US5025013A - Benzopyran derivatives, their preparation and pharmaceutical compositions containing them - Google Patents
Benzopyran derivatives, their preparation and pharmaceutical compositions containing them Download PDFInfo
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- US5025013A US5025013A US07/465,330 US46533090A US5025013A US 5025013 A US5025013 A US 5025013A US 46533090 A US46533090 A US 46533090A US 5025013 A US5025013 A US 5025013A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Definitions
- the present invention relates to new benzopyran derivatives of general formula: ##STR8## to their salts, to their preparation and to pharmaceutical compositions containing them.
- R 1 , R 2 , R 8 , R 9 , R 10 and R 11 can represent hydrogen atoms
- R 3 , R 4 , R 5 and R 6 can be hydrogen atoms or alkyloxy radicals
- R 12 to R 16 can be inter alia, hydrogen atoms or alkyloxy radicals, or 2 of these adjacent radicals can form a methylenedioxy radical,
- --NR 7 --CR 8 R 9 --CR 10 R 11 --X-- can represent a piperazinyl radical.
- R 1 represents a hydrogen or halogen atom or a hydroxy, alkyloxy, nitro, amino, alkylsulphonamido or acylamino radical
- R represents
- R 2 and R 3 which may be identical or different, represent hydrogen or halogen atoms or hydroxy, alkyl, alkyloxy, amino, alkylsulphonamido or nitro radicals, or alternatively
- R 4 is a hydrogen atom, an alkyl radical or a radical of structure: ##STR12## in which R 5 and R 6 are hydrogen or halogen atoms or an alkyloxy radical, and Q represents an acyl or alkylsulphonyl radical or a radical of structure: ##STR13## in which R 2 and R 3 are defined as above, Y represents a carbonyl or sulphonyl radical and Z represents a single bond or a methylene or imino radical, or alternatively
- n 0 or 1
- m 0 to 2
- W represents a single bond or an imino radical
- Ar represents a pyridyl, indolyl, quinolyl or 2-alkylquinolyl radical or Ar represents a phenyl radical optionally substituted with radicals R 2 and R 3 as defined above, provided that m is other than 0 when X is a nitrogen atom, or alternatively
- R 1 and/or R 2 , R 3 , R 5 or R 6 represent a halogen atom
- the letter may be selected from fluorine, chlorine, bromine or iodine.
- the alkyl or acyl radicals and portions may be linear or branched and they contain 1 to 4 carbon atoms.
- the products of general formula (I) may be obtained by the action of a product of general formula:
- Y 1 represents a halogen atom, it may be selected from chlorine and bromine atoms.
- Y 1 represents an alkylsulphonyloxy radical, it represents, in particular, a methylsulphonyloxy radical, and when it represents an arylsulphonyloxy radical, it can be, inter alia, a p-toluenesulphonyloxy radical.
- an alkali metal hydroxide or alkaline earth metal hydroxide e.g. sodium hydroxide or potassium hydroxide
- an alkali metal carbonate e.g. sodium bicarbonate, potassium carbonate
- a nitrogenous organic base such as, e.g. triethylamine
- the reaction is performed in an inert solvent such as a ketone (e.g. acetone, butanone), an ether (e.g. tetrahydrofuran or dioxane), an alcohol (e.g. methanol or ethanol), a hydrocarbon (e.g. hexane or toluene), acetonitrile, dimethylformamide or dimethyl sulphoxide, or in a mixture of such solvents, at a temperature between 20° C. and the refluxing temperature of the reaction mixture.
- a ketone e.g. acetone, butanone
- an ether e.g. tetrahydrofuran or dioxane
- an alcohol e.g. methanol or ethanol
- a hydrocarbon e.g. hexane or toluene
- acetonitrile dimethylformamide or dimethyl sulphoxide
- R 1 , R 2 and/or R 3 represent an amino radical
- R 2 and/or R 3 represent a hydroxy radical
- the protection is accomplished with any compatible group whose use and removal do not adversely effect the remainder of the molecule. It is performed, in particular, according to the methods described by T. W. Greene, Protective Groups in Organic Synthesis, A. Wiley - Interscience Publication (1981), or by McOmie, Protective Groups in Organic Chemistry, Plenum Press (1973).
- the oxidation is performed by any known method which does not adversely effect the remainder of the molecule.
- the reaction is accomplished, in particular, by means of an oxidizing agent such as an organic peracid, e.g. peracetic acid or monoperphthalic acid, in an organic solvent such as an ether (e.g. ethyl ether, tetrahydrofuran) or a chlorinated solvent (e.g. chloroform, dichloromethane), at a temperature of between 0° and 25° C.
- an oxidizing agent such as an organic peracid, e.g. peracetic acid or monoperphthalic acid
- an organic solvent such as an ether (e.g. ethyl ether, tetrahydrofuran) or a chlorinated solvent (e.g. chloroform, dichloromethane)
- a chlorinated solvent e.g. chloroform, dichloromethane
- the reaction is generally performed in the presence of a base (e.g. sodium hydroxide), in an alcohol (absolute ethanol), at a temperature of between 20° and 80° C.
- a base e.g. sodium hydroxide
- alcohol absolute ethanol
- the products of general formula (I) for which the radicals R 1 , R 2 and/or R 3 represent a hydroxy radical may also be obtained from the corresponding product of general formula (I) for which the radical R 1 , R 2 and/or R 3 to be converted represents an alkyloxy radical, by treatment in a concentrated acid medium.
- the reaction is generally performed by treatment with hydrobromic acid, or a mixture of acids, e.g. by treatment with a hydrobromic acid/acetic acid mixture, at the refluxing temperature of the reaction mixture.
- the products of general formula (I) for which R is defined as above at 1) and 2) and the symbols R 1 , R 2 and/or R 3 represent an amino or alkylsulphonamido radical, or for which R 1 represents an acylamino radical may also be obtained by catalytic hydrogenation in an acid medium of the corresponding benzopyran derivative of general formula (I) for which the radical R 1 , R 2 , and/or R 3 to be converted represents a nitro radical, and then, when it is desired to obtain a product of general formula (I) for which R 1 , R 2 and/or R 3 represent an alkylsulphonamido radical, or for which R 1 is an acylamino radical, the amino derivative obtained is converted by sulphonylation or by acylation, respectively.
- the hydrogenation is advantageously performed at a temperature of between 20° and 50° C., in an acid such as, e.g., acetic acid or hydrochloric acid, in an organic solvent such as an alcohol (e.g. methanol, ethanol, isopropanol), in a mixture of solvents or in an aqueous-organic medium (e.g. alcohol/water). It is also possible to work directly in the acid without the further addition of a solvent.
