WO1994004166A1 - Device to be placed in the vascular system to prevent or limit damage caused by diabetes - Google Patents

Device to be placed in the vascular system to prevent or limit damage caused by diabetes Download PDF

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Publication number
WO1994004166A1
WO1994004166A1 PCT/BE1992/000034 BE9200034W WO9404166A1 WO 1994004166 A1 WO1994004166 A1 WO 1994004166A1 BE 9200034 W BE9200034 W BE 9200034W WO 9404166 A1 WO9404166 A1 WO 9404166A1
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
iron
degree
adaptations
damage caused
Prior art date
Application number
PCT/BE1992/000034
Other languages
French (fr)
Inventor
Silvia Cristina Vanderhoeven
Original Assignee
Silvia Cristina Vanderhoeven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BE9100764A external-priority patent/BE1005182A4/en
Application filed by Silvia Cristina Vanderhoeven filed Critical Silvia Cristina Vanderhoeven
Priority to PCT/BE1992/000034 priority Critical patent/WO1994004166A1/en
Publication of WO1994004166A1 publication Critical patent/WO1994004166A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof

Definitions

  • Diabetes is characterized by a set of symptoms which arise from the insufficiency of insulin to regulate hyperglycemia, the first symptom observed in diabetics.
  • Treatment by oral route or by intravenous injections presents a fairly significant dependency problem for diabetics.
  • the present invention does not pretend to cure the diabetic but to propose a preventive means against the development of the disease and to limit the damage.
  • Hyperglycemia (and / or the presence of excess male sex hormones) would create in the immediate environment of the action of insulin a more basic environment than in the normal state and this basicity would cause the transformation of primary structure of the molecule as follows: the amino acid NH2-terminal of the B chain (phenylalanine) would be transformed into tyrosine. This reaction involving nicotinamide is actually favored in a more basic environment.
  • PLASMA-REGULON A special device placed in the bloodstream would restore its normal pH to the bloodstream.
  • This device consists of a fine wire in a synthetic sleeve. Depending on the pathological case diagnosed, it is necessary to adapt: - the degree of iron oxidation depending on the desired effects on the one hand,
  • the ferrous ions released are eliminated by the natural way and do not present any danger for the patient, - and the electrons released by the oxidation combine with nicotinamide, favoring the formation of phenylalanine.
  • the device also eliminates the major drawbacks of the usual treatments mentioned above. Finally, this device can also be proposed as a more comforting alternative for the patient who has revealed himself to be a potential diabetic during screening.

Abstract

A device preventing the start or the development of the disease is designed to offer several advantages: by minor surgery, the disadvantages of the treatment methods used can be overcome; it presents no danger to the organism since it consists of a wire (iron) and a synthetic protective sheath; by defining possible variants, it can be easily adapted to the different cases of diabetes observed.

