WO1989003232A1 - Dispositif medical destine a etre introduit dans une cavite du corps - Google Patents
Dispositif medical destine a etre introduit dans une cavite du corps Download PDFInfo
- Publication number
- WO1989003232A1 WO1989003232A1 PCT/DK1988/000163 DK8800163W WO8903232A1 WO 1989003232 A1 WO1989003232 A1 WO 1989003232A1 DK 8800163 W DK8800163 W DK 8800163W WO 8903232 A1 WO8903232 A1 WO 8903232A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- matrix
- active substance
- substance
- body cavity
- agents
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
Definitions
- the present invention relates to a medical device intended for intro ⁇ duction into a body cavity, the device comprising a therapeutically active substance which is gradually released from the device.
- bacterial glycocalyx This term is understood to mean any polysaccharide-containing component found outside the bacterial cell wall.
- the glycocalyx is usually composed of fibrous polysaccharides and/or globular glycoproteins, and these molecules are essentially the sole components found on the surface of wild-type bacterial strains capable of growing and surviving in com ⁇ petitive environments.
- the bacterial glycocalyx serves an important function for the adhesion of bacteria to each other as well as to inert surfaces to form adherent colonies which are the predominant form of bacterial growth.
- coagulase-negative staphylococci appear to be infrequent pathogens unless they adhere to foreign bodies such as medical devices introduced into a body cavity, but coagulase-negative staphylococci have become increasingly recognized to be important pathogens in the presence of devices such as intravascular grafts, prosthetic heart valves, vascular catheters and orthopaedic and neurosurgical implants.
- the organism gains access to the device at the time of surgery or catheter placement and forms colonies, although infection may not become clinically evident until several days or even several months after the initial contamination event.
- the present invention relates to a medical device in ⁇ tended for introduction into a body cavity, the device comprising, at one end thereof adapted to be inserted into said body cavity, a matrix in which an active substance is embedded and from which it is released at a predetermined rate, the matrix being composed of a substance which is not or only slightly penetrable to water.
- the device preferably comprises a tube and/or rod for the drainage and/or delivery of fluids into said body cavity.
- the substance composing the matrix must be one which is substantially impenetrable to the body fluids present in the body cavity into which the device of the invention is inserted in order to avoid degradation of the active substance residing in the matrix due to the action of water in case of an ac €ive substance which is susceptible to hydro ⁇ lysis.
- the inclusion of the active substance in a matrix into which water will not diffuse or only diffuse to a limited extent will thus impart a long-term stability to the drug so that the active substance will in fact remain active even when the device has lodged in the body cavity for quite some time.
- body fluids can only act on the surface of a matrix of this type, the active substance embedded therein is only exposed to the body fluids in question when it is released or immediately prior to its release from the matrix.
- a ma ⁇ trix of a type which is substantially not penetrable to water will therefore ensure the stability of the active substance in the matrix for the entire period of time when the device is present in the body cavity, until the time when the active substance is released, and will also ensure a constant and reproducible release rate of the ac ⁇ tive substance from the matrix since the release proceeds gradually from the surface or surfaces of the matrix exposed to the body fluids in question.
- the release rate of the drug is constant either in the sense that a constant amount of active substance is released at any point during the presence of the device in the body cavity or in the sense that the drug is released in "bursts" (relatively larger amounts at a time) at constant intervals.
- the expression "drainage and/or delivery of fluids” is understood to mean that the device of the invention may be one used either for the removal of waste materials from a body cavi ⁇ ty, e.g. a urethral catheter or ostomy appliance, or one which, con ⁇ versely, is used for the supply of nutrients or medicaments to a per ⁇ son in need thereof, e.g. by infusion through a venous catheter.
- the body cavity in which the tube and/or rod portion of the device is inserted may for instance be a blood vessel, the stomach, a selected part of the intestines, the middle ear, the urinary bladder, the renal pelvis, the gall bladder, the uterus, the respiratory tract, or an infectious, malignant, traumatic or similar cavity.
- the rate at which the active substance is released from the matrix is a predetermined rate, i.e. a rate which is controllable and prefer ⁇ ably constant over a certain period of time.
- the release rate re ⁇ quired in each particular instance may inter alia depend on the amount of active substance to be released for it to exert the desired effect, as well as on the overall dosage of the active substance con ⁇ tained in the matrix.
- the substance of which the matrix is composed may therefore be selected according to one or more of these criteria to ensure the desired level of release of the active substance.
- the present invention relates to a method of delivering an active substance to a body cavity, the method compris- ing introducing a medical device of the invention into said body cavity. More specifically, the invention relates to a method of pre ⁇ venting or reducing the incidence of infections arising from the use of medical devices comprising a tube and/or rod one end of which is introduced into a body cavity, the method comprising providing the end of said tube and/or rod inserted into said body cavity with a body formed from a matrix of a hydrophobic substance in which an active substance selected from an antimicrobial, antiviral, antiinflammatory or antiseptic agent is embedded.
- Local administration of an antibiotic or similar agent at the site where infections may potentially occur has the.advantage that lower dosages of the drug will normally be required when the antibiotic is adminis ⁇ tered systemically.
- the present invention relates to the use of a matrix of a hydrophobic substance in which an active substance is embedded, the active substance being selected from an antimocrobial, antiviral, antiinflammatory or antiseptic agent, for preventing or reducing the incidence of infections arising from the use of medical devices comprising a tube and/or rod, one end of which is inserted into a body cavity, the matrix being provided at said end of the tube and/or rod.
- the invention also relates to a method of preventing or treating can ⁇ cers or neoplasms which comprises introducing a medical device as described above as well as in the following detailed disclosure of the invention into a body cavity, preferably the body cavity where the malignancy is found, the active substance embedded in the matrix being selected from antineoplastic and cytostatic agents.
- the invention further relates to the use of a device according to the invention for the treatment or prevention of cancers or neoplasms, the active substance being embedded in the matrix being selected from an antineoplastic and cytostatic agent.
