WO1994001095A3 - Medicaments for the treatment of visceral pain and migraine - Google Patents

Medicaments for the treatment of visceral pain and migraine Download PDF

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Publication number
WO1994001095A3
WO1994001095A3 PCT/GB1993/001377 GB9301377W WO9401095A3 WO 1994001095 A3 WO1994001095 A3 WO 1994001095A3 GB 9301377 W GB9301377 W GB 9301377W WO 9401095 A3 WO9401095 A3 WO 9401095A3
Authority
WO
WIPO (PCT)
Prior art keywords
migraine
treatment
visceral pain
medicaments
dose
Prior art date
Application number
PCT/GB1993/001377
Other languages
French (fr)
Other versions
WO1994001095A2 (en
Inventor
Gareth John Sanger
Stephen Edward Banner
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to EP93914854A priority Critical patent/EP0650355A1/en
Priority to AU45076/93A priority patent/AU4507693A/en
Priority to CA002139440A priority patent/CA2139440A1/en
Priority to JP6503078A priority patent/JPH07508530A/en
Publication of WO1994001095A2 publication Critical patent/WO1994001095A2/en
Publication of WO1994001095A3 publication Critical patent/WO1994001095A3/en
Priority to KR1019940704887A priority patent/KR950702112A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the use of those 5-HT3 receptor antagonists, which are active in the Rat Model of Colo-rectal Distension at a dose determined as the dose at which 5-HT3 receptor antagonist activity is observed in standard tests, such as the Bezold-Jarisch model, in the treatment of visceral pain, such as the pain symptoms of IBS, and also migraine.
PCT/GB1993/001377 1992-07-03 1993-06-30 Medicaments for the treatment of visceral pain and migraine WO1994001095A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP93914854A EP0650355A1 (en) 1992-07-03 1993-06-30 Medicaments for the treatment of visceral pain and migraine
AU45076/93A AU4507693A (en) 1992-07-03 1993-06-30 Medicaments for the treatment of visceral pain and migraine
CA002139440A CA2139440A1 (en) 1992-07-03 1993-06-30 Medicaments for the treatment of visceral pain and migraine
JP6503078A JPH07508530A (en) 1992-07-03 1993-06-30 Medicines for treating visceral pain and migraines
KR1019940704887A KR950702112A (en) 1992-07-03 1994-12-31 Medicines for the treatment of visceral pain and migraine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929214184A GB9214184D0 (en) 1992-07-03 1992-07-03 Pharmaceuticals
GB9214184.5 1992-07-03

Publications (2)

Publication Number Publication Date
WO1994001095A2 WO1994001095A2 (en) 1994-01-20
WO1994001095A3 true WO1994001095A3 (en) 1994-04-14

Family

ID=10718169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001377 WO1994001095A2 (en) 1992-07-03 1993-06-30 Medicaments for the treatment of visceral pain and migraine

Country Status (7)

Country Link
EP (1) EP0650355A1 (en)
JP (1) JPH07508530A (en)
KR (1) KR950702112A (en)
AU (1) AU4507693A (en)
CA (1) CA2139440A1 (en)
GB (1) GB9214184D0 (en)
WO (1) WO1994001095A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
US5726187A (en) * 1992-10-16 1998-03-10 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists
GB9721139D0 (en) * 1997-10-07 1997-12-03 Glaxo Group Ltd Medicaments
DE19807535A1 (en) * 1998-02-21 1999-08-26 Asta Medica Ag Drug combination for treating migraine, migraine-type headaches or pain accompanied by nausea, vomiting or delayed gastric emptying
ES2327600T3 (en) 1999-02-18 2009-11-02 Novasearch Ag USE OF ANTAGONISTS OF THE 5-HT3 RECEPTOR FOR THE TREATMENT OF MUSCLE SKELETIC DISEASES.
TWI263496B (en) * 1999-12-10 2006-10-11 Novartis Ag Pharmaceutical combinations and their use in treating gastrointestinal disorders
GB0216027D0 (en) 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
MXPA05007379A (en) 2003-01-13 2006-02-10 Dynogen Pharmaceuticals Inc Method of treating nausea, vomiting, retching or any combination thereof.
GB0302662D0 (en) * 2003-02-05 2003-03-12 Strakan Ltd Transdermal granisetron
US20060263421A1 (en) 2005-05-18 2006-11-23 Abeille Pharmaceuticals Inc Transdermal Method and Patch for Nausea

