WO1991015600A1 - Detection de maladies residuelles imperceptibles dans des malignites lymphoides - Google Patents

Detection de maladies residuelles imperceptibles dans des malignites lymphoides Download PDF

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Publication number
WO1991015600A1
WO1991015600A1 PCT/US1991/001547 US9101547W WO9115600A1 WO 1991015600 A1 WO1991015600 A1 WO 1991015600A1 US 9101547 W US9101547 W US 9101547W WO 9115600 A1 WO9115600 A1 WO 9115600A1
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WIPO (PCT)
Prior art keywords
product
residual disease
primers
chain reaction
polymerase chain
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Application number
PCT/US1991/001547
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English (en)
Inventor
Jonathan Ben-Ezra
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City Of Hope
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Publication date
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Publication of WO1991015600A1 publication Critical patent/WO1991015600A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Procédé de détection de maladies résiduelles imperceptibles dans des malignités lymphoïdes comprenant les étapes consistant: (i) à amplifier de l'ADN provenant d'une tumeur originelle à l'aide d'amorces J et V universelles dans une amplification enzymatique de l'ADN, (ii) à préparer une sonde monocaténaire à partir d'un fragment discret du produit d'amplification de l'étape (i), (iii) à amplifier de l'ADN provenant d'un échantillon de test soupçonné de contenir une maladie résiduelle à l'aide des mêmes amorces J et V dans une amplification enzymatique de l'ADN, (iv) à hybrider les produits des étapes (ii) et (iii), (v) à soumettre le produit d'hybridation à une digestion de nucléase S1, et (vi) à déterminer la présence ou l'absence dans le produit de digestion d'une séquence ayant sensiblement la même longueur que celle de la sonde préparée dans l'étape (ii).
PCT/US1991/001547 1990-03-30 1991-03-07 Detection de maladies residuelles imperceptibles dans des malignites lymphoides WO1991015600A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50149690A 1990-03-30 1990-03-30
US501,496 1990-03-30

Publications (1)

Publication Number Publication Date
WO1991015600A1 true WO1991015600A1 (fr) 1991-10-17

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ID=23993800

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/001547 WO1991015600A1 (fr) 1990-03-30 1991-03-07 Detection de maladies residuelles imperceptibles dans des malignites lymphoides

Country Status (2)

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AU (1) AU7762091A (fr)
WO (1) WO1991015600A1 (fr)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0721016A2 (fr) * 1994-10-21 1996-07-10 Affymax Technologies N.V. Banque d'acides nucléiques immobilisées, procédés pour leur fabrication et procédés de séquençage et de screening les utilisant
WO1996021743A1 (fr) * 1995-01-09 1996-07-18 Ambion, Inc. Procedes et compositions utilises dans la coupure et dans la detection de defauts de complementarite de paires de bases dans des acides nucleiques bicatenaires
WO1996029431A2 (fr) * 1995-03-17 1996-09-26 Sequenom, Inc. Diagnostics de l'adn par spectrometrie de masse
WO1996036731A2 (fr) * 1995-05-19 1996-11-21 Trustees Of Boston University Procedes de detection d'acides nucleiques
WO1997008344A2 (fr) * 1995-08-30 1997-03-06 Visible Genetics Inc. Procede permettant de reconnaitre des mutations au moyen d'une ligature de sondes oligonucleotidiques multiples
WO1997033000A1 (fr) 1996-03-04 1997-09-12 Genetrace Systems, Inc. Methodes de criblage des acides nucleiques par spectrometrie de masse
EP0843736A1 (fr) * 1995-05-11 1998-05-27 Ulf Landegren Detection d'erreurs d'appariement par clivage de resolvase sur un support solide
WO1998023776A1 (fr) * 1996-11-29 1998-06-04 Amersham Pharmacia Biotech Uk Ltd. Procede pour determiner la longueur de sequences repetes en tandem
US5811239A (en) * 1996-05-13 1998-09-22 Frayne Consultants Method for single base-pair DNA sequence variation detection
WO1998042867A1 (fr) * 1997-03-21 1998-10-01 Greg Firth Extraction et utilisation d'alleles vntr
WO1999014366A2 (fr) * 1997-09-18 1999-03-25 Erasmus Universiteit Rotterdam Detection d'une pathologie residuelle minime dans des tumeurs malignes lymphoides
US5891629A (en) * 1995-09-28 1999-04-06 Ambion, Inc. Compositions for improving RNase cleavage of base pair mismatches in double-stranded nucleic acids
GB2338553A (en) * 1997-03-21 1999-12-22 Greg Firth Extraction and utilisation of VNTR alleles
WO2000037684A1 (fr) * 1998-12-22 2000-06-29 Kris Richard M Systeme d'analyse a haut rendement mettant en oeuvre la spectrometrie de masse
US6104028A (en) * 1998-05-29 2000-08-15 Genetrace Systems Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US7413852B2 (en) 1996-12-31 2008-08-19 High Throughput Genomics Multiplexed diagnostic and therapeutics
WO2013006195A1 (fr) * 2011-07-01 2013-01-10 Htg Molecular Diagnostics, Inc. Procédés de détection de fusions de gènes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683195B1 (fr) * 1986-01-30 1990-11-27 Cetus Corp

