WO1993002660A1 - Emulsifier concentrates - Google Patents

Emulsifier concentrates Download PDF

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Publication number
WO1993002660A1
WO1993002660A1 PCT/EP1992/001673 EP9201673W WO9302660A1 WO 1993002660 A1 WO1993002660 A1 WO 1993002660A1 EP 9201673 W EP9201673 W EP 9201673W WO 9302660 A1 WO9302660 A1 WO 9302660A1
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WO
WIPO (PCT)
Prior art keywords
alcohols
emulsifier
emulsifier concentrates
concentrates
alcohol
Prior art date
Application number
PCT/EP1992/001673
Other languages
German (de)
French (fr)
Inventor
Achim Ansmann
Willi Breitzke
Axel Böttcher
Original Assignee
Henkel Kommanditgesellschaft Auf Aktien
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Filing date
Publication date
Application filed by Henkel Kommanditgesellschaft Auf Aktien filed Critical Henkel Kommanditgesellschaft Auf Aktien
Priority to EP92916196A priority Critical patent/EP0596953A1/en
Priority to JP5503226A priority patent/JPH06509740A/en
Publication of WO1993002660A1 publication Critical patent/WO1993002660A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent

Definitions

  • the invention relates to a clear, liquid, at temperatures of 10 to 35 ° C. stable emulsifier concentrate based on sterols and / or wool wax alcohols and branched, saturated alcohols with 16 to 20 carbon atoms.
  • Sterols and wool wax alcohols are known auxiliaries for the production of cosmetic and pharmaceutical preparations.
  • they are used for the production of water-in-oil and oil-in-water emulsions, which are commercially available, for example, in the form of creams.
  • Commercial emulsifier concentrates which contain sterols or wool wax alcohols in a carrier consisting of paraffin oil are frequently used to produce such preparations.
  • such concentrates are cloudy at normal temperature and must be stirred and heated evenly before further processing.
  • the emulsifier concentrates according to the invention are in a clear, liquid form in a wide temperature range from 10 to 35 ° C. This means a considerable improvement over the conventional emulsifier concentrates based on sterols or wool wax alcohols in a mineral oil carrier, since the latter products are only in a clear form at higher temperatures.
  • the stars to be used according to the invention are steroids in which there is a hydroxyl group on the third carbon atom of the steroid structure and which are therefore chemically attributable to the alcohols.
  • the steroids occur in all animal and plant cells. According to their occurrence, they are divided into zoosterols, for example cholesterol, and phytosterols, which are predominantly found in higher plants.
  • wool wax alcohols are understood to mean complex mixtures of sterols and aliphatic alcohols from wool wax.
  • Suitable branched, saturated alcohols (B) are 2-hexyldecanol, 2-0ctyldodecanol or other branched, saturated alcohols having 16 to 20 carbon atoms.
  • e.g. 2- Hexyldecanol which is sold by the applicant under the name Eutanol G 16.
  • those emulsifier concentrates according to the invention in which the alcohol (B) is 2-octyldodecanol and are marketed by the applicant under the name Eutanol G are particularly well suited.
  • the emulsifier concentrates according to the invention can advantageously be used for the production of cosmetic or pharmaceutical preparations. They are particularly suitable for the preparation of preparations in the form of emulsions, preferably of the water-in-oil type.
  • the cosmetic or pharmaceutical emulsions produced on the basis of the emulsifier concentrates according to the invention are distinguished in particular by good storage stability. Storage stability means that after several months of storage the emulsions show no signs of separation or creaming and that the consistency is almost unchanged; This means in particular that the viscosity of the emulsions based on the emulsifier concentrates according to the invention remains approximately constant in the course of storage.
  • Croda CB 3896 Lanolin alcohols in mineral oil (Croda / Nettetal)
  • Amerchol L-101 Lanolin alcohols in mineral oil (Amerchol Europe / Vi-Ivorde-Belgium)
  • Lameform ( R ) TGI triglycerol diisostearate (company Henkel / Düsseldorf)
  • Emerv HP-2050 anhydrous lanolin according to DAB 9: mixture of esters, diesters and hydroxyesters of high molecular weight lanolin alcohols and lanolin fatty acids (company Henkel / Düsseldorf)
  • Monomuls ( R ) 90-0 18 oleic acid monoglyceride, molecularly distilled (company Henke1 / Düsse1dorf) 1.2.5. Oils
  • Myritol ( R ) 318 caprylic / capric acid triglyceride (company Henkel / Düsseldorf)
  • Vaseline Vaseline-DAB 9 (Riedel de Haen)
  • Permul ⁇ in ( R ) 3224 microcrystalline wax (A. Schmidt successor / -
  • Germall ( R ) 115 Idazolidinyl urea used as a preservative (Che ag / Frankfurt)
  • compositions and the turbidity behavior of the emulsifier concentrates EK 1 and EK 2 according to the invention and the comparisons EK 3 and EK 4 are summarized in Table 1.
  • This table shows that the concentrates according to the invention are in clear, liquid form over a wide temperature range, while the commercial comparisons in this range are only available in cloudy form.
  • Water-in-oil emulsions were prepared on the basis of concentrates EK 1 to EK 3, the compositions of which can be found in Table 2.
  • the emulsifier concentrates, co-emulsifiers, oils and consistency agents were combined at room temperature and heated to 75 ° C. with stirring. Water and the other auxiliaries were then introduced at this temperature with stirring. The emulsions thus obtained were cooled to about 35 ° C. and homogenized by further stirring. After further cooling to 20 ° C 93/02660
  • Viscosity of examples B1 and B3 according to the invention and comparisons VI and V2 measured using a Brookfield viscometer (Helipath) using spindle C at 5 rpm. The emulsions were then stored at room temperature for 12 weeks and the viscosities were determined again. The results of these measurements are summarized in Table 3.
  • Table 3 shows that the viscosity of the water-in-oil emulsions based on the emulsifier concentrates according to the invention changes over the course of the 93/02660 8 -

