US3904059A - Sterile closure for solution bottles - Google Patents
Sterile closure for solution bottles Download PDFInfo
- Publication number
- US3904059A US3904059A US228027A US22802772A US3904059A US 3904059 A US3904059 A US 3904059A US 228027 A US228027 A US 228027A US 22802772 A US22802772 A US 22802772A US 3904059 A US3904059 A US 3904059A
- Authority
- US
- United States
- Prior art keywords
- disc
- plug
- rigid
- closure
- resilient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/03—Medical
Definitions
- the closure is of the type havl Field Of Searfih 215/37 ing a resilient plug mounted in the bottle neck and a 21 /25 1, 247, 341, 343, 347, 34 cap anchored to the bottle neck and overlying the pe- 220/39 riphery of the disc
- the cap retains a rigid, malleable disc in position overlying the plug.
- the rigid, malleable disc defines an an- UNITED STATES PATENTS nular ridge facing and pressing against the plug to pro- 360,!3l 3/1887 Ashby 11 215 40 a Pressure LOIOJBS ll/l9ll Mackin 215/40 2,072,853 3 1937 Baxter 215/1310.
- an elastomeric plug having open passages extending therethrough is mounted in a bottle neck.
- a resilient, latex disc overlies the elastomeric plug, and is held in position by an inner cap which grips the latex disc about its periphery.
- the inner cap has an aperture adjacent the central portion of the latex disc.
- An aluminum disc then overlies the inner cap, and is held in position by an outer cap having a tear-away feature for opening.
- Sterility is achieved by an annular ridge defined in the top periphery of the rubber plug fitting in the bottle mouth. This annular ridge presses against the underside of the latex disc to provide a circular pressure seal, which assures the sterility of the underside of the latex disc and the top portion of the rubber plug within the annular ridge.
- the aluminum disc is dished to press gently against the latex disc, there is a question in this prior art closure with respect to the sterility of the upper side of the latex disc. Accordingly, certain precautions should be taken upon opening this closure. For example, if the outer cap and aluminum disc are removed, but one wishes to puncture through the latex disc to gain entry to the contents of the container. it is desirable to swab the top of the latex disc with alcohol to prevent any traces of contamination entering the solution.
- the flange which is part of the inner cap and overlies the latex disc must be undesirably large in order to assure a sterile pressure sea]. This in turn interferes with the opening of the container in the instance when the operator removes the latex disc by pulling it laterally through a notch in the inner cap. Because of the above construction, the pulling force required to remove the latex disc is often undesirably high.
- the invention of this application provides improved solutions to the above problems.
- the closure of this invention can be used to create a sterile field not only on the bottom of the resilient latex disc of the type described above, but also on the top of the central portion of the latex disc. This permits puncturing through the latex disc without fear of contamination.
- the flange of the inner cap holding the latex disc in place can, in the closure of this invention, be narrower than in the prior art because of the presence of additional means for forming a pressure seal against the latex disc, which additional means can be removed prior to pulling the latex disc free from under the inner cap. Accordingly, the pulling f the latex disc free can be effected with less effort.
- Another commercial closure system utilizes an annular ridge defined on the outer surface of a molded elastomeric plug in a container mouth, and a flat, rigid, aluminum disc pressed against the annular ridge with a high pressure seal by a cap attached to the container mouth. A sterile area results between the plug and disc within the annular ridge.
- any small nick or other defect in the annular ridge of the plug of this prior art structure may serve to permit the entry of contamination under the aluminum disc.
- a molded elastomeric plug has a substantial likelihood of receiving a nick during handling. Also, molded articles are manufactured relatively slowly and generally in a commercial operation many dozens or hundreds of molds are used, each of which must be individually inspected with care for defects at frequent intervals.
- annular seal produced by an annular rib on a rigid, malleable disc which can be stamped to shape very rapidly on a mass production basis with a single stamping die, and which, being made of rigid metal or the like rather than elastomer, is less likely to suffer accidental nicks or dents which might endanger the sterile seal.
- the previously known closure systems are improved by forming in the rigid, malleable disc an annular rib pressing against the resilient (e.g., latex) disc or the plug directly to provide an annular pressure seal band by the focused pressure of the annular rib against the elastic plug in the bottle mouth, which pressure seal provides a sterilizable sealed area defined between the central portions of the facing sides of the resilient disc or plug and the rigid, malleable disc.