Citations (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189002A2 (en) * 1984-12-20 1986-07-30 Sandoz Ag Treatment of gastrointestinal disorders using 5-HT3 antagonists
EP0254584A2 (en) * 1986-07-25 1988-01-27 Beecham Group Plc Azabicyclic compounds, process for their preparation, and their pharmaceutical use
GB2192885A (en) * 1986-07-23 1988-01-27 Glaxo Group Ltd Heterocyclic compounds
EP0266899A2 (en) * 1986-10-03 1988-05-11 Glaxo Group Limited Indole derivatives
EP0272876A2 (en) * 1986-12-17 1988-06-29 Glaxo Group Limited Use of heterocyclic derivatives for the manufacture of medicaments
EP0279512A2 (en) * 1987-01-19 1988-08-24 Beecham Group Plc Use of certain 5-HT3 receptor antagonists in the treatment of visceral pain
EP0287196A1 (en) * 1987-02-18 1988-10-19 Beecham Group Plc Indole derivatives, process for their preparation and pharmaceutical compositions containing them
EP0289170A2 (en) * 1987-04-25 1988-11-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
EP0315390A2 (en) * 1987-11-04 1989-05-10 Beecham Group Plc Novel 4-oxobenzotriazines and 4-oxoquinazolines
EP0315316A2 (en) * 1987-10-02 1989-05-10 Beecham Group Plc Imidazole derivatives, process for their preparation, pharmaceutical compositions containing them and their pharmaceutical use
EP0317088A1 (en) * 1987-10-22 1989-05-24 Glaxo Group Limited Ketone derivatives
WO1989009217A1 (en) * 1988-03-23 1989-10-05 Beecham Group Plc Novel compounds
EP0336759A1 (en) * 1988-04-07 1989-10-11 Glaxo Group Limited Imidazole derivatives
EP0345956A1 (en) * 1988-05-20 1989-12-13 Glaxo Group Limited Tricyclic ketones
EP0347229A1 (en) * 1988-06-16 1989-12-20 Glaxo Group Limited Indole derivatives
EP0351385A2 (en) * 1988-07-12 1990-01-17 BOEHRINGER INGELHEIM ITALIA S.p.A. New amidino and guanidino derivatives
EP0356098A2 (en) * 1988-08-15 1990-02-28 Glaxo Group Limited Lactam derivatives
EP0357416A2 (en) * 1988-09-01 1990-03-07 Glaxo Group Limited Use of serotonin antagonists in the treatment of drug addiction
EP0358903A2 (en) * 1988-07-29 1990-03-21 Dainippon Pharmaceutical Co., Ltd. Indazole-3-carboxylic acid derivatives
EP0361317A2 (en) * 1988-09-27 1990-04-04 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
EP0364274A1 (en) * 1988-10-13 1990-04-18 Glaxo Group Limited Imidazole derivatives
EP0376624A1 (en) * 1988-12-22 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation
EP0377967A2 (en) * 1988-12-13 1990-07-18 Beecham Group Plc 9-Aza-3-(oxa/thia)-bicyclo[3,2,1]nonane derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
EP0381422A1 (en) * 1989-02-02 1990-08-08 Yamanouchi Pharmaceutical Co. Ltd. Tetrahydrobenzimidazole derivatives
EP0385722A2 (en) * 1989-02-28 1990-09-05 Glaxo Group Limited Tricyclic lactam derivatives and pharmaceutical compositions containing them
EP0387431A1 (en) * 1989-03-14 1990-09-19 Beecham Group Plc Imidazole derivatives, process for their preparation and their pharmaceutical use
WO1991001316A1 (en) * 1989-07-21 1991-02-07 Beecham Group Plc New 9-azabicyclo[3.3.1]nonane-derivate
EP0417746A2 (en) * 1989-09-11 1991-03-20 G.D. Searle & Co. N-Azabicyclo/3.3.0/octane amides of aromatic acids
EP0419397A1 (en) * 1989-09-08 1991-03-27 Novo Nordisk A/S Substituted urea compounds and their preparation and use
WO1991007402A1 (en) * 1989-11-17 1991-05-30 Pfizer Inc. Azabicyclo amides and esters as 5-ht3 receptor antagonists
WO1991012254A1 (en) * 1990-02-16 1991-08-22 Novo Nordisk A/S Substituted urea compounds and their preparation and use
EP0450757A2 (en) * 1990-02-22 1991-10-09 Glaxo Group Limited Use of 5-hydroxytryptamine-antagonists in the treatment of mental disorders originating in childhood
EP0451538A2 (en) * 1990-03-19 1991-10-16 Fujisawa Pharmaceutical Co., Ltd. Use of pyridoindole derivatives in the treatment of ischemic disorders
EP0454121A2 (en) * 1990-04-27 1991-10-30 G.D. Searle & Co. Azatetracyclic compounds
WO1992005174A1 (en) * 1990-09-26 1992-04-02 Beecham Group Plc 3,9-diazabicyclo (3.3.1) nonan-7-yl derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
WO1992011259A1 (en) * 1990-12-19 1992-07-09 Beecham Group Plc Azabicyclic amides or esters of halogenated benzoic acids
WO1992012149A1 (en) * 1991-01-09 1992-07-23 Smithkline Beecham Plc Azabicydic and azatricydic derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
US5137893A (en) * 1991-03-07 1992-08-11 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
WO1992014733A1 (en) * 1991-02-23 1992-09-03 Smithkline Beecham P.L.C. Pharmaceuticals
EP0504679A1 (en) * 1991-03-07 1992-09-23 G.D. Searle & Co. New imidazopyridines as serotonergic 5-HT3 antagonists
EP0518767A2 (en) * 1991-06-11 1992-12-16 Merrell Pharmaceuticals Inc. Derivatives of amide analogs of certain methano bridged quinolizines
EP0554794A1 (en) * 1992-02-04 1993-08-11 Eisai Co., Ltd. Aminobenzoic acid derivatives