- the device of the invention has the further advantage that the dosage of the active substance included in the matrix may be measured so that an appropriate constant dosage thereof will be available at the site where the active substance exerts its activity for the entire period of time that the device is present in the body cavity; the nature of the matrix substance, i.e. its water-impenetrability, pre ⁇ vents degradation by hydrolysis or other means of the drug due to diffusion of water into the matrix even if the drug in itself is un ⁇ stable in an aqueous environment.
- the device of the invention may also be employed to prevent the occurrence of a dis ⁇ ease, e.g. an infection, over longer periods of time.
- the device according to the present inven ⁇ tion presents the important advantage that it permits substantially direct delivery of an active substance to or close to the site where it will exert its activity. It may therefore be possible to use con ⁇ siderably lower dosages of the active substance in question by such local administration than when the active substance is administered systemically. This may be particularly important in the case of chemotherapeutic agents used as cytostatic or antineoplastic agents many of which have extremely unpleasant side effects at the dosage levels at which they are currently administered.
- the matrix is one which is gradually eroded in the presence of body fluids whereby the active substance embedded in the matrix is released.
- the matrix may be one which is eroded by blood, saliva, peritoneal fluid, cerebrospinal fluid, lymph, interstitial fluid, vaginal or uterine discharge, urine or gastric juice. It is an important requirement that the erosion be of the so-called “heterogenous” type, i.e. the erosion proceeds only from the surface or surfaces of the matrix ex- posed to the erosive agent, rather than by homogeneous erosion which involves simultaneous degradation of the entire matrix.
- a het- erogenous erosion will result in a constant release, as defined above, of the active substance since the surface area of the matrix may be designed to remain substantially constant. Furthermore, the release rate of the active substance will correspond to the rate of erosion of the matrix, and a desired release rate of a specific ac ⁇ tive substance may therefore be obtained by selecting the substance composing the matrix according to it erosion properties in a particu- lar erosive agent.
- the desired erosion rate will vary according to the intended use of the device of the invention, and the nature of the active substance included therein and the surface area of the matrix exposed to erosion, the erosion of the matrix should preferably proceed at a slow rate, e.g. a rate of about 0.01-10 mm a day, in a specific body fluid at a temperature of 37°C +/- 2°C.
- the matrix substance itself as well as its degradation products be biocompatible so that it does not give rise to adverse reactions either locally or systemically in the form of allergic or toxic reactions.
- the matrix material is also preferably compatible with the materials used for medical devices of the present type, e.g. polyvinyl chloride or polyurethane.
- the erosion reaction may, for instance, be of the following types: a reaction whereby water-insoluble macromolecules are converted to water-soluble macromolecules by reaction of -a side chain, e.g. meth- yl, or a reaction whereby high molecular weight water-insoluble macromolecules are converted to smaller water-soluble molecules by hydrolytic cleavage of labile bonds in the polymer backbone.
- matrix substances including erodible substances as de ⁇ fined above, which are useful for the present purpose are a polymer, e.g. polyamide, polyurethane, silicone, polyester, polycarbonate, polyacetal, polycetal, polycaprolactone, a polyalkylene glycol such as polyethylene glycol or polypropylene glycol, a polyalkylene such as polyethylene, a polyalkylene oxide such as polyethylene oxide, poly(ortho)ester, a peptide, polypeptide or protein such as collagen or gelatin, a polysaccharide such as starch or a starch derivative, cellulose or a cellulose derivative, polylactic acid, polyglycolic acid, or any derivative, mixture or copolymer thereof; a higher alkane such as an alkane with 14 or more carbon atoms; a higher alkene such as an alkene with 18 or more carbon atoms; a fatty acid or fatty acid alcohol or fatty acid ester; or a steroid,
- the active substance may be substantially uniformly distributed through ⁇ out the matrix. This will ensure a substantially constant or uniform release rate of the active substance which is desirable in some cases.
- the active substance may be arranged in sub ⁇ stantially transverse layers in the matrix. This will lead to the release of the active substance in bursts occurring at set, predeter ⁇ mined intervals. These two release patterns may also be combined so that a uniform release of one active substance (perhaps at a fairly low dosage level) alternates with the release in bursts of the same or another active substance (possibly at a higher dosage level) .
- the matrix is not necessarily erodible, but the active substance em- bedded in the matrix is a hydrophilic substance which is at least partly accessible to body fluids when the device is inserted into a body cavity and which dissolves in the presence of said body fluids so as to attract liquid into the solution of said active substance by osmosis, resulting in an increased volume of the solution and thus a localized disruption of the matrix in the vicinity of the active sub ⁇ stance, whereby the active substance is released.
- the active substance in itself a hydrophilic substance, it may be combined with a hydrophilic substance which is at least partly acces ⁇ sible to body fluids when the device is inserted into a body cavity and which dissolves in the presence of said body fluids so as to at ⁇ tract liquid into the solution of said hydrophilic substance by os ⁇ mosis, resulting in an increased volume of the solution and thus a localized disruption of the matrix in the vicinity of the hydrophilic substance, whereby the active substance with which it is combined is released.
- the hydrophilic substance is, in the following, occasionally defined as a hydrophilic auxiliary sub- stance.
- the hydrophilic substance, whether active or auxiliary may be further defined as water-soluble.
- the hydrophilic active substance or, if the active substance is not in itself hydrophilic, the hydrophilic auxiliary substance should be present in an amount which gives rise to a concentration of ions in the solution of the substance which will create a sufficiently high osmotic pressure to attract the required quantity of water resulting in a localized disruption of the matrix.
- the extent of the localized disruption will inter alia be determined by the desired rate of release of the active substance, but should in any case be sufficient to make another part of the hydrophilic substance accessible to body fluids so as to ensure a progressive disruption of the matrix from the surface inwards at a substantially uniform rate.
- the amount of hydrophilic water-soluble substance to be included in the matrix varies according to the specific substance selected and the way in which it is arranged in the matrix, but the water-soluble substance is generally included in amounts up to 50Z by weight of the matrix.