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Colloid Chemistry (AREA)

Abstract

Disclosed are emulsifier concentrates containing (A) 7 to 15 % by wt. of an alcohol selected from the group comprising sterols and wool-grease alcohols and (B) 85 to 93 % by wt. of a branched-chain saturated alcohol with 16 to 20 C-atoms. Such emulsifier concentrates are clear and fluid, and are stable to clouding at temperature from 10 to 35 °C. They are suitable for use in the production of cosmetic and pharmaceutical preparations.

Description

93/02660 93/02660
1 -1 -
"E ulgatorkonzentrat""E ulgator concentrate"
Die Erfindung betrifft ein klares, flüssiges, bei Temperaturen von 10 bis 35 °C gegen Austrübung stabiles Emulgatorkonzentrat auf Basis von Sterinen und/oder Wollwachsalkoholen sowie verzweigten, gesättigten Alkoholen mit 16 bis 20 C-Atomen.The invention relates to a clear, liquid, at temperatures of 10 to 35 ° C. stable emulsifier concentrate based on sterols and / or wool wax alcohols and branched, saturated alcohols with 16 to 20 carbon atoms.
Sterine und Wollwachsalkohole sind bekannte Hilfsmittel zur Herstellung kosmetischer und pharmazeutischer Zubereitungen. Insbesondere finden sie Verwendung zur Herstellung von Wasser-in-Öl- und Öl-in-Wasser-Emulsionen, die zum Beispiel in Form von Cremes in den Handel kommen. Zur Herstellung derartiger Zubereitungen werden häufig handelsübliche Emulgatorkonzentrate eingesetzt, die Sterine oder Wollwachsalkohole in einem aus Paraffinöl bestehenden Träger enthalten. Derartige Konzentrate sind jedoch bei Nor¬ maltemperatur trübe und müssen vor der weiteren Verarbeitung gleichmäßig verrührt und erhitzt werden. D. Kruse et al. haben nun zwar gezeigt, daß sich die Löslichkeit von Lanolin, das chemisch ein komplexes Gemisch von Estern darstellt, in pharmazeutischen Weißölen durch Hexadecylalkohol bei Raumtemperatur (25 °C) verbessern läßt (Seifen-Öle-Fette-Wachse, 1971 [97] 827). Sie haben jedoch keine Untersuchungen zur Löslichkeit von Lanolin¬ alkoholen (Wollwachsalkoholen) in Hexadecylalkohol durchgeführt. Ebenso¬ wenig liegen Erkenntnisse bei Temperaturen unterhalb Raumtemperatur vor. Es wäre jedoch wünschenswert, die Einsatzmöglichkeiten von Emulgatorkon- zentraten auf Basis von Sterinen und Wollwachsalkoholen dadurch zu ver¬ bessern, daß sie in einem weiten Temperaturbereich gegen Austrübungen stabil sind und dadurch vorteilhaft verarbeitet werden können.Sterols and wool wax alcohols are known auxiliaries for the production of cosmetic and pharmaceutical preparations. In particular, they are used for the production of water-in-oil and oil-in-water emulsions, which are commercially available, for example, in the form of creams. Commercial emulsifier concentrates which contain sterols or wool wax alcohols in a carrier consisting of paraffin oil are frequently used to produce such preparations. However, such concentrates are cloudy at normal temperature and must be stirred and heated evenly before further processing. D. Kruse et al. have now shown that the solubility of lanolin, which is a chemically complex mixture of esters, in pharmaceutical white oils can be improved by hexadecyl alcohol at room temperature (25 ° C) (soap-oil-fat waxes, 1971 [97] 827) . However, they have not carried out any studies on the solubility of lanolin alcohols (wool wax alcohols) in hexadecyl alcohol. There is also no knowledge at temperatures below room temperature. However, it would be desirable to improve the possible uses of emulsifier concentrates based on sterols and wool wax alcohols in that they are stable against clouding over a wide temperature range and can therefore be processed advantageously.