- This creates a more reliable sterile field in the closure.
- additional safety is provided to the user of the parenteral solutions.
- a sterile space results between the resilient disc or plug and the rigid disc portion within the annular rib for improved sterilization of the surfaces surrounding the space.
- FIG. 1 is a top plan view of a parenteral solution bottle equipped with one embodiment of the closure of this invention.
- FIG. 2 is a view similar to FIG. 1, but with the outer portion of the closure removed.
- FIG. 3 is a vertical fragmentary sectional view taken along line 33 of FIG. 1, showing the improved closure mounted on a bottle mouth.
- FIG. 4 is an exploded perspective view of the individual parts of the closure shown in the previous views.
- closure 10 includes resilient plug 12 having a pair of passages l4, 16 extending therethrough for communication with the interior of the bottle 18.
- Plug 12 has an annular flange 20 adjacent its outer edge for overlying the mouth of bottle 18, and an annular ridge 22 on its outer face disposed about passages l4, 16 for the purpose of providing a pressure seal against the under surface of resilient disc 24, which is typically made of latex.
- Plug 12 can have a pair of notched out portions 13 which serve to orient the stopper 12 for the automated emplacement of air tube 15.
- Plug 12 and resilient disc 24 are secured to the mouth of bottle 18 by an inner cap 26 which is one of a pair of nested, cup-shaped members comprising a cap assembly as part of said closure member.
- Inner cap 26 is bent around annular bead 28 of bottle 18 for securance to the bottle mouth, and defines an annular flange 30 which presses latex disc 24 against ridge 22 to provide a sterile pressure seal about the underside of disc 24.
- Flange 30 defines a central aperture 32 (FIG. 4) in inner cap 26 which is adjacent the central portion of resilient disc 24.
- Inner cap 26 has a cutaway portion 34 in flange 30 and a portion of the side wall of inner cap 26 to provide a site for manually gripping resilient disc 24 and pulling it away from its position overlying plug 12 without removing cap 26. Because of the improvements of this invention, flange 30 can be made of reduced width without endangering the sterile field, which makes it easier to pull resilient disc 24 laterally out of its position.
- Outer cap 36 constitutes the second cup-shaped member of the cap assembly, and overlies inner cap 26. Outer cap 36 is also bent about head 28 for securance to the bottle mouth. Cap 36 also defines an annular flange 38 which presses against the periphery of rigid, malleable disc 40, to press disc 40 with substantial pressure against resilient disc 24 and plug 12. Rigid disc 40 is held in place between the flanges of inner cap 26 and outer cap 36, and defines an annular rib 42 which is typically positioned inside of integral circular ridge 22 of plug 12, and presses with high pressure against resilient disc 24 and plug to provide a circular pressure seal which serves as an added barrier to contamination after sterilization of the closure.
- Outer cap 36 is generally pressed on the bottle 18 with a force of 200 to 280 p.s.i. for a closure about to mm. in diameter, and accordingly, the circular pressure area created by annular rib 42 focuses or concentrates the force to provide a high pressure seal having initial pressure substantially in excess of the above stated figure.
- rib 42 results in the creation of space 44, which facilitates the sterilization of the underside of rigid disc and the upper side of resilient disc 24 in their central portions.
- the portion 43 of disc 40 within rib 42 is typically coplanar with the portion 45 of disc 40 outside of rib 42, but may be dome shaped to contact tab 48 of cap 36 and thus maintain tab 48 in an exposed and accessible position.
- Outer cap 36 has an aperture 46 generally defined by flange 38.
- the two apertures 32 and 46 are occluded by rigid malleable disc 40, which is typically made of a metal such as aluminum.
- malleable it is meant that the disc can be readily stamped to form rib 42, which is the case when disc 40 is made of aluminum, steel, or an appropriate metal alloy.
- Aperture 46 is occupied by opening tab 48, which is connected by neck 50 to lines of weakness 52 for tearing outer cap 36 open in the conventional manner.
