US3907389A - Glove box chamber - Google Patents
Glove box chamber Download PDFInfo
- Publication number
- US3907389A US3907389A US426672A US42667273A US3907389A US 3907389 A US3907389 A US 3907389A US 426672 A US426672 A US 426672A US 42667273 A US42667273 A US 42667273A US 3907389 A US3907389 A US 3907389A
- Authority
- US
- United States
- Prior art keywords
- enclosure
- access
- chamber
- opening
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/14—Incubators; Climatic chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L1/00—Enclosures; Chambers
- B01L1/02—Air-pressure chambers; Air-locks therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B25—HAND TOOLS; PORTABLE POWER-DRIVEN TOOLS; MANIPULATORS
- B25J—MANIPULATORS; CHAMBERS PROVIDED WITH MANIPULATION DEVICES
- B25J21/00—Chambers provided with manipulation devices
- B25J21/02—Glove-boxes, i.e. chambers in which manipulations are performed by the human hands in gloves built into the chamber walls; Gloves therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F7/00—Shielded cells or rooms
- G21F7/04—Shielded glove-boxes
- G21F7/047—Shielded passages; Closing or transferring means between glove-boxes
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F7/00—Shielded cells or rooms
- G21F7/04—Shielded glove-boxes
- G21F7/053—Glove mounting means
Definitions
- ABSTRACT An environmental chamber is described which enables an operators hands to have direct access within the chamber without compromising a special atmosphere within such chamber.
- a pair of sleeves of a flexible material are sealed to the chamber around associated access apertures and project outwardly from such chamber. Each aperture is closed by a door which is openable from within the sleeve associated therewith so that upon an operator inserting his hand and arm through the sleeve, the operator can open the door to have access to the interior of the chamber.
- a container which is selectively separable from the remainder of the chamber is also provided to allow objects to be transferred from the chamber without such objects having to pass through the ambient atmosphere, and an antechamber permitting objects to be passed directly into the chamber from the ambient atmosphere is included.
- the present invention relates to a chamber for maintaining an object within an isolated environment and, more particularly, to such a chamber which facilitates hand manipulation of an object so maintained from the exterior of the chamber, as. well as passage of the object into or out of the chamber without deleterious contamination from. the surrounding atmosphere.
- Small environment isolation chambers or, as they are more commonly called, :glove boxes are extensively used in research, industry and medicineto. facilitate the hand manipulation of an object of one sort or another within an isolated environment.
- glove boxes are used in clinical laboratories in connection with the culturing of anaerobic bacteria in an oxygen free atmosphere.
- rubber gloves are normally provided projecting into the chamber enclosure with their sleeve ends sealed around an opening through a wall of such enclosure. The gloves provide, in effect, aycontinuation of the chamber enclosure wall and separate not only an operators hands extended through the opening from the interior of the enclosure, but also prevent the ambient atmosphere from entering into;the enclosure through such opening. 1 t
- the rubber gloves normally have relatively thick walls in order to increase their life and reduce the chances of a leak through them.
- such thickness reduces the feel which an operator can have through the gloves for objects within the enclosure, as well as the operators manual dexterity.
- glove leaks often occur, especially in old gloves, in spite of the thickness, due to the continual flexing of the glove material and the careless handling of Sharp instruments or the like within the enclosure.
- typical laboratory glove boxes include a pass-through or preaccess chamber having both a door to the exterior and a door to the main chamber enclosurefor this purpose.
- An object to be introduced into the chamber enclosure is first placed within the pass-through enclosure and then the desired special atmosphere introduced into such passthrough enclosurebefore communication is provided between the same and the main chamber enclosure. While this procedure will assure that none of theambient atmosphere is allowed to enter the main chamber enclosure, it does not provide any protection for the object or specimen before it enters the passthrough enclosure.
- the removal of an undesired atmosphere from the pass-through enclosure prior to its communication with the main chamber is often a time-consuming operation.
- the chamber includes, as is'usual, an enclosure" for separating the object from the surrounding atmo'- sphere.
- At least one access port is provided into the en"- closure enabling admission of the hand of an operator for the desired manipulation.
- the access port includes adoor which seals the aperturein the wall of the chamber through which the operators hand is extendable, and a sleeve which is sealed to such enclosure in communication with the aperture.
