WO1991006537A3 - Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole- alkanoic acid derivatives as inhibitors of pla2 and lipoxygenase - Google Patents
Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole- alkanoic acid derivatives as inhibitors of pla2 and lipoxygenase Download PDFInfo
- Publication number
- WO1991006537A3 WO1991006537A3 PCT/US1990/006251 US9006251W WO9106537A3 WO 1991006537 A3 WO1991006537 A3 WO 1991006537A3 US 9006251 W US9006251 W US 9006251W WO 9106537 A3 WO9106537 A3 WO 9106537A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lower alkyl
- phenyl
- halo
- hydrogen
- pyranoindole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR909007790A BR9007790A (en) | 1989-10-27 | 1990-10-27 | DERIVATIVES OF INDOL-, INDENO-, PYRANINDOL-AND TETRAHYDROCARBAZOL-ALKANOIC ACIDS REPLACED AS PLA2 AND LIPOXYGENASE INHIBITORS |
KR1019920700971A KR920702345A (en) | 1989-10-27 | 1990-10-27 | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA_2 and lipoxygenase |
FI921865A FI921865A (en) | 1989-10-27 | 1992-04-24 | SUBSTITUERADE INDOL-, INDEN-, PYRANOINDOL- OCH TETRAHYDROCARBAZOLE-ALKANSYRADERIVAT SOM INHIBITORER AV PLA2 OCH LIPOXIGENAS. |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US596,134 | 1984-04-02 | ||
US42826089A | 1989-10-27 | 1989-10-27 | |
US428,260 | 1989-10-27 | ||
US59613490A | 1990-10-11 | 1990-10-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991006537A2 WO1991006537A2 (en) | 1991-05-16 |
WO1991006537A3 true WO1991006537A3 (en) | 1991-10-17 |
Family
ID=27027687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/006251 WO1991006537A2 (en) | 1989-10-27 | 1990-10-27 | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole- alkanoic acid derivatives as inhibitors of pla2 and lipoxygenase |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0502106A1 (en) |
JP (1) | JPH05502222A (en) |
KR (1) | KR920702345A (en) |
AU (1) | AU643996B2 (en) |
BR (1) | BR9007790A (en) |
CA (1) | CA2070422A1 (en) |
FI (1) | FI921865A (en) |
HU (1) | HUT63407A (en) |
IE (1) | IE903872A1 (en) |
PT (1) | PT95692A (en) |
WO (1) | WO1991006537A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229516A (en) * | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
US5221678A (en) * | 1990-07-26 | 1993-06-22 | Merck Frosst Canada, Inc. | (quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes |
US5187180A (en) * | 1990-07-26 | 1993-02-16 | Merck Frosst Canada, Inc. | (quinolin-2-ylmethoxy)heterotetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes |
US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
US5389650A (en) * | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
CA2079374C (en) * | 1991-09-30 | 2003-08-05 | Merck Frosst Canada Incorporated | (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
GB9122590D0 (en) * | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
AU3488693A (en) * | 1992-02-13 | 1993-09-03 | Merck Frosst Canada Inc. | (Azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis |
DE4219765A1 (en) * | 1992-06-17 | 1993-12-23 | Bayer Ag | Substituted (benzothiazolyl and quinoxalyl-methoxy) phenylacetic acid derivatives |
US5374635A (en) * | 1993-03-29 | 1994-12-20 | Merck Frosst Canada, Inc. | Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis |
US5496957A (en) * | 1993-09-01 | 1996-03-05 | Virginia Commonwealth University | Tryptamine analogs with 5-HT1D selectivity |
DE4338770A1 (en) * | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indole-2-alkanoic acids and their derivatives as inhibitors of phospholipase A¶2¶ |