Es bestand daher die Aufgabe, klare, flüssige, bei Normaltemperatur gegen Austrübung stabile Emulgatorkonzentrate mit einem Gehalt an Sterinen und/oder Wollwachsalkoholen zur Verfügung zu stellen. Unter Normaltempe¬ ratur wird dabei ein Temperaturbereich von 10 bis 35 °C verstanden.It was therefore an object to provide clear, liquid emulsifier concentrates which are stable at normal temperature against clouding and contain sterols and / or wool wax alcohols. Normal temperature is understood to mean a temperature range from 10 to 35 ° C.
Diese Aufgabe wurde erfindungsgemäß gelöst durch ein klares, flüssiges, bei Normaltemperatur gegen Austrübung stabiles Emulgatorkonzentrat umfas¬ sendThis object has been achieved according to the invention by a clear, liquid emulsifier concentrate which is stable at normal temperature against clouding
(A) 7 bis 15 Gew.-% eines Alkohols ausgewählt aus der Gruppe der Sterine und Wollwachsalkohole(A) 7 to 15% by weight of an alcohol selected from the group of sterols and wool wax alcohols
(B) 85 bis 93 Gew.-% eines verzweigten, gesättigten Alkohols mit 16 bis 20 C-Atomen.(B) 85 to 93% by weight of a branched, saturated alcohol having 16 to 20 carbon atoms.
Die erfindungsgemäßen Emulgatorkonzentrate liegen in einem weiten Tempe¬ raturbereich von 10 bis 35 °C in klarer, flüssiger Form vor. Dies bedeutet eine erhebliche Verbesserung gegenüber den herkömmlichen Emulgatorkonzen- traten auf Basis von Sterinen bzw. Wollwachsalkoholen in einem Träger aus Mineralöl, da die letztgenannten Produkte erst bei höheren Temperaturen in klarer Form vorliegen.The emulsifier concentrates according to the invention are in a clear, liquid form in a wide temperature range from 10 to 35 ° C. This means a considerable improvement over the conventional emulsifier concentrates based on sterols or wool wax alcohols in a mineral oil carrier, since the latter products are only in a clear form at higher temperatures.
Unter den erfindungsgemäß einzusetzenden Ster nen sind Steroide zu ver¬ stehen, bei denen sich am dritten C-Atom des Steroidgerüstes eine Hydro¬ xylgruppe befindet und die daher chemisch den Alkoholen zuzurechnen sind. Die Steroide treten in allen tierischen und pflanzlichen Zellen auf. Nach ihren Vorkommen teilt man sie in Zoosterine, zum Beispiel Cholesterin, und Phytosterine, die vorwiegend in höheren Pflanzen vorkommen, auf. Unter Wollwachsalkoholen sind im Sinne des Deutschen Arzneimittelbuches (9. Ausgabe) komplexe Gemische von Sterinen und aliphatischen Alkoholen aus dem Wollwachs zu verstehen.The stars to be used according to the invention are steroids in which there is a hydroxyl group on the third carbon atom of the steroid structure and which are therefore chemically attributable to the alcohols. The steroids occur in all animal and plant cells. According to their occurrence, they are divided into zoosterols, for example cholesterol, and phytosterols, which are predominantly found in higher plants. In the sense of the German Medicinal Products Book (9th edition), wool wax alcohols are understood to mean complex mixtures of sterols and aliphatic alcohols from wool wax.