- a free end portion of the sleeve extends to the exterior of the enclosure and provides a pre-access chamber for separating the hand of the operator from the ambient atmosphere prior to the opening of' the door for access of such handinto the enclosure.
- such sleeve is one of an elastic material, such as latex, which sealingly engages or grips the arm of the operator to define the pre-access chamber.
- means are most desirably provided for evacuating the pre-access chamber prior to the door opening.
- the chamber enclosure includes an access opening through its wall over which is positionable, which a slide cover slide cover is guided by slide guides along a path traversing the opening between. a closed position in which such openingiscovered and an open position in which it is exposed.
- The; container to which the object is to be transferred also includes an access opening within a wall thereof which includes slide guides complementary to the slide guides on the main enclosure to guide such container wall across the enclosure access opening to replace the slide cover thereover when the slide cover is moved to its open position.
- Such container wall thus closes the enclosure opening'and provides access between the enclosure opening and its own access opening.
- the cover over the container opening is sized to fit through the enclosure opening so that such coveris removable from the interior of the main chamber enclosure to enable the container and chamber to be simply communicated, without the container cover having to be removed from the container when the container opening is exposed to the ambient atmosphere.
- an object is movable between the closure in order to obtain a desired gas reduction is reduced.
- FIG. -l is an overall perspective view illustrating a preferred embodiment of the isolation chamber of the invention.
- FIG. 2 is a partial and broken-away elevation view of the access port providing a pre-access chamber for the hand of an operator to be introduced into the chamber;
- FIGS. 3 and 4 are elevation views, taken on planes indicated by the lines 3-3 and 44 in FIG. 2, respectively;
- FIG. 5 is a partial view similar to FIG. 2 illustrating the access port of the invention with an operators hand within the pre-access chamber defined thereby;
- FIG. 6 is an elevation view similar to FIG. 5 but illustrating the operators hand gaining access to the interior of the main chamber
- FIG. 7 is a partial perspective view illustrating the communication of a container for an object with the main chamber.
- FIGS. 8 and 9 are generally schematic, broken away perspective and elevation views, respectively, of the pass-through for the chamber of the invention.
- FIG. 1 is an overall perspective view of a chamber, generally referred to by the reference numeral 11, of the invention for defining an isolated environment for an object.
- a chamber generally referred to by the reference numeral 11, of the invention for defining an isolated environment for an object.
- such chamber includes a main, gastight enclosure 12 for separating an object to be maintained in an isolated environment from the ambient atmosphere.
- the material providing the walls of the enclosure 12 is not critical, most desirably such material is transparent, such as of a clear rigid plastic, to facilitate an operator observing manipulations within the interior of such enclosure.
- Means are provided for introducing a desired atmosphere into the enclosure 12. More particularly, such enclosure is communicated via a nipple l3 and tubular line 14 with a three-way valve 16 in a valve manifold 17.
- the input to such valve manifold is provided through line 18 to a source (not shown) of vacuum, and through line 19 to a source (also not shown) of a desiredgas or gas mixture.
- Valve 16 is similar to the other valves in the valve manifold in that it has a first position in which it communicates the vacuum source with the enclosure, a second position in which it communicates the gas supplied by line 19 with the enclosure, and a third position in which it closes line 14.
- the other valves within the manifold are communicated through suitable lines with other components of the chamber as will be described hereinafter.
- the instant invention includes a pair of access ports which enable an operator to insert both of his hands into the interior of the enclosure for manipulating an object therein, without opening the enclosure to the ambient atmosphere.
- the invention accomplishes this without requiring the use of rubber gloves with their inherent disadvantages as discussed above.
- a pair of access ports 21 and 22 are provided in the front wall 23 of the enclosure, which access ports are positioned to facilitate admission into the chamber of an operators right and left hands, respectively.
- Such access ports are essentially identical, and only one of the same, access port 22, will be described in detail.
- the access port 22 includes a circular aperture 24 through enclosure wall 23, which aperture is closed or sealed by a circular door plate 26.
- the door plate has a diameter greater than that of the aperture 24 so that the peripheral edge of such plate will overlap the aperture and provide an annular surface area which engagesthe interior surface of the wall 23 for sealing thereagainst.
- An O-ring 27 assures that such seal is a gas-tight seal.