- a substance which dissolves in the presence of body fluids and which fulfil the criteria indicated above with respect to their ability to create an adequate osmotic pressure are a salt, e.g. an alkali metal or alkaline earth metal salt such as sodium chloride, sodium bicarbonate, sodium sulfate, sodium fluoride, potassium chlo ⁇ ride, potassium bicarbonate, magnesium chloride, magnesium phosphate, calcium chloride, etc., a sugar such as glucose, fructose, sucrose, lactose etc., an amino acid such as glycine, an alcohol such as pro- pylene glycol, glycerol, etc., urea, or a polymer such as a starch, a peptide or polyethylene glycol, polyethylene oxide, polyvinylpyrroli- done, polyvinyl alcohol or salts or derivatives thereof, or a mixture thereof.
- an alkali metal or alkaline earth metal salt such as sodium chloride, sodium bicarbonate, sodium sulfate
- the active substance or the substance with which is combined may be a hydro ⁇ philic substance which is at least partly accessible to body fluids and which swells in the presence of said body fluids resulting in a localized disruption of the matrix in the vicinity of the hydrophilic substance whereby the active substance with which the active sub- stance is combined is released.
- the considerations indicated above concerning the ability of water-soluble hydrophilic substances to cause localized disruption of the matrix are also applicable to hydrophilic swellable substances.
- the amount of hydrophilic swellable substance incorporated in the matrix varies according to its swelling power and the way in which it is arranged in the matrix, but the swellable substance is generally included in amounts up to 50% by weight of the matrix in order to ensure the desired result.
- the hydrophilic substance may be a hygroscopic substance which swells in the presence of water, and may, for instance be selected from a polymer such as a cellulose derivative, e.g. methyl cellulose, car- boxymethyl cellulose, sodium carboxymethyl cellulose, methylpropyl cellulose, hydroxypropylmeth l cellulose, cellulose acetate, cellu ⁇ lose acetate phthalate, gelatin, agar, karaya, guar gum, acacia, pec- tin, etc.
- a cellulose derivative e.g. methyl cellulose, car- boxymethyl cellulose, sodium carboxymethyl cellulose, methylpropyl cellulose, hydroxypropylmeth l cellulose, cellulose acetate, cellu ⁇ lose acetate phthalate, gelatin, agar, karaya, guar gum, acacia, pec- tin, etc.
- hydro ⁇ philic is understood to mean a substance which has a strong affinity for water in the sense that it either is soluble in water or swells in the presence of water.
- the active substance or the hydrophilic substance with which it is combined forms particles which are substantially uniformly dis ⁇ tributed throughout the matrix.
- the matrix may be pro ⁇ quizd by mixing the active substance or a pre-formed combination of the active substance and the hydrophilic substance with the matrix material so as to obtain a substantially uniform dispersion of the active substance or combination of active substance with hydrophilic substance therein.
- the optional combination of the active substance with the hydrophilic substance may be in the form of either a mixture of particles of either substance, or particles of the active sub ⁇ stance may be coated with the hydrophilic substance.
- the limited progressive disruption of the matrix gives rise to the formation of a honeycombed or sponge-like structure in the matrix.
- the active sub ⁇ stance or the hydrophilic substance with which the active substance is combined forms one or more rod-like bodies extending substantially longitudinally through the matrix.
- the hydrophilic sub- stance will preferably be one which swells in the presence of body fluids since, if it is a water-soluble substance, it and the active substance combined with it, will simply be flushed fairly quickly from the matrix so that no adequate sustained release effect will be obtained.
- a swellable substance on the other hand, will gradually take up water followed by swelling and disruption of the matrix in the vicinity of the swollen portion of the hydrophilic substance and consequently a gradual release of the active substance.
- the active substance may be combined with the hydrophilic substance by mixing the active substance with the hydrophilic substance.
- the active substance or the hydrophilic substance with which the active substance is combined forms one or more layers extending substantial ⁇ ly longitudinally or transversely through the matrix, alternating with layers of the matrix. If the layers are longitudinally extend ⁇ ing, the hydrophilic substance should preferably be a swellable sub ⁇ stance for the reasons stated above. If the layers are transversely extending, the hydrophilic substance may be either water-soluble or swellable, use of a water-soluble substance, however, tending to lead to an immediate release in bursts of the active substance.
- the matrix may be produced by placing alternating layers of the ma ⁇ trix material and the active substance, optionally combined with a hydrophilic substance, on top of each other in a sandwich-like struc ⁇ ture.
- sheets of such alternating layers may be prepared and matrix bodies of the desired size and shape may be punched from the sheets.
- the thickness of the matrix layers alternating with the layers comprising the ac ⁇ tive substance should be so calculated that the matrix will be dis ⁇ rupted, due to the increased volume of the solution of the soluble substance caused by osmosis or due to swelling of the hydrophilic substance, to such an extent that at least part of the next layer of the hydrophilic active or auxiliary substance will be exposed to body fluids.
- the thickness of the matrix and hydrophilic layers may be so designed that the matrix will disrupt substantially immediately on contact with body fluids so that all of the active substance will be released at once. This may be advantageous in case of, for instance, an already established and progressing infection where a large initial dosage of an antibiotic is needed to combat it.
- a type of matrix may be combined with a slow-release matrix, e.g. one of the other embodiments described above so that the tube and/or rod end of the device of the invention will contain two types of matrices, one intended for immediate effect and the other intended for long-term action of the active substance.
- the matrix comprises an active substance optionally combined with a hydrophilic substance
- the matrix may fur ⁇ ther comprise the same or another active substance which is not in itself hydrophilic or combined with a hydrophilic substance.
- This active substance may be embedded in the matrix material and released as a result of the limited disruption of the matrix.
- the hydrophilic substance with which it is combined need not neces ⁇ sarily be a therapeutically inert auxiliary substance but may advan ⁇ tageously be another active substance.
- a matrix of the types described above may be used to prepare combination formulations of active substances which are released gradually and substantially simultaneously to exert different therapeutic effects or possibly a synergistic effect.
- the active substance or substances included in the device of the in ⁇ vention may be selected from many therapeutic categories, in particu- lar from substances which may advantageously be administered locally in or through a body cavity.
- examples of such substances are an ⁇ timicrobial agents, anesthetics, analgesics, antiinflammatory agents, antiseptic agents, growth factors, hormones, disinfectants, counterirritants, coagulation modifying agents, wound-healing promoters, antiviral agents and antineoplastic or cytostatic agents or other agents with anticancer properties, or a combination thereof.
