US9504847B2 - Method for performing phototherapy - Google Patents
Method for performing phototherapy Download PDFInfo
- Publication number
- US9504847B2 US9504847B2 US12/964,779 US96477910A US9504847B2 US 9504847 B2 US9504847 B2 US 9504847B2 US 96477910 A US96477910 A US 96477910A US 9504847 B2 US9504847 B2 US 9504847B2
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- biological tissue
- supplement
- phototherapy
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- circulation
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- 238000000034 method Methods 0.000 title claims abstract description 32
- 238000001126 phototherapy Methods 0.000 title claims abstract description 19
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000013589 supplement Substances 0.000 claims abstract description 13
- 230000004089 microcirculation Effects 0.000 claims abstract description 10
- 230000017531 blood circulation Effects 0.000 claims abstract description 7
- 206010047141 Vasodilatation Diseases 0.000 claims abstract description 6
- 230000024883 vasodilation Effects 0.000 claims abstract description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 14
- 238000006552 photochemical reaction Methods 0.000 claims description 6
- 244000131360 Morinda citrifolia Species 0.000 claims description 4
- 235000017524 noni Nutrition 0.000 claims description 4
- 235000008898 Morinda citrifolia Nutrition 0.000 claims description 2
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000006 Nitroglycerin Substances 0.000 claims description 2
- 229960003116 amyl nitrite Drugs 0.000 claims description 2
- 229960003711 glyceryl trinitrate Drugs 0.000 claims description 2
- CSDTZUBPSYWZDX-UHFFFAOYSA-N n-pentyl nitrite Chemical compound CCCCCON=O CSDTZUBPSYWZDX-UHFFFAOYSA-N 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 238000011282 treatment Methods 0.000 abstract description 6
- 230000011664 signaling Effects 0.000 abstract description 3
- 210000001519 tissue Anatomy 0.000 description 16
- 230000008901 benefit Effects 0.000 description 8
- 235000020729 noni extract Nutrition 0.000 description 5
- 230000009471 action Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 239000010776 emu oil Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000250 revascularization Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
Definitions
- This invention relates to a method for performing phototherapy.
- Phototherapy is a medical and veterinary technique which uses lasers, LEDs (light emitting diodes), or other types of light sources to stimulate or inhibit cellular function. Recently, this technique has been widely used for treating soft tissue injury, chronic pain, and promoting wound healing for both human and animal targets.
- the method comprises a step of applying a supplement to the patient before/after light treatment, which produces nitric oxide in the subject biological tissue to be treated.
- the nitric oxide serves as signaling molecules to cause vasodilatation and increase blood flow and micro-circulation in the biological tissue so as to enhance the effectiveness of phototherapy.
- FIGURES where like reference numerals refer to identical or functionally similar elements throughout the separate views and which together with the detailed description below are incorporated in and form part of the specification, serve to further illustrate various embodiments and to explain various principles and advantages all in accordance with the present invention.
- FIG. 1 shows an exemplary embodiment of the improved phototherapy method.
- FIG. 1 shows an exemplary embodiment of the improved phototherapy method.
- a spray of Morinda Citrifolia (noni) plant extract 112 is applied onto the surface of the biological tissue (e.g. skin tissue) 110 .
- the noni extract 112 serves as a supplement to be absorbed by the tissue 110 and produce nitric oxide (NO), which acts as signaling molecules that cause smooth muscle surrounding blood vessels to relax, thus resulting in vasodilatation (widening of blood vessels) and increased blood flow and micro-circulation.
- NO nitric oxide
- therapeutic light 108 is applied to the biological tissue 110 for performing phototherapy.
- the therapeutic light 108 is produced by a diode laser light source 100 and delivered through an optical fiber 104 to an output wand 106 .
- the laser light source 100 may comprise a plurality of diode lasers with different output wavelengths.
- a touch-screen based user interface 102 allows the user to control the parameters (e.g. output power, wavelength, treatment time, and pulsing parameters) of the laser light source 100 .
- the output wand 106 provides further control of the power density of the therapeutic light 108 , which is applied onto the biological tissue 110 .
- the output wavelength of the laser light source 100 preferably falls in the near infrared (NIR) region so that the laser light can penetrate deeper into the tissue.
- the therapeutic light 108 produces photochemical reaction in the biological tissue 110 , e.g. up-regulation and down-regulation of adenosine triphosphate (ATP), reactive oxygen species, and nitric oxide.
- ATP adenosine triphosphate
- reactive oxygen species e.g. up-regulation and down-regulation of adenosine triphosphate (ATP), reactive oxygen species, and nitric oxide.
- the photochemical reaction in turn produces the following therapeutic effects: (i) stimulating white blood cell activity; (ii) accelerating macrophage activity, growth factor secretion and collagen synthesis; (iii) promoting revascularization and micro-circulation; (iv) increasing fibroblast numbers and collagen production; (v) accelerating epithelial cell regeneration and speeding up wound healing; (vi) increasing growth-phase-specific DNA synthesis; (vii) stimulating higher activity in cell proliferation and differentiation; (viii) increasing the intra and inter-molecular hydrogen bonding.
- nitric oxide (NO) induced increase in blood flow and micro-circulation not only speeds up toxin removal and nutrient/oxygen transportation in the biological tissue but also facilitates the transportation of the products of the photochemical reaction.
- both the tissue under direct laser illumination and the surrounding tissues can benefit from the above disclosed phototherapy effects.