- Locking means manipulatable from the exterior of the enclosure are provided for opening the door 26. That is, a latch bar 28 is pivotally mounted centrally of the exterior side of the door by a bolt 29 which freely passes therethrough. As is illustrated, a wing nut 31 is on the threaded end of such bolt on the exterior side of the door. As is best illustrated in FIGS. 3 and 4, the length of the latch bar 28 is greater than the diameter of the aperture 24 so that the wall 23 can be sandwiched between the door plate and the latch bar as illustrated to provide a tight seal around the periphery of such aperture. However, the aperture is provided with opposed notches 32 through which the ends of the latch bar 28 will fit to enable removal of the door into the interior of the enclosure 12.
- a sleeve 33 of a gas impermeable, flexible material has one end sealed to the enclosure in communication with the aperture 24. More particularly, an annular flange 34 is provided on the exterior side of the wall 23 projecting outwardly therefrom and circumscribing aperture 24. As is illustrated, one end of the sleeve 33 is fitted around the flange 34 and is tightly and sealingly held in position by an adjustable ring clamp 36. The sleeve 33 thus provides, in effect, a flexible extension of the flange 34.
- the sleeve 33 projects outwardly from the enclosure 12 and terminates in a free end portion 37.
- Such free end portion provides a pre-access chamber for separating the hand of an operator from the ambient atmosphere prior to the opening of the door 26 for access of such hand into the enclosure.
- the sleeve end portion 29 is most desirably of a highly elastic, as well as flexible, material such as latex rubber and has a diameter which assures that it sealingly engages the arm of an operator inserted therethrough toward the enclosure.
- Such construction of the sleeve will assure that it automatically provides a gas-tight seal about the arm of an operator inserted therein, without requiring a clamp or other structure providing a seal between the operators arm and the sleeve end portion.
- Means are provided for evacuating the pre-access chamber defined by the sleeve of its ambient pressure prior to the opening of the door 26 for access of an operators hand into the enclosure 12. That is, a threeway valve 38 in manifold 17 is communicated with a nipple 39 in flange 34 via a tubular line 41. The valve 38 enables communication of the interior of the sleeve 33 with the vacuum source, in order to remove ambient atmosphere therefrom. Because of the sleeves inherent flexibility, evacuation of its interior in this manner will result in the same being drawn around the full arm and hand of the operator, as is represented in FIG. 5 by the arrows 42.
- the pre-access chamber defined by the sleeve can then be communicated with the special atmosphere within the enclosure 12 also via the valve 38.
- the operator may then loosen the wing nut 31 and rotate the latch bar 28 from within the pre-access chamber to permit access of his hand into the chamber without concern for the integrity of the atmosphere within the enclosure. He is then free to perform desired manipulations within the enclosure.
- Such gloves can be thin and tightly fitting, such as surgical gloves, rather than the heavy rubber gloves normally associated with glove boxes. Thus, the operators dexterity and feel within the glove box will be essentially unaffected by the gloves.
- the chamber of the invention further includes a pair of essentially identical containers 43 and 44, which are especially adapted to selectively communicate with the enclosure 12.
- such containers communicate with the enclosure 12 at back walls of the enclosures which obliquely face the access ports to facilitate access of the operator's hand into such containers from within the enclosure.
- each ofthe containers 43 and 44 is rectangular in shape and includes an end wall 46 which extends beyond the side walls thereof for a purpose which will be described.
- An access opening 47 into the container is provided in the end wall 46 and is closed when the container is not in communication with the enclosure by a cover 48.
- cover 48 is illustrated in FIG. 1 within the interior of the enclosure 12 removed from the container access opening 47.
- the container access opening 47 of each of the containers is designed to communicate with a corresponding access opening 49 in a back wall panel of the enclosure 12.
- a slide cover plate 51 is provided on the exterior side of the enclosure wall for normally closing each enclosure access opening 49.
- Slide guide means are provided on the enclosure for defining a path for the slide cover traversing the enclosure access opening between a closed position covering the opening as illustrated. and an open position exposing such opening.
- Such slide guide means is in the form of a pair of parallel guide rails 52 and 53 respectively facing one another from opposite sides of the enclosure access opening 49.
- Such guide rails define with the wall of the enclosure to which they are secured parallel channels which receive opposite side edges of the slide cover plate 51 as shown.
- Suitable clamps such as provided by wing nut and bolt combinations 54, can be provided on each of the guide rails for clamping the cover plate tightly against the enclosure back wall to assure a gas-tight seal around the opening 49.