- Suitable antimicrobial agents may be selected from aminoglycosides e.g. gentamycin, quinolones, chloramphenicols, teteracyclins, penicillins, cephalosporins, monobactams, fosidic acid, sulfonamides, sulfones, neomycin, polymyxin B, bacitracin and combinations thereof, the combination of neomycin and polymyxin B being particularly preferred.
- aminoglycosides e.g. gentamycin, quinolones, chloramphenicols, teteracyclins, penicillins, cephalosporins, monobactams, fosidic acid, sulfonamides, sulfones, neomycin, polymyxin B, bacitracin and combinations thereof, the combination of neomycin and polymyxin B being particularly preferred.
- Suitable antimicrobial agents include nitrofurantoin, hexamine and derivatives thereof, nalidixic acid, oxolinic acid and other quinoline derivatives, trimethoprim, cephamycins, lincomycins, macrolides, rifamycins, spectinomycin and vancomycin. Any of the above antimicrobial agents may further be used in combination with penicillinase inhibitors.
- Suitable antifungal agents include griseofulvin, candidicin, amphotericin, natamycin, nystatin, imidazole derivatives and fatty acid antifungals.
- Suitable antiparasitic agents include metronidazole and other antiprotozoal agents.
- Suitable antiviral agents include idoxuridine, cytarubine, amantadine, acyclovir, interferons, ribavirin and vidarabine.
- Suitable antiinflammatory agents include steroids and NSAID agents.
- Suitable antiseptic agents may be selected from mandelic acid and derivatives thereof, hippuric acid, dyes and formaldehyde.
- Suitable antineoplastic and cytostatic agents include, but are not limited to, doxorubicin (adriamycin) , methotrexate, BCG vaccine, fluorouracil and thio-TEPA.
- Suitable counterirritants may be selected from antihista- mines, camphor and bismuth salts.
- Suitable wound-healing promoters include, but are not limited to, collagen, hyaluronic acid, polysulfated saccharides such as sucralfate, zinc salts and vita ⁇ min A.
- the matrix may be provided with a coating which has an opening of a defined size and geometry through which opening the active substance is released.
- the coating is one which is substantially impermeable and resistant to the body fluid with which the device is contacted so as to substantially prevent release of the active substance through the coating.
- Such a coating may be selected from polyurethane, polyethylene, silicone, latex, polyvinylchloride, polyhydroxybutyrate, polyhydroxyvalerate, or a mixture thereof.
- the coating may be applied by spraying a coating material onto the matrix in such a way that an opening is left in the coating (this may, for instance, be done by spraying a rod formed from the matrix with a coating solution or suspension and subsequent ⁇ ly cut it into smaller segments, the end portions of which are not coated).
- the coating may also be applied by dipping a pre-formed body of the matrix into a coating solution or suspension, taking care that not all of the body is immersed, or by coextrusion.
- the matrix is preferably formed into a body of a suitable shape and size adapted to the intended end use of the device.
- the body formed from the matrix may be attached to or form the tip of the tube and/or rod.
- the matrix may be formed into a rod of a suitable diameter (determined by the type of device to which the matrix will be attached) which is divided into smaller segments of an appropriate length, optionally after applying a coating as described above. These segments may then be glued to the tip of the tube and/or rod by means of a non-toxic, pharmaceutically acceptable glue in a manner known per se from the prepartion of conventional catheters.
- the tip end thereof Before or after attachment of the matrix body, the tip end thereof is preferably rounded so as to avoid discomfort and/or damage when the tube and/or rod is inserted into the body cavity in question.
- the matrix may also be formed into a conventional suppository body of an appropriate size, for instance by moulding in a manner known per se . Such matrix bodies may then be attached to the tip of the tube and/or rod as indicated above, optionally after applying a coating as described above.
- the matrix may be extruded into a pre-formed tube of an appropriate diameter, and the tube is subsequently cut into smaller segments of an appropriate size so as to leave well-defined openings at the ends of the segments.
- the segments may then be at ⁇ tached to the tip of the device as explained above leaving an opening at the tip end of the segment where the matrix is accessible to body fluids.
- the tip end of the segment is preferably l ⁇ rounded so as to avoid possible injury or discomfort arising from the insertion of the tube.
- the wall portion of the tube segment comprising the matrix is also considered to constitute a coating.
- the body formed from the matrix is located inside the tube and/or rod part of the device. This may for instance be done by extruding the matrix into the tube at an appropriate site.
- the matrix body will often be placed into a tip portion of the tube (in particular if the tube forms part of a catheter) , but the matrix may, however, also be placed at a different site of the tube, the exact location of the matrix body being determined by the nature of the device of which it forms a part. In this case, no coating need be applied on the matrix as the surface area from which release of the active substance takes place is delimited by the wall(s) of the tube portion of the device itself.
- the device of the invention may be any device of the type which is provided with a tube and/or rod to be inserted into a body cavity.
- the device may be selected from a catheter, such as an arterial, venous or urethral catheter, probe, drainage tube, e.g. a middle ear drainage tube, endoscopic device, respiratory aid device and ostomy device.
- Fig. 1 is a partly sectional side view of a currently preferred em ⁇ bodiment of a device of the present invention.
- Fig 2. is ' an enlarged sectional view of a tip of the device shown in Fig. 1.
- a urethral catheter 10 comprising a tube portion 12 and a tip portion 14 attached thereto.
- the tube portion 12 is pro ⁇ vided with a thin-walled outer sheath of a flexible plastic material which sheath is adapted to provide a balloon 16 by inflation adjacent to the tip of the catheter 10.
- the catheter is further provided with a drainage inlet 18, a drainage outlet 20, and an inlet end 22 for the introduction of liquid for the inflation of the balloon 16 so as to retain the tip portion 14 in the bladder.
- the tip portion 14 is shown comprising a matrix body 30 provided with a coating 26 and comprising particles 28 of an active substance.
- the matrix was extruded into a pre-formed silicone tube with an internal diameter of 4 mm by means of a syringe.
- the tube was then cut into segments with a length of about 2 cm which were glued to the tip of an Arguille catheter No. 12 (composed of latex coated with silicone) in a manner known per se for attaching tips to catheters.
