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Priority to UY26667ApriorityCriticalpatent/UY26667A1/en
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Compuestos de amino - pirazol que modulan y/o inhiben la actividad de kinasas proteínicas. Estos compuestos y las composiciones farmacéuticas que los contienen son capaces de mediar y/o inhibir la actividad de kinasas dependientes de la ciclina, por tanto modulando y/o inhibiendo la proliferación celular indeseada. El invento está también dirigido al uso terapéutico o profiláctico de composiciones farmacéuticas que contienen tales compuestos, y a métodos de tratamiento de cáncer además de otros estados de enfermedad asociados con angiogénesis indeseada y/o proliferación celular, tal como retinopatía diabética, glaucoma neovascular, artritis reumática y soriasis, administrando cantidades eficaces de tales compuestos.Amino-pyrazole compounds that modulate and / or inhibit the activity of protein kinases. These compounds and the pharmaceutical compositions containing them are capable of mediating and / or inhibiting the activity of cyclin-dependent kinases, thereby modulating and / or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer in addition to other disease states associated with unwanted angiogenesis and / or cell proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatic arthritis. and psoriasis, administering effective amounts of such compounds.
UY26667A2001-04-162001-04-16
COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR INHIBITING PROTEIN KINASES
UY26667A1
(en)
COMPOUNDS WITH HETEROCICLYCLE-HYDROXIMINE-FLUORENE NUCLEES AND PHARMACEUTICAL COMPOSITIONS FOR THE INHIBITION OF KINASE PROPHASES AND THE METHODS FOR USE.
Pharmaceutical composition and products comprising substituted acrylamide distamycin derivatives, taxanes and / or antimetabolites for combined tumor therapy and their use