- the end wall 46 of each of the containers defines slide guide means which are complimentary to the slide guide rails 52 and 53 to enable such container wall to traverse the enclosure access opening 49 to replace the slide cover thereover. More particularly, the container end wall 46 has an outer periphery substantially the same as the outer periphery of the cover plate 48 and, in this connection, opposite and parallel side edges 56 and 57 thereof engage within the channels defined by the guide rails 52 and 53. It will be appreciated that with this arrangement, as the slide cover plate 51 is moved, for example, downward from over the opening 49, the container can be moved downward to replace such slide cover. The downward movement of the container can be performed simultaneously with the downward movement of the slide plate so that there is essentially no time at which the access opening 47 is exposed to the atmosphere ambient to the chamber.
- the face of the container wall 46 which slides against the enclosure wall is provided with substantially the same geometry as the face of the slide cover plate 51 which also slides against such enclosure wall.
- the container wall is provided with a recess at the container access opening within which the container cover 48 fits to provide the container cover with a smooth planar surface when the cover is on the container.
- Means are also provided for both maintaining each container in position over its associated enclosure access opening and holding the cover plate 51 in its open position. More particularly, a stop bar 80 extends transversely between the guide rails 52 and 53.
- a central slot 82 in the stop bar is engaged by a limit pin 61 projecting from the cover plate adjacent its top edge, when the cover plate is in its lowered position.
- the container bottom wall also engages the stop bar in order to prevent further downward movement of the container.
- container opening 47 is smaller than enclosure opening 49 so that the cover 48 for the container is removable through the enclosure opening into the enclosure.
- the integrity of the atmosphere within the interior of the container can be maintained until such time as the container is in position to provide access between it and the enclosure.
- the container cover is replaced on its opening and then as such container is moved upward for disengagement from the enclosure, the enclosure opening door is moved upward to close the enclosure opening.
- the container is provided with a suitable nipple 59 which can be communicated through line 58 with one of the valves of the manifold 17. Such communication allows the container to be evacuated of any ambient or other undesired atmosphere therein prior to the time such container is communicated with the enclosure 12.
- the environmental chamber of the invention includes an improved pass-through or antechamber for introducing objects into enclosure 12 without opening the latter to the ambient atmosphere.
- an antechamber 62 is provided exteriorly of the main enclosure 12 and communicating therewith through a selectively closable post 63 adapted for passage of an object it is desired to introduce into the enclosure.
- port 63 is closed via a door 64 which is hinged adjacent its bottom for swinging operation.
- Suitable clamps such as those schematically illustrated at 65, are provided for sealing the door closed.
- Another door 66 is also provided, closing an opening providing access to the interior of the antechamber from its exterior and, thus, also from the exterior of the main enclosure 12.
- Suitable clamps 65 operable from the exterior of the chamber are also provided for sealing door 66 closed.
- Means are also provided for evacuating antechamber 62 when the doors 64 and 66 are closed.
- a nipple 67 in the top wall of the antechamber is provided communicating through a gas line 68 with a valve 69 of manifold 17.
- the antechamber 62 is of a generally conventional nature.
- an object to be introduced into the main enclosure 12 is first introduced into the antechamber through the door 66 at a time when the door 63 is closed so that the main chamber is not communicated through the antechamber with the ambient atmosphere.
- the ambient atmosphere within the antechamber is evacuated.
- Such evacuation is achieved by reducing the pressure in the antechamber via the valve 69 and the vacuum source and then, if desired, introducing into such antechamber the special atmosphere which is within the container 12.
- the door 64 can be opened from the interior of such antechamber 12 to enable the object to be passed from the antechamber into the main enclosure.
- the antechamber 62 of the invention includes means for substantially reducing the time involved in such operation. More particularly, as can best be seen from the schematic illustrations in FIGS. 8 and 9, a pair of inflatable bags 71 and 72 are provided within the interior of the antechamber with their stems 73 and 74, respectively, communicating with the ambient atmosphere through apertures 76 and 77 in the side walls of the antechamber.
- Each of the bags provides, in effect, a wall portion of the antechamber which responds to the reduction of gas pressure therein by moving inwardly of such antechamber to reduce its volume. More particularly, because the stems 73 and 74 extend to the exterior of the antechamber, the interior of each of the bags is communicated with the ambient atmosphere. Thus, when the valve 69 is actuated to communicate the vacuum source with the interior of the antechamber and its pressure is correspondingly reduced relative to the ambient atmosphere pressure, each of the inflatable bags 71 and 72 will expand due to such difference in pressure.