- the tip end of the tube segment was rounded by shaving it with a scalpel.
- Patent Blue was mixed thoroughly with a molten polyethylene glycol (PEG) 20000 matrix material.
- the final matrix contained 25% of Patent Blue and 75% of PEG 20000.
- the matrix was extruded into a I 8 pre-formed silicone tube with an internal diameter of 4 mm by means of a syringe and left to cool.
- the tube was then cut into segments with a length of about 2 cm.
- the tube segments were then glued to the tip of a catheter as described in Example 1.
- tube segments were prepared containing 75% of the matrix material and 25% of Patent Blue. The tube segments were then glued to the tip of a catheter as described in Example 1.
- tube segments were prepared containing 75% PEG 20000, 10% of neomycin and 15% of Patent Blue. The tube segments were then glued to the tip of a catheter as described in Example 1.
- Example 2 The catheter produced in Example 2 was inserted into the bladder of a female pig through the urether. The amount of pigment (Patent Blue) released from the matrix was measured spectrophotometrically and was found to be constant over a period of three days.
- Pig Blue Pig Blue
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- Materials For Medical Uses (AREA)
Abstract
Un dispositif médical destiné à être introduit dans une cavité du corps comprend, à l'une de ses extrémités devant être introduitedans la cavité, une matrice dans laquelle est incorporée une substance active et à partir de laquelle cette substance est libérée à une cadence prédéterminée, la matrice étant composée d'une substance imperméable ou seulement légèrement perméable à l'eau. Ledit dispositif comprend en outre de préférence un tube et/ou une tige servant au drainage et/ou à l'acheminement de fluide dans la cavité. La substance active peut être choisie parmi des agents antimicrobiens, des anesthésiants, des analgésiques, des agents anti-inflammatoires, des agents antiseptiques, des facteurs de croissance, des hormones, des désinfectants, des anti-irritants, des agents modifiant la coagulation, des activateurs de cicatrisation, des agents antiviraux et des agents antinéoplastiques ou cytostatiques ou d'autres agents ayant d'autres propriétés anticancéreuses, ou une combinaison de ces différents agents. Le dispositif permet l'acheminement sensiblement direct d'une substance active jusq'au ou près du site où elle doit exercer son activité, par exemple via un cathéter, et a la capacité d'empêcher ou de réduire l'incidence d'infections causées par l'utilisation de dispositifs médicaux introduits dans une cavité du corps.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK530787A DK530787D0 (da) | 1987-10-09 | 1987-10-09 | Indretning til indfoering i en legemshulhed |
DK5307/87 | 1987-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1989003232A1 true WO1989003232A1 (fr) | 1989-04-20 |
Family
ID=8141363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK1988/000163 WO1989003232A1 (fr) | 1987-10-09 | 1988-10-07 | Dispositif medical destine a etre introduit dans une cavite du corps |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPH03502053A (fr) |
AU (1) | AU2550288A (fr) |
DK (1) | DK530787D0 (fr) |
WO (1) | WO1989003232A1 (fr) |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990013332A1 (fr) * | 1989-05-11 | 1990-11-15 | Cedars-Sinai Medical Center | Support pour medicaments a liberation progressive |
US5007897A (en) * | 1989-05-30 | 1991-04-16 | Kalb Irvin M | Drug delivery catheter |
WO1991012779A1 (fr) * | 1990-02-28 | 1991-09-05 | Medtronic, Inc. | Prothese pour l'elution intraluminale d'un medicament |
EP0501772A1 (fr) * | 1991-02-28 | 1992-09-02 | SURGICAL SYSTEMS & INSTRUMENTS Inc. | Système d'athérectomie destinée à éviter les recitives de sténose |
GB2268066A (en) * | 1992-06-25 | 1994-01-05 | Univ Manchester | Catheter with porous matrix material |
EP0604022A1 (fr) * | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Endoprothèse résorbable, à plusieurs couches, pour le maintien des vaisseaux, et sa méthode de fabrication |
EP0615458A1 (fr) * | 1991-12-06 | 1994-09-21 | North Shore Univ Hospital | Procede de reduction d'infections associees a des dispositifs medicaux. |
WO1994022519A1 (fr) * | 1993-03-30 | 1994-10-13 | Aigner Karl R | Catheter a ballonnet et dispositif de perfusion le comportant |
US5441515A (en) * | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
FR2722413A1 (fr) * | 1994-07-13 | 1996-01-19 | Devonec Marian | Implant therapeutique destine au traitement cytoreducteur selectif de l'obstruction d'une lumiere ouvoie naturelle d'un corps humain ou animal |
US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
WO1996031250A1 (fr) * | 1995-04-06 | 1996-10-10 | Richwood Pharmaceuticals Company, Inc. | Systeme de perfusion pour l'administration de medicaments dans une cavite du corps |
US5688239A (en) * | 1995-07-10 | 1997-11-18 | Walker; Frank J. | Urinary tract treating assembly with prostate flushing |
US5782907A (en) * | 1995-07-13 | 1998-07-21 | Devices For Vascular Intervention, Inc. | Involuted spring stent and graft assembly and method of use |
US5851231A (en) * | 1990-02-28 | 1998-12-22 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
WO2000053253A2 (fr) * | 1999-03-09 | 2000-09-14 | Durect Corporation | Dispositif implantable permettant l'acces a un site de traitement |
