WO1990015067A3 - NOUVEAUX PROCEDES D'OBTENTION DE 6-METHYL 19-NOR STEROIDES ET LEUR CONVERSION EN 19-NOR PREGNADIENES 17α-SUBSTITUES - Google Patents

NOUVEAUX PROCEDES D'OBTENTION DE 6-METHYL 19-NOR STEROIDES ET LEUR CONVERSION EN 19-NOR PREGNADIENES 17α-SUBSTITUES Download PDF

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Publication number
WO1990015067A3
WO1990015067A3 PCT/FR1990/000363 FR9000363W WO9015067A3 WO 1990015067 A3 WO1990015067 A3 WO 1990015067A3 FR 9000363 W FR9000363 W FR 9000363W WO 9015067 A3 WO9015067 A3 WO 9015067A3
Authority
WO
WIPO (PCT)
Prior art keywords
methyl
obtaining
pregnadienes
steroids
converting
Prior art date
Application number
PCT/FR1990/000363
Other languages
English (en)
Other versions
WO1990015067A2 (fr
Inventor
Claude Tchernatinsky
Nejib Mohamed Nasraoui
Alain Piasco
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Publication of WO1990015067A2 publication Critical patent/WO1990015067A2/fr
Priority to KR1019910700091A priority Critical patent/KR920701231A/ko
Priority to FI910351A priority patent/FI910351A0/fi
Priority to NO91910266A priority patent/NO910266L/no
Publication of WO1990015067A3 publication Critical patent/WO1990015067A3/fr
Priority to NO920207A priority patent/NO920207D0/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0055—Estrane derivatives not substituted in position 17

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention se rapporte au domaine de la chimie organique et plus particulièrement à la chimie des stéroïdes. Elle a plus particulièrement pour objet de nouveaux 6-méthyl estra 4,6-diènes de formule générale (I) dans laquelle A représente de l'hydrogène ou un radical oxoalcoyle inférieur et B représente de l'hydrogène ou bien A est un hydroxyle libre ou estérifié, et B est un radical alcoyle inférieur, ou un radical alcynyle inférieur ou bien A et B forment ensemble l'oxygène d'une cétone. Cette invention a également pour objet un procédé d'obtention des composés de formule générale (I). Ces composés sont des intermédiaires de synthèse précieux qui permettent l'accès à des 6-méthyl 19-nor pregna 4,6-diènes pharmacologiquement actifs.
PCT/FR1990/000363 1989-05-24 1990-05-23 NOUVEAUX PROCEDES D'OBTENTION DE 6-METHYL 19-NOR STEROIDES ET LEUR CONVERSION EN 19-NOR PREGNADIENES 17α-SUBSTITUES WO1990015067A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1019910700091A KR920701231A (ko) 1989-05-24 1991-01-23 6-메틸 19-노르 스테로이드의 제조방법 및 이 화합물을 17α-치환된 19-노르 프레그나디엔으로 전환시키는 방법
FI910351A FI910351A0 (fi) 1989-05-24 1991-01-23 Nya foerfaranden foer framstaellning av 6-metyl-19-norsteroider och oeverfoering av desamma till 17a-substituerade 19-norpregnadiener.
NO91910266A NO910266L (no) 1989-05-24 1991-01-23 Nye 6-methyl-19-nor-steroider, fremgangsmaate for fremstilling av disse, farmasoeytiske preparater inneholdende disse, og deres omdannelse til 17alfa-substituerte 19-nor-pregnadiener.
NO920207A NO920207D0 (no) 1989-05-24 1992-01-16 Fremgangsmaate for fremstilling av 6-methyl-oestra-4,6-diener

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR89/06790 1989-05-24
FR8906790A FR2647452A1 (fr) 1989-05-24 1989-05-24 Nouveaux 19-nor steroides 6-methyles leurs procedes d'obtention, les compositions pharmaceutiques en renfermant et leur conversion en 19-nor pregnadienes 17-substitues

Publications (2)

Publication Number Publication Date
WO1990015067A2 WO1990015067A2 (fr) 1990-12-13
WO1990015067A3 true WO1990015067A3 (fr) 1991-01-24

Family

ID=9381962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1990/000363 WO1990015067A2 (fr) 1989-05-24 1990-05-23 NOUVEAUX PROCEDES D'OBTENTION DE 6-METHYL 19-NOR STEROIDES ET LEUR CONVERSION EN 19-NOR PREGNADIENES 17α-SUBSTITUES

Country Status (12)