Description

DISPOSITIF A PLACER DANS LE SYSTEME VASCULAIRE EN VUE DE PREVENIR OU DE LIMITER LES DEGATS CAUSES PAR LE DIABETE. DEVICE TO BE PLACED IN THE VASCULAR SYSTEM WITH A VIEW TO PREVENTING OR LIMITING DAMAGE CAUSED BY DIABETES.
Le diabète se caractérise par un ensemble de symptômes qui découlent de l'insuffisance de l'insuline à régler l'hyperglycémie, premier symptôme observé chez le diabétique. Diabetes is characterized by a set of symptoms which arise from the insufficiency of insulin to regulate hyperglycemia, the first symptom observed in diabetics.
Le traitement par voie orale ou par injections intraveineuses présente pour le diabétique un problème de dépendance assez important. La présente invention n'a pas la prétention de guérir le diabétique mais de proposer un moyen préventif contre le développement de la maladie et d'en limiter les dégâts. Treatment by oral route or by intravenous injections presents a fairly significant dependency problem for diabetics. The present invention does not pretend to cure the diabetic but to propose a preventive means against the development of the disease and to limit the damage.
Après avoir entamé des recherches bibliographiques sur le diabète en général et ses conséquences dans différents organes, il est apparu nécessaire d'aborder le problème au niveau du déclenchement de la maladie de manière à dégager les possibilités d'empêcher son développement. After starting bibliographic research on diabetes in general and its consequences in different organs, it appeared necessary to address the problem at the level of the onset of the disease so as to identify the possibilities of preventing its development.
L'hyperglycémie (et/ou la présence d'hormones sexuelles mâles en excès) créerait dans l'environnement immédiat de l'action de l'insuline un milieu plus basique qu'à l'état normal et cette basicité provoquerait la transformation de la structure primaire de la molécule de la façon suivante: l'acide aminé NH2-terminal de la chaîne B (phénylalanine) serait transformé en tyrosine. Cette réaction mettant en jeu la nicotinamide est effectivement favorisée dans un milieu plus basique. Hyperglycemia (and / or the presence of excess male sex hormones) would create in the immediate environment of the action of insulin a more basic environment than in the normal state and this basicity would cause the transformation of primary structure of the molecule as follows: the amino acid NH2-terminal of the B chain (phenylalanine) would be transformed into tyrosine. This reaction involving nicotinamide is actually favored in a more basic environment.
Un dispositif particulier (appelé PLASMA-REGULON), placé dans la circulation sanguine restituerait au milieu sanguin son pH normal. A special device (called PLASMA-REGULON), placed in the bloodstream would restore its normal pH to the bloodstream.
Ce dispositif est constitué d'un fin fil de fer dans un manchon synthétique. Selon le cas pathologique diagnostiqué, il y a lieu d'adapter : - le degré d'oxydation du fer en fonction des effets désirés d'une part,  This device consists of a fine wire in a synthetic sleeve. Depending on the pathological case diagnosed, it is necessary to adapt: - the degree of iron oxidation depending on the desired effects on the one hand,
- et la forme et la dimension du dispositif en fonction de l'endroit choisi pour son placement d'autre part.  - And the shape and size of the device depending on the place chosen for its placement on the other hand.
Les avantages d'un tel dispositif sont assez évidents : - la facilité de placement par une petite opération chirurgicale, The advantages of such a device are quite obvious: - the ease of placement by a small surgical operation,
- les ions ferreux dégagés sont éliminés par la voie naturelle et ne présentent aucun danger pour le patient, - et les électrons dégagés par l'oxydation se combinent à la nicotinamide, favorisant la formation du phénylalanine. Le dispositif élimine également les inconvénients majeurs des traitements habituels cités plus haut. Enfin, ce dispositif peut être encore proposé comme alternative plus réconfortante pour le patient qui s'est révélé un diabétique potentiel lors d'un dépistage.  - the ferrous ions released are eliminated by the natural way and do not present any danger for the patient, - and the electrons released by the oxidation combine with nicotinamide, favoring the formation of phenylalanine. The device also eliminates the major drawbacks of the usual treatments mentioned above. Finally, this device can also be proposed as a more comforting alternative for the patient who has revealed himself to be a potential diabetic during screening.