US6183437B1 (en) | 1995-07-10 | 2001-02-06 | Frank J. Walker | Electronic control unit and tubing assembly system for automatically controlling urinary irrigation |
EP1159957A2 (fr) | 1996-12-02 | 2001-12-05 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Dispositif d'administration locale de formulations solides ou semi-solides, formulations retard pour administration parentérale et procédé de préparation |
US6527801B1 (en) | 2000-04-13 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
EP1764104A1 (fr) * | 2005-09-16 | 2007-03-21 | Domenico Russo | Composition pharmaceutique à base de sucralfate, d'acétate d'aluminium et de vitamines pour la guérison des plaies |
US8715706B2 (en) | 2009-06-18 | 2014-05-06 | RDD Pharma, Ltd. | Methods and devices for delivery of pharmaceutical agents within orifices of the body |
US8846070B2 (en) | 2004-03-29 | 2014-09-30 | Advanced Cardiovascular Systems, Inc. | Biologically degradable compositions for medical applications |
US8925177B2 (en) | 2006-06-19 | 2015-01-06 | Abbott Cardiovascular Systems Inc. | Methods for improving stent retention on a balloon catheter |
US9038260B2 (en) | 2006-05-26 | 2015-05-26 | Abbott Cardiovascular Systems Inc. | Stent with radiopaque markers |
US9072820B2 (en) | 2006-06-26 | 2015-07-07 | Advanced Cardiovascular Systems, Inc. | Polymer composite stent with polymer particles |
US9173733B1 (en) | 2006-08-21 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
US9198785B2 (en) | 2010-01-30 | 2015-12-01 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
EP2682138B1 (fr) | 2007-08-03 | 2015-12-02 | Invatec Technology Center GMBH | Produits médicaux améliorés avec revêtement médicamenteux et leur fabrication |
US9248034B2 (en) | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
US9283099B2 (en) | 2004-08-25 | 2016-03-15 | Advanced Cardiovascular Systems, Inc. | Stent-catheter assembly with a releasable connection for stent retention |
US9295570B2 (en) | 2001-09-19 | 2016-03-29 | Abbott Laboratories Vascular Enterprises Limited | Cold-molding process for loading a stent onto a stent delivery system |
US9532888B2 (en) | 2006-01-04 | 2017-01-03 | Abbott Cardiovascular Systems Inc. | Stents with radiopaque markers |
WO2017174715A1 (fr) * | 2016-04-07 | 2017-10-12 | Saxonia R + D GmbH & Co. KG | Cathéter urinaire amélioré |
US9827119B2 (en) | 2010-01-30 | 2017-11-28 | Abbott Cardiovascular Systems Inc. | Polymer scaffolds having a low crossing profile |
US9999527B2 (en) | 2015-02-11 | 2018-06-19 | Abbott Cardiovascular Systems Inc. | Scaffolds having radiopaque markers |
CN108245222A (zh) * | 2018-01-23 | 2018-07-06 | 青岛星创医疗科技有限公司 | 医用取石球囊的制备方法 |
US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US10145811B2 (en) | 2006-07-13 | 2018-12-04 | Abbott Cardiovascular Systems Inc. | Radio frequency identification monitoring of stents |
US10307274B2 (en) | 2011-07-29 | 2019-06-04 | Abbott Cardiovascular Systems Inc. | Methods for uniform crimping and deployment of a polymer scaffold |
US10610387B2 (en) | 2015-06-12 | 2020-04-07 | Abbott Cardiovascular Systems Inc. | Scaffolds having a radiopaque marker and methods for attaching a marker to a scaffold |
US10857324B2 (en) | 2014-08-26 | 2020-12-08 | C. R. Bard, Inc. | Urinary catheter |
CN112295088A (zh) * | 2020-10-29 | 2021-02-02 | 合肥达米医疗科技有限公司 | 具有控制器的连续缓释给药镇痛引流管 |
CN112295087A (zh) * | 2020-10-29 | 2021-02-02 | 合肥达米医疗科技有限公司 | 连续缓释给药镇痛引流管 |
US11167064B2 (en) | 2016-07-14 | 2021-11-09 | Hollister Incorporated | Hygienic medical devices having hydrophilic coating |
EP3378506B1 (fr) | 2010-03-25 | 2023-06-07 | Lutonix, Inc. | Revêtements de libération de médicament pour dispositifs médicaux |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9602352D0 (sv) * | 1996-06-14 | 1996-06-14 | Astra Ab | Catheter package |
EP2447055B1 (fr) * | 2002-06-24 | 2017-12-06 | Tufts University | Biomatériaux en soie et leurs procédés d'utilisation |
KR20130100029A (ko) * | 2005-12-30 | 2013-09-06 | 모르 리서치 애플리케이션즈 리미티드 | 항문 괄약근을 치료하기 위한 장치 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1888349A (en) * | 1932-02-15 | 1932-11-22 | Charles M Jacoby | Catheter |
US2882900A (en) * | 1957-11-19 | 1959-04-21 | John W Holter | Surgical instrument |
US3297031A (en) * | 1966-02-07 | 1967-01-10 | Henry F Bray | Suppository applicator |
US3924622A (en) * | 1973-10-11 | 1975-12-09 | Mead Johnson & Co | Zero-order release method |
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US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
DE3419876A1 (de) * | 1984-05-28 | 1985-11-28 | S. Mitchell Ellicott City Harman, Md. | Verabreichungseinrichtung fuer medizin |
US4603152A (en) * | 1982-11-05 | 1986-07-29 | Baxter Travenol Laboratories, Inc. | Antimicrobial compositions |
-
1987
- 1987-10-09 DK DK530787A patent/DK530787D0/da not_active Application Discontinuation
-
1988
- 1988-10-07 JP JP50839488A patent/JPH03502053A/ja active Pending
- 1988-10-07 AU AU25502/88A patent/AU2550288A/en not_active Abandoned
- 1988-10-07 WO PCT/DK1988/000163 patent/WO1989003232A1/fr unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1888349A (en) * | 1932-02-15 | 1932-11-22 | Charles M Jacoby | Catheter |
US2882900A (en) * | 1957-11-19 | 1959-04-21 | John W Holter | Surgical instrument |
US3297031A (en) * | 1966-02-07 | 1967-01-10 | Henry F Bray | Suppository applicator |
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US3924622A (en) * | 1973-10-11 | 1975-12-09 | Mead Johnson & Co | Zero-order release method |