Country Link
EP (1) EP0431107A1 (fr)
JP (1) JPH04503362A (fr)
KR (1) KR920701231A (fr)
AU (1) AU643218B2 (fr)
FI (1) FI910351A0 (fr)
FR (1) FR2647452A1 (fr)
GR (1) GR900100394A (fr)
HU (1) HU209590B (fr)
MA (1) MA21851A1 (fr)
PT (1) PT94134A (fr)
TN (1) TNSN90066A1 (fr)
WO (1) WO1990015067A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2679236B1 (fr) * 1991-07-18 1997-01-24 Theramex Nouveaux sterouides substitues en position 6, leurs procedes d'obtention et des compositions pharmaceutiques en renfermant.
AU2002357610A1 (en) * 2001-12-19 2003-06-30 Chugai Seiyaku Kabushiki Kaisha Androstane derivative having substituent in 7- and 17-positions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3190880A (en) * 1963-02-28 1965-06-22 Syntex Corp 17-tetrahydropyranyl ethers of androstanes
GB1277266A (en) * 1968-07-30 1972-06-07 American Home Prod 07-acetylgonanes and derivatives therefor
DE3346204A1 (de) * 1983-12-21 1985-07-11 Council Of Scientific And Industrial Research, New Delhi Verfahren zur herstellung von 17ss-((l-oxoheptyl)oxy)19-norpregn-4-en-20-in-3on norethisteronoenanthat) und estern davon und diese enthaltende arzneimittel
EP0188396A2 (fr) * 1985-01-14 1986-07-23 Roussel-Uclaf Nouveaux stéroides substitués en position 10, leur procédé et les intermédiaires de préparation, leur application comme médicaments, les compositions pharmaceutiques les contenant
EP0201452A2 (fr) * 1985-05-10 1986-11-12 Schering Aktiengesellschaft Procédé de préparation de 17-alpha-éthnyl-17-bêta-hydroxy-18-méthyl-estra-4,15-diène-3-one et les produits de départ nécessaires à ce procédé

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204281C1 (de) * 1982-02-05 1983-07-21 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 6-Methyl-delta?-3-ketosteroiden

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3190880A (en) * 1963-02-28 1965-06-22 Syntex Corp 17-tetrahydropyranyl ethers of androstanes
GB1277266A (en) * 1968-07-30 1972-06-07 American Home Prod 07-acetylgonanes and derivatives therefor
DE3346204A1 (de) * 1983-12-21 1985-07-11 Council Of Scientific And Industrial Research, New Delhi Verfahren zur herstellung von 17ss-((l-oxoheptyl)oxy)19-norpregn-4-en-20-in-3on norethisteronoenanthat) und estern davon und diese enthaltende arzneimittel
EP0188396A2 (fr) * 1985-01-14 1986-07-23 Roussel-Uclaf Nouveaux stéroides substitués en position 10, leur procédé et les intermédiaires de préparation, leur application comme médicaments, les compositions pharmaceutiques les contenant
EP0201452A2 (fr) * 1985-05-10 1986-11-12 Schering Aktiengesellschaft Procédé de préparation de 17-alpha-éthnyl-17-bêta-hydroxy-18-méthyl-estra-4,15-diène-3-one et les produits de départ nécessaires à ce procédé

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bulletin de la Societe Chimique de France, Nos 3-4, partie 2, Mars 1978 (Paris, FR) R. JACQUESY et al.: "Nouvelle Synthese de Methyl-6-Estranediones-3,17 et-2,17 de Configurations 'Non Naturelles'" pages 163-159, voir page 166, compose No. 23 *
Tetrahedron, Vol. 20, No. 3, Mars 1964, Pergamon Press Ltd D. BURN et al.: "Modified Steroid Hormones-XXXIII. Steroidal 6-Formyl-3-Alkoxy-3,5-Dienes and some of their Transformations", pages 597-609, voir l'article en entier *
Tetrahedron, Vol. 21, No. 6, Juin 1965, Pergamon Press Ltd D. BURN et al.: "Modified Steroid Hormones-XXXVIII. Some Transformations of Steroidal 3-Alkoxy-6-Formyl-3,5-Dienes and Related Compounds", pages 1619-1624 voir l'article en entier *

Also Published As

Publication number Publication date
HUT59154A (en) 1992-04-28
EP0431107A1 (fr) 1991-06-12
WO1990015067A2 (fr) 1990-12-13
HU905221D0 (en) 1991-07-29
GR900100394A (el) 1991-10-10
TNSN90066A1 (fr) 1991-03-05
FI910351A0 (fi) 1991-01-23
MA21851A1 (fr) 1990-12-31
AU5742690A (en) 1991-01-07
PT94134A (pt) 1991-01-08
AU643218B2 (en) 1993-11-11
JPH04503362A (ja) 1992-06-18
KR920701231A (ko) 1992-08-11
HU209590B (en) 1994-08-29
FR2647452A1 (fr) 1990-11-30

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