- an acid such as, e.g., acetic acid or hydrochloric acid
- organic solvent such as an alcohol (e.g. methanol, ethanol, isopropanol)
- a mixture of solvents e.g. ethanol/water
- aqueous-organic medium e.g. alcohol/water
- the reaction is optionally performed under pressure.
- the sulphonylation or acylation is accomplished, respectively, by the action of an activated form of an acid alkSO 3 H or alk'COOH (alk and alk' being alkyl radicals), in particular the acid halide (e.g. acid chloride) or anhydride, and the reaction is carried out in the presence of an acid-acceptor, e.g. a nitrogenous organic base such as a trialkylamine (e.g. triethylamine) or such as pyridine, in an inert organic solvent such as a chlorinated solvent (e.g. dichloromethane, chloroform) or an ether (e.g. ethyl ether, tetrahydrofuran), or in a mixture of these solvents, at a temperature of between -70° and +40° C.
- an acid-acceptor e.g. a nitrogenous organic base such as a trialkylamine (e.g. triethylamine) or such as pyridine
- the reaction is optionally performed under nitrogen.
- the products of general formula (I) for which R is defined as above at 1) and 3) when X is a nitrogen atom may also be prepared by the action of a halide of structure: ##STR18##
- R 2 , R 3 , W, Ar and m are defined as above and Hal is a halogen atom selected from chlorine or bromine, on a benzopyran derivative of general formula: ##STR19## in which R 1 , R' and R" are defined as above.
- R 1 , R 2 and/or R 3 denote amino or hydroxy radicals, the latter are protected prior to the reaction.
- the reaction is performed either in an organic medium, optionally in the presence of an acid-acceptor such as a nitrogenous organic base (e.g. a trialkylamine or a pyridine), in the solvent as mentioned above or a mixture of these solvents, at a temperature of between 0° and 20° C., or in an aqueous-organic medium in the presence of an alkaline condensing agent such as an alkali metal carbonate or bicarbonate or alkaline earth metal carbonate or bicarbonate, at a temperature of between 5° and 20° C.
- an acid-acceptor such as a nitrogenous organic base (e.g. a trialkylamine or a pyridine)
- an alkaline condensing agent such as an alkali metal carbonate or bicarbonate or alkaline earth metal carbonate or bicarbonate
- R when R is defined as at 2): according to the method described in French Patent M 2430, or according to the methods mentioned by Anwer Basha, Tet. Lett., 29(21), 2525 (1988);
- R when R is defined as at 3), X being a nitrogen atom and W an imino radical: from a benzylpiperazine, by application of the methods mentioned by Anwer Basha, Tet. Lett., 29(21), 2525 (1988) followed by removal of the radical protecting the piperazine;
- R when R is defined as at 5): according to the method described by A. Quevauviller et al., Ann. Pharm. Franc., 24, 39 (1966).
- the products of general formula (IX) may be obtained by the action of a halogenating agent or an activated form of an alkylsulphonic or arylsulphonic acid or a 4-(hydroxyalkyl)benzopyran of general formula ##STR22## in which R 1 , R' and R" are defined as above.
- the halogenating agents may be selected from thionyl chloride or halogenated phosphorus derivatives such as phosphorus oxychloride or phosphorus tribromide. It is also possible to react allyl bromide in the presence of N,N'-carbonyldiimidazole.
- the reaction is generally performed in the presence of a nitrogenous organic base such as triethylamine or pyridine, in an organic solvent such as a chlorinated solvent (e.g. methylene chloride) or an ether (e.g. tetrahydrofuran, dioxane), working at a temperature between 0° C. and the refluxing temperature of the reaction mixture.
- a nitrogenous organic base such as triethylamine or pyridine
- organic solvent such as a chlorinated solvent (e.g. methylene chloride) or an ether (e.g. tetrahydrofuran, dioxane)
- the products of general formula (IX) in which R 1 is a hydroxy radical may also be obtained from a product of general formula (IX) in which R 1 is an alkyloxy radical, by treatment in a concentrated acid medium.
- the reaction is performed under the conditions described above for the production of a product of general formula (I) for which R 1 represents a hydroxy radical from the corresponding product for which R 1 is an alkyloxy radical.
- the 4-(hydroxyalkyl)benzopyran derivative of general formula (XIV) may be prepared by reduction of the corresponding ester of general formula: ##STR23## in which R 1 , R' and R" are defined as above.
- the reaction is generally performed using lithium aluminum hydride in an organic solvent such as an ether (e.g. tetrahydrofuran) at a temperature of between 0° and 30° C.
- organic solvent such as an ether (e.g. tetrahydrofuran) at a temperature of between 0° and 30° C.
- ester of general formula (XVII) may be obtained by reduction of the benzopyran derivative of general formula: ##STR24## in which R 1 , R' and R" are defined as above.
- the reaction is performed by catalytic hydrogenation in the presence of palladium, in an organic solvent such as an alcohol (e.g. methanol, ethanol), at a temperature of between 10° and 50° C.
- an organic solvent such as an alcohol (e.g. methanol, ethanol), at a temperature of between 10° and 50° C.
- the benzopyran derivative of general formula (XVI) may be prepared by a WITTIG reaction, from a 4-chromanone derivative of general formula: ##STR25## in which R 1 , R' and R" are defined as above.
- the reaction is advantageously performed using ethyl diethylphosphonoacetate in the presence of sodium hydride, in an organic solvent such as an ether (e.g. tetrahydrofuran or dimethoxyethane), at a temperature between 0° C. and the refluxing temperature of the reaction mixture.
- an organic solvent such as an ether (e.g. tetrahydrofuran or dimethoxyethane)
- the 4-chromanone derivative of general formula (XVII) in which R 1 is other than hydrogen may be prepared by application of the method described by PFEIFFER et al., Chem. Ber., 58 (1954), or according to the methods described in G. P. Ellis, Heterocyclic compounds, chromenes, chromanones, and chromones, John Wiley and Sons (1977).
- the 4-chromanone derivative of general formula (XVII) in which R 1 is a fluorine atom may be prepared according to the method described in French Patent Application 2,588,860.
- the 4-chromanone derivatives of general formula (XVII) in which R 1 is an amino, alkylsulphonamido or acylamino radical may be obtained from the 4-chromanone derivative of general formula (XVII) for which R 1 is a nitro radical, by a procedure similar to the methods described for the preparation of the products of general formula (I) for which radical R 1 is defined as above.
- 2,2-Dimethyl-4-chromanone may be obtained according to the method described in Belgian Patent 844,943.