Patent Citations (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189002A2 (en) * 1984-12-20 1986-07-30 Sandoz Ag Treatment of gastrointestinal disorders using 5-HT3 antagonists
GB2192885A (en) * 1986-07-23 1988-01-27 Glaxo Group Ltd Heterocyclic compounds
EP0254584A2 (en) * 1986-07-25 1988-01-27 Beecham Group Plc Azabicyclic compounds, process for their preparation, and their pharmaceutical use
EP0266899A2 (en) * 1986-10-03 1988-05-11 Glaxo Group Limited Indole derivatives
EP0272876A2 (en) * 1986-12-17 1988-06-29 Glaxo Group Limited Use of heterocyclic derivatives for the manufacture of medicaments
EP0279512A2 (en) * 1987-01-19 1988-08-24 Beecham Group Plc Use of certain 5-HT3 receptor antagonists in the treatment of visceral pain
EP0287196A1 (en) * 1987-02-18 1988-10-19 Beecham Group Plc Indole derivatives, process for their preparation and pharmaceutical compositions containing them
EP0289170A2 (en) * 1987-04-25 1988-11-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
EP0315316A2 (en) * 1987-10-02 1989-05-10 Beecham Group Plc Imidazole derivatives, process for their preparation, pharmaceutical compositions containing them and their pharmaceutical use
EP0317088A1 (en) * 1987-10-22 1989-05-24 Glaxo Group Limited Ketone derivatives
EP0315390A2 (en) * 1987-11-04 1989-05-10 Beecham Group Plc Novel 4-oxobenzotriazines and 4-oxoquinazolines
WO1989009217A1 (en) * 1988-03-23 1989-10-05 Beecham Group Plc Novel compounds
EP0336759A1 (en) * 1988-04-07 1989-10-11 Glaxo Group Limited Imidazole derivatives
EP0345956A1 (en) * 1988-05-20 1989-12-13 Glaxo Group Limited Tricyclic ketones
EP0347229A1 (en) * 1988-06-16 1989-12-20 Glaxo Group Limited Indole derivatives
EP0351385A2 (en) * 1988-07-12 1990-01-17 BOEHRINGER INGELHEIM ITALIA S.p.A. New amidino and guanidino derivatives
EP0358903A2 (en) * 1988-07-29 1990-03-21 Dainippon Pharmaceutical Co., Ltd. Indazole-3-carboxylic acid derivatives
EP0356098A2 (en) * 1988-08-15 1990-02-28 Glaxo Group Limited Lactam derivatives
EP0357416A2 (en) * 1988-09-01 1990-03-07 Glaxo Group Limited Use of serotonin antagonists in the treatment of drug addiction
EP0361317A2 (en) * 1988-09-27 1990-04-04 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
EP0364274A1 (en) * 1988-10-13 1990-04-18 Glaxo Group Limited Imidazole derivatives
EP0377967A2 (en) * 1988-12-13 1990-07-18 Beecham Group Plc 9-Aza-3-(oxa/thia)-bicyclo[3,2,1]nonane derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
EP0376624A1 (en) * 1988-12-22 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation
EP0381422A1 (en) * 1989-02-02 1990-08-08 Yamanouchi Pharmaceutical Co. Ltd. Tetrahydrobenzimidazole derivatives
EP0385722A2 (en) * 1989-02-28 1990-09-05 Glaxo Group Limited Tricyclic lactam derivatives and pharmaceutical compositions containing them
EP0387431A1 (en) * 1989-03-14 1990-09-19 Beecham Group Plc Imidazole derivatives, process for their preparation and their pharmaceutical use