- closure of this invention is opened in the conventional manner of prior art closures by tearing off outer cap 36, removing disc 40, and then optionally grasping resilient disc 24 and pulling it through notch 34 to expose apertures l4, 16 in plug 12.
- the invention of this application typically provides a closure member having an added sterile field on the top of resilient disc 24, as well as a second sterile field along the bottom thereof, which provides an added margin of safety during use. For example, it becomes unnecessary to swab resilient disc 24 with alcohol if one desires to puncture through it to gain access to the solution in the bottle, and there is less risk of a trace of contamination being left behind as resilient disc 24 is pulled laterally through notch 34.
- a rigid disc 40 having pressure rib 42 can optionally give a more reliable sterile seal than has been previously known when the disclosed double seal configuration is used, as well as providing a reduced likelihood of failure of the seal because of the use of rigid disc 40.
- rib 42 provides more reliable sealing in the region in notch 34 where the seal between resilient disc 24 and ridge 22 is maintained only by disc 40.
- flange 30 of inner cap 26 can be made narrower in the closure of this invention, which results in easier removal of resilient disc 24 through notch 34.
- a closure for a parenteral solution container having a resilient plug mounted in a container opening, and a rigid cap assembly anchored to said container and overlying said plug, and including a separate, rigid, malleable disc held in said cap assembly in a position overlying and pressing against said plug to provide a closed, sealed cap assembly
- the improvement comprising a rigid annular rib defined in said rigid disc and cooperating with said plug to provide an annular, focused pressure seal whereby a space exists between the portion of said rigid disc within the annular rib and said plug for facilitating the sterilization of the underside of said rigid disc and other surfaces defining said space.
- a resilient plug mounted in a container opening, said plug also having an annular ridge adjacent its periphery, a resilient disc overlying the outer end of the plug and annular ridge, a rigid, cup-shaped assembly anchored to said container and overlying the periphery of said disc, said cap assembly comprising a pair of nested, cupshaped members, each of the members defining a central aperture overlying the resilient disc, a separate, rigid, malleable disc carried by said cap assembly and occluding each central aperture and overlying the resilient disc and plug, said rigid disc defining a rigid annular rib facing and pressing against said resilient disc and plug to provide a focused pressure seal by the pressure of said annular rib against said resilient disc whereby a space exists between the portion of said rigid disc within the annular rib and said resilient disc for facilitating the sterilization of the underside of said rigid disc and the upper side of said resilient disc.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Closures For Containers (AREA)
- Sealing Of Jars (AREA)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE794248D BE794248A (fr) | 1972-02-22 | Perfectionnements apportes aux fermetures steriles pour bouteilles ou flacons a solution | |
US228027A US3904059A (en) | 1972-02-22 | 1972-02-22 | Sterile closure for solution bottles |
CA161,373A CA975323A (en) | 1972-02-22 | 1973-01-16 | Sterile closure for solution bottles |
ZA730399A ZA73399B (en) | 1972-02-22 | 1973-01-19 | Hovel sterile closure for solution bottles |
AU51337/73A AU474871B2 (en) | 1972-02-22 | 1973-01-22 | Novel sterile closure for solution bottles |
JP1280373A JPS572584B2 (de) | 1972-02-22 | 1973-01-30 | |
IT20238/73A IT987012B (it) | 1972-02-22 | 1973-02-09 | Chiusura sterile per flaconi di soluzione |
ES1973188693U ES188693Y (es) | 1972-02-22 | 1973-02-13 | Cierre esteril perfeccionado de recipientes para solucionesparenterales. |
