WO1992020400A1 - Instrument for applying pharmaceutical to inside of brain - Google Patents
Instrument for applying pharmaceutical to inside of brain Download PDFInfo
- Publication number
- WO1992020400A1 WO1992020400A1 PCT/JP1992/000658 JP9200658W WO9220400A1 WO 1992020400 A1 WO1992020400 A1 WO 1992020400A1 JP 9200658 W JP9200658 W JP 9200658W WO 9220400 A1 WO9220400 A1 WO 9220400A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- guide
- drug
- administration
- needle
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0208—Subcutaneous access sites for injecting or removing fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0693—Brain, cerebrum
Definitions
- the present invention relates to a device for intracerebral administration of a drug, specifically to a device for intracerebrally administering a drug-containing agent for treating a drug in the brain in the medical field.
- a biological function is regulated by a physiologically active substance which is produced and exerts an action in a specific part of a living body.
- a physiologically active substance which is produced and exerts an action in a specific part of a living body.
- living organisms produce necessary bioactive substances and regulate brain activity.
- a physiologically active substance called nerve growth factor is known.
- This is one of the neurotrophic factors that have the effect of maintaining and differentiating the survival of neurons, and is a senile dementia that has recently become a problem, for example, neurodegenerative diseases such as Alzheimer's disease, one of the presenile dementias. It is a protein that is expected to be developed as a therapeutic drug.
- oral administration and intravenous administration which are currently widely used, can be considered.However, in oral administration, degradation in the digestive organs Almost no pharmacological effect is exerted due to the first-pass effect, etc.
- intravenous administration causes a major obstacle to the blood-brain barrier, making it difficult to transfer the drug into the brain.
- the capillaries in the brain parenchyma are covered by cells with poor material permeability, and have a special structure in which the inner cells are tightly bound by tight junctions. Many substances are unsuitable because the intervening blood-wave barrier prevents the disordered transfer and distribution of components in the blood and drugs administered or absorbed into the blood to the brain tissue. Therefore, there is a problem that a proteinaceous physiologically active substance such as the nerve growth factor does not transfer to the brain by ordinary intravenous administration or oral administration.
- Means for solving these problems include (1) a method of administering a physiologically active substance to the spine, and (2) a method of performing a craniotomy or craniotomy.
- a method is conceivable in which the active substance is directly administered into the brain.
- the method (1) is not suitable because high molecular substances such as protein * peptides are blocked at the cerebrospinal barrier as well as at the blood-brain barrier.
- the method (2) requires a surgical operation, which not only complicates the operation but also has the problems of economical efficiency, physical and psychological burden on the patient, and a high risk of infection. .
- the half-life of the physiologically active substance is short even when it is directly administered into the brain, so that it has to be administered frequently to enhance its therapeutic effect.
- Ommaya reservoir which distills force tetra into the ventricle. It has been known. Although this reservoir can administer the drug into the brain, it has the drawback that it cannot deliver the drug continuously, and that it can only administer the drug in the form of a narrow stomach. It is unsuitable for administration of preparations containing bioactive substances that require repeated administration.
- the above-mentioned subject is constituted by a preparation administration means for holding a preparation, and a plunger which is detachably attached to the preparation administration means and pushes out a part of the preparation to one end side of the preparation administration means.
- the problem can be solved by providing a drug delivery device to be used in combination with a drug delivery guide previously embedded in the patient's head.
- the formulation guide is attached to a guide main body having a guide hole for introducing a formulation, and a lower end side of the guide main body is connected to the guide hole so as to communicate with the guide hole. Inject the formulation introduced into And a flexible conduit for guiding to the application site.
- the guide body has a guide hole formed of a tapered introduction portion and a circular portion connected thereto, and a backflow preventing elastic member that is forcibly fitted to a cylindrical portion of the guide hole and closes the guide hole, and a taper. It has a cylindrical guide hole, and is provided with a cylindrical pressing member fitted in the guide hole and fixing the backflow preventing elastic member.
- the preparation administration means is formed in a hollow needle structure.
- the preparation administration means may have a double needle structure including a hollow outer needle and an inner needle detachably attached to the outer sleeve.
- a preparation holder comprising a preparation holder body containing the preparation and a plunger removably attached to the preparation holder is provided.
- the formulation holder is attached to the outer needle of the formulation administration means, and the formulation inside the formulation holder body is externally needled with the plunger. Pushing into is done.
- the above object is used in combination with a preparation guiding guide having a flexible suppository conduit for guiding a preparation introduced into a preparation introduction guide hole to a target site in the brain.