- the benzopyran derivatives of general formula (XI) may be obtained by the action of piperazine on a benzopyran derivative of general formula (IX).
- reaction is performed under the conditions described above for the reaction of the products of general formula (VIII) with the benzopyran derivatives of general formula (IX), in the presence of an excess of piperazine (2 equivalents), without further addition of an acid-acceptor.
- the enantiomers of the products according to the invention may be separated according to known methods.
- optically active derivative of general formula (XIV) is obtained by preparation of an optically active amide of general formula: ##STR26## in which R 1 , R' and R" are defined as above, separation of the isomers by chromatography, hydrolysis of the desired isomer and then reduction of the acid obtained.
- the hydrolysis of the isomer of the product of general formula (XIX) may be performed by any known method which does not adversely effect the remainder of the molecule; it is advantageous to work in an acid medium (mixtures of acetic acid and hydrochloric acid) at the refluxing temperature of the reaction mixture.
- the reduction of the acid to the alcohol is carried out according to the usual methods.
- diborane is used by way of a reducing agent, and it is advantageous to work in an ether such as tetrahydrofuran at temperatures of between 0° and 30° C.
- the product of general formula (XIX) may be prepared from the acid of general formula: ##STR27## in which R 1 , R' and R" are defined as above, by any known method for preparing an amide from an acid.
- the reaction is advantageously performed using the acid chloride of general formula (XX) (which may be prepared in situ), in an inert organic solvent such as a chlorinated solvent (e.g. dichloromethane), in the presence of an acid-acceptor agent such as a nitrogenous organic base (e.g. triethylamine), at a temperature of between 0° and 30° C.
- an inert organic solvent such as a chlorinated solvent (e.g. dichloromethane)
- an acid-acceptor agent such as a nitrogenous organic base (e.g. triethylamine)
- the acid of general formula (XX) may be obtained from the corresponding ester by any known method for obtaining an acid from an ester without affecting the remainder of the molecule.
- the acid chloride is prepared by treating the corresponding acid with thionyl chloride at the refluxing temperature of the reaction mixture.
- the new benzopyran derivatives according to the invention may be purified, where appropriate, by physical methods such as crystallization or chromatography.
- the products according to the invention may be converted to addition salts with acids.
- the salt formed precipitates after concentration, where appropriate, of the solution, and is separated by filtration, decantation or lyophilization. According to the process of the present invention, the products are generally obtained in the state of an oxalate. These salts may be liberated and converted to salts of other acids according to the usual methods.
- salts there may be mentioned the addition salts with inorganic acids (hydrochlorides, hydrobromides, sulphates, nitrates, phosphates) or organic acids (succinates, fumarates, acetates, propionates, maleates, methanesulphonates, p-toluenesulphonates, isethionates) or substitution derivatives of these compounds.
- inorganic acids hydroochlorides, hydrobromides, sulphates, nitrates, phosphates
- organic acids succinates, fumarates, acetates, propionates, maleates, methanesulphonates, p-toluenesulphonates, isethionates
- the products according to the invention exhibit anti-arrhythmic properties.
- their especially advantageous antifibrillating properties characteristic of VAUGHAN WILLIAM's class III, result in prolongation of the refractory periods.
- benzopyran derivatives according to the invention exhibit low toxicity. They have been generally shown to be non-toxic at 300 mg/kg when administered orally to mice.
- R 1 , R' and R" are hydrogen atoms, and R represents a radical as defined at 1) for which R 2 and R 3 are hydrogen atoms, or
- R represents a radical as defined at 2) for which n equals 0,
- R 4 is hydrogen atom, an alkyl radical or a radical of structure (IVa) in which R 5 and R 6 are hydrogen or halogen atoms or alkyloxy radicals and Q represents an acetyl or methylsulphonyl radical or a radical of general formula (IVb) in which Y is a carbonyl or sulphonyl radical and Z is a bond or a methylene or imino radical, and R 2 and R 3 are hydrogen or halogen atoms or alkyl or methylsulphonamido radicals, or
- R represents a radical as defined at 3) for which n equals 0, m equals 0 to 2, W is bond or an imino radical, Ar is pyridyl, indolyl or phenyl optionally substituted with a halogen atom or alkyl or alkyloxy radicals and X is a carbon or nitrogen atom, or R represents a radical as defined at 4) for which R 7 represents a hydrogen atom.
- reaction mixture is filtered through sintered glass, then, after evaporation of the solvent under reduced pressure (5.2 kPa), the oil obtained is taken up with potassium carbonate solution (5N) (10 cc) and water (40 cc) is added, and the mixture is then extracted with ethyl acetate (2 ⁇ 75 cc).
- the organic phase is then dried over magnesium sulphate and thereafter concentrated to dryness under reduced pressure.
- the evaporation residue is chromatographed on a column 2.8 cm in diameter containing silica gel (25 g), eluting with a dichloromethane/isopropanol mixture (90:10 by volume) (210 cc) and collecting 30-cc fractions.
- the fractions between 60 and 210 cc are concentrated to dryness.
- the oil obtained is taken up in the minimum amount of acetone and oxalic acid (0.39 g), dissolved in acetone, is added, the mixture is then concentrated to dryness and the product is crystallized in 2-butanone.
- N-(4-Piperidyl)-3,4-dimethoxyacetanilide may be prepared by application of the method described in French Patent M 2430, but starting with N-(1-benzyl-4-piperidyl)-3,4-dimethoxyacetanilide (8.4 g), palladium on charcoal (5%) (0.85 g) in an acetic acid/water mixture (70:30 by volume) (100 cc) and performing the hydrogenation at 60° C.
- N-(4-Piperidyl)-3,4-dimethoxyacetanilide (6.3 g) is thereby obtained in the form of a whitish powder m.p. 210° C.
- N-(1-Benzyl-4-piperidyl)-3,4-dimethoxyacetanilide may be prepared according to the method described in French Patent M 2430, but starting with N-benzyl-4-(3,4-dimethoxyanilino)piperidine (10 g) and acetic anhydride (20 cc) in acetic acid (30 cc).
- N-(1-Benzyl-4-piperidyl)-3,4-dimethoxyacetanilide (10.9 g) is thereby obtained in the form of a whitish solid, m.p. 117° C.
- N-Benzyl-4-(3,4-dimethoxyanilino)piperidine may be prepared according to the method described in French Patent M 2430, but starting with N-benzylpiperidone (37.8 g) and 3,4-dimethoxyaniline (19.2 g) in toluene (200 cc) with the addition of para-toluenesulphonic acid (0.017 g) and lithium aluminum hydride (1.4 g) in ethyl ether (200 cc).