Als verzweigte, gesättigte Alkohole (B) kommen beispielsweise 2- Hexyldecanol, 2-0ctyldodecanol oder andere verzweigte, gesättigte Alkohole mit 16 bis 20 C-Atomen in Frage. Bevorzugt geeignet ist z.B. 2- Hexyldecanol, das von der Anmelderin unter der Bezeichung Eutanol G 16 vertrieben wird. Besonders gut geeignet sind aber diejenigen erfindungsgemäßen Emulgatorkonzentrate, worin der Alkohol (B) 2- Octyldodecanol ist und von der Anmelderin unter der Bezeichnung Eutanol G vertrieben wird.Examples of suitable branched, saturated alcohols (B) are 2-hexyldecanol, 2-0ctyldodecanol or other branched, saturated alcohols having 16 to 20 carbon atoms. Preferably, e.g. 2- Hexyldecanol, which is sold by the applicant under the name Eutanol G 16. However, those emulsifier concentrates according to the invention in which the alcohol (B) is 2-octyldodecanol and are marketed by the applicant under the name Eutanol G are particularly well suited.
Die erfindungsgemäßen Emulgatorkonzentrate lassen sich vorteilhaft zur Herstellung kosmetischer oder pharmazeutischer Zubereitungen verwenden. Insbesondere eignen sie sich zur Herstellung von Zubereitungen in der Form von Emulsionen, vorzugsweise vom Typ der Wasser-in-Öl-Emulsionen. Die auf Basis der erfindungsgemäßen Emulgatorkonzentrate hergestellten kosmeti¬ schen oder pharmazeutischen Emulsionen zeichnen sich insbesondere durch eine gute Lagerstabilität aus. Unter Lagerstabilität wird dabei verstan¬ den, daß die Emulsionen nach mehrmonatiger Lagerung keine Trennungs- bzw. Aufrahmerscheinungen zeigen und daß die Konsistenz nahezu unverändert ist; dies bedeutet insbesondere, daß die Viskosität der Emulsionen auf Basis der erfindungsgemäßen Emulgatorkonzentrate im Laufe der Lagerung annähernd konstant bleibt.The emulsifier concentrates according to the invention can advantageously be used for the production of cosmetic or pharmaceutical preparations. They are particularly suitable for the preparation of preparations in the form of emulsions, preferably of the water-in-oil type. The cosmetic or pharmaceutical emulsions produced on the basis of the emulsifier concentrates according to the invention are distinguished in particular by good storage stability. Storage stability means that after several months of storage the emulsions show no signs of separation or creaming and that the consistency is almost unchanged; This means in particular that the viscosity of the emulsions based on the emulsifier concentrates according to the invention remains approximately constant in the course of storage.
Die folgenden Beispiele dienen der Erläuterung der Erfindung und sind nicht einschränkend zu verstehen. O 93/02660The following examples serve to illustrate the invention and are not to be understood as restrictive. O 93/02660
- 4 -- 4 -
B e i s p i e l eB e i s p i e l e
1. Allgemeines 1.1. Abkürzungen a) Zur Kennzeichnung des Gehalts wäßriger Lösungen an Aktivsubstanz wird die Abkürzung AS-Gehalt verwendet. b) In den Kopfzeilen der Tabelle 1 wurden die erfindungsgemäßen Emulga¬ torkonzentrate mit EX 1 und EK 2, die handelsüblichen Emulgatorkonzentrate mit EK 3 und EK 4 abgekürzt. In den KopfZeilen der Tabelle 2 sind die Beispiele der erfindungsgemäßen kosmetischen Zubereitungen mit Bl bis B4, die Vergleiche mit VI und V2 kenntlich gemacht.1. General 1.1. Abbreviations a) The abbreviation AS content is used to identify the content of aqueous solutions of active substance. b) In the headers of Table 1, the emulsifier concentrates according to the invention were abbreviated EX 1 and EK 2, and the commercial emulsifier concentrates were abbreviated EK 3 and EK 4. The headers of Table 2 show the examples of the cosmetic preparations according to the invention with B1 to B4 and the comparisons with VI and V2.