- a chamber for maintaining an object in an isolated environment comprising an enclosure for separating said object from an atmosphere ambient to said chamber; and at least one access port enabling admission of the hand of an operator into said enclosure for manipulation of an object therein, said access port including a door sealing an aperture in the wall of said enclosure through which said hand is extendable into the interior of said enclosure, and a sleeve sealed to said enclosure in communication with said aperture, a free end portion of said sleeve extending to the exterior of said enclosure and providing a pre-access chamber for separating the hand of the operator from the ambient atmosphere prior to the opening of said door for access of said hand into said enclosure.
- the chamber of claim 1 further including means for evacuating said pre-access chamber of said ambient pressure prior to the opening of said door for access of said hand into said enclosure.
- the chamber of claim 4 further including means for evacuating said pre-access chamber prior to the opening of said door and wherein said door includes locking means manipulatable from within said sleeve exteriorly of said enclosure for opening the same inwardly of said enclosure, whereby said hand of said operator can open said door from said pre-access chamber for access into said enclosure.
- the chamber of claim 4 further including an antechamber for introducing said object into said enclosure without opening the same to the ambient atmosphere comprising a second enclosure exterior of said first enclosure and communicating therewith through a selectively closable port adapted for passage of said object, a door on said second enclosure to provide access thereinto for said object from the exterior of both said first and second enclosures, means for reducing the pressure of gas within said second enclosure when said port and said door are closed, and a wall portion on said second enclosure which responds to reduction of gas pressure within said second enclosure by moving inwardly of said second enclosure to reduce the volume thereof.
- a chamber for maintaining an object in an isolated environment comprising an enclosure for separating said object from an ambient atmosphere; a container for said object when it is outside of said enclosure having a cover in a wall thereof sealing an access opening therein; and means for transferring said object between said container and said enclosure without opening either said container or said enclosure to the atmosphere ambient thereto, said means including an access opening through the wall of said enclosure, a slide cover on the exterior side of said enclosure for closing said enclosure access opening, slide guide means on said enclosure defining a path for said slide cover transversing said enclosure access opening between a closed position covering said opening and an open position exposing said opening, and slide guide means on the wall of said container through which the container access opening extends complementary to said slide guide means on said enclosure for guiding said container wall traversing said enclosure access opening to replace said slide cover thereover upon said slide cover moving to said open position.
- the chamber of claim 7 further including an antechamber for introducing said object into said enclosure without opening the same to the ambient atmosphere comprising a second enclosure exterior of said first enclosure and communicating therewith through a selectively closable port adapted for passage of said object, a door on said second enclosure to provide access thereinto for said object from the exterior of both said first and second enclosures, means for reducing the pressure of gas within said second enclosure when said port and said door are closed, and a wall portion on said second enclosure which responds to reduction of gas pressure within said second enclosure by moving inwardly of said second enclosure to reduce the volume thereof.
- said enclosure further includes at least one access port enabling admission of the hand of an operator into said enclosure for manipulation of an object therein, said access port including a door sealing an aperture in the wall of said enclosure through which said hand is extendable into the interior of said enclosure and a sleeve sealed to said enclosure in communication with said aperture, a free end portion of said sleeve extending to the exterior of said enclosure and providing a pre-access chamber for separating the hand of the operator from the ambient atmosphere prior to the opening of said door for access of said hand into said enclosure.
- An antechamber for introducing an object into an enclosure defining an isolated environment without opening said enclosure to the ambient atmosphere comprising a second enclosure exterior of said first enclosure and communicating therewith through a selectively closable port adapted for passage of said object, a door on said second enclosure to provide access thereinto for said object from the'exterior of both said first and said second enclosures, means for reducing the pressure within said second enclosure when said port and said door are closed, and a wall portion of said second enclosure which responds to reduction of gas pressure within said second enclosure by moving inwardly of said enclosure to reduce the volume thereof.
- said wall portion of a flexible material is the wall of an inflatable bag, the interior of which is communicated with the ambient atmosphere for expansion of its volume into said second enclosure and a consequent reduction of the volume of said second enclosure upon said reduction of gas pressure within said second enclosure.
