WO1987005779A1 - Prophylaxis method and composition therefor - Google Patents

Prophylaxis method and composition therefor Download PDF

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Publication number
WO1987005779A1
WO1987005779A1 PCT/US1987/000634 US8700634W WO8705779A1 WO 1987005779 A1 WO1987005779 A1 WO 1987005779A1 US 8700634 W US8700634 W US 8700634W WO 8705779 A1 WO8705779 A1 WO 8705779A1
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Prior art keywords
person
toilet seat
aerosol composition
lower alkanol
germ
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PCT/US1987/000634
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French (fr)
Inventor
Jonah Shacknai
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Jonah Shacknai
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Publication of WO1987005779A1 publication Critical patent/WO1987005779A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A01N25/06—Aerosols
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • This invention relates to the field of medicine and more specifically to a method and composition for prevention of disease encountered in public washroom facilities.
  • Disinfectants have been known for many years, with a primary object of household sanitation in modern society being to keep restroom surfaces, and particularly those associated with the toilet, free from germs that can cause infection of a person coming into skin contact, typically when seated on a toilet.
  • hexamethylenebisbiguanide compound known as Chlorhexidine gluconate. which is typically administered to a surface in a four percent solution in a mild, sudsing base which is adjusted to a pH of from about 5.0 to about 6.5, and used in that form to treat skin.
  • Patent 4,364,515 granted December 21, 1982, teaches a water-in-air emulsion or suspension as an improvement in aerosol compositions which are stated as generally used for bath and body powders, make-up powders, foot powders, personal deodorant and antiperspirant powders, and a variety of other uses. (column 2, lines 18-18). Prussin teaches the use of hydrophobic metal oxides, particularly silane treated silicas (column 2, lines 28-0).
  • Schleppnik U.S. Patent 4,310,512, granted December 4, 1979, discloses treatment of offensive odors with a combination of a perfume and fragrances.
  • an object of the present invention is to provide a method of keeping a toilet surface germ-free.
  • an airport washroom facility is used numerous times by all types of persons over the course of a day and between cleaning by airport personnel. It is highly desirable to provide the traveller with a convenient means of sanitizing washroom surfaces in such public facilities, without the need to carry cleaning fluids, cloths, and other items necessary to provide safety from infection.
  • a toilet seat cleansing unit which comprises a pressurized container housing a toilet seat aerosol composition capable of being ejected at a distance of from about six inches to two feet from said pressurized container, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said toilet seat, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat.
  • the lower alkanol is isopropyl alcohol.
  • said lower alkanol is ethanol.
  • a mixture of about one part isopropyl alcohol and one part ethanol forms yet a further aspect of the invention.
  • said Chlorhexidine gluconate is present in an amount of about 0.1 to 3.0 percent by weight of said lower alkanol.
  • a method of prevention of infection of a person through direct skin contact of said person to a germ-containing surface in a washroom facility which comprises applying a coating of an aerosol composition over said germ-containing surface at the point of expected skin contact therewith, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said germ-containing surface, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said germ-containing surface there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said germ-containing surface.
  • a method of prevention of infection of a person through direct skin contact of said person to a toilet seat which comprises applying a coating of an aerosol composition over said toilet seat at the point of expected skin contact therewith, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said toilet seat, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat.
  • a purse- or pocket-sized cleansing unit which contains a pressurized toilet seat aerosol composition capable of being ejected at a distance of from about six inches to two feet from said pressurized container, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said toilet seat, said aerosol composition containing a disinfectant, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat.
  • An aerosol composition is prepared with a 4 percent Chlorhexidine gluconate in an ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
  • An aerosol composition is prepared with a 3 percent Chlorhexidine gluconate in an alkanol mixture of one half isopropyl alcohol and one half ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches.
  • a brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
  • EXAMPLE III An aerosol composition is prepared with a 2 percent Chlorhexidine gluconate in an ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
  • EXAMPLE IV An aerosol composition is prepared with a 2 percent Chlorhexidine gluconate in an ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
  • An aerosol composition is prepared with a 4 percent Chlorhexidine gluconate in an isopropanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
  • EXAMPLE V An aerosol composition is prepared with a 1 percent Chlorhexidine gluconate in an ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
  • EXAMPLE VI An aerosol composition of Example 1 is useful for killing germs on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Staphylococcus aureus. The composition kills the germ and, thus, provides a surface free from the germ such that bodily contact with the surface is undertaken without fear of germicidal contamination.
  • EXAMPLE VII An aerosol composition of Example 1 is useful for killing germs on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Staphylococcus aureus. The composition kills the germ and, thus, provides a surface free from the germ such that bodily contact with the surface is undertaken without fear of germicidal contamination.
  • An aerosol composition of Example 2 is useful for killing germs on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Pseudomonas aeruginosa. The composition kills the germ and, thus, provides a surface free from the germ such that bodily contact with the surface is undertaken without fear of germicidal contamination.
  • EXAMPLE VIII An aerosol composition of Example 3 is useful for killing germs on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with
  • Salmonella choleraesuis The composition kills the germ and, thus, provides a surface free from the germ such that bodily contact with the surface is undertaken without fear of germicidal contamination.
  • Example 4 An aerosol composition of Example 4 is useful for killing viruses on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Herpes simplex virus type I. The composition kills the virus and, thus, provides a surface free from the virus such that bodily contact with the surface is undertaken without fear of virucidal contamination.
  • EXAMPLE X EXAMPLE X
  • An aerosol composition of Example 5 is useful for killing viruses on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Herpes simplex virus type II. The composition kills the virus and, thus, provides a surface free from the virus such that bodily contact with the surface is undertaken without fear of virucidal contamination.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
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  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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Abstract