1.2. Verwendete Substanzen1.2. Substances used
1.2.1. Sterine und Wollwachsalkohole Emerv HP 2095:1.2.1. Sterols and wool wax alcohols Emerv HP 2095:
Gemisch von Sterinen und aliphatischen Alkoholen aus dem Wollwachs gemäßMixture of sterols and aliphatic alcohols from the wool wax according to
DAB9.DAB9.
Generol(R) 122: Raffiniertes Sojasterin (Fa. Henkel Corp./USA)Generol ( R ) 122: Refined soy aaster (Henkel Corp./USA)
1.2.2. Alkohole (B)1.2.2. Alcohols (B)
Eutanol G: 2-0ctyldodecanol (Firma Henkel/Düsseldorf)Eutanol G: 2-0ctyldodecanol (company Henkel / Düsseldorf)
1.2.3. Handelsübliche Emulgatorkonzentrate1.2.3. Commercial emulsifier concentrates
Croda CB 3896: Lanolinalkohole in Mineralöl (Firma Croda/Nettetal) Amerchol L-101: Lanolinalkohole in Mineralöl (Firma Amerchol Europe/Vi- Ivorde-Belgien)Croda CB 3896: Lanolin alcohols in mineral oil (Croda / Nettetal) Amerchol L-101: Lanolin alcohols in mineral oil (Amerchol Europe / Vi-Ivorde-Belgium)
1.2.4. Coe ulgatoren1.2.4. Coe ulgators
Lameform(R) TGI: Triglycerindiisostearat (Firma Henkel/Düsseldorf) Emerv HP-2050: Wasserfreies Lanolin gemäß DAB 9: Mischung aus Estern, Diestern und Hydroxyestern der hochmolekularen Lanolinalkohole und Lano¬ linfettsäuren (Firma Henkel/Düsseldorf)Lameform ( R ) TGI: triglycerol diisostearate (company Henkel / Düsseldorf) Emerv HP-2050: anhydrous lanolin according to DAB 9: mixture of esters, diesters and hydroxyesters of high molecular weight lanolin alcohols and lanolin fatty acids (company Henkel / Düsseldorf)
Monomuls(R) 90-0 18: Ölsäuremonoglycerid, molekulardestilliert (Firma Henke1/Düsse1dorf) 1.2.5. ÖleMonomuls ( R ) 90-0 18: oleic acid monoglyceride, molecularly distilled (company Henke1 / Düsse1dorf) 1.2.5. Oils
Myritol(R) 318: Capryl/Caprinsäure-Triglycerid (Firma Henkel/Düsseldorf)Myritol ( R ) 318: caprylic / capric acid triglyceride (company Henkel / Düsseldorf)
1.2.6. Konsistenzgeber1.2.6. Consistency generator
Lanette( ) 0: Gemisch höherer, gesättigter Fettalkohole, vorwiegend Cetyl- und Stearylalkohol (Firma Henkel/Düsseldorf)Lanette () 0: Mixture of higher, saturated fatty alcohols, mainly cetyl and stearyl alcohol (company Henkel / Düsseldorf)
Vaseline: Vaseline-DAB 9 (Fa. Riedel de Haen)Vaseline: Vaseline-DAB 9 (Riedel de Haen)
Permulαin(R) 3224: Mikrokristallines Wachs (Firma A. Schmidt Nachfolger/-Permulαin ( R ) 3224: microcrystalline wax (A. Schmidt successor / -
Celle)Celle)
1.2.7. Hilfsstoffe1.2.7. Auxiliaries
Glycerin, 86 %iq: Firma Henkel/Düsseldorf qS04 ' 7 H2O Magnesiumsulfat-HeptahydratGlycerin, 86% iq: Henkel / Düsseldorf qS04 '7 H2O magnesium sulfate heptahydrate
Formalin: Wäßrige Formaldehydlösung; AS-Gehalt: 35 %Formalin: aqueous formaldehyde solution; AS content: 35%
Germall(R) 115: Als Konservierungsmittel verwendeter I idazolidinylharn- stoff (Firma Che ag/Frankfurt)Germall ( R ) 115: Idazolidinyl urea used as a preservative (Che ag / Frankfurt)
2. Beispiele2. Examples
2.1. Emu1gatorkonzentrate2.1. Emulsifier concentrates