Abstract
Description
Claims (16)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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US426672A US3907389A (en) | 1973-12-12 | 1973-12-12 | Glove box chamber |
FR7441003A FR2254409B1 (en) | 1973-12-12 | 1974-12-12 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US426672A US3907389A (en) | 1973-12-12 | 1973-12-12 | Glove box chamber |
Publications (1)
Publication Number | Publication Date |
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US3907389A true US3907389A (en) | 1975-09-23 |
Family
ID=23691742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US426672A Expired - Lifetime US3907389A (en) | 1973-12-12 | 1973-12-12 | Glove box chamber |
Country Status (2)
Country | Link |
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US (1) | US3907389A (en) |
FR (1) | FR2254409B1 (en) |
Cited By (103)
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US4026286A (en) * | 1975-05-29 | 1977-05-31 | National Research Development Corporation | Isolators |
US4059903A (en) * | 1976-03-31 | 1977-11-29 | Futurecraft Corporation | Controlled environment work enclosure |
US4089571A (en) * | 1976-04-08 | 1978-05-16 | Landy Jerome J | Glove port and insert |
US4111753A (en) * | 1976-06-07 | 1978-09-05 | National Appliance Company | Controlled atmosphere apparatus and method of transferring specimens to same |
US4262091A (en) * | 1979-04-27 | 1981-04-14 | Anaerobe Systems | Preparation of contaminant free containers of culture medium |
US4505190A (en) * | 1982-04-19 | 1985-03-19 | Nuclear & Environmental Protection, Inc. | Portable maintenance exhaust hood |
US4566293A (en) * | 1984-12-03 | 1986-01-28 | The B. F. Goodrich Company | Method of sample preparation and apparatus therefor |
WO1986000870A1 (en) * | 1984-07-30 | 1986-02-13 | Asyst Technologies | Sealed standard interface apparatus |
US4612916A (en) * | 1983-06-06 | 1986-09-23 | Calspan Corporation | Method for treating casualties in a contaminated area |
WO1986006272A1 (en) * | 1985-04-23 | 1986-11-06 | Lone Star Medical Products, Inc. | Isolator for use in surgery |
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US4922807A (en) * | 1989-09-29 | 1990-05-08 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Ballast system for maintaining constant pressure in a glove box |
US4950222A (en) * | 1985-04-23 | 1990-08-21 | Lone Star Medical Products, Inc. | Isolator for use in surgery or as a clean room and method of using the same |
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US4995420A (en) * | 1990-08-10 | 1991-02-26 | The United States Of America As Represented By The United States Department Of Energy | Glove box valve system |
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US5380077A (en) * | 1991-07-11 | 1995-01-10 | Kaltenbach & Voigt Gmbh & Co. | Machining device for machining precision, in particular dental, workpieces in a machining chamber surrounded by a housing |
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US6383162B1 (en) | 1999-11-12 | 2002-05-07 | Paul H. Sugarbaker | Apparatus and method for abdomino-pelvic chemotherapy perfusion and lavage |
US6428122B1 (en) * | 2001-02-06 | 2002-08-06 | The United States Of America As Represented By The Secretary Of The Army | Portable glovebox and filtration system |
US20030078478A1 (en) * | 1998-12-01 | 2003-04-24 | Atropos Limited | Surgical device for retracting and/or sealing an incision |
US6620379B1 (en) | 1998-04-09 | 2003-09-16 | S.P.M. Recovery Ltd. | Apparatus and method of treatment of wounds, burns and immune system disorders |
US20030193272A1 (en) * | 2001-11-09 | 2003-10-16 | Bryan John I. | Mail handling safety system |
FR2842739A1 (en) * | 2002-07-24 | 2004-01-30 | Sylvain Bellity | Procedure for placing materials in an isolation chamber uses individually identified batches transferred in separate baskets |
US20040049100A1 (en) * | 1999-10-14 | 2004-03-11 | Atropos Limited | Retractor |
US20040060926A1 (en) * | 2001-09-14 | 2004-04-01 | Michael Weiss | Electric heating device comprising a coated heat conductor |
US20040215362A1 (en) * | 2003-04-25 | 2004-10-28 | Mamoru Kokubo | Aseptic system and method for using the same |
US20040215063A1 (en) * | 1993-09-06 | 2004-10-28 | Atropos Ltd. | Apparatus for use in surgery and a valve |
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