US3926188A (en) * | 1974-11-14 | 1975-12-16 | Alza Corp | Laminated drug dispenser |
US4603152A (en) * | 1982-11-05 | 1986-07-29 | Baxter Travenol Laboratories, Inc. | Antimicrobial compositions |
DE3419876A1 (de) * | 1984-05-28 | 1985-11-28 | S. Mitchell Ellicott City Harman, Md. | Verabreichungseinrichtung fuer medizin |
Cited By (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990013332A1 (fr) * | 1989-05-11 | 1990-11-15 | Cedars-Sinai Medical Center | Support pour medicaments a liberation progressive |
US5007897A (en) * | 1989-05-30 | 1991-04-16 | Kalb Irvin M | Drug delivery catheter |
US5871535A (en) * | 1990-02-28 | 1999-02-16 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
WO1991012779A1 (fr) * | 1990-02-28 | 1991-09-05 | Medtronic, Inc. | Prothese pour l'elution intraluminale d'un medicament |
US5997468A (en) * | 1990-02-28 | 1999-12-07 | Medtronic, Inc. | Intraluminal drug eluting prosthesis method |
US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5851231A (en) * | 1990-02-28 | 1998-12-22 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
EP0501772A1 (fr) * | 1991-02-28 | 1992-09-02 | SURGICAL SYSTEMS & INSTRUMENTS Inc. | Système d'athérectomie destinée à éviter les recitives de sténose |
EP0615458A4 (fr) * | 1991-12-06 | 1995-02-08 | North Shore Univ Hospital | Procede de reduction d'infections associees a des dispositifs medicaux. |
US5716406A (en) * | 1991-12-06 | 1998-02-10 | North Shore University Hospital Research Corp. | Method of reducing medical device related infections |
EP0615458A1 (fr) * | 1991-12-06 | 1994-09-21 | North Shore Univ Hospital | Procede de reduction d'infections associees a des dispositifs medicaux. |
GB2268066A (en) * | 1992-06-25 | 1994-01-05 | Univ Manchester | Catheter with porous matrix material |
EP0604022A1 (fr) * | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Endoprothèse résorbable, à plusieurs couches, pour le maintien des vaisseaux, et sa méthode de fabrication |
WO1994022519A1 (fr) * | 1993-03-30 | 1994-10-13 | Aigner Karl R | Catheter a ballonnet et dispositif de perfusion le comportant |
US5746717A (en) * | 1993-03-30 | 1998-05-05 | Aigner; Karl R. | Balloon catheter and device for perfusion with the balloon catheter |
US5441515A (en) * | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
US5618299A (en) * | 1993-04-23 | 1997-04-08 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
FR2722413A1 (fr) * | 1994-07-13 | 1996-01-19 | Devonec Marian | Implant therapeutique destine au traitement cytoreducteur selectif de l'obstruction d'une lumiere ouvoie naturelle d'un corps humain ou animal |
US6949083B2 (en) | 1994-07-13 | 2005-09-27 | Marian Devonec | Therapeutic device for the selective cytoreduction treatment of an obstruction in a natural lumen or passage of the human or animal body |
US6238368B1 (en) | 1994-07-13 | 2001-05-29 | Marian Devonec | Therapeutic device for the selective cytoreduction treatment of an obstruction |
US8211085B2 (en) | 1994-07-13 | 2012-07-03 | Marian Devonec | Therapeutic device for the selective cytoreduction treatment of an obstruction in a natural lumen or passage of the human or animal body |
WO1996002210A1 (fr) * | 1994-07-13 | 1996-02-01 | Marian Devonec | Dispositif therapeutique destine au traitement cytoreducteur selectif de l'obstruction d'une lumiere ou voie naturelle d'un corps humain ou animal |
US5846216A (en) * | 1995-04-06 | 1998-12-08 | G & P Technologies, Inc. | Mucous membrane infusor and method of use for dispensing medications |
GB2314777B (en) * | 1995-04-06 | 1999-04-28 | Richwood Pharmaceuticals Compa | Mucous membrane infusor |
GB2314777A (en) * | 1995-04-06 | 1998-01-14 | Richwood Pharmaceuticals Compa | Infusor system for delivery of medication to a body cavity |
WO1996031250A1 (fr) * | 1995-04-06 | 1996-10-10 | Richwood Pharmaceuticals Company, Inc. | Systeme de perfusion pour l'administration de medicaments dans une cavite du corps |
US5688239A (en) * | 1995-07-10 | 1997-11-18 | Walker; Frank J. | Urinary tract treating assembly with prostate flushing |
US6102888A (en) * | 1995-07-10 | 2000-08-15 | Walker; Frank J. | Method of irrigating and draining urinary tract |
US6183437B1 (en) | 1995-07-10 | 2001-02-06 | Frank J. Walker | Electronic control unit and tubing assembly system for automatically controlling urinary irrigation |
US5782907A (en) * | 1995-07-13 | 1998-07-21 | Devices For Vascular Intervention, Inc. | Involuted spring stent and graft assembly and method of use |
EP1159957A2 (fr) | 1996-12-02 | 2001-12-05 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Dispositif d'administration locale de formulations solides ou semi-solides, formulations retard pour administration parentérale et procédé de préparation |
US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
WO2000053253A2 (fr) * | 1999-03-09 | 2000-09-14 | Durect Corporation | Dispositif implantable permettant l'acces a un site de traitement |
WO2000053253A3 (fr) * | 1999-03-09 | 2001-01-11 | Durect Corp | Dispositif implantable permettant l'acces a un site de traitement |
US6527801B1 (en) | 2000-04-13 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
US10166131B2 (en) | 2001-09-19 | 2019-01-01 | Abbott Laboratories Vascular Enterprises Limited | Process for loading a stent onto a stent delivery system |
US9295570B2 (en) | 2001-09-19 | 2016-03-29 | Abbott Laboratories Vascular Enterprises Limited | Cold-molding process for loading a stent onto a stent delivery system |