GB826173A GB1406776A (en) | 1972-02-22 | 1973-02-20 | Closure device especially for parenteral solution bottles |
DE19732308205 DE2308205A1 (de) | 1972-02-22 | 1973-02-20 | Steriler verschluss, insbesondere fuer behaelter mit parenteralen loesungen |
NO699/73A NO135355C (no) | 1972-02-22 | 1973-02-21 | Lukkeanordning for en beholder for parenteral oppl¦sning. |
IE269/73A IE37394B1 (en) | 1972-02-22 | 1973-02-21 | Closure device especially for parenteral solution bottles |
FR7306034A FR2173082B1 (de) | 1972-02-22 | 1973-02-21 | |
DK93173*#A DK132861C (da) | 1972-02-22 | 1973-02-21 | Beholderlukke for beholdere til parenterale oplosninger |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US228027A US3904059A (en) | 1972-02-22 | 1972-02-22 | Sterile closure for solution bottles |
Publications (1)
Publication Number | Publication Date |
---|---|
US3904059A true US3904059A (en) | 1975-09-09 |
Family
ID=22855443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US228027A Expired - Lifetime US3904059A (en) | 1972-02-22 | 1972-02-22 | Sterile closure for solution bottles |
Country Status (14)
Country | Link |
---|---|
US (1) | US3904059A (de) |
JP (1) | JPS572584B2 (de) |
AU (1) | AU474871B2 (de) |
BE (1) | BE794248A (de) |
CA (1) | CA975323A (de) |
DE (1) | DE2308205A1 (de) |
DK (1) | DK132861C (de) |
ES (1) | ES188693Y (de) |
FR (1) | FR2173082B1 (de) |
GB (1) | GB1406776A (de) |
IE (1) | IE37394B1 (de) |
IT (1) | IT987012B (de) |
NO (1) | NO135355C (de) |
ZA (1) | ZA73399B (de) |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4163500A (en) * | 1978-01-23 | 1979-08-07 | Siemens Aktiengesellschaft | Bottle seal |
US4243150A (en) * | 1978-01-23 | 1981-01-06 | Siemens Aktiengesellschaft | Bottle seal |
US4265364A (en) * | 1978-08-25 | 1981-05-05 | Zenyu Kinzoku Co., Ltd. | Bottle cap |
WO1984000530A1 (en) * | 1982-07-21 | 1984-02-16 | Schubert & Co A S | A closure for a container, such as an infusion bottle |
US4484916A (en) * | 1982-01-20 | 1984-11-27 | American Hospital Supply Corporation | Medical solution container and port construction |
US4501372A (en) * | 1983-03-22 | 1985-02-26 | Gerhard Hansen | Tear-open closure for a container |
US4589879A (en) * | 1983-11-04 | 1986-05-20 | Baxter Travenol Laboratories, Inc. | Cannula assembly having closed, pressure-removable piercing tip |
US4717668A (en) * | 1986-12-12 | 1988-01-05 | Baxter Travenol Laboratories, Inc. | Plastic roller bottle for suspension cultures |
US5016771A (en) * | 1990-09-04 | 1991-05-21 | J. G. Finneran Associates | Cap closure and liner |
US5016770A (en) * | 1988-04-18 | 1991-05-21 | Napoleone Rizzardi | Sealing cap especially for antibiotic, infusion and transfusion bottles |
US5332113A (en) * | 1989-11-30 | 1994-07-26 | Elan Pharmaceutical Research Corporation | Cap assembly |
US5421469A (en) * | 1993-03-02 | 1995-06-06 | Morihiro Sudo | Synthetic resin sealing cap for a fluid bottle |
US5555988A (en) * | 1994-05-04 | 1996-09-17 | Hoechst Aktiengesellschaft | Closure with tamper-indicating cap for injecton and infusion bottles |
US5573046A (en) * | 1993-12-09 | 1996-11-12 | Ciba Corning Diagnostics Corp. | Value housing for a fluid delivery system |
US5588547A (en) * | 1993-12-09 | 1996-12-31 | Carl Freudenberg | Covering developed for infusion bottle |
US5658260A (en) * | 1988-01-25 | 1997-08-19 | Baxter International Inc. | Bayonet lock cannula for pre-slit y-site |
US5776125A (en) * | 1991-07-30 | 1998-07-07 | Baxter International Inc. | Needleless vial access device |
US5797897A (en) * | 1988-01-25 | 1998-08-25 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US6193697B1 (en) | 1987-03-17 | 2001-02-27 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US6213996B1 (en) | 1988-01-25 | 2001-04-10 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US20050115917A1 (en) * | 2002-04-22 | 2005-06-02 | Tetra Laval Holdings & Finance S.A. | Sealing device, receptacle fitted with one such device and method for the production |
US20060138070A1 (en) * | 2004-12-23 | 2006-06-29 | John Domkowski | Port closure system for intravenous fluid container |