A toilet seat cleansing unit including a pressurized container housing a toilet seat aerosol composition capable of being ejected at a distance of from about six inches to two feet from the pressurized container. The aerosol composition used is suitable for prophylaxis against infections of persons coming into time direct physical contact with the toilet seat. Such an aerosol composition includes an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate. Upon administration of the aerosol composition to the toilet seat, the germs capable of otherwise topically infecting the person at the point of bodily contact with the toilet seat are rendered ineffective.

Description

PROPHYLAXIS METHOD AND COMPOSITION THEREFOR FIELD OF THE INVENTION
This invention relates to the field of medicine and more specifically to a method and composition for prevention of disease encountered in public washroom facilities.
BACKGROUND OF THE INVENTION Disinfectants have been known for many years, with a primary object of household sanitation in modern society being to keep restroom surfaces, and particularly those associated with the toilet, free from germs that can cause infection of a person coming into skin contact, typically when seated on a toilet.
Numerous products and compositions are well known in the art for the purpose of providing such safety and freedom from infection, with antiseptic cleaners having been provided and well known in the art. As an example of such a known compound that has disinfectant properties may be mentioned the hexamethylenebisbiguanide compound known as Chlorhexidine gluconate. which is typically administered to a surface in a four percent solution in a mild, sudsing base which is adjusted to a pH of from about 5.0 to about 6.5, and used in that form to treat skin.
Certain long chain linear polyunsaturated acids, aldehydes and primary alcohols are proposed as effective for topical treatment as a virucide for herpes lesions in Reviσi et al, U.S. Patent 4,513,008 granted April 23, 1985. Prevention of the spread of the virus is suggested by incorporating such compounds in a hand cream or lotion for use by physicians, or in fluids used to kill virus on examining tables, instruments, gloves, towels and other surfaces. (col. 5, line 65 - col. 6, line 3).
Martin, U.S. Patent 4,469,614, granted September 4, 1984, teaches a chemical disinfectant and sterilant that includes glutaraldehyde, o-phenyl phenol, p-tert-amyl phenol, benzotriazole and a large number of other specific ingredients. Martin teaches that his composition may be used on contaminated dental or surgical instruments, or as a "secondary" use by dilution as a hand disinfectant. (col. 2, lines 3-6). Prussin, U.S. Patent 4,364,515, granted December 21, 1982, teaches a water-in-air emulsion or suspension as an improvement in aerosol compositions which are stated as generally used for bath and body powders, make-up powders, foot powders, personal deodorant and antiperspirant powders, and a variety of other uses. (column 2, lines 18-18). Prussin teaches the use of hydrophobic metal oxides, particularly silane treated silicas (column 2, lines 28-0).
Reinchr et al., U.S. Patent 4,357,476, granted November 2, 1982, teach nonadienylamines and related compounds as suitable for combatting microorganisms, particularly in "material protection" (column 32, line 40) and to protect "organic substrates" (column 32, line 43). Protection of industrial products is stated as including glues, binders, paints and a variety of other things, and also as a disinfective for plastics. Plastics are also included in a list of materials that can be protected, including plastics to be used for foot mats, bathroom curtains, toilet seats, foot grids .in swimming pools, wall coverings and the like. (column 33, lines 4-10). The Reinchr et al. patent discloses that the compounds may be included in an aqueous solution or dispersion with appropriate surface-active agent. (column 33, line 55). There is also a generic listing of the use of the composition in either a liquid form or aerosol. (column 33, line 54).
Schleppnik, U.S. Patent 4,310,512, granted December 4, 1979, discloses treatment of offensive odors with a combination of a perfume and fragrances.
DETAILED DESCRIPTION OF THE INVENTION While the treatment of the skin is well known to remove germs, an object of the present invention is to provide a method of keeping a toilet surface germ-free.
It is a further object of the invention to provide a means for keeping toilet seats and other surfaces in public restroo s germ-free. Typically an airport washroom facility is used numerous times by all types of persons over the course of a day and between cleaning by airport personnel. It is highly desirable to provide the traveller with a convenient means of sanitizing washroom surfaces in such public facilities, without the need to carry cleaning fluids, cloths, and other items necessary to provide safety from infection.