- N-Benzyl-4-(3,4-dimethoxyanilino)piperidine (15 g) is thereby obtained in the form of a whitish solid, m.p. 66° C.
- the mixture is stirred for 3 hours 10 minutes at approximately 20° C. and then 2 hours under reflux.
- reaction mixture is then concentrated under reduced pressure (5.2 kPa) and the residue obtained is chromatographed on a column 5.5 cm in diameter containing silica gel (200 g), eluting with dichloromethane (550 cc) and collecting 100-cc fractions. The fractions between 350 and 550 cc are concentrated to dryness.
- 2-(3,4-Dihydro-2H-1-benzopyran-4-yl)ethanol may be prepared in the following manner:
- Tetrahydrofuran 500 cc is added to lithium aluminum hydride (5.96 g) and the mixture is cooled to 0° C.
- Ethyl 2-(3,4-dihydro-2H-1-benzopyran-4-yl)-ethanoate 17.25 g in tetrahydrofuran (60 cc) is then added with stirring.
- Ethyl (3,4-dihydro-2H-1-benzopyran-4-yl)ethanoate may be prepared in the following manner:
- Ethyl (E,Z)-(3,4-dihydro-2H-1-benzopyran-4-ylidene)acetate may be prepared in the following manner:
- the evaporation residue is chromatographed on a column 9 cm in diameter containing silica gel (1.6 kg), eluting with a cyclohexane/ethyl acetate mixture (90:10 by volume) (6.3 liters) and collecting 250-cc fractions. Fractions between 2.8 and 6.3 liters are concentrated to dryness.
- the oil obtained is chromatographed on a column 2.8 cm in diameter containing silica gel (25 g), eluting with dichloromethane/isopropanol mixture (90:10 by volume) and collecting 30-cc fractions.
- the fractions between 60 and 240 cc are concentrated to dryness.
- the oil obtained is dissolved in the minimum amount of acetone at 40° C. and a solution of oxalic acid (0.71 g) in acetone (10 cc) is added.
- N-(4-Piperidyl)acetanilide may be prepared according to the method described in French Patent M 2430.
- reaction mixture is filtered through sintered glass and then, after evaporation of the solvent under reduced pressure (5.2 kPa), the reaction mixture is taken up with distilled water (20 cc) and extracted with ethyl acetate (3 ⁇ 70 cc). The organic phase is then dried over magnesium sulphate and thereafter concentrated to dryness under reduced pressure (5.2 kPa).
- the residue obtained is purified by chromatography on a column 5.5 cm in diameter containing silica gel (32-63 ⁇ ) (200 g), eluting with a dichloromethane/ethanol mixture (95:5 by volume) (1.6 liters) and then a dichloromethane/ethanol mixture (90:10 volume) (4.4 liters) and collecting 200-cc fractions. The fractions between 2.6 and 4.4 liters are concentrated to dryness.
- the product obtained is dissolved in the minimum amount of acetone at 40° C. and a solution of oxalic acid (0.6 g) in acetone is added.
- the white precipitate formed is filtered off on sintered glass and then recrystallized a first time in ethanol (250 cc) and a second time in a mixture (100 cc) of ethanol and 2-butanone (75:25 by volume).
- Aluminum chloride (47 g) is added gradually in portions (5-6 g) to a solution of 1,2-dimethoxybenzene (140 cc) in dichloromethane (200 cc) and 1-benzoyl-4-piperidylpropionic acid chloride (75 g).
- reaction mixture is then heated for 9 hours to boiling and thereafter left overnight at room temperature.
- the reaction mixture is then poured into ice and, after settling has taken place and washes with distilled water, the organic phase is concentrated to dryness.
- the oil obtained is taken up with 3N sodium hydroxide solution (200 cc) and the mixture is extracted with ethyl acetate. The organic phase is separated and then, after washes with distilled water, is concentrated to dryness and the oil obtained is brought to reflux for 48 hours in 3.25N hydrochloric acid solution (1.2 liters).
- 1-Benzoyl-4-piperidylpropionic acid chloride may be prepared in the following manner:
- 1-Benzoyl-4-piperidylpropionic acid may be prepared according to the methods described in Beil., 22 (III/IV), 161 and by C. F. Koelschr, J. Am. Chem. Soc., 65, 2460 (1943).
- the reaction mixture is filtered through sintered glass and then, after evaporation of the solvent under reduced pressure (5.2 kPa), the yellow oil obtained is taken up with dichloromethane (100 cc) and washed with 20% strength ammonia solution. After washing with water, the organic phase is then dried over magnesium sulphate and thereafter concentrated to dryness under reduced pressure (5.2 kPa).
- the yellow oil obtained is purified by chromatography on a column 5.5 cm in diameter containing silica gel (63-200 ⁇ ) (100 g), eluting with a dichloromethane/ethanol mixture (95:5 by volume) (810 cc) and collecting 30-cc fractions. The fractions between 200 and 810 cc are concentrated to dryness.
- the yellow oil obtained is taken up in the minimum amount of acetone and oxalic acid (0.90 g), dissolved in acetone, is added.
- the white precipitate formed is filtered off on sintered glass and is then recrystallized in ethanol (50 cc).
- N- ⁇ 1-[2-(3,4-Dihydro-2H-1-benzopyran-4-yl)ethyl]-4-piperidyl ⁇ -N-(4-fluorophenyl)-4-fluorobenzamide acid oxalate (2 g) is thereby obtained in the form of a white powder, m.p. 150° C.
- N-(4-Fluorophenyl)-N-(4-piperidyl)-4-fluorobenzamide hydrochloride may be prepared in the following manner:
- N-(1-Benzyl-4-piperidyl)-N-(4-fluorophenyl)-4-fluorobenzamide hydrochloride (3.2 g) in 95% strength ethanol (50 cc) is hydrogenated at 60° C. at atmospheric pressure in the presence of palladium hydroxide (0.5 g). After filtration through kieselguhr and concentration to dryness under reduced pressure (5.2 kPa), N-(4-fluorophenyl)-N-(4-piperidyl)-4-fluorobenzamide hydrochloride (2.3 g) is obtained in the form of a white powder, m.p. 170° C.
- N-(1-Benzyl-4-piperidyl)-N-(4-fluorophenyl)-4-fluorobenzamide hydrochloride may be prepared in the following manner:
- N-Benzyl-4-(4-fluoroanilino)piperidine (2.8 g), dissolved in trichloromethane (30 cc), is stirred for 18 hours with 4-fluorobenzoic acid chloride (2 cc) and in the presence of triethylamine (5 cc).
- the reaction mixture is then washed twice with sodium hydroxide solution (3N) (30 cc) thereafter with water (30 cc).
