UY26708A1 - PROCESS TO PREPARE ACID 6 - (4 - CHLOROPHENYL) - 2, 2 - DIMETHYL - 7 - PHENYL - 2, 3 - DIHYDRO - 1 H - PIRROLIZIN - 5 - ILACETIC. - Google Patents

PROCESS TO PREPARE ACID 6 - (4 - CHLOROPHENYL) - 2, 2 - DIMETHYL - 7 - PHENYL - 2, 3 - DIHYDRO - 1 H - PIRROLIZIN - 5 - ILACETIC.

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Publication number
UY26708A1
UY26708A1 UY26708A UY26708A UY26708A1 UY 26708 A1 UY26708 A1 UY 26708A1 UY 26708 A UY26708 A UY 26708A UY 26708 A UY26708 A UY 26708A UY 26708 A1 UY26708 A1 UY 26708A1
Authority
UY
Uruguay
Prior art keywords
compound
formula
pirrolizin
ilacetic
chlorophenyl
Prior art date
Application number
UY26708A
Other languages
Spanish (es)
Inventor
Thomas Kammermeier
Stefan Laufer
Philipp Merckle
Striegel Hans-Gunter
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Priority to UY26708A priority Critical patent/UY26708A1/en
Publication of UY26708A1 publication Critical patent/UY26708A1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un proceso para preparar el compuesto de la fórmula I donde el compuesto de la fórmula III se hace reaccionar con cloruro de oxálico y el producto obtenido se trata con hidracina y un hidróxido de metal alcalino en presencia de una fase acuosa a temperatura elevada; luego de concluir el tratamiento, se produce un sistema trifásico por adición de un éter, obteniéndose el compuesto de la fórmula I por acidificación de la fase intermedia. La invención se refiere también a un polimorfo del compuesto de la fórmula I.The present invention relates to a process for preparing the compound of formula I where the compound of formula III is reacted with oxalic chloride and the product obtained is treated with hydrazine and an alkali metal hydroxide in the presence of an aqueous phase at elevated temperature; After concluding the treatment, a triphasic system is produced by adding an ether, obtaining the compound of formula I by acidification of the intermediate phase. The invention also relates to a polymorph of the compound of formula I.

UY26708A 2001-05-15 2001-05-15 PROCESS TO PREPARE ACID 6 - (4 - CHLOROPHENYL) - 2, 2 - DIMETHYL - 7 - PHENYL - 2, 3 - DIHYDRO - 1 H - PIRROLIZIN - 5 - ILACETIC. UY26708A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY26708A UY26708A1 (en) 2001-05-15 2001-05-15 PROCESS TO PREPARE ACID 6 - (4 - CHLOROPHENYL) - 2, 2 - DIMETHYL - 7 - PHENYL - 2, 3 - DIHYDRO - 1 H - PIRROLIZIN - 5 - ILACETIC.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UY26708A UY26708A1 (en) 2001-05-15 2001-05-15 PROCESS TO PREPARE ACID 6 - (4 - CHLOROPHENYL) - 2, 2 - DIMETHYL - 7 - PHENYL - 2, 3 - DIHYDRO - 1 H - PIRROLIZIN - 5 - ILACETIC.

Publications (1)

Publication Number Publication Date
UY26708A1 true UY26708A1 (en) 2001-07-31

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ID=38812417

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26708A UY26708A1 (en) 2001-05-15 2001-05-15 PROCESS TO PREPARE ACID 6 - (4 - CHLOROPHENYL) - 2, 2 - DIMETHYL - 7 - PHENYL - 2, 3 - DIHYDRO - 1 H - PIRROLIZIN - 5 - ILACETIC.

Country Status (1)

Country Link
UY (1) UY26708A1 (en)

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Effective date: 20140203