WO1991001316A1 (en) * 1989-07-21 1991-02-07 Beecham Group Plc New 9-azabicyclo[3.3.1]nonane-derivate
EP0419397A1 (en) * 1989-09-08 1991-03-27 Novo Nordisk A/S Substituted urea compounds and their preparation and use
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
EP0417746A2 (en) * 1989-09-11 1991-03-20 G.D. Searle & Co. N-Azabicyclo/3.3.0/octane amides of aromatic acids
WO1991007402A1 (en) * 1989-11-17 1991-05-30 Pfizer Inc. Azabicyclo amides and esters as 5-ht3 receptor antagonists
WO1991012254A1 (en) * 1990-02-16 1991-08-22 Novo Nordisk A/S Substituted urea compounds and their preparation and use
EP0450757A2 (en) * 1990-02-22 1991-10-09 Glaxo Group Limited Use of 5-hydroxytryptamine-antagonists in the treatment of mental disorders originating in childhood
EP0451538A2 (en) * 1990-03-19 1991-10-16 Fujisawa Pharmaceutical Co., Ltd. Use of pyridoindole derivatives in the treatment of ischemic disorders
EP0454121A2 (en) * 1990-04-27 1991-10-30 G.D. Searle & Co. Azatetracyclic compounds
WO1992005174A1 (en) * 1990-09-26 1992-04-02 Beecham Group Plc 3,9-diazabicyclo (3.3.1) nonan-7-yl derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
WO1992011259A1 (en) * 1990-12-19 1992-07-09 Beecham Group Plc Azabicyclic amides or esters of halogenated benzoic acids
WO1992012149A1 (en) * 1991-01-09 1992-07-23 Smithkline Beecham Plc Azabicydic and azatricydic derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
WO1992014733A1 (en) * 1991-02-23 1992-09-03 Smithkline Beecham P.L.C. Pharmaceuticals
US5137893A (en) * 1991-03-07 1992-08-11 G. D. Searle & Co. Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
EP0504679A1 (en) * 1991-03-07 1992-09-23 G.D. Searle & Co. New imidazopyridines as serotonergic 5-HT3 antagonists
EP0518767A2 (en) * 1991-06-11 1992-12-16 Merrell Pharmaceuticals Inc. Derivatives of amide analogs of certain methano bridged quinolizines
EP0554794A1 (en) * 1992-02-04 1993-08-11 Eisai Co., Ltd. Aminobenzoic acid derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A. PRIOR ET AL.: "REDUCTION OF RECTAL SENSITIVITY AND POST-PRANDIAL MOTILITY BY GRANISETRON, A 5-HT3 RECEPTOR ANTAGONIST, IN PATIENTS WITH IRRITABLE BOWEL SYNDROME (IBS)", GUT, vol. 31, no. 10, 1990, pages A1174 *
N.J.TALLEY: "REVIEW ARTICLE: 5-HYDROXYTRYPTAMINE AGONISTA AND ANTAGONISTS IN THE MODULATION OF GASTROINTESTINAL MOTILITY AND SENSATION: CLIMICAL IMPLICATIONS", ALIMENT.PHARMACOL.THER., vol. 6, no. 3, June 1992 (1992-06-01), pages 273 - 289 *
R.BERKOW, ED.: "THE MERCK MANUAL OF DIAGNOSIS AND THERAPY, 15TH EDITION", MERCK & CO., RAHWAY, N.J. *

Also Published As

Publication number Publication date
EP0650355A1 (en) 1995-05-03
GB9214184D0 (en) 1992-08-12
WO1994001095A2 (en) 1994-01-20
JPH07508530A (en) 1995-09-21
KR950702112A (en) 1995-06-19
AU4507693A (en) 1994-01-31
CA2139440A1 (en) 1994-01-20

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