- the organic phase is then dried over magnesium sulphate and thereafter concentrated under reduced pressure (5.2 kPa).
- N-(1-benzyl-4-piperidyl)-N-(4-fluorophenyl)-4-fluorobenzamide hydrochloride (3.2 g) is obtained in the form of a white powder, m.p. 210° C.
- N-Benzyl-4-(4-fluoroanilino)piperidine may be prepared in the following manner:
- N-Phenyl-N-(4-piperidyl)-4-fluorobenzamide hydrochloride is prepared as described in Example 4 for N-(4-fluorophenyl)-N-(4-piperidyl)-4-fluorobenzamide.
- N-Phenyl-N-(4-piperidyl)benzamide hydrochloride is prepared as described in Example 4 for N-(4-fluorophenyl)-N-(4-piperidyl)-4-fluorobenzamide.
- the 2-butanone is evaporated off under reduced pressure (5.2 kPa) and the residue is taken up in water (50 cc) and extracted with dichloromethane (100 cc, 2 ⁇ 50 cc). The combined organic phases are dried over magnesium sulphate and then concentrated to dryness under reduced pressure (5.2 kPa).
- the oil obtained is chromatographed on a column 4 cm in diameter containing silica gel (150 g), eluting with a dichloromethane/ethanol mixture (98:2 by volume) and collecting 25-cc fractions. The fractions between 125 and 11100 cc are concentrated to dryness.
- the oil obtained is dissolved in absolute ethanol (45 cc) and treated with oxalic acid (0.83 g) in the heated state. The product is left to crystallize at ⁇ 5° C.
- N- ⁇ 1-[2-(3,4-Dihydro-2H-1-benzopyran-4-yl)ethyl]-4-piperidyl ⁇ -N-(2,6-dimethylphenyl)-4-fluorobenzamide acid oxalate (3.75 g) is thereby obtained in the form of a white solid, m.p. 205° C.
- N-(2,6-Dimethylphenyl)-N-(4-piperidyl)-4-fluorobenzamide may be prepared in the following manner:
- the ethanol is evaporated off under reduced pressure (5.2 kPa).
- the solid obtained is taken up in water (50 cc), treated with 10N sodium hydroxide (2.5 cc) and extracted with dichloromethane (7 ⁇ 50 cc).
- the combined organic phases are concentrated to dryness under reduced pressure (5.2 kPa).
- N-(2,6-Dimethylphenyl)-N-(4-piperidyl)-4-fluorobenzamide (6.6 g) is obtained in the form of a brown oil.
- N-(2,6-Dimethylphenyl)-N-(1-benzyl-4-piperidyl)-4-fluorobenzamide may be prepared in the following manner:
- Triethylamine (4.5 cc) and then 4-fluorobenzoic acid chloride (3.1 cc) are added to a solution of N-(2,6-dimethylphenyl)-N-(1-benzyl-4-piperidyl)amine (6.5 g) in trichloromethane (100 cc) while the temperature is maintained at ⁇ 25° C. After 30 minutes, water (100 cc) is poured in, and then after 16 hours, settling is allowed to take place and the aqueous phase is re-extracted with trichloromethane (2 ⁇ 50 cc). The combined organic phases are dried over magnesium sulphate and then concentrated to dryness under reduced pressure (5.2 kPa).
- the oil obtained is chromatographed on a column 6 cm in diameter containing silica gel (500 g), eluting first with a dichloromethane/ethanol mixture (98:2 by volume) (2750 cc) and then with the same solvent mixture (95:5 by volume). 125-cc fractions are collected. The fractions between 3500 and 4500 cc are concentrated to dryness. N-(1-Benzyl-4-piperidyl)-N-(2,6-dimethylphenyl)-4-fluorobenzamide (8.7 g) is obtained in the form of a brown resin.
- N-(2,6-Dimethylphenyl)-N-(1-benzyl-4-piperidyl)amine may be prepared in the following manner:
- 2,6-Dimethylaniline (14.8 cc) is added during 2 hours to a solution of N-benzyl-4-piperidone (18.9 g) in toluene (100 cc), collecting the water formed using a Dean and Stark apparatus.
- the toluene is evaporated off under reduced pressure (5.2 kPa).
- the oil obtained is dissolved in methanol (100 cc) and added to a mixture of sodium cyanoborohydride (12.65 g) and zinc chloride (13.6 g) in methanol (150 cc), at a temperature below 20° C. After 2 hours at 20° C., 10N sodium hydroxide solution (50 cc) is poured in, water (100 cc) is added and the mixture is heated to reflux for 30 minutes. It is cooled to room temperature for 16 hours and dichloromethane (200 cc) is added. The aqueous phase is separated after settling has taken place and re-extracted with dichloromethane (2 ⁇ 100 cc).
- the organic phases are combined and dried over magnesium sulphate, and then concentrated to dryness (5.2 kPa).
- the oil obtained is chromatographed on a column 7 cm in diameter containing silica gel (900 g), eluting first with pure dichloromethane (2500 cc) and then with a dichloromethane/ethanol mixture (97:3 by volume) and collecting 250-cc fractions.
- the combined fractions between 7250 cc and 10,500 cc are concentrated to dryness to give N-(2,6-dimethylphenyl)-N-(1-benzyl-4-piperidyl)amine (6.5 g) in the form of a brown oil.
- the oil obtained is taken up in the minimum amount of acetone and oxalic acid (0.6 g), dissolved in acetone, is added.
- the white precipitate formed is filtered off on sintered glass and then recrystallized in ethanol (50 cc).
- N-(4-Chlorophenyl)-N-(4-piperidyl)phenylacetamide hydrochloride has been prepared in a similar manner to N-(3-chlorophenyl)-N-(4-piperidyl)phenylacetamide, Chem. Abstr., 93 132380.
- the combined organic phases are dried over dry magnesium sulphate and then concentrated to dryness under reduced pressure (5.2 kPa).
- the oil obtained is chromatographed on a column 3 cm in diameter containing silica gel (100 g), eluting with a dichloromethane/ethanol mixture (95:5 by volume) and collecting 25-cc fractions. The fractions between 150 and 950 cc are concentrated to dryness.
- the oil obtained is dissolved in ethyl acetate (30 cc) and treated with a 5N solution (1.5 cc) of hydrochloric acid in isopropanol.
- N-Isopropyl-N-(4-piperidyl)-4-fluorobenzamide hydrochloride may be prepared in the following manner:
- N-Isopropyl-N-(4-piperidyl)-4-fluorobenzamide hydrochloride (2.6 g) is thereby obtained in the form of a white solid, m.p. above 260° C.