In accordance with a first aspect of the invention, there is provided a toilet seat cleansing unit which comprises a pressurized container housing a toilet seat aerosol composition capable of being ejected at a distance of from about six inches to two feet from said pressurized container, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said toilet seat, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat. in accordance with a preferred aspect of the invention, the lower alkanol is isopropyl alcohol. Alternatively, in accordance with yet another preferred aspect of the present invention, said lower alkanol is ethanol. A mixture of about one part isopropyl alcohol and one part ethanol forms yet a further aspect of the invention.
In a preferred embodiment, said Chlorhexidine gluconate is present in an amount of about 0.1 to 3.0 percent by weight of said lower alkanol.
In accordance with a second aspect of the present -V- invention there is provided a method of prevention of infection of a person through direct skin contact of said person to a germ-containing surface in a washroom facility, which comprises applying a coating of an aerosol composition over said germ-containing surface at the point of expected skin contact therewith, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said germ-containing surface, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said germ-containing surface there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said germ-containing surface.
In accordance with a more preferred embodiment of this second aspect of the present invention there is provided a method of prevention of infection of a person through direct skin contact of said person to a toilet seat, which comprises applying a coating of an aerosol composition over said toilet seat at the point of expected skin contact therewith, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said toilet seat, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat.
In accordance with a further aspect of the present invention there is provided a purse- or pocket-sized cleansing unit which contains a pressurized toilet seat aerosol composition capable of being ejected at a distance of from about six inches to two feet from said pressurized container, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said toilet seat, said aerosol composition containing a disinfectant, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat. The following examples illustrate the invention: EXAMPLE I
An aerosol composition is prepared with a 4 percent Chlorhexidine gluconate in an ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
EXAMPLE II
An aerosol composition is prepared with a 3 percent Chlorhexidine gluconate in an alkanol mixture of one half isopropyl alcohol and one half ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
EXAMPLE III An aerosol composition is prepared with a 2 percent Chlorhexidine gluconate in an ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats. EXAMPLE IV
An aerosol composition is prepared with a 4 percent Chlorhexidine gluconate in an isopropanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
EXAMPLE V An aerosol composition is prepared with a 1 percent Chlorhexidine gluconate in an ethanol solution, together with conventional aerosol spray adjuvants, to provide a spray to be administered to a toilet seat from a distance of about eight to ten inches. A brief spray of this aerosol composition instantly kills the usual bathroom germs that are found on toilet seats.
EXAMPLE VI An aerosol composition of Example 1 is useful for killing germs on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Staphylococcus aureus. The composition kills the germ and, thus, provides a surface free from the germ such that bodily contact with the surface is undertaken without fear of germicidal contamination. EXAMPLE VII
An aerosol composition of Example 2 is useful for killing germs on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Pseudomonas aeruginosa. The composition kills the germ and, thus, provides a surface free from the germ such that bodily contact with the surface is undertaken without fear of germicidal contamination.
EXAMPLE VIII An aerosol composition of Example 3 is useful for killing germs on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with
Salmonella choleraesuis. The composition kills the germ and, thus, provides a surface free from the germ such that bodily contact with the surface is undertaken without fear of germicidal contamination.
EXAMPLE IX
An aerosol composition of Example 4 is useful for killing viruses on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Herpes simplex virus type I. The composition kills the virus and, thus, provides a surface free from the virus such that bodily contact with the surface is undertaken without fear of virucidal contamination. EXAMPLE X
An aerosol composition of Example 5 is useful for killing viruses on surfaces where they proliferate. Such an aerosol composition is sprayed onto a surface contaminated with Herpes simplex virus type II. The composition kills the virus and, thus, provides a surface free from the virus such that bodily contact with the surface is undertaken without fear of virucidal contamination.