Die Zusammensetzungen sowie das Trübungsverhalten der erfindungsgemäßen Emulgatorkonzentrate EK 1 und EK 2 sowie der Vergleiche EK 3 und EK 4 sind in der Tabelle 1 zusammengestellt. Aus dieser Tabelle geht hervor, daß die erfindungsgemäßen Konzentrate über einen weiten Temperaturbereich in klarer, flüssiger Form vorliegen, während die handelsüblichen Vergleiche in diesen Bereich ausschließlich in trüber Form vorliegen. The compositions and the turbidity behavior of the emulsifier concentrates EK 1 and EK 2 according to the invention and the comparisons EK 3 and EK 4 are summarized in Table 1. This table shows that the concentrates according to the invention are in clear, liquid form over a wide temperature range, while the commercial comparisons in this range are only available in cloudy form.
O 93/02660 - 6O 93/02660 - 6
Tabelle la)Table l a )
Figure imgf000008_0001
a) Angaben in Gew.-% 2.2. Emulsionen
Figure imgf000008_0001
a ) Figures in% by weight 2.2. Emulsions
Auf Basis der Konzentrate EK 1 bis EK 3 wurden Wasser-in-Öl-Emulsionen hergestellt, deren Zusammensetzungen der Tabelle 2 entnommen werden kön¬ nen.Water-in-oil emulsions were prepared on the basis of concentrates EK 1 to EK 3, the compositions of which can be found in Table 2.
Zur Herstellung dieser Dispersionen wurden die Emulgatorkonzentrate, Co- e ulgatoren, Öle und Konsistenzgeber bei Raumtemperatur zusammengegeben und unter Rühren auf 75 °C erwärmt. Anschließend wurden bei dieser Tempe¬ ratur Wasser sowie die weiteren Hilfsstoffe unter Rühren eingetragen. Die so erhaltenen Emulsionen wurden auf ca. 35 °C abgekühlt und durch weiteres Rühren homogenisiert. Nach weiterem Abkühlen auf 20 °C wurde die 93/02660To prepare these dispersions, the emulsifier concentrates, co-emulsifiers, oils and consistency agents were combined at room temperature and heated to 75 ° C. with stirring. Water and the other auxiliaries were then introduced at this temperature with stirring. The emulsions thus obtained were cooled to about 35 ° C. and homogenized by further stirring. After further cooling to 20 ° C 93/02660
Viskosität der erfindungsgemäßen Beispiele Bl und B3 sowie der Vergleiche VI und V2 mit einem Brookfield-Viskosimeter (Helipath) unter Verwendung von Spindel C bei 5 UpM gemessen. Die Emulsionen wurden anschließend 12 Wochen bei Raumtemperatur gelagert und die Viskositäten erneut bestimmt. Die Ergebnisse dieser Messungen sind in Tabelle 3 zusammengestellt.Viscosity of examples B1 and B3 according to the invention and comparisons VI and V2 measured using a Brookfield viscometer (Helipath) using spindle C at 5 rpm. The emulsions were then stored at room temperature for 12 weeks and the viscosities were determined again. The results of these measurements are summarized in Table 3.
Tabelle 2 a)Table 2 a )
Figure imgf000009_0001
a) Angaben in Gew.-
Figure imgf000009_0001
a ) Figures in weight
Aus Tabelle 3 geht hervor, daß sich die Viskosität der Wasser-in-Öl-Emul- sionen auf Basis der erfindungsgemäßen Emulgatorkonzentrate im Laufe der 93/02660 8 -Table 3 shows that the viscosity of the water-in-oil emulsions based on the emulsifier concentrates according to the invention changes over the course of the 93/02660 8 -
Lagerung nicht verändert hat, während bei den Vergleichsprodukten deut¬ liche Viskositätsveränderungen beobachtet wurden.Storage did not change, while significant changes in viscosity were observed in the comparison products.
Tabelle 3a)Table 3 a )
Figure imgf000010_0001
a) Angaben in Pas (bei 20 °C)
Figure imgf000010_0001
a ) Data in Pas (at 20 ° C)