- N-(1-Benzyl-4-piperidyl)-N-isopropyl-4-fluorobenzamide may be prepared in the following manner:
- 4-fluorobenzoic acid chloride (3.7 cc) is added to a solution of 1-benzyl-4-isopropylaminopiperidine dihydrochloride hydrate (3.83 g) and triethylamine (15 cc) in trichloromethane (50 cc). After 6 hours' stirring at 20° C., water (50 cc) is poured in and the mixture is left to stand for 16 hours. Settling is allowed to take place and the aqueous phase is extracted with trichloromethane (50 cc). The organic phases are washed with water (50 cc), then dried over magnesium sulphate and concentrated to dryness under reduced pressure (5.2 kPa).
- the oil obtained is chromatographed on a column 4 cm in diameter containing silica gel (200 g), eluting first with a dichloromethane/ethanol mixture (95:5 by volume) (1400 cc) and collecting 60-cc fractions.
- the fractions between 480 and 1980 cc are concentrated to dryness to give an ocher solid which is recrystallized in a diisopropylether/ethanol mixture (95:5 by volume) to obtain N-(1-benzyl-4-piperidyl)-N-isopropyl-4-fluorobenzamide (1.2 g) in the form of a white solid, m.p. 98° C.
- 1-Benzyl-4-isopropylaminopiperidine dihydrochloride may be prepared in the following manner:
- the solid residue obtained is taken up in the minimum amount of acetone and oxalic acid (0.6 g) dissolved in acetone, is added.
- the shite precipitate formed is filtered on sintered glass and is then recrystallized in 95% strength aqueous ethanol (150 cc).
- Example 2 The procedure is as in Example 1, but starting with 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran (2.65 g), N-(2,6-dimethylphenyl)-4-piperidineacetamide (2.46 g), dry potassium carbonate (2.76 g) and potassium iodide (1.66 g) in dry dimethylformamide (25 cc), heating for 4 hours to 60° C. The dimethylformamide is evaporated off under reduced pressure (1 kPa) and the residue is taken up in water (50 cc) which is extracted with dichloromethane (3 ⁇ 50 cc). The combined organic phases are dried over magnesium sulphate and then concentrated to dryness under reduced pressure (5 kPa).
- the solid obtained is chromatographed on a column 4 cm in diameter containing silica gel (120 g), eluting with a toluene/diethylamine mixture (95:5 by volume) and collecting 25-cc fractions. The fractions between 175 and 1000 cc are concentrated to dryness. The solid obtained is recrystallized in acetone (20 cc).
- N-(2,6-Dimethylphenyl)-4-piperidineacetamide is prepared as described in Chem. Abstr., 76, 152718x.
- the oil obtained is chromatographed on a column 4 cm in diameter containing silica gel (200 g), eluting with a toluene/diethylamine mixture (95:5 by volume) and collecting 60-cc fractions.
- the fractions between 1140 and 1500 cc are concentrated to dryness.
- the oil obtained is dissolved in absolute ethanol (20 cc) and treated with a 5N solution (2.5 cc) of hydrochloric acid in isopropanol.
- N-(Nicotinoyl)piperazine is prepared as described in Chem. Abstr., 42, 6002 g (1948).
- Example 2 The procedure is as in Example 1, but starting with 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran (2.9 g), 4-benzoylpiperidine (2.05 g), dry potassium carbonate (3 g) and potassium iodide (1.8 g) in 2-butanone (25 cc), heating for 1 hour 30 minutes.
- the butanone is evaporated off under reduced pressure (5.2 kPa) and the oil obtained is taken up in water (50 cc) which is extracted with dichloromethane (50 cc, then 2 ⁇ 25 cc).
- the combined organic phases are dried over magnesium sulphate and then concentrated to dryness under reduced pressure (5.2 kPa).
- the oil obtained is chromatographed on a column 4 cm in diameter containing silica gel (200 g), eluting with a dichloromethane/ethanol mixture (95:5 by volume) and collecting 60-cc fractions. The fractions between 360 and 1560 cc are concentrated to dryness (5.2 kPa). The oil obtained is dissolved in acetone (40 cc) and treated with a 5N solution (2.2 cc) of hydrochloric acid in isopropanol.
- Example 2 The procedure is as in Example 1, but starting with 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran (2.41 g), 4-(4-fluorobenzoyl)piperidine paratoluenesulphonate (3.8 g), dry potassium carbonate (2.75 g) and potassium iodide (1.66 g) in 2-butanone (25 cc), heating for 2 hours.
- the butanone is evaporated off under reduced pressure (5.2 kPa) and the oil obtained is taken up in water (50 cc) which is extracted with dichloromethane (50 cc, then 2 ⁇ 25 cc).
- the combined organic phases are dried over magnesium sulphate and then concentrated to dryness under reduced pressure (5.2 kPa).
- the solid obtained is dissolved in lukewarm acetone (70 cc) and treated with a 5N solution (2.1 cc) of hydrochloric acid in isopropanol.
- Hydroxylamine hydrochloride (0.3 g) is added to a solution of 4-benzoyl-1-[2-(3,4-dihydro-2H-1-benzopyran-4-yl)ethyl]piperidine hydrochloride (0.63 g) and an N solution (3.3 cc) of sodium hydroxide in absolute ethanol (20 cc), and the mixture is stirred at +20° C. for 16 hours.
- the solvents are evaporated off under reduced pressure (5.2 kPa) and the residue is taken up in water (25 cc) which is extracted with dichloromethane (3 ⁇ 25 cc).
- the combined organic phases are dried over magnesium sulphate and then concentrated to dryness under reduced pressure.
- the solid obtained is dissolved in boiling acetone (10 cc) and treated with oxalic acid (0.12 g) which is dissolved at the boil.
- Triethylamine (1.03 cc) is added to a solution, cooled to between 0° to 5° C., of 1-[2-(3,4-dihydro-2H-1-benzopyran-4-yl)ethyl]piperazine (1.64 g) in dichloromethane (25 cc), and benzenesulphonic acid chloride (0.85 cc) is then introduced dropwise.
- the residue obtained is chromatographed on a column 3 cm in diameter containing 60 g of silica gel, eluting with a dichloromethane/acetone mixture (70:30 by volume) and collecting 30-cc fractions.
- the fractions between 90 and 210 cc are concentrated to dryness under reduced pressure (5.2 kPa).
- 1-[2-(3,4-Dihydro-2H-1-benzopyran-4-yl) ethyl]piperazine may be prepared in the following manner;
- Example 2 The procedure is as in Example 1, starting with 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran (9.7 g), piperazine (10.4 g) and then potassium iodide (13.4 g) in 2-butanone (300 cc) but without the addition of potassium carbonate.