Claims

WHAT IS CLAIMED IS: 1. A toilet seat cleansing unit which comprises a pressurized container housing a toilet seat aerosol composition capable of being ejected at a distance of from about six inches to two feet from said pressurized container, said aerosol composition being suitable for prophylaxis against infections of persons coming into direct physical contact with said toilet seat, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat.
2. A toilet seat cleansing unit containing an aerosol composition of claim 1, wherein said lower alkanol is isopropyl alcohol.
3. A toilet seat cleansing unit containing an aerosol composition of claim 1, wherein said lower alkanol is ethanol.
4. A toilet seat cleansing unit containing an aerosol composition of claim 1, wherein said lower alkanol is a mixture of about one part isopropyl alcohol and one part ethanol.
5. A toilet seat cleansing unit containing an aerosol composition of claim 1, wherein said Chlorhexidine gluconate is present in amount of about 0.1 to 3.0 percent by weight of said lower alkanol.
6. A method of prevention of infection of a person through direct skin contact of said person to a germ- containing surface in a washroom facility, which comprises applying a coating of an aerosol composition over said germ- containing surface at the point of expected skin contact therewith, said aerosol composition being suitable for prophylaxis against infections of persons coming into direct physiσal contact with said germ-containing surface, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said germ-containing surface there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said germ-containing surface.
7. A method of prevention of infection of a person through direct skin contact of said person to a germ- containing surface in a washroom facility of claim 6, wherein said lower alkanol is isopropyl alcohol.
8. A method of prevention of infection of a person through direct skin contact of said person to a germ- containing surface in a washroom facility of claim 6, wherein said lower alkanol is ethanol.
9. A method of prevention of infection of a person through direct skin contact of said person to a germ- containing surface in a washroom facility of claim 6, wherein said lower alkanol is a mixture of about one part isopropyl alcohol and one part ethanol.
10. A method of prevention of infection of a person through direct skin contact of said person to a germ- containing surface in a washroom facility of claim 6, wherein said Chlorhexidine gluconate is present in an amount of about 0.1 to 3.0 percent by weight of said lower alkanol.
11. A method of prevention of infection of a person through direct skin contact of said person to a toilet seat, which comprises applying a coating of an aerosol composition over said toilet seat at the point of expected skin contact therewith, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said toilet seat, said aerosol composition comprising an aqueous lower alkanol solution with up to about 4.0 percent by weight of Chlorhexidine gluconate, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat.
12. A method of prevention of infection of a person through direct skin contact of said person to a toilet seat of claim 11, wherein said lower alkanol is isopropyl alcohol.
13. A method of prevention of infection of a person through direct skin contact of said person to a toilet seat of claim 11, wherein said lower alkanol is ethanol.
14. A method of prevention of infection of a person through direct skin contact of said person to a toilet seat of claim 11, wherein said lower alkanol is a mixture of about one part isopropyl alcohol and one part ethanol.
15. A method of prevention of infection of a person through direct skin contact of said person to a germ- containing surface in a washroom facility of claim 11, wherein said Chlorhexidine—gluconate is present in an amount of about 0.1 to 3.0 percent by weight of said lower alkanol.
16. A purse- or pocket-sized cleansing unit which contains a pressurized toilet seat aerosol composition capable of being ejected at a distance of from about six inches to two feet from said pressurized container, said aerosol composition being suitable for prophylaxis against infections of persons coming into time direct physical contact with said toilet seat, said aerosol composition containing a disinfectant, whereby upon administration of said aerosol composition to said toilet seat there are rendered ineffective germs capable of otherwise topically infecting the person at the point of bodily contact with said toilet seat.
PCT/US1987/000634 1986-03-28 1987-03-26 Prophylaxis method and composition therefor WO1987005779A1 (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0257824A2 (en) * 1986-08-06 1988-03-02 Kobayashi Pharmaceutical Co. Ltd. Paper and liquid sprayer for wiping clean toilet seat
WO2006082393A1 (en) * 2005-02-01 2006-08-10 Sinclair Pharmaceuticals Limited Use of morpholino compounds for the prevention of bacterial contamination
US8603393B1 (en) * 2009-12-01 2013-12-10 Albert Charles DolceAmore Oral sanitary system for sports