- a device for intracerebral administration of a pharmaceutical preparation comprising: a tubular pharmaceutical indwelling member capable of enclosing a pharmaceutical and moving in and out of the flexible guiding tube ⁇ of the pharmaceutical inducing guide; and the pharmaceutical inducing guide holding the pharmaceutical indwelling member.
- the preparation dispensing device includes a needle member for introducing the 12-drug indwelling member into the preparation guide.
- the needle member may be composed of only a cylindrical member having an inner diameter that can be passed by the preparation indwelling member holder.
- the needle member may be an outer needle having an inner diameter that can be passed by the preparation indwelling member holder, and a preparation guide. It is preferable that the inner needle is detachably fitted to the outer needle for positioning by fitting into the guide hole.
- Preparations suitable for administration with the intracerebral administration device include working-iron-type solid preparations and semisolid preparations.
- the solid preparations can be classified into two types according to their carrier components: biodegradable solid preparations and non-biodegradable solid preparations.
- the biodegradable pharmaceutical preparation includes a sustained-release preparation containing collagen, gelatin, albumin, polylactic acid, polyglycolic acid, lactic acid-glycolic acid copolymer, chitin, and chitosan as carrier components.
- Non-degradable solid formulations include, but are not limited to, silicones, vinyl copolymers, and the like.
- the semi-solid preparation also includes a gel-like semi-solid preparation.
- the preparation guide is embedded in the head in advance so that the tip is located at the administration site.
- the needle-shaped member is loaded with the formulation, and administration may be performed by operating the device for intracerebrally administering the formulation. in this case, The preparation is guided from the needle-shaped member to the administration site in the brain through the preparation guide and is reliably administered.
- the device for intracerebral administration of a drug product is constituted by a rod fixed to one end side and a drug product holding member holder that integrally holds the drug product member together with a push rod inserted therein. It should be noted that the push rod constituting the above-mentioned device for intracerebral administration of the preparation may be omitted.
- the device for injecting the preparation is loaded into a preparation guide embedded in the patient's head and left as it is, whereby the preparation on the distal end side of the preparation placement member is administered to a predetermined site in the brain.
- the device for intracerebral administration of the drug product is taken out of the product specialty guide, and a new device for intracerebral administration is loaded into the product guide, enabling repeated administration. I have.
- a substance that produces and secretes a drug or a biologically active substance that is effective for a certain period of time for example, certain cells, etc.
- a therapeutic effect can be obtained semipermanently.
- FIG. 1 is a cross-sectional view showing a set of a pharmaceutical preparation intracerebral administration device and a pharmaceutical preparation guide according to the present invention.
- FIG. 2 is an explanatory view showing a state in which the preparation guide of FIG. 1 is buried in the head.
- Figure 3 is Ru SurudoAkira view showing a state of use of the formulation intracerebral administration apparatus of Figure 1 ⁇
- FIG. 4 is a cross-sectional view of a device for intracerebral administration of a pharmaceutical preparation according to another embodiment of the present invention.
- FIG. 6 shows the use of a device for intracerebral administration of a pharmaceutical preparation according to yet another embodiment of the present invention. It is explanatory drawing which shows a state.
- the device for intracerebral administration of the preparation according to the present invention shown in FIG. 1 is suitable for administration of a preparation that disintegrates / dissolves or decomposes in the brain and does not need to be taken out again.
- the double needle 1 is composed of an outer needle 6 and an inner needle 11, and the outer needle 6 is composed of a force neuron 7 formed of stainless steel or another material, and an R-shaped cylindrical holding portion 8 for holding the same.
- the R-shaped holding portion 8 is formed of a plastic material having good biocompatibility, for example, silicon, and has a Taber-shaped fitting hole 10 connected to the tube hole 9 of the force neurette 7.
- Inner needle 1 1 is outer needle 6 has a tapered protruding portion 12 removably fitted into the fitting hole 10 of the same.
- a solid insertion needle 13 having a sharp tip is mounted on the protruding portion 12.
- the insertion needle 13 is formed of stainless steel or another suitable material, and has a length protruding beyond the tip of the force neuller 7 when the inner needle 11 is completely inserted into the outer needle 6.
- the preparation holder 3 comprises a cylindrical body 15 having a tapered projection 14 and an arrow-shaped plunger 17 provided with an extrusion rod 16 at one end.
- the preparation 2 loaded in the holding member main body 15 can be loaded into the preparation guide 5 by being removably fitted into the fitting hole 10 of the outer needle 6.
