UY32888A - Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparación y uso de las mismas - Google Patents
Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparación y uso de las mismasInfo
- Publication number
- UY32888A UY32888A UY0001032888A UY32888A UY32888A UY 32888 A UY32888 A UY 32888A UY 0001032888 A UY0001032888 A UY 0001032888A UY 32888 A UY32888 A UY 32888A UY 32888 A UY32888 A UY 32888A
- Authority
- UY
- Uruguay
- Prior art keywords
- oxazolopirimidinonas
- dihydrobenzocicloalquiloximetil
- replaced
- preparation
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a una serie de dihidro-benzocicloalquiloximetil-oxazolopirimidinas sustituidas de fórmula (I): En la que n, R1, R2, R3, R4, R5 y R6 son como se define en la presente memoria. Se divulgan los métodos para preparar estos compuestos, incluyendo nuevos compuestos intermedios. Los compuestos de esta invención son moduladores de receptores metabotrópicos de glutamato (mGluR), particularmente, el receptor mGluR2 y son útiles especialmente en el tratamiento y/o prevención de una diversidad de trastornos del sistema nervioso central (SNC).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24258609P | 2009-09-15 | 2009-09-15 | |
FR1055806 | 2010-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY32888A true UY32888A (es) | 2011-04-29 |
Family
ID=43003494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001032888A UY32888A (es) | 2009-09-15 | 2010-09-15 | Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparación y uso de las mismas |
Country Status (22)
Country | Link |
---|---|
US (1) | US9051331B2 (es) |
EP (1) | EP2477994B1 (es) |
JP (1) | JP5628320B2 (es) |
KR (1) | KR101721423B1 (es) |
CN (1) | CN102498116B (es) |
AR (1) | AR078171A1 (es) |
AU (1) | AU2010295802B2 (es) |
BR (1) | BR112012005736A2 (es) |
CA (1) | CA2773555C (es) |
CO (1) | CO6511237A2 (es) |
DK (1) | DK2477994T3 (es) |
ES (1) | ES2451348T3 (es) |
IL (1) | IL218490A (es) |
MA (1) | MA33659B1 (es) |
MX (1) | MX2012002725A (es) |
NZ (1) | NZ598743A (es) |
PT (1) | PT2477994E (es) |
RU (1) | RU2543384C2 (es) |
SG (1) | SG178997A1 (es) |
TW (1) | TWI495639B (es) |
UY (1) | UY32888A (es) |
WO (1) | WO2011034830A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
MY147757A (en) | 2007-03-09 | 2013-01-15 | Sanofi Aventis | Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof |
AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
BRPI0816767B8 (pt) | 2007-09-14 | 2021-05-25 | Addex Pharmaceuticals Sa | composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos |
ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
EP2346505B1 (en) | 2008-10-16 | 2014-04-23 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
NZ596053A (en) | 2009-05-12 | 2013-05-31 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-***并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
US8993591B2 (en) | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
JP2015006994A (ja) * | 2011-10-28 | 2015-01-15 | 大正製薬株式会社 | ジヒドロイミダゾオキサゾール誘導体 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
DK3096790T3 (da) | 2014-01-21 | 2019-10-07 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
DK3431106T3 (da) | 2014-01-21 | 2021-03-15 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH517688A (de) | 1969-07-09 | 1972-01-15 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Aryloxy-essigsäurederivaten |
FR2724171B1 (fr) | 1994-09-05 | 1997-01-03 | Synthelabo | Derives de 3,3a,4,5-tetrahydro-1h-oxazolo(3,4-a)quinolein-1-one, leur preparation et leur application en therapeutique |
DE19801646A1 (de) * | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte alpha,beta-annellierte Butyrolactone |
CA2437505C (en) | 2001-02-21 | 2010-02-09 | Janssen Pharmaceutica N.V. | Isoxazoline derivatives as anti-depressants |