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU254337A (en) * 1937-06-21 1938-07-07 McKenzie and Holland Australia Proprietary Limited Improvements relating to signal apparatus of the search light type
BE893125A (en) * 1982-05-07 1982-08-30 Gilliard Christian Disinfectant compsns. for lavatory seats - contg. germicide in aq. alcoholic vehicle
EP0099209A1 (en) * 1982-07-01 1984-01-25 JOHNSON & JOHNSON MEDICAL, INC. Aqueous disinfectant solutions having residual biocidal activity
EP0132038A1 (en) * 1983-06-09 1985-01-23 Rizla Limited Improvements in sprayable germicide materials

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU254337A (en) * 1937-06-21 1938-07-07 McKenzie and Holland Australia Proprietary Limited Improvements relating to signal apparatus of the search light type
BE893125A (en) * 1982-05-07 1982-08-30 Gilliard Christian Disinfectant compsns. for lavatory seats - contg. germicide in aq. alcoholic vehicle
EP0099209A1 (en) * 1982-07-01 1984-01-25 JOHNSON & JOHNSON MEDICAL, INC. Aqueous disinfectant solutions having residual biocidal activity
EP0132038A1 (en) * 1983-06-09 1985-01-23 Rizla Limited Improvements in sprayable germicide materials

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0257824A2 (en) * 1986-08-06 1988-03-02 Kobayashi Pharmaceutical Co. Ltd. Paper and liquid sprayer for wiping clean toilet seat
EP0257824A3 (en) * 1986-08-06 1988-12-14 Kobayashi Pharmaceutical Co. Ltd. Paper and liquid sprayer for wiping clean toilet seat
WO2006082393A1 (en) * 2005-02-01 2006-08-10 Sinclair Pharmaceuticals Limited Use of morpholino compounds for the prevention of bacterial contamination
US8999365B2 (en) 2005-02-01 2015-04-07 Sinclair Pharmaceuticals Limited Prevention of bacterial contamination
US8603393B1 (en) * 2009-12-01 2013-12-10 Albert Charles DolceAmore Oral sanitary system for sports

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