UY31466A1 - MONOCLONAL ANTIBODIES THAT JOIN THE HGM-CSF AND THE MEDICAL COMPOSITIONS THAT UNDERSTAND THEM - Google Patents

MONOCLONAL ANTIBODIES THAT JOIN THE HGM-CSF AND THE MEDICAL COMPOSITIONS THAT UNDERSTAND THEM

Info

Publication number
UY31466A1
UY31466A1 UY31466A UY31466A UY31466A1 UY 31466 A1 UY31466 A1 UY 31466A1 UY 31466 A UY31466 A UY 31466A UY 31466 A UY31466 A UY 31466A UY 31466 A1 UY31466 A1 UY 31466A1
Authority
UY
Uruguay
Prior art keywords
hgm
csf
monoclonal antibodies
join
understand
Prior art date
Application number
UY31466A
Other languages
Spanish (es)
Inventor
John Park
Barbara Kistler
Kantou Nakazima
Kenzo Takada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UY31466A1 publication Critical patent/UY31466A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente revela los anticuerpos monoclonales anti-hGM-CSF y fragmentos de union al antígeno de dichos anticuerpos, con una capacidad de neutralizacion mejorada a la actividad de hGM-CSF. Asimismo, se proporcionan composiciones farmacéuticas que comprenden dicho anticuerpo o fragmento de union al antígeno. La presente invencion es util para el tratamiento de varias enfermedades que están asociadas con la expresion aberrante de hGM-CSFThe present discloses anti-hGM-CSF monoclonal antibodies and antigen binding fragments of said antibodies, with an enhanced neutralization ability to hGM-CSF activity. Also, pharmaceutical compositions comprising said antibody or antigen binding fragment are provided. The present invention is useful for the treatment of various diseases that are associated with the aberrant expression of hGM-CSF

UY31466A 2007-11-13 2008-11-12 MONOCLONAL ANTIBODIES THAT JOIN THE HGM-CSF AND THE MEDICAL COMPOSITIONS THAT UNDERSTAND THEM UY31466A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007294945 2007-11-13
JP2008052471 2008-02-14

Publications (1)

Publication Number Publication Date
UY31466A1 true UY31466A1 (en) 2009-07-17

Family

ID=40329216

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31466A UY31466A1 (en) 2007-11-13 2008-11-12 MONOCLONAL ANTIBODIES THAT JOIN THE HGM-CSF AND THE MEDICAL COMPOSITIONS THAT UNDERSTAND THEM

Country Status (32)

Country Link
US (2) US8679502B2 (en)
EP (3) EP2535353A1 (en)
KR (1) KR20100102108A (en)
CN (2) CN101970489B (en)
AR (1) AR069290A1 (en)
AU (1) AU2008321429A1 (en)
BR (1) BRPI0820530A2 (en)
CA (1) CA2705539A1 (en)
CL (1) CL2008003361A1 (en)
CO (1) CO6382188A2 (en)
DK (1) DK2215119T3 (en)
EC (1) ECSP10010251A (en)
ES (1) ES2401536T3 (en)
HK (1) HK1146729A1 (en)
HR (1) HRP20130204T1 (en)
IL (1) IL205576A0 (en)
MA (1) MA31899B1 (en)
ME (1) ME01005B (en)
MX (1) MX2010005291A (en)
NZ (2) NZ597023A (en)
PE (1) PE20091420A1 (en)
PL (1) PL2215119T3 (en)
PT (1) PT2215119E (en)
RS (1) RS52713B (en)
RU (2) RU2517596C2 (en)
SG (1) SG176499A1 (en)
SI (1) SI2215119T1 (en)
TN (1) TN2010000210A1 (en)
TW (2) TWI434854B (en)
UY (1) UY31466A1 (en)
WO (1) WO2009064399A1 (en)
ZA (1) ZA201003467B (en)