HUT72048A (en) * | 1994-04-01 | 1996-03-28 | Lilly Co Eli | 1h-indole-3-glyoxylamide spla2 inhibitors and pharmaceutical compositions containing these compounds |
US5504101A (en) * | 1994-05-06 | 1996-04-02 | Allelix Biopharmaceuticals, Inc. | 5-HT-1D receptor ligands |
FR2721610B1 (en) * | 1994-06-28 | 1996-08-23 | Adir | New (thia) cycloalkyl [b] indole derivatives, process for their preparation and pharmaceutical compositions containing them. |
US6121321A (en) * | 1996-06-13 | 2000-09-19 | Cell Pathways, Inc. | Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions |
US5998477A (en) * | 1996-06-13 | 1999-12-07 | Cell Pathways Inc. | Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions |
US6063818A (en) * | 1996-06-13 | 2000-05-16 | Cell Pathways Inc. | Substituted benzylidene indenyl formamides, acetamides and propionamides |
US5965619A (en) * | 1996-06-13 | 1999-10-12 | Cell Pathways Inc. | Method for treating patients having precancerous lesions with substituted indene derivatives |
DE59711058D1 (en) * | 1996-08-01 | 2004-01-08 | Merckle Gmbh | ACYLPYRROLDICARBONIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AS AN INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A2 |
US5948779A (en) * | 1997-12-12 | 1999-09-07 | Cell Pathways, Inc. | Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6028116A (en) * | 1998-04-03 | 2000-02-22 | Cell Pathways, Inc. | Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia |
DZ2769A1 (en) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Substituted tricyclics. |
IL129484A0 (en) * | 1998-04-17 | 2000-02-29 | Lilly Co Eli | Substituted tricyclics |
US6706752B1 (en) | 1999-07-19 | 2004-03-16 | Eli Lilly And Company | sPLA2 inhibitors |
EP1202963B1 (en) * | 1999-07-19 | 2007-01-03 | Eli Lilly And Company | Spla2 inhibitors |
JP2003525901A (en) * | 2000-03-09 | 2003-09-02 | イーライ・リリー・アンド・カンパニー | Method for treating renal dysfunction with sPLA2 inhibitor |
WO2002020478A1 (en) * | 2000-08-24 | 2002-03-14 | Dublin City University | N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer |
EP1395554B1 (en) * | 2001-03-28 | 2007-02-14 | Eli Lilly And Company | Substituted carbazoles as inhibitors of spla2 |
US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
GB2407318A (en) * | 2003-10-23 | 2005-04-27 | Oxagen Ltd | Substituted Indol-3-yl acetic acid derivatives |
US7579002B2 (en) * | 2003-12-05 | 2009-08-25 | Wisconsin Alumni Research Foundation | Method for improving body weight uniformity and increasing carcass yield in animals |
GT200600228A (en) | 2005-05-27 | 2006-12-26 | INHIBITORS OF PHOSPHOLIPASE A2 CITOSOLICA | |
GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
CN101410366A (en) * | 2006-03-30 | 2009-04-15 | 旭化成制药株式会社 | Substituted bicyclic derivatives and use thereof |
CN104311472B9 (en) * | 2008-07-23 | 2020-03-17 | 艾尼纳制药公司 | Substituted 1,2,3, 4-tetrahydrocyclopenta [ b ] indol-3-yl acetic acid derivatives |
EA036955B1 (en) | 2008-08-27 | 2021-01-19 | Арена Фармасьютикалз, Инк. | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
JP5856980B2 (en) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R) -2- (7- (4-Cyclopentyl-3- (trifluoromethyl) benzyloxy) -1,2,3,4-tetrahydrocyclopenta [b] indol-3-yl) acetic acid and its salts Process for preparation |
CA2789480A1 (en) | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
MX2017008925A (en) | 2015-01-06 | 2017-10-11 | Arena Pharm Inc | Methods of treating conditions related to the s1p1 receptor. |