- the oil obtained is chromatographed on a column 4.4 cm in diameter containing silica gel (100 g), using a dichloromethane/ethanol/diethylamine mixture (80:18:2 by volume) as eluent. The fractions between 200 and 500 cc are concentrated to dryness.
- reaction mixture is filtered through sintered glass and the solvent is then evaporated off under reduced pressure (5.2 kPa).
- N-(2,6-Dimethylphenyl)-3-chloropropanamide may be prepared according to the method described in Beil, 12 III, 2464.
- the oil obtained is taken up with ethanol (30 cc) and a 5.5N solution (1.3 cc) of hydrochloric acid in isopropanol is added.
- N-(2,6-Dimethylphenyl)chloroacetamide may be prepared according to the method described in Beil., 12 III, 2464.
- Example 4 The procedure is as in Example 4, but starting with 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran (1.9 g), N-(4-piperidyl)-4-fluorobenzamide hydrochloride (2 g), dry potassium carbonate (2.15 g) and potassium iodide (0.95 g) in 2-butanone (60 cc).
- the yellow oil obtained is purified by chromatography on a column 4 cm in diameter containing a silica gel (110 g), eluting with a toluene/diethylamine/ethanol mixture (60:20:20 by volume) (300 cc) and collecting 30-cc fractions.
- N- ⁇ 1-[2-(3,4-dihydro-2H-1-benzopyran-4-yl)ethyl]-4-piperidyl ⁇ -4-fluorobenzamide hydrochloride (2.05 g) is obtained in the form of a crystalline white solid, m.p. 240° C.
- N-(4-Piperidyl)-4-fluorobenzamide hydrochloride may be prepared in the following manner:
- N-(1-Benzyl-4-piperidyl)-4-fluorobenzamide hydrochloride (2.70 g) in 95% strength ethanol (50 cc) are hydrogenated at 60° C. at atmospheric pressure in the presence of palladium hydroxide (0.6 g). After filtration through kiselguhr and concentration to dryness under reduced pressure (5.2 kPa), white crystals are obtained, which are used without further treatment in the next step.
- N-(1-Benzyl-4-piperidyl)-4-fluorobenzamide hydrochloride may be prepared in the following manner:
- the yellow crystals obtained are purified by chromatography on a column 4 cm in diameter containing silica gel (70 g), eluting with a toluene/diethylamine/ethanol mixture (80:10:10 by volume) (480 cc) and collecting 30 cc fractions. The fractions between 120 cc and 4800 cc are concentrated to dryness.
- the white crystals obtained are taken up with dichloromethane (20 cc) and a 3.5N solution (3 cc) of hydrochloric acid in isopropanol. N-(1-Benzyl-4-piperidyl) -4-fluorobenzamide hydrochloride (2.70 g), m.p. 236° C., is thereby obtained.
- Example 4 The procedure is as in Example 4, but starting with 4-(2-bromoethyl)-3,4-dihydro-2H-benzopyran (0.70 g), N-phenyl-N-(4-piperidyl)methanesulphonamide hydrochloride (0.75 g), dry potassium carbonate (0.75 g) and potassium iodide (0.35 g) in 2-butanone (45 cc).
- the yellow oil obtained is purified by chromatography on a column 4 cm in diameter containing silica gel (60 g), eluting with a dichloromethane/ethanol mixture (95:5 by volume) (660 cc) and collecting 30-cc fractions.
- the fractions between 120 cc and 660 cc are concentrated to dryness.
- the oil obtained is taken up with ethanol (10 cc) and fumaric acid (0.35 g), dissolved in ethanol (10 cc) is added.
- the mixture is concentrated to dryness and the crystals are washed with acetone and recrystallized in isopropanol (20 cc).
- N-Phenyl-N-(4-piperidyl)methanesulphonamide hydrochloride may be prepared in the following manner:
- N-(1-Benzyl-4-piperidyl)-N-phenylmethanesulphonamide hydrochloride (1.16 g) in 95% strength ethanol (50 cc) is hydrogenated at 60° C. at atmospheric pressure in the presence of palladium hydroxide (0.3 g).
- N-(1-Benzyl-4-piperidyl)-N-phenylmethanesulphonamide may be prepared in the following manner:
- N-(1-Benzyl-4-piperidyl)-N-phenylmethanesulphonamide (1.05 g) is thereby obtained in the form of a white solid, m.p. 125° C.
- the oil obtained is taken up in the minimum amount of ethanol and benzensulphonic acid (1 g), dissolved in ethanol, is added.
- the white precipitate formed is filtered off on sintered glass and then recrystallized in an ethanol/methanol mixture (50:50 by volume) (80 cc).
- N-Phenyl-N-(4-piperidyl)benzenesulphonamide hydrochloride may be prepared as described in Example 22 for N-phenyl-N-(4-piperidyl)methanesulphonamide.
- the present invention also relates to pharmaceutical compositions consisting of a product of general formula (I), in free form or in the form of an addition salt with a pharmaceutically acceptable acid, in the pure state or in the form of a combination with any other pharmaceutically compatible product, which can be inert or physiologically active.
- compositions according to the invention may be used orally or parenterally.
- compositions for oral administration tablets, pills, powders or granules may be used.
- the active product according to the invention (optionally combined with another pharmaceutically compatible product) is mixed with one or more inert adjuvants or diluents such as sucrose, lactose or starch.
- these compositions can also comprise substances other than diluents, for example a lubricant such as magnesium stearate.
- compositions for oral administration emulsions of a pharmaceutically acceptable nature, solutions, suspensions, syrups or elixirs containing inert diluents such as water or liquid paraffin may be used.
- inert diluents such as water or liquid paraffin
- These compositions can also comprise substances other than diluents, e.g. wetting products, sweeteners or flavourings.
- the sterile compositions for parenteral administration can preferably be solutions, aqueous or non-aqueous, suspensions or emulsions.
- a solvent or vehicle water, propylene glycol, a polyethylene glycol, vegetable oils, especially olive oil, injectable organic esters, e.g. ethyl oleate, or other suitable organic solvents may be employed.
- These compositions can also contain adjuvants, especially wetting agents, tonicity regulators, emulsifiers, dispersants and stabilizers.
- the sterilization may be carried out in several ways, e.g. be asptic filtration by incorporating sterilizing agents int he composition, by irradiation or by heating. They may also be prepared in the form of sterile solid compositions which can be dissolved at the time of use in a sterile injectable medium.