- the plunger 4 is composed of a flexible mouth 18 and a plunger handle 19, and in use, the flexible rod 18 is inserted into the outer needle 6 and advanced to bring the preparation 2 to the administration site. Push forward.
- the material of the flexible rod 18 is not limited, but it must have the same flexibility as the water pipe. Typical examples of the material include vinyl chloride and polypropylene. Commercial molecular materials such as pyrene, nylon 12 and Teflon, and stainless steels such as SUS316.
- the formulation guide 5 is composed of a silicon guide body 20, a backflow preventing elastic member 21, a cylindrical holding member 22, and a flexible conduit 23. It has a tapered guide hole 20a and a cylindrical guide hole 2Ob connected to the tapered guide hole 20a.
- the guide member 24 is buried in the cylindrical guide hole. Have been.
- the guide member 24 is formed of silicon or other biocompatible plastic material or stainless steel net, and is connected to the cylindrical recess 25 connected to the tapered guide hole 20 a of the guide body 20.
- a funnel-shaped guide hole 26 is formed, and a backflow preventing elastic member 21 slightly larger in diameter than its diameter is forcibly fitted to the cylindrical Gfl portion 25, and a circular pressing member 22 is formed.
- the backflow preventing elastic member 21 is formed of an elastic material, for example, silicon rubber.
- the holding member 22 has a bosh-shaped guide hole 27, and the cannula 7 of the needle is arranged in line with the guide hole 26.
- a flexible gun conduit 23 is mounted on the tapered projection 28 protruding from the lower end of the guide body 20 coaxially with the funnel-shaped guide hole 26 of the guide member 24. It communicates with the shape guide hole 26.
- the water-soluble conduit 23 is made of a plastic material having good biocompatibility such as silicon.
- the composition-guiding guide 5 Prior to using the device for intracerebral administration of the above-described composition, as shown in FIG. 2, the composition-guiding guide 5 is fixed to the head X of the patient by surgical operation. At this time, the distal end of the conduit 23 of the formulation guide 5 is fixed to the site to which the formulation 2 is to be administered, that is, the application site, but the guide body 20 is on the skull and bone X and the scalp Y It is fixed below, and the appearance is slightly bulging. (4) If a dot line or the like is written on the outer surface of the conduit 23 with a contrast agent, it is possible to confirm whether the fixation site is appropriate by X-ray inspection at the time of or after the preparation of the preparation guide. As shown in Fig.
- the plunger 17 of the preparation holder 3 is pushed forward to load the preparation into the outer needle 6 (see FIG. 3 (b)).
- the preparation holder 3 is removed from the outer needle 6, and the plunger 4 is inserted into the fitting hole 10 of the outer needle 6 and gradually pushed forward.
- the formulation 2 is administered to the target site in the brain (see FIG. 3 (c)).
- the needle 1 may be inserted into the preparation guide 5 and operated as described above.
- the preparation intracerebral administration device by using the preparation intracerebral administration device according to the present invention, if the preparation guide is hidden in the head, it can be easily placed at a predetermined position in the brain without performing a surgical procedure. Administration can be repeated. In addition, frequent administration is unnecessary by administering a formulation that maintains drug efficacy for a long time, for example, a sustained-release formulation. It also reduces the time, effort and risk of infection, and reduces the physical, mental and financial burden on patients.
- the preparation 2 is stored in the preparation guide 5 using the preparation holding member 3, but the preparation holding member 3 is always Alternatively, the preparation 2 aseptically packaged may be loaded into the fitting hole 10 of the outer needle 6 by means of a bin set or other appropriate means, and pushed with the plunger 4.
- a semi-solid preparation When a semi-solid preparation is used as the preparation, administration may be performed using a tube having an outer diameter that allows passage through the preparation guide, or by covering with a capsule or film that dissolves rapidly in the brain.
- a wavy preparation can be enclosed and administered.
- FIG. 4 also shows an example of the present invention, in which the preparation is not disintegrated / dissolved or decomposed in the brain, or is not complete, so that when it is repeatedly thrown, the remaining preparation is taken out and a new one is taken out. It is designed so that the preparation can be administered.
- the device for intracerebral administration of a drug comprises a drug indwelling member 30 enclosing the drug formulation 2, a push rod 31 removably inserted in the fibrous member 30 of the drug formulation, and integrally holding and fixing them. It consists of a holder 32 and 2.