HUE060476T2 (en) | 2015-06-22 | 2023-03-28 | Arena Pharm Inc | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in s1p1 receptor-associated disorders |
WO2017073060A1 (en) * | 2015-10-29 | 2017-05-04 | 国立大学法人東北大学 | Collagen production inhibitor |
WO2018151873A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
US11478448B2 (en) | 2017-02-16 | 2022-10-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
MX2020003242A (en) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors. |
IL272667B (en) | 2017-10-18 | 2022-09-01 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
WO2019102494A1 (en) | 2017-11-24 | 2019-05-31 | Jubilant Biosys Limited | Heterocyclic compounds as prmt5 inhibitors |
CN112105610B (en) | 2018-03-13 | 2024-01-26 | 朱比连特普罗德尔有限责任公司 | Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB970440A (en) * | 1961-08-14 | 1964-09-23 | Merck & Co Inc | Anti-inflammatory compositions comprising steroids and indole derivatives |
DE1816993A1 (en) * | 1967-12-27 | 1969-10-16 | Lodzkie Zaklady Farma | Process for the preparation of 1-aoyl- or 1-heteroaroyl- or 1-benzheteroaroyl-2-methyl-5-alkoxy- (or 5-aralkoxy) -indolyl-3-acetic acids |
DE2337340A1 (en) * | 1972-07-24 | 1974-02-14 | Hoffmann La Roche | CARBAZOLE |
US3974179A (en) * | 1971-06-01 | 1976-08-10 | American Home Products Corporation | 1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives |
US4041169A (en) * | 1975-03-05 | 1977-08-09 | Ayerst Mckenna And Harrison Ltd. | Pharmaceutical method for using pyrano-and thiopyranoindole derivatives |
EP0301813A1 (en) * | 1987-07-31 | 1989-02-01 | American Home Products Corporation | Naphthalenepropionic acid derivatives |
US4810699A (en) * | 1987-02-20 | 1989-03-07 | American Home Products Corporation | Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them |
-
1990
- 1990-10-25 PT PT95692A patent/PT95692A/en not_active Application Discontinuation
- 1990-10-26 IE IE387290A patent/IE903872A1/en unknown
- 1990-10-27 AU AU77404/91A patent/AU643996B2/en not_active Ceased
- 1990-10-27 KR KR1019920700971A patent/KR920702345A/en not_active Application Discontinuation
- 1990-10-27 WO PCT/US1990/006251 patent/WO1991006537A2/en not_active Application Discontinuation
- 1990-10-27 HU HU921383A patent/HUT63407A/en unknown
- 1990-10-27 CA CA002070422A patent/CA2070422A1/en not_active Abandoned
- 1990-10-27 JP JP3500787A patent/JPH05502222A/en active Pending
- 1990-10-27 BR BR909007790A patent/BR9007790A/en not_active Application Discontinuation
- 1990-10-27 EP EP19910900547 patent/EP0502106A1/en not_active Withdrawn
-
1992
- 1992-04-24 FI FI921865A patent/FI921865A/en not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB970440A (en) * | 1961-08-14 | 1964-09-23 | Merck & Co Inc | Anti-inflammatory compositions comprising steroids and indole derivatives |
DE1816993A1 (en) * | 1967-12-27 | 1969-10-16 | Lodzkie Zaklady Farma | Process for the preparation of 1-aoyl- or 1-heteroaroyl- or 1-benzheteroaroyl-2-methyl-5-alkoxy- (or 5-aralkoxy) -indolyl-3-acetic acids |
US3974179A (en) * | 1971-06-01 | 1976-08-10 | American Home Products Corporation | 1,3,4,9-Tetrahydropyrano[3,4-b]indole-1-acetamides and derivatives |
DE2337340A1 (en) * | 1972-07-24 | 1974-02-14 | Hoffmann La Roche | CARBAZOLE |
US4041169A (en) * | 1975-03-05 | 1977-08-09 | Ayerst Mckenna And Harrison Ltd. | Pharmaceutical method for using pyrano-and thiopyranoindole derivatives |
US4810699A (en) * | 1987-02-20 | 1989-03-07 | American Home Products Corporation | Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them |