- compositions according to the invention which reduce heart rhythm disorders due to re-entry phenomena, treated or untreated, are especially useful in human therapy in treatments following myocardial infarction, as well as in chronic anginal states and ischaemic type cardiopathies.
- the doctor will determine the dosage he considers most appropriate in accordance with the age, weight and other factors characteristic of the subject to be treated.
- the doses are between 0.25 and 1.5 g per day of active product administered orally or intravenously for an adult.
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Applications Claiming Priority (2)
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FR8900657 | 1989-01-20 | ||
FR8900657A FR2642069B1 (fr) | 1989-01-20 | 1989-01-20 | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
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US5025013A true US5025013A (en) | 1991-06-18 |
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US07/465,330 Expired - Fee Related US5025013A (en) | 1989-01-20 | 1990-01-16 | Benzopyran derivatives, their preparation and pharmaceutical compositions containing them |
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US (1) | US5025013A (no) |
EP (1) | EP0379441A1 (no) |
JP (1) | JPH02233675A (no) |
KR (1) | KR900011760A (no) |
AU (1) | AU622265B2 (no) |
CA (1) | CA2008157A1 (no) |
FI (1) | FI900313A0 (no) |
FR (1) | FR2642069B1 (no) |
HU (1) | HUT58078A (no) |
NO (1) | NO900276L (no) |
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ZA (1) | ZA90387B (no) |
Cited By (24)
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US5240943A (en) * | 1991-12-19 | 1993-08-31 | G. D. Searle & Co. | Benzopyran class iii antiarrhythmic agents |
WO2001051469A1 (de) * | 2000-01-11 | 2001-07-19 | Merck Patent Gmbh | Piperidin- und piperazinderivate als 5-ht2a rezeptor antagonisten |
US20030176461A1 (en) * | 2000-04-20 | 2003-09-18 | Egle Ian R. | Aminopiperidines |
US20040106600A1 (en) * | 2002-06-24 | 2004-06-03 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
US20040147568A1 (en) * | 2002-09-04 | 2004-07-29 | Guixue Yu | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
US20040213816A1 (en) * | 2003-01-16 | 2004-10-28 | Weiner David M. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
US20050014757A1 (en) * | 2000-03-06 | 2005-01-20 | Andersson Carl-Magnus A. | Azacyclic compounds |
US20050137229A1 (en) * | 2003-06-17 | 2005-06-23 | Pfizer Inc | Novel compounds |
US20050256108A1 (en) * | 2001-12-28 | 2005-11-17 | Nathalie Schlienger | Spiroazacyclic compounds as monoamine receptor modulators |
US20050261340A1 (en) * | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
US20050288328A1 (en) * | 2004-05-21 | 2005-12-29 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
US20060094758A1 (en) * | 2002-06-24 | 2006-05-04 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
US20060111399A1 (en) * | 2004-09-27 | 2006-05-25 | Thygesen Mikkel B | Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation |
US20060199818A1 (en) * | 2002-06-24 | 2006-09-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
US20070260064A1 (en) * | 2004-09-27 | 2007-11-08 | Bo-Ragnar Tolf | Synthesis of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
US20080280879A1 (en) * | 2007-05-09 | 2008-11-13 | Pfizer Inc | Substituted heterocyclic derivatives and their pharmaceutical use and compositions |
US20090082388A1 (en) * | 2007-09-21 | 2009-03-26 | Acadia Pharmaceuticals Inc. | Co-administration of pimavanserin with other agents |
US9050343B2 (en) | 2007-03-19 | 2015-06-09 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and risperidone for the treatment of psychosis |
US10449185B2 (en) | 2017-08-30 | 2019-10-22 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
US10517860B2 (en) | 2016-03-25 | 2019-12-31 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
US10981870B2 (en) | 2015-07-20 | 2021-04-20 | Acadia Pharmaceuticals Inc. | Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form |
US11135211B2 (en) | 2017-04-28 | 2021-10-05 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
US11464768B2 (en) | 2016-12-20 | 2022-10-11 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of Alzheimer's disease psychosis |
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FR2705674B1 (fr) * | 1993-05-26 | 1996-01-05 | Smithkline Beecham Labo Pharma | Nouveaux composés et leur procédé de préparation et leur utilisation en tant que médicaments. |
JPH09501404A (ja) * | 1993-05-26 | 1997-02-10 | スミスクライン・ビーチャム・ラボラトワール・ファルマソーティク | 新規化合物 |
CA2237647A1 (en) * | 1995-12-15 | 1997-06-26 | Keith M. Devries | Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine |
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FR2618437B1 (fr) * | 1987-07-23 | 1989-11-17 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les medicaments qui les contiennent |
EP0322361A3 (de) * | 1987-12-23 | 1990-01-24 | Ciba-Geigy Ag | Weitere hydrierte 1-Benzooxacycloalkylpyridincarbonsäureverbindungen |
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- 1990-01-19 NO NO90900276A patent/NO900276L/no unknown
- 1990-01-19 FI FI900313A patent/FI900313A0/fi not_active Application Discontinuation
- 1990-01-19 PT PT92916A patent/PT92916A/pt not_active Application Discontinuation
- 1990-01-19 HU HU90206A patent/HUT58078A/hu unknown
- 1990-01-19 KR KR1019900000639A patent/KR900011760A/ko not_active Application Discontinuation
- 1990-01-19 ZA ZA90387A patent/ZA90387B/xx unknown
- 1990-01-19 AU AU48584/90A patent/AU622265B2/en not_active Expired - Fee Related
- 1990-01-19 EP EP90400153A patent/EP0379441A1/fr not_active Withdrawn
- 1990-01-19 CA CA002008157A patent/CA2008157A1/fr not_active Abandoned
- 1990-01-20 JP JP2011666A patent/JPH02233675A/ja active Pending
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Also Published As
Publication number | Publication date |
---|---|
HUT58078A (en) | 1992-01-28 |
NO900276L (no) | 1990-07-23 |
AU622265B2 (en) | 1992-04-02 |
CA2008157A1 (fr) | 1990-07-20 |
HU900206D0 (en) | 1990-03-28 |
AU4858490A (en) | 1990-07-26 |
NO900276D0 (no) | 1990-01-19 |
JPH02233675A (ja) | 1990-09-17 |
FR2642069A1 (fr) | 1990-07-27 |
FI900313A0 (fi) | 1990-01-19 |
EP0379441A1 (fr) | 1990-07-25 |
KR900011760A (ko) | 1990-08-02 |
PT92916A (pt) | 1990-07-31 |
FR2642069B1 (fr) | 1991-04-12 |
ZA90387B (en) | 1991-11-27 |
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