Claims

REVENDICATIONS. CLAIMS.
1- Dispositif à placer dans le système vasculaire en vue de prévenir ou de limiter les dégâts causés par le diabète. 1- Device to be placed in the vascular system in order to prevent or limit the damage caused by diabetes.
Ce dispositif est caractérisé par la présence d'un fil métallique (fer) empêchant ou limitant les modifications du milieu d'action de l'insuline et par une gaine protectrice synthétique.  This device is characterized by the presence of a metallic wire (iron) preventing or limiting the modifications of the insulin action medium and by a synthetic protective sheath.
2- Le type et le degré de pathologie dans, le cas du diabète nécessite des adaptations du dispositif au cas particulier. 2- The type and degree of pathology in, in the case of diabetes requires adaptations of the device to the particular case.
Ces adaptations se font par le réglage du degré d'oxydation du fer et la modification de la forme ou des dimensions en fonction de l'endroit choisi pour son placement.  These adaptations are made by adjusting the degree of oxidation of the iron and changing the shape or dimensions depending on the location chosen for its placement.
3- La recherché du dispositif adéquat et du matériel approprié nécessite une étude plus approfondie des cas particuliers. 3- The search for the right device and the right equipment requires a more in-depth study of specific cases.
REVENDICATIONS MODIFIEES AMENDED CLAIMS
[reçues par le Bureau International le 8 février 1994 (08.02.94); revendications 2 et 3 modifiéés; revendication 4 ajoutée,  [received by the International Bureau on February 8, 1994 (08.02.94); claims 2 and 3 amended; claim 4 added,
revendication 1 inchangée (1 page)  claim 1 unchanged (1 page)
1- Dispositif à placer dans le système vasculaire en vue de prévenir ou de limiter les dégâts causés par le diabète. 1- Device to be placed in the vascular system in order to prevent or limit the damage caused by diabetes.
Ce dispositif est caractérisé par la présence d'un fil métallique (fer) empêchant ou limitant les modifications du milieu d'action de l'insuline et par une gaine protectrice synthé tique.  This device is characterized by the presence of a metallic wire (iron) preventing or limiting the modifications of the insulin action medium and by a synthetic protective sheath.
2- Le type et le degré de pathologie dans le cas du diabète nécessite des adaptations du dispositif au cas particulier, et selon qu'il s'agisse d'une prévention ou pas.2- The type and degree of pathology in the case of diabetes requires adaptations of the device to the particular case, and depending on whether it is prevention or not.
Ces adaptations se feraient par le réglage du degré d'oxydation du fer et par la modification de la forme ou des dimensions, en fonction de l'endroit choisi pour le placement. These adaptations would be made by adjusting the degree of oxidation of the iron and by modifying the shape or the dimensions, depending on the location chosen for placement.
3- La recherche du dispositif adéquat et du matériel approprié nécessite une étude plus approfondie des cas particuliers. 3- The search for the appropriate device and the appropriate equipment requires a more in-depth study of specific cases.
L'expérimentation se fera sur animal essentiellement et la publication s'appuiera sur des données de cas cliniques observés, dans le respect des considérations éthiques.  The experimentation will mainly be carried out on animals and the publication will be based on data from observed clinical cases, in accordance with ethical considerations.
4- Dans le cadre de la prévention, le dispositif peut être utilisé à titre de moyen contraceptif, qu'il y ait ou non présomption d'apparition de diabète. 4- In the context of prevention, the device can be used as a contraceptive method, whether or not there is a presumption of the onset of diabetes.
PCT/BE1992/000034 1991-08-21 1992-08-24 Device to be placed in the vascular system to prevent or limit damage caused by diabetes WO1994004166A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/BE1992/000034 WO1994004166A1 (en) 1991-08-21 1992-08-24 Device to be placed in the vascular system to prevent or limit damage caused by diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9100764A BE1005182A4 (en) 1991-08-21 1991-08-21 System placed in the vascular system with a view to preventing or limitingdamage caused by diabetes
PCT/BE1992/000034 WO1994004166A1 (en) 1991-08-21 1992-08-24 Device to be placed in the vascular system to prevent or limit damage caused by diabetes

Publications (1)

Publication Number Publication Date
WO1994004166A1 true WO1994004166A1 (en) 1994-03-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE1992/000034 WO1994004166A1 (en) 1991-08-21 1992-08-24 Device to be placed in the vascular system to prevent or limit damage caused by diabetes

Country Status (1)

Country Link
WO (1) WO1994004166A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1012804A4 (en) * 1999-07-29 2001-03-06 Vanderhoeven Silvia Cristina Anti-diabetes system (dicodia)
WO2003103628A1 (en) * 2002-06-10 2003-12-18 Silvia Cristina Vanderhoeven Device against diabetes (dicodia)
US7879367B2 (en) * 1997-07-18 2011-02-01 Alfons Fischer Metallic implant which is degradable in vivo

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3712291A (en) * 1968-10-02 1973-01-23 M Freeman Method for administering iron and other metals
US4544550A (en) * 1982-10-05 1985-10-01 Rodolfo Almanzor Y Method for the treatment of diabetes
US4606354A (en) * 1985-05-21 1986-08-19 Ezekiel Jacob J Gold coated carbon implant and method of treating arthritis therewith

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3712291A (en) * 1968-10-02 1973-01-23 M Freeman Method for administering iron and other metals
US4544550A (en) * 1982-10-05 1985-10-01 Rodolfo Almanzor Y Method for the treatment of diabetes
US4606354A (en) * 1985-05-21 1986-08-19 Ezekiel Jacob J Gold coated carbon implant and method of treating arthritis therewith

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPIL Week 8441, Derwent Publications Ltd., London, GB; AN 84-255728 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879367B2 (en) * 1997-07-18 2011-02-01 Alfons Fischer Metallic implant which is degradable in vivo
BE1012804A4 (en) * 1999-07-29 2001-03-06 Vanderhoeven Silvia Cristina Anti-diabetes system (dicodia)
WO2003103628A1 (en) * 2002-06-10 2003-12-18 Silvia Cristina Vanderhoeven Device against diabetes (dicodia)

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