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DE102005035891A1 (en) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as pharmaceuticals
PE20080251A1 (en) 2006-05-04 2008-04-25 Boehringer Ingelheim Int USES OF DPP IV INHIBITORS
AU2008253608A1 (en) * 2007-05-23 2008-11-27 Crc For Asthma And Airways Ltd Neutralizing antibodies
WO2009062238A1 (en) * 2007-11-12 2009-05-22 Crc For Asthma And Airways Ltd Epitope for neutralizing antibodies
NZ597023A (en) 2007-11-13 2013-07-26 Boehringer Ingelheim Int Monoclonal antibodies that bind to hGM-CSF and medical compositions comprising same
PE20091730A1 (en) 2008-04-03 2009-12-10 Boehringer Ingelheim Int FORMULATIONS INVOLVING A DPP4 INHIBITOR
UY32030A (en) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "TREATMENT FOR DIABETES IN INAPPROPRIATE PATIENTS FOR THERAPY WITH METFORMIN"
MX2011002558A (en) 2008-09-10 2011-04-26 Boehringer Ingelheim Int Combination therapy for the treatment of diabetes and related conditions.
EP3056217B1 (en) * 2008-12-22 2021-06-30 The University of Melbourne Osteoarthritis treatment
KR101761324B1 (en) 2008-12-22 2017-07-25 더 유니버시티 오브 멜버른 Pain treatment
EA201991014A1 (en) 2010-06-24 2019-09-30 Бёрингер Ингельхайм Интернациональ Гмбх DIABETES TREATMENT
AR083878A1 (en) 2010-11-15 2013-03-27 Boehringer Ingelheim Int VASOPROTECTORA AND CARDIOPROTECTORA ANTIDIABETIC THERAPY, LINAGLIPTINA, TREATMENT METHOD
KR20140061379A (en) 2011-07-06 2014-05-21 모르포시스 아게 Therapeutic combinations of anti-cd20 and anti-gm-csf antibodies and uses thereof
KR20230041086A (en) 2012-09-20 2023-03-23 모르포시스 아게 Treatment for rheumatoid arthritis
AR093297A1 (en) 2012-10-31 2015-05-27 Amgen Res (Munich) Gmbh LIQUID FORMULATION THAT INCLUDES A GM-CSF NEUTRALIZING COMPOUND
US9833410B2 (en) * 2012-10-31 2017-12-05 Takeda Gmbh Lyophilized formulation comprising GM-CSF neutralizing compound
US20160024200A1 (en) * 2013-03-14 2016-01-28 John Schrader Human monoclonal antibodies that neutralize bioactivity of granulocyte macrophage colony-stimulating factor and methods and uses thereof
BR112016003293A8 (en) 2013-08-30 2022-08-16 Takeda Gmbh GM-CSF NEUTRALIZING ANTIBODIES FOR USE IN THE TREATMENT OF RHEUMATOID ARTHRITIS OR AS ANALGESICS
MX2016014411A (en) 2014-05-07 2017-04-06 Takeda Gmbh Liquid formulation comprising gm-csf neutralizing compound.
CA3036509C (en) * 2016-09-19 2022-10-25 I-Mab Anti-gm-csf antibodies and uses thereof
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EP3732203A4 (en) * 2017-12-28 2021-12-15 Nanjing Legend Biotech Co., Ltd. Antibodies and variants thereof against pd-l1
US11655293B2 (en) * 2018-02-22 2023-05-23 Universitat Zurich Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT
EP3623382A1 (en) * 2018-09-14 2020-03-18 Universität Zürich Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct

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Also Published As

Publication number Publication date
PT2215119E (en) 2013-02-11
PL2215119T3 (en) 2013-06-28
CN101970489B (en) 2014-06-11
SI2215119T1 (en) 2013-04-30
WO2009064399A1 (en) 2009-05-22
BRPI0820530A2 (en) 2015-06-16
CN101970489A (en) 2011-02-09
EP2535353A8 (en) 2013-04-03
RS52713B (en) 2013-08-30
NZ597023A (en) 2013-07-26
CN104072613A (en) 2014-10-01
EP2559706A1 (en) 2013-02-20
IL205576A0 (en) 2010-11-30
TW200927760A (en) 2009-07-01
US8679502B2 (en) 2014-03-25
ECSP10010251A (en) 2010-08-31
AR069290A1 (en) 2010-01-13
ME01005B (en) 2012-10-20
PE20091420A1 (en) 2009-10-17
RU2517596C2 (en) 2014-05-27
KR20100102108A (en) 2010-09-20
CO6382188A2 (en) 2012-02-15
US20140205611A1 (en) 2014-07-24
CL2008003361A1 (en) 2010-02-05
CA2705539A1 (en) 2009-05-22
RU2010123693A (en) 2011-12-20
AU2008321429A1 (en) 2009-05-22
RU2013141223A (en) 2015-03-20
NZ586027A (en) 2012-01-12
US20110182905A1 (en) 2011-07-28
TN2010000210A1 (en) 2011-11-11
MA31899B1 (en) 2010-12-01
DK2215119T3 (en) 2013-02-04
EP2215119A1 (en) 2010-08-11
MX2010005291A (en) 2010-11-12
EP2215119B1 (en) 2012-12-26
TW201206955A (en) 2012-02-16
TWI434854B (en) 2014-04-21
SG176499A1 (en) 2011-12-29
EP2535353A1 (en) 2012-12-19
ES2401536T3 (en) 2013-04-22
HRP20130204T1 (en) 2013-04-30
ZA201003467B (en) 2012-01-25
HK1146729A1 (en) 2011-07-08

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Effective date: 20171017