Claims

93/02660 g _P a t e n t a n s p r ü c h e 93/02660 g _P claims
1. Klares, flüssiges, bei Normaltemperatur gegen Austrübung stabiles Emulgatorkonzentrat umfassend1. A clear, liquid emulsifier concentrate which is stable at normal temperature against clouding
(A) 7 bis 15 Gew.-% eines Alkohols ausgewählt aus der Gruppe der Ste¬ rine und Wollwachsalkohole(A) 7 to 15% by weight of an alcohol selected from the group of the stones and wool wax alcohols
(B) 85 bis 93 Gew.-% eines verzweigten, gesättigten Alkohols mit 16 bis 20 C-Atomen.(B) 85 to 93% by weight of a branched, saturated alcohol having 16 to 20 carbon atoms.
2. Emulgatorkonzentrat nach Anspruch 1, worin der Alkohol (B) 2-0ctyldo- decanol ist.2. Emulsifier concentrate according to claim 1, wherein the alcohol (B) is 2-0ctyldodecanol.
3. Verwendung eines Emulgatorkonzentrats nach Anspruch 1 oder 2 zur Her¬ stellung kosmetischer oder pharmazeutischer Zubereitungen. 3. Use of an emulsifier concentrate according to claim 1 or 2 for the manufacture of cosmetic or pharmaceutical preparations.
PCT/EP1992/001673 1991-07-31 1992-07-22 Emulsifier concentrates WO1993002660A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP92916196A EP0596953A1 (en) 1991-07-31 1992-07-22 Emulsifier concentrates
JP5503226A JPH06509740A (en) 1991-07-31 1992-07-22 emulsifier concentrate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4125332A DE4125332A1 (en) 1991-07-31 1991-07-31 EMULSIFIER CONCENTRATE
DEP4125332.9 1991-07-31