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLOOD, Vol. 72, No. 5, issued November 1988, "Detection of Oceult Folicular Lymphoma by Specific DNA Amplification", pp. 1822-1825. *
CELL, Vol. 27, issued December 1981, RAUETCH et al., "Structure of the Human Immunoglobulin U-Locus: Characterization of Embrionic and Rearranged J and D Genes", pp. 583-591. *
EMBO JOURNAL, Vol. 7, No. 3, issued 1988, BERMAN et al., "Content and Organization of the Human Ig vh Locus: Definition of Three New Vh Families and Linkage of the Ig Ch Locus", pp- 727-738. *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE, Vol. 85, issued July 1988, CRESCENZI et al., "Thermoestable DNA Polymerase Chain Amplification of t(14;18), Chromosome Breakpoints and Detection at Minimal Residual Disease", pp. 4869-4873. *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 86, issued July 1989, YAMADA et al., "Detection of Minimal Disease in Hematopoietic Malignancies of the B-Cell Lineage by Using Third-Complementarily-Determining Region, (C2R-III)-Specific Probes", pp. 5213-5127. *

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0721016A3 (fr) * 1994-10-21 1999-11-03 Affymax Technologies N.V. Banque d'acides nucléiques immobilisées, procédés pour leur fabrication et procédés de séquençage et de screening les utilisant
EP0721016A2 (fr) * 1994-10-21 1996-07-10 Affymax Technologies N.V. Banque d'acides nucléiques immobilisées, procédés pour leur fabrication et procédés de séquençage et de screening les utilisant
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
WO1996021743A1 (fr) * 1995-01-09 1996-07-18 Ambion, Inc. Procedes et compositions utilises dans la coupure et dans la detection de defauts de complementarite de paires de bases dans des acides nucleiques bicatenaires
US6221601B1 (en) 1995-03-17 2001-04-24 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US6221605B1 (en) 1995-03-17 2001-04-24 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US6235478B1 (en) 1995-03-17 2001-05-22 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US6043031A (en) * 1995-03-17 2000-03-28 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US6258538B1 (en) 1995-03-17 2001-07-10 Sequenom, Inc. DNA diagnostics based on mass spectrometry
WO1996029431A3 (fr) * 1995-03-17 1996-12-27 Sequenom Inc Diagnostics de l'adn par spectrometrie de masse
US6268144B1 (en) 1995-03-17 2001-07-31 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US6277573B1 (en) 1995-03-17 2001-08-21 Sequenom, Inc. DNA diagnostics based on mass spectrometry
WO1996029431A2 (fr) * 1995-03-17 1996-09-26 Sequenom, Inc. Diagnostics de l'adn par spectrometrie de masse
US6300076B1 (en) 1995-03-17 2001-10-09 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US6197498B1 (en) 1995-03-17 2001-03-06 Sequenom, Inc DNA diagnostics based on mass spectrometry
EP0843736A4 (fr) * 1995-05-11 1998-12-02 Ulf Landegren Detection d'erreurs d'appariement par clivage de resolvase sur un support solide
EP0843736A1 (fr) * 1995-05-11 1998-05-27 Ulf Landegren Detection d'erreurs d'appariement par clivage de resolvase sur un support solide
US5876941A (en) * 1995-05-11 1999-03-02 Landegren; Ulf Detection of mismatches by resolvase cleavage on a solid support
WO1996036731A3 (fr) * 1995-05-19 1997-02-06 Univ Boston Procedes de detection d'acides nucleiques