- the indwelling member for the drug product 30 is made of a material with excellent biocompatibility.
- a hollow fiber membrane made of polyethersulfone, and the tip is sealed.
- the formulation retainer E member may be a tube made of hexafluoroethylene, perfluoroethylene, tetrafluoroethylene, or the like, in which a hole smaller than the formulation is made.
- the drug storage material 30 can be formed to any size, but is usually set to have an inner diameter of 0.5 to 1.5 mm and an outer diameter of 0.8 to 1.5 mm.
- the preparation indwelling member 30 is formed to be long so that the preparation can be administered to the site of the window, and if necessary, for example, as shown in FIG. It is preferable that the length can be adjusted by cutting with a pair of scissors or the like together with the push rod 31 in the degree.
- the push rod 31 is formed of a flexible material, for example, nylon, silicone, Teflon, polyacetal, tetrafluoroethylene, or the like, to have a diameter equal to or slightly smaller than the inner diameter of the drug storage member 30.
- the pellet-shaped preparation 2 loaded in the base material 30 is maintained at the leading end of the preparation detent member 30.
- the commutating tube 23 is formed of a flexible material that is softer than the flexible guide tube because the inside of the commutating tube 23 moves forward and backward along its entire length without being displaced.
- the holder 13 is composed of a cylindrical holder body 33, a holding ring 34 made of an elastic material such as silicon rubber, a holding ring 35 made of a relatively hard material such as a silicone resin, and a cylindrical shape.
- the device for intracerebral administration of the above-described composition is used in combination with the product guide 5 previously embedded in the head as in the example of IS, but in this case, the product guide is As shown in the figure, ,
- the guide body 20 is composed of a taper part 37a and a cylindrical part 37b connected to the taper part 37a.
- a flexible guide tube 23 is mounted in the conduit mounting hole 38 in the same glaze as the guide hole 37.
- the preparation indwelling member 30 in which the preparation 2 and the push rod 31 are set in advance is cut according to the length to the application site. Note that this length is determined by X-ray imaging of the product guide 5 previously fixed to the patient's head by a surgical operation.
- the drug storage member 30 is fixed to the holder 32 to form a drug administration device, and the drug storage IS member 30 is cut into the guide hole 3 of the drug guide 5 through the scalp Y cut with a scalpel. 7 and push it in until the holder 13 2 is stored in the guide hole 3 7 of the preparation guide 5, the preparation 2 in the preparation placement member 30 is located at a predetermined position S in the brain.
- a seal ring may be attached between the holder body 33 and the fixing member 36 to securely seal the space between the holder 32 and the guide hole 36 with the seal ring.
- the pharmaceutical preparation 2 in the pharmaceutical storage E member penetrates into the outer tube that forms the pharmaceutical storage member 30. It gradually dissolves in greed and is administered by osmotic pressure to the site of the brain for complaints.
- the scalp Y is cut with a scalpel or the like so that the preparation indwelling member 30 passes, and a screw to be screwed into the screw hole 39 formed in the head of the fixing member 36 of the holder 32 is set.
- the preparation can be reliably administered to the target site, and when the release of the drug is completed or when the administration of the drug is to be stopped, the residue or the preparation can be collected by removing the preparation holding member.
- FIG. 6 shows another embodiment of the preparation intracerebral administration device according to the present invention.
- the preparation does not disintegrate, dissolve or decompose in the brain or is incomplete because In the case of repeated administration, the remaining product can be removed and a new product can be administered.
- This device for intracerebrally administering the drug is obtained by adding a double needle 41 to the administration device shown in FIG. 4, and the double needle 41 is composed of a circular outer cylinder 42 and the outer cylinder 42.
- the inner needle 43 is detachably inserted into the inner needle 43.
- the inner needle 43 has a tapered distal end 43a, which can be removed from the guide hole 37 of the preparation guide 5. is there.
- the product retention member 30 in which the product 2 and the push rod 31 have been set in advance is pressed according to the length to the application site, and then fixed to the holder 32 to set the product retention device.
- the scalp Y is cut with a scalpel in accordance with the position of the prepared formulation S guide 5, and the double needle 41 is inserted into the guide hole 37 of the formulation guide 5 from above the scalp.
- the double needle 41 is positioned by pushing the flange 42 of the outer sleeve 42 until it comes into contact with the scalp, and then the inner needle 43 is moved to the outer cylinder 42.
- the use of the drug in combination with a drug guide that is embedded in the head in advance allows the drug to be reliably administered to the target site without performing any surgical treatment, and also reduces drug release.