Publications (1)

Publication Number Publication Date
WO1993002660A1 true WO1993002660A1 (en) 1993-02-18

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DE (1) DE4125332A1 (en)
WO (1) WO1993002660A1 (en)

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FR2807323A1 (en) * 2000-04-10 2001-10-12 Oreal COMPOSITION, ESPECIALLY COSMETIC, CONTAINING A STEROID AND A 2-ALKYL ALKANOL OR AN ESTER
WO2003035025A1 (en) * 2001-07-10 2003-05-01 Cognis Japan Ltd. Oil-based composition comprising sterols
EP1347734B2 (en) † 2000-12-15 2009-07-29 Merz Pharma GmbH & Co. KGaA Vesicle forming skin oil containing w/o-emulsifiers with a hydrophilic-lipophilic balance of 2-5.9, method for the production and use thereof
US9493726B2 (en) 2014-09-08 2016-11-15 The Procter & Gamble Company Detergent compositions containing a predominantly C15 branched alkyl alkoxylated surfactant
US9493725B2 (en) 2014-09-08 2016-11-15 The Procter & Gamble Company Detergent compositions containing a predominantly C15 alkyl branched surfactant

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DE19539429C1 (en) * 1995-10-24 1997-04-24 Kawes S L Water / oil mixed emulsifier and its use in cosmetic and pharmaceutical ointments, creams, lotions, soaps, shampoos and bath additives
US7217432B2 (en) * 2002-04-19 2007-05-15 Cognis Corporation Vegetable substitute for lanolin
US7220432B2 (en) * 2002-04-19 2007-05-22 Cognis Corporation Vegetable substitute for lanolin

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US3422204A (en) * 1963-11-13 1969-01-14 Exxon Research Engineering Co Cosmetic composition containing lanolin and hexadecyl alcohol
EP0034126A1 (en) * 1980-01-25 1981-08-19 Luigi Maggesi Cosmetic and dermatological compositions for shaving the skin
US4853222A (en) * 1986-08-01 1989-08-01 Intercos Italiana S.P.A. Ointment for concealing skin blemishes and scars

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US3422204A (en) * 1963-11-13 1969-01-14 Exxon Research Engineering Co Cosmetic composition containing lanolin and hexadecyl alcohol
EP0034126A1 (en) * 1980-01-25 1981-08-19 Luigi Maggesi Cosmetic and dermatological compositions for shaving the skin
US4853222A (en) * 1986-08-01 1989-08-01 Intercos Italiana S.P.A. Ointment for concealing skin blemishes and scars

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807323A1 (en) * 2000-04-10 2001-10-12 Oreal COMPOSITION, ESPECIALLY COSMETIC, CONTAINING A STEROID AND A 2-ALKYL ALKANOL OR AN ESTER
US6486147B2 (en) 2000-04-10 2002-11-26 L'oreal Cosmetic composition containing a steroid and a 2-alkylalkanol or an ester thereof
EP1347734B2 (en) † 2000-12-15 2009-07-29 Merz Pharma GmbH & Co. KGaA Vesicle forming skin oil containing w/o-emulsifiers with a hydrophilic-lipophilic balance of 2-5.9, method for the production and use thereof
WO2003035025A1 (en) * 2001-07-10 2003-05-01 Cognis Japan Ltd. Oil-based composition comprising sterols
US9493726B2 (en) 2014-09-08 2016-11-15 The Procter & Gamble Company Detergent compositions containing a predominantly C15 branched alkyl alkoxylated surfactant
US9493725B2 (en) 2014-09-08 2016-11-15 The Procter & Gamble Company Detergent compositions containing a predominantly C15 alkyl branched surfactant

Also Published As

Publication number Publication date
JPH06509740A (en) 1994-11-02
EP0596953A1 (en) 1994-05-18
DE4125332A1 (en) 1993-02-04

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