US7476673B2 (en) | 2003-12-30 | 2009-01-13 | Allergan, Inc. | Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors |
DE602005004287T2 (de) * | 2004-06-21 | 2008-12-24 | F. Hoffmann-La Roche Ag | Pyrrazolopyrimidinderivate |
CN101087771A (zh) | 2004-11-10 | 2007-12-12 | 辉瑞大药厂 | 经取代n-磺酰基氨基苄基-2-苯氧基乙酰胺化合物 |
MY147757A (en) * | 2007-03-09 | 2013-01-15 | Sanofi Aventis | Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof |
JP5309162B2 (ja) * | 2008-03-06 | 2013-10-09 | サノフイ | 置換されたジヒドロ、トリヒドロ及びテトラヒドロシクロアルキルオキサゾロピリミジノン、その製造及び使用 |
AR078173A1 (es) * | 2009-09-15 | 2011-10-19 | Sanofi Aventis | Bifeniloximetil dihidro oxazolopirimidinonas sustituidas, su preparacion y su uso |
AR078172A1 (es) * | 2009-09-15 | 2011-10-19 | Sanofi Aventis | Fenoximetil dihidro oxazolopirimidinonas sustituidas y uso de las mismas como moduladores de receptores metabotropicos de mglur |
-
2010
- 2010-09-13 AR ARP100103337A patent/AR078171A1/es not_active Application Discontinuation
- 2010-09-14 CA CA2773555A patent/CA2773555C/en not_active Expired - Fee Related
- 2010-09-14 ES ES10757346.1T patent/ES2451348T3/es active Active
- 2010-09-14 DK DK10757346.1T patent/DK2477994T3/en active
- 2010-09-14 JP JP2012529822A patent/JP5628320B2/ja not_active Expired - Fee Related
- 2010-09-14 RU RU2012114602/04A patent/RU2543384C2/ru not_active IP Right Cessation
- 2010-09-14 NZ NZ598743A patent/NZ598743A/xx not_active IP Right Cessation
- 2010-09-14 BR BR112012005736A patent/BR112012005736A2/pt not_active IP Right Cessation
- 2010-09-14 AU AU2010295802A patent/AU2010295802B2/en not_active Ceased
- 2010-09-14 MX MX2012002725A patent/MX2012002725A/es active IP Right Grant
- 2010-09-14 SG SG2012015491A patent/SG178997A1/en unknown
- 2010-09-14 CN CN201080041010.XA patent/CN102498116B/zh not_active Expired - Fee Related
- 2010-09-14 WO PCT/US2010/048695 patent/WO2011034830A1/en active Application Filing
- 2010-09-14 EP EP10757346.1A patent/EP2477994B1/en active Active
- 2010-09-14 PT PT107573461T patent/PT2477994E/pt unknown
- 2010-09-14 TW TW099130956A patent/TWI495639B/zh not_active IP Right Cessation
- 2010-09-14 KR KR1020127006839A patent/KR101721423B1/ko active IP Right Grant
- 2010-09-15 UY UY0001032888A patent/UY32888A/es not_active Application Discontinuation
-
2012
- 2012-03-02 US US13/410,723 patent/US9051331B2/en not_active Expired - Fee Related
- 2012-03-05 IL IL218490A patent/IL218490A/en not_active IP Right Cessation
- 2012-03-14 CO CO12044041A patent/CO6511237A2/es active IP Right Grant
- 2012-04-04 MA MA34754A patent/MA33659B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
DK2477994T3 (en) | 2014-03-17 |
IL218490A0 (en) | 2012-04-30 |
BR112012005736A2 (pt) | 2016-03-08 |
EP2477994B1 (en) | 2013-12-11 |
KR101721423B1 (ko) | 2017-03-30 |
PT2477994E (pt) | 2014-03-13 |
CA2773555C (en) | 2014-01-28 |
TW201121977A (en) | 2011-07-01 |
CA2773555A1 (en) | 2011-03-24 |
AU2010295802A1 (en) | 2012-04-05 |
AU2010295802B2 (en) | 2014-09-11 |
MX2012002725A (es) | 2013-05-28 |
IL218490A (en) | 2015-05-31 |
KR20120068005A (ko) | 2012-06-26 |
JP2013504622A (ja) | 2013-02-07 |
SG178997A1 (en) | 2012-04-27 |
US9051331B2 (en) | 2015-06-09 |
WO2011034830A1 (en) | 2011-03-24 |
ES2451348T3 (es) | 2014-03-26 |
NZ598743A (en) | 2013-02-22 |
JP5628320B2 (ja) | 2014-11-19 |
RU2012114602A (ru) | 2013-10-27 |
US20120184566A1 (en) | 2012-07-19 |
CN102498116B (zh) | 2014-08-06 |
RU2543384C2 (ru) | 2015-02-27 |
MA33659B1 (fr) | 2012-10-01 |
EP2477994A1 (en) | 2012-07-25 |
AR078171A1 (es) | 2011-10-19 |
CO6511237A2 (es) | 2012-08-31 |
CN102498116A (zh) | 2012-06-13 |
TWI495639B (zh) | 2015-08-11 |
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Legal Events
Date | Code | Title | Description |
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109 | Application deemed to be withdrawn |
Effective date: 20190222 |