- the residue or the drug product can be recovered by removing the drug placement member.
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Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002109955A CA2109955A1 (en) | 1991-05-24 | 1992-05-22 | Equipment for intracerebral administration of preparations |
US08/900,135 US5800390A (en) | 1991-05-24 | 1992-05-22 | Equipment for intracerebral administration of preparations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12011591 | 1991-05-24 | ||
JP3/120115 | 1991-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992020400A1 true WO1992020400A1 (en) | 1992-11-26 |
Family
ID=14778324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1992/000658 WO1992020400A1 (en) | 1991-05-24 | 1992-05-22 | Instrument for applying pharmaceutical to inside of brain |
Country Status (4)
Country | Link |
---|---|
US (1) | US5800390A (ja) |
EP (1) | EP0586700A4 (ja) |
CA (1) | CA2109955A1 (ja) |
WO (1) | WO1992020400A1 (ja) |
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WO1997002047A1 (fr) * | 1995-07-03 | 1997-01-23 | Koken Co., Ltd. | Preparations de genes |
JP2005538755A (ja) * | 2002-07-02 | 2005-12-22 | パットン メディカル ディヴァイシーズ, リミテッド パートナーシップ | 輸液デバイスおよび輸液方法 |
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JP2010510030A (ja) * | 2006-11-21 | 2010-04-02 | メドトロニック,インコーポレイテッド | 目標の生体組織部位に材料又は流体を繰り返し間欠的にデリバリーするための長期にわたって植え込み可能なガイドチューブ |
US7829694B2 (en) | 2002-11-26 | 2010-11-09 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
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- 1992-05-22 WO PCT/JP1992/000658 patent/WO1992020400A1/ja not_active Application Discontinuation
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- 1992-05-22 US US08/900,135 patent/US5800390A/en not_active Expired - Fee Related
- 1992-05-22 CA CA002109955A patent/CA2109955A1/en not_active Abandoned
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Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994015663A1 (en) * | 1992-12-30 | 1994-07-21 | Brown University Research Foundation | Implantable therapy systems and methods |
WO1997002047A1 (fr) * | 1995-07-03 | 1997-01-23 | Koken Co., Ltd. | Preparations de genes |
JP2005538755A (ja) * | 2002-07-02 | 2005-12-22 | パットン メディカル ディヴァイシーズ, リミテッド パートナーシップ | 輸液デバイスおよび輸液方法 |
US9486575B2 (en) | 2002-07-02 | 2016-11-08 | Medtronic Minimed, Inc. | Infusion device |
US8415319B2 (en) | 2002-11-26 | 2013-04-09 | Medtronic, Inc. | Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA |
US7829694B2 (en) | 2002-11-26 | 2010-11-09 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
US7618948B2 (en) | 2002-11-26 | 2009-11-17 | Medtronic, Inc. | Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA |
US8957198B2 (en) | 2003-02-03 | 2015-02-17 | Medtronic, Inc. | Compositions, devices and methods for treatment of Huntington's disease through intracranial delivery of sirna |
US11654221B2 (en) | 2003-11-05 | 2023-05-23 | Baxter International Inc. | Dialysis system having inductive heating |
US9133517B2 (en) | 2005-06-28 | 2015-09-15 | Medtronics, Inc. | Methods and sequences to preferentially suppress expression of mutated huntingtin |
US11771823B2 (en) | 2005-11-03 | 2023-10-03 | Medtronic Minimed, Inc. | Fluid delivery devices, systems and methods |
US10342919B2 (en) | 2005-11-03 | 2019-07-09 | Medtronic Minimed, Inc. | Fluid delivery devices, systems and methods |
US9273356B2 (en) | 2006-05-24 | 2016-03-01 | Medtronic, Inc. | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
US9375440B2 (en) | 2006-11-03 | 2016-06-28 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
JP2010510030A (ja) * | 2006-11-21 | 2010-04-02 | メドトロニック,インコーポレイテッド | 目標の生体組織部位に材料又は流体を繰り返し間欠的にデリバリーするための長期にわたって植え込み可能なガイドチューブ |
JP2015507992A (ja) * | 2012-02-28 | 2015-03-16 | レニショー ピーエルシー | 神経外科的装置 |
Also Published As
Publication number | Publication date |
---|---|
US5800390A (en) | 1998-09-01 |
EP0586700A1 (en) | 1994-03-16 |
CA2109955A1 (en) | 1992-11-26 |
EP0586700A4 (en) | 1994-10-19 |
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