- the effectiveness of the therapeutic light 108 is greatly enhanced.
- the required treatment time can be reduced.
- a noni extract 112 is applied to the biological tissue 110 after the phototherapy procedure such that the effects of phototherapy can be maintained and prolonged before next laser treatment.
- the noni extract can be mixed with other supplements, e.g. emu oil, to further enhance the effect of phototherapy. It is also possible to use a cooling agent together with the noni extract for cooling down the skin or dampening the fur of animals, thus resulting in a more comfortable treatment and avoiding laser induced tissue damage.
- other types of supplements e.g. nitroglycerin, amyl nitrite
- NO nitric oxide
- the supplement can be applied in other forms such as tablets, sprays, patches, and ointments.
- the therapeutic light can be produced by other types of light sources such as light emitting diodes (LEDs).
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/964,779 US9504847B2 (en) | 2009-12-11 | 2010-12-10 | Method for performing phototherapy |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28578909P | 2009-12-11 | 2009-12-11 | |
US12/964,779 US9504847B2 (en) | 2009-12-11 | 2010-12-10 | Method for performing phototherapy |
Publications (2)
Publication Number | Publication Date |
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US20110144726A1 US20110144726A1 (en) | 2011-06-16 |
US9504847B2 true US9504847B2 (en) | 2016-11-29 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US12/964,779 Active 2033-04-06 US9504847B2 (en) | 2009-12-11 | 2010-12-10 | Method for performing phototherapy |
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US (1) | US9504847B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11147984B2 (en) | 2020-03-19 | 2021-10-19 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11318323B2 (en) | 2018-02-23 | 2022-05-03 | GlobaLaseReach, LLC | Device for delivering precision phototherapy |
US11524173B2 (en) | 2015-07-28 | 2022-12-13 | Know Bio, Llc | Systems and methods for phototherapeutic modulation of nitric oxide |
US11654294B2 (en) | 2021-03-15 | 2023-05-23 | Know Bio, Llc | Intranasal illumination devices |
US11986666B2 (en) | 2020-03-19 | 2024-05-21 | Know Bio, Llc | Illumination devices for inducing biological effects |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10743929B2 (en) * | 2009-07-01 | 2020-08-18 | Ralph Zipper | Bulbous tipped surgical device and method for decreasing the size and/or changing the shape of pelvic tissues |
US20110004203A1 (en) * | 2009-07-01 | 2011-01-06 | Ralph Zipper | Laser Device and Method for Decreasing the Size and/or Changing the Shape of Pelvic Tissues |
US8795264B2 (en) * | 2008-07-01 | 2014-08-05 | Ralph Zipper | Method for decreasing the size and/or changing the shape of pelvic tissues |
US20150065943A1 (en) * | 2013-08-27 | 2015-03-05 | Matthew DeBow | Method to Accelerate Healing |
US10888708B2 (en) | 2015-11-11 | 2021-01-12 | Qc, Llc | Phototherapy device with real-time morphologic feedback and guidance |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5464436A (en) | 1994-04-28 | 1995-11-07 | Lasermedics, Inc. | Method of performing laser therapy |
US6454791B1 (en) | 1994-03-21 | 2002-09-24 | Marvin A. Prescott | Laser therapy for foot conditions |
US20090110712A1 (en) * | 2007-10-30 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems for use of photolyzable nitric oxide donors |
US7527737B2 (en) | 2006-05-09 | 2009-05-05 | Wang Xiangyu | Hemodialysis apparatus and methods |
-
2010
- 2010-12-10 US US12/964,779 patent/US9504847B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6454791B1 (en) | 1994-03-21 | 2002-09-24 | Marvin A. Prescott | Laser therapy for foot conditions |
US5464436A (en) | 1994-04-28 | 1995-11-07 | Lasermedics, Inc. | Method of performing laser therapy |
US7527737B2 (en) | 2006-05-09 | 2009-05-05 | Wang Xiangyu | Hemodialysis apparatus and methods |
US20090110712A1 (en) * | 2007-10-30 | 2009-04-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems for use of photolyzable nitric oxide donors |
Non-Patent Citations (2)
Title |
---|
"Connection Between Oxidative Stress, Nitric Oxide and Asymmetric Dimethylarginine in Light of Clinical and Basic Science" Toth, Janos, 2007. * |
"Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide: An Overview", Ignarro, Louis J., Napoli, Claudio, Loscalzo, Joseph, Circulation Research 2002, 90:21-28, 2002. * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11524173B2 (en) | 2015-07-28 | 2022-12-13 | Know Bio, Llc | Systems and methods for phototherapeutic modulation of nitric oxide |
US11617895B2 (en) | 2015-07-28 | 2023-04-04 | Know Bio, Llc | Systems and methods for phototherapeutic modulation of nitric oxide |
US11318323B2 (en) | 2018-02-23 | 2022-05-03 | GlobaLaseReach, LLC | Device for delivering precision phototherapy |
US11147984B2 (en) | 2020-03-19 | 2021-10-19 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11684798B2 (en) | 2020-03-19 | 2023-06-27 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11752359B2 (en) | 2020-03-19 | 2023-09-12 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11986666B2 (en) | 2020-03-19 | 2024-05-21 | Know Bio, Llc | Illumination devices for inducing biological effects |
US11654294B2 (en) | 2021-03-15 | 2023-05-23 | Know Bio, Llc | Intranasal illumination devices |
Also Published As
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US20110144726A1 (en) | 2011-06-16 |
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