US8846070B2 (en) | 2004-03-29 | 2014-09-30 | Advanced Cardiovascular Systems, Inc. | Biologically degradable compositions for medical applications |
US9283099B2 (en) | 2004-08-25 | 2016-03-15 | Advanced Cardiovascular Systems, Inc. | Stent-catheter assembly with a releasable connection for stent retention |
US9248034B2 (en) | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
EP1764104A1 (fr) * | 2005-09-16 | 2007-03-21 | Domenico Russo | Composition pharmaceutique à base de sucralfate, d'acétate d'aluminium et de vitamines pour la guérison des plaies |
US10070975B2 (en) | 2006-01-04 | 2018-09-11 | Abbott Cardiovascular Systems Inc. | Stents with radiopaque markers |
US9532888B2 (en) | 2006-01-04 | 2017-01-03 | Abbott Cardiovascular Systems Inc. | Stents with radiopaque markers |
US9038260B2 (en) | 2006-05-26 | 2015-05-26 | Abbott Cardiovascular Systems Inc. | Stent with radiopaque markers |
US9358325B2 (en) | 2006-05-26 | 2016-06-07 | Abbott Cardiovascular Systems Inc. | Stents with radiopaque markers |
US9694116B2 (en) | 2006-05-26 | 2017-07-04 | Abbott Cardiovascular Systems Inc. | Stents with radiopaque markers |
US10342688B2 (en) | 2006-06-19 | 2019-07-09 | Abbott Cardiovascular Systems Inc. | Methods for improving stent retention on a balloon catheter |
US8925177B2 (en) | 2006-06-19 | 2015-01-06 | Abbott Cardiovascular Systems Inc. | Methods for improving stent retention on a balloon catheter |
US9259341B2 (en) | 2006-06-19 | 2016-02-16 | Abbott Cardiovascular Systems Inc. | Methods for improving stent retention on a balloon catheter |
US9579225B2 (en) | 2006-06-19 | 2017-02-28 | Abbott Cardiovascular Systems Inc. | Methods for improving stent retention on a balloon catheter |
US9072820B2 (en) | 2006-06-26 | 2015-07-07 | Advanced Cardiovascular Systems, Inc. | Polymer composite stent with polymer particles |
US10145811B2 (en) | 2006-07-13 | 2018-12-04 | Abbott Cardiovascular Systems Inc. | Radio frequency identification monitoring of stents |
US9173733B1 (en) | 2006-08-21 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
US9833342B2 (en) | 2006-08-21 | 2017-12-05 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
EP2682138B1 (fr) | 2007-08-03 | 2015-12-02 | Invatec Technology Center GMBH | Produits médicaux améliorés avec revêtement médicamenteux et leur fabrication |
US8715706B2 (en) | 2009-06-18 | 2014-05-06 | RDD Pharma, Ltd. | Methods and devices for delivery of pharmaceutical agents within orifices of the body |
US10821274B2 (en) | 2009-06-18 | 2020-11-03 | Rdd Pharma Ltd. | Methods and devices for delivery of pharmaceutical agents within orifices of the body |
US9763818B2 (en) | 2010-01-30 | 2017-09-19 | Abbott Cardiovascular Systems Inc. | Method of crimping stent on catheter delivery assembly |
US9198785B2 (en) | 2010-01-30 | 2015-12-01 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
US11324614B2 (en) | 2010-01-30 | 2022-05-10 | Abbott Cardiovascular Systems Inc. | Balloon expanded polymer stent |
US9867728B2 (en) | 2010-01-30 | 2018-01-16 | Abbott Cardiovascular Systems Inc. | Method of making a stent |
US10123894B2 (en) | 2010-01-30 | 2018-11-13 | Abbott Cardiovascular Systems Inc. | Method of crimping stent on catheter delivery assembly |
US9827119B2 (en) | 2010-01-30 | 2017-11-28 | Abbott Cardiovascular Systems Inc. | Polymer scaffolds having a low crossing profile |
US9770351B2 (en) | 2010-01-30 | 2017-09-26 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
EP3378506B1 (fr) | 2010-03-25 | 2023-06-07 | Lutonix, Inc. | Revêtements de libération de médicament pour dispositifs médicaux |
US10307274B2 (en) | 2011-07-29 | 2019-06-04 | Abbott Cardiovascular Systems Inc. | Methods for uniform crimping and deployment of a polymer scaffold |
US11850370B2 (en) | 2014-08-26 | 2023-12-26 | C. R. Bard, Inc. | Urinary catheter |
US10857324B2 (en) | 2014-08-26 | 2020-12-08 | C. R. Bard, Inc. | Urinary catheter |
US10874825B2 (en) | 2014-08-26 | 2020-12-29 | C. R. Bard, Inc. | Urinary catheter |
US9999527B2 (en) | 2015-02-11 | 2018-06-19 | Abbott Cardiovascular Systems Inc. | Scaffolds having radiopaque markers |
US10610387B2 (en) | 2015-06-12 | 2020-04-07 | Abbott Cardiovascular Systems Inc. | Scaffolds having a radiopaque marker and methods for attaching a marker to a scaffold |
US11478370B2 (en) | 2015-06-12 | 2022-10-25 | Abbott Cardiovascular Systems Inc. | Scaffolds having a radiopaque marker and methods for attaching a marker to a scaffold |
WO2017174715A1 (fr) * | 2016-04-07 | 2017-10-12 | Saxonia R + D GmbH & Co. KG | Cathéter urinaire amélioré |
US11103675B2 (en) | 2016-04-07 | 2021-08-31 | Saxonia R + D GmbH & Co. KG | Urinary catheter |
US11167064B2 (en) | 2016-07-14 | 2021-11-09 | Hollister Incorporated | Hygienic medical devices having hydrophilic coating |
CN108245222A (zh) * | 2018-01-23 | 2018-07-06 | 青岛星创医疗科技有限公司 | 医用取石球囊的制备方法 |
CN112295087A (zh) * | 2020-10-29 | 2021-02-02 | 合肥达米医疗科技有限公司 | 连续缓释给药镇痛引流管 |
CN112295088B (zh) * | 2020-10-29 | 2023-06-06 | 合肥达米医疗科技有限公司 | 具有控制器的连续缓释给药镇痛引流管 |
CN112295087B (zh) * | 2020-10-29 | 2023-06-06 | 合肥达米医疗科技有限公司 | 连续缓释给药镇痛引流管 |
CN112295088A (zh) * | 2020-10-29 | 2021-02-02 | 合肥达米医疗科技有限公司 | 具有控制器的连续缓释给药镇痛引流管 |
Also Published As
Publication number | Publication date |
---|---|
AU2550288A (en) | 1989-05-02 |
DK530787D0 (da) | 1987-10-09 |
JPH03502053A (ja) | 1991-05-16 |
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