3 true WO1994006447A3 (fr) 1994-09-01

Family

ID=27363458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/008741 WO1994006447A2 (fr) 1992-09-15 1993-09-15 Morphogenese induite par la proteine 60a

Country Status (2)

Country Link
AU (1) AU5129293A (fr)
WO (1) WO1994006447A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2323078A1 (fr) * 1998-03-14 1999-09-23 Creative Biomolecules, Inc. Compositions pour moduler la differentiation des cellules comprenant un lipide et un morphogene

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004692A1 (fr) * 1991-08-30 1993-03-18 Creative Biomolecules, Inc. Modulation, induite par morphogene, de reaction inflammatoire
WO1993005751A2 (fr) * 1991-08-30 1993-04-01 Creative Biomolecules, Inc. Proteines osteogeniques pour le traitement de maladies osseuses
WO1994003200A1 (fr) * 1992-07-31 1994-02-17 Creative Biomolecules, Inc. Regeneration et reparation du systeme nerveux induites par morphogene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004692A1 (fr) * 1991-08-30 1993-03-18 Creative Biomolecules, Inc. Modulation, induite par morphogene, de reaction inflammatoire
WO1993005751A2 (fr) * 1991-08-30 1993-04-01 Creative Biomolecules, Inc. Proteines osteogeniques pour le traitement de maladies osseuses
WO1994003200A1 (fr) * 1992-07-31 1994-02-17 Creative Biomolecules, Inc. Regeneration et reparation du systeme nerveux induites par morphogene

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
K.A.WHARTON: "Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins.", PROC. NATL. ACAD. SCI. USA, vol. 88, no. 20, 1991, pages 9214 - 9218 *
T.K. SAMPATH: "Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.", PROC. NATL. ACAD. SCI. USA, vol. 90, no. 13, July 1993 (1993-07-01), pages 6004 - 6008 *

Also Published As

Publication number Publication date
WO1994006447A2 (fr) 1994-03-31
AU5129293A (en) 1994-04-12

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