UY28533A1 - Aminoacidos con afinidad por la proteina alfa2delta - Google Patents
Aminoacidos con afinidad por la proteina alfa2deltaInfo
- Publication number
- UY28533A1 UY28533A1 UY28533A UY28533A UY28533A1 UY 28533 A1 UY28533 A1 UY 28533A1 UY 28533 A UY28533 A UY 28533A UY 28533 A UY28533 A UY 28533A UY 28533 A1 UY28533 A1 UY 28533A1
- Authority
- UY
- Uruguay
- Prior art keywords
- amino acids
- alfa2delta
- affinity
- protein
- subunit
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 108090000312 Calcium Channels Proteins 0.000 abstract 1
- 102000003922 Calcium Channels Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Neurosurgery (AREA)
- Psychiatry (AREA)
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- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
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- AIDS & HIV (AREA)
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Abstract
Se describen ciertos B-aminoácidos que se unen a la subunidad alfa- 2- delta (alfa2delta) de un canal de calcio. Estos compuestos y sus sales farmacéuticamente aceptables son útiles en el tratamiento de diversos trastornos psiquiátircos, del dolor y otros.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50595303P | 2003-09-25 | 2003-09-25 | |
US50744303P | 2003-09-30 | 2003-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY28533A1 true UY28533A1 (es) | 2005-04-29 |
Family
ID=34396281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY28533A UY28533A1 (es) | 2003-09-25 | 2004-09-24 | Aminoacidos con afinidad por la proteina alfa2delta |
Country Status (27)
Country | Link |
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US (3) | US20050124668A1 (es) |
EP (1) | EP1667957A2 (es) |
JP (2) | JP4001349B2 (es) |
KR (2) | KR20070039986A (es) |
AP (1) | AP2006003544A0 (es) |
AR (1) | AR046022A1 (es) |
AU (1) | AU2004276072A1 (es) |
BR (1) | BRPI0414781A (es) |
CA (1) | CA2540208A1 (es) |
CO (1) | CO5680413A2 (es) |
CR (1) | CR8290A (es) |
EA (1) | EA200600467A1 (es) |
EC (1) | ECSP066450A (es) |
IL (1) | IL173764A0 (es) |
IS (1) | IS8308A (es) |
MA (1) | MA28048A1 (es) |
MX (1) | MXPA06003395A (es) |
NL (2) | NL1027115C2 (es) |
NO (1) | NO20061812L (es) |
OA (1) | OA13258A (es) |
PA (1) | PA8613101A1 (es) |
PE (1) | PE20050434A1 (es) |
RS (1) | RS20060210A (es) |
TN (1) | TNSN06095A1 (es) |
TW (1) | TW200528420A (es) |
UY (1) | UY28533A1 (es) |
WO (1) | WO2005030700A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080019732A (ko) * | 2004-07-09 | 2008-03-04 | 워너-램버트 캄파니 엘엘씨 | 알파-2-델타 단백질에 대한 친화도를 갖는 베타-아미노산의제조 방법 |
BRPI0609435A2 (pt) * | 2005-03-24 | 2010-04-06 | Pharmacia & Upjohn Co Llc | preparação de beta-aminoácidos opticamente puros tendo afinidade com a proteìna alfa-2-delta |
JP2009516675A (ja) * | 2005-11-17 | 2009-04-23 | ファイザー・リミテッド | 疼痛を治療するためのイソシステイン誘導体 |
BRPI0708671A2 (pt) * | 2006-03-06 | 2011-06-07 | Pfizer Prod Inc | ligantes alfa-2-delta para sono não restaurador |
AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
EP1903027A1 (en) | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
US20110124705A1 (en) * | 2009-11-24 | 2011-05-26 | Xenoport, Inc. | Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
US20110130454A1 (en) * | 2009-11-24 | 2011-06-02 | Xenoport, Inc. | Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
WO2014069626A1 (ja) * | 2012-11-01 | 2014-05-08 | 協和発酵キリン株式会社 | ピリミドジアゼピノン化合物の製造方法 |
CA2952934A1 (en) | 2014-06-26 | 2015-12-30 | Island Breeze Systems Ca, Llc | Mdi related products and methods of use |
CN114700006B (zh) * | 2022-06-07 | 2023-03-24 | 北京先通国际医药科技股份有限公司 | 一种液体组合物的生产设备及其制备方法和用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US5578606A (en) * | 1992-10-30 | 1996-11-26 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
ATE361909T1 (de) * | 1996-10-23 | 2007-06-15 | Warner Lambert Co | Substituierte gamma-aminobuttersäurederivate als arzneimittel |
US6306909B1 (en) * | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
DE60041256D1 (de) * | 1999-06-10 | 2009-02-12 | Warner Lambert Co | Mono-substituierte 3-propyl-gamma-aminobuttersäure |
NI200300043A (es) * | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
US7419981B2 (en) * | 2002-08-15 | 2008-09-02 | Pfizer Inc. | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor |
GB0219024D0 (en) * | 2002-08-15 | 2002-09-25 | Pfizer Ltd | Synergistic combinations |
US20050043406A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
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- 2004-09-13 OA OA1200600094A patent/OA13258A/en unknown
- 2004-09-13 EP EP04769374A patent/EP1667957A2/en not_active Withdrawn
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