EP0301813A1 (en) * | 1987-07-31 | 1989-02-01 | American Home Products Corporation | Naphthalenepropionic acid derivatives |
Non-Patent Citations (1)
Title |
---|
Chemical Abstracts, volume 98, 1983, (Columbus, Ohio, US) A. Roy et al.: "Further studies on antiinflammatory activity of two potent indan-1-acetic acids", see page 26 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
Also Published As
Publication number | Publication date |
---|---|
AU7740491A (en) | 1991-05-31 |
BR9007790A (en) | 1992-09-15 |
IE903872A1 (en) | 1991-05-22 |
KR920702345A (en) | 1992-09-03 |
CA2070422A1 (en) | 1991-04-28 |
JPH05502222A (en) | 1993-04-22 |
FI921865A0 (en) | 1992-04-24 |
PT95692A (en) | 1991-09-13 |
WO1991006537A2 (en) | 1991-05-16 |
EP0502106A1 (en) | 1992-09-09 |
AU643996B2 (en) | 1993-12-02 |
HUT63407A (en) | 1993-08-30 |
FI921865A (en) | 1992-04-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1991006537A3 (en) | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole- alkanoic acid derivatives as inhibitors of pla2 and lipoxygenase | |
BG95818A (en) | Herbicides | |
CA2230936A1 (en) | 5-azabicyclo(3.1.0)hexylalkyl-2-piperidones and -glutarimides as neurokinin receptor antagonists | |
IL160304A (en) | Compounds and composition for activating peroxisome proliferators-responsive receptor ?? | |
MY111814A (en) | Watersoluble azole antifungals | |
ATE542821T1 (en) | 11-HYDROXY-5H-PYRROLOÄ2,1-CÜÄ1,4ÜBENZODIAZEPINE- - ON DERIVATIVES AS INTERMEDIATE COMPOUNDS FOR THE PRODUCTION OF C2 SUBSTITUTED PYRROLOBENZODIAZEPINES | |
CY1109835T1 (en) | KEYWORDS USED AS ATM SUSPENSIONS | |
TW200621755A (en) | Oxime ester compound and photopolymerization initiator containing such compound | |
ES8105298A1 (en) | Imidazole guanidines, their preparation and compositions containing them. | |
ES8605511A1 (en) | 2-(N-substituteguanidino)-4-hetero-arylthiazole antiulcer agents. | |
ES8203845A1 (en) | Pyridoxine derivatives, process for their preparation and their therapeutical use. | |
DK0503844T3 (en) | Thienopyridine derivatives and pharmaceutical compositions containing them | |
ES8801289A1 (en) | Antibacterial compounds, their production and use. | |
RO84716B (en) | Fungicide herbicide and plant growth regulation composition | |
DE69432542D1 (en) | Tetradivatives, their production and use | |
SE8503466D0 (en) | aminophenol compounds | |
AP9901578A0 (en) | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents. | |
DE69617226D1 (en) | Piperidine. | |
ATE17239T1 (en) | ANTIFUNGI TRIAZOLE COMPOUNDS. | |
ATE58135T1 (en) | 1,3-OXATHIAN DERIVATIVES. | |
EP0201349A3 (en) | Tetrazole derivatives | |
SE321467B (en) | ||
AU2442488A (en) | Heterocyclically substituted n-sultamsulfonamides, process for their preparation and their use as herbicides and plant growth regulators | |
ATE105565T1 (en) | PRADIMIC DERIVATIVES. | |
MY128711A (en) | Use of thiazole derivatives for the manufacture of a medicament for the treatment of chronic obstructive pulmonary disease |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AU BR CA FI HU JP KR SU |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AU BR CA FI HU JP KR SU |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2070422 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 921865 Country of ref document: FI |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1991900547 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1991900547 Country of ref document: EP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1991900547 Country of ref document: EP |