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
WO1996036731A2 (fr) * 1995-05-19 1996-11-21 Trustees Of Boston University Procedes de detection d'acides nucleiques
US5888731A (en) * 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
AU704962B2 (en) * 1995-08-30 1999-05-13 Bayer Healthcare Llc Method for identification of mutations using ligation of multiple oligonucleotide probes
US6025139A (en) * 1995-08-30 2000-02-15 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
WO1997008344A3 (fr) * 1995-08-30 1997-08-14 Visible Genetics Inc Procede permettant de reconnaitre des mutations au moyen d'une ligature de sondes oligonucleotidiques multiples
WO1997008344A2 (fr) * 1995-08-30 1997-03-06 Visible Genetics Inc. Procede permettant de reconnaitre des mutations au moyen d'une ligature de sondes oligonucleotidiques multiples
US5891629A (en) * 1995-09-28 1999-04-06 Ambion, Inc. Compositions for improving RNase cleavage of base pair mismatches in double-stranded nucleic acids
WO1997033000A1 (fr) 1996-03-04 1997-09-12 Genetrace Systems, Inc. Methodes de criblage des acides nucleiques par spectrometrie de masse
US6051378A (en) * 1996-03-04 2000-04-18 Genetrace Systems Inc. Methods of screening nucleic acids using mass spectrometry
US5811239A (en) * 1996-05-13 1998-09-22 Frayne Consultants Method for single base-pair DNA sequence variation detection
WO1998023776A1 (fr) * 1996-11-29 1998-06-04 Amersham Pharmacia Biotech Uk Ltd. Procede pour determiner la longueur de sequences repetes en tandem
US6083701A (en) * 1996-11-29 2000-07-04 Amersham Pharmacia Biotech Uk Limited Method for determining tandem repeat sequence length
US7413852B2 (en) 1996-12-31 2008-08-19 High Throughput Genomics Multiplexed diagnostic and therapeutics
GB2338553B (en) * 1997-03-21 2001-08-15 Greg Firth Extraction and utilisation of VNTR alleles
WO1998042867A1 (fr) * 1997-03-21 1998-10-01 Greg Firth Extraction et utilisation d'alleles vntr
GB2338553A (en) * 1997-03-21 1999-12-22 Greg Firth Extraction and utilisation of VNTR alleles
WO1999014366A3 (fr) * 1997-09-18 1999-05-06 Univ Erasmus Detection d'une pathologie residuelle minime dans des tumeurs malignes lymphoides
WO1999014366A2 (fr) * 1997-09-18 1999-03-25 Erasmus Universiteit Rotterdam Detection d'une pathologie residuelle minime dans des tumeurs malignes lymphoides
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6104028A (en) * 1998-05-29 2000-08-15 Genetrace Systems Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
US6265716B1 (en) 1998-05-29 2001-07-24 Genetrace Systems, Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
US7659063B2 (en) 1998-07-02 2010-02-09 High Throughput Genomics, Inc. High throughput assay system
WO2000037684A1 (fr) * 1998-12-22 2000-06-29 Kris Richard M Systeme d'analyse a haut rendement mettant en oeuvre la spectrometrie de masse
WO2013006195A1 (fr) * 2011-07-01 2013-01-10 Htg Molecular Diagnostics, Inc. Procédés de détection de fusions de gènes
US10294515B2 (en) 2011-07-01 2019-05-21 Htg Molecular Diagnostics, Inc. Methods of detecting gene fusions
US11268133B2 (en) 2011-07-01 2022-03-08 Htg Molecular Diagnostics, Inc. Methods of detecting gene fusions

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Publication number Publication date
AU7762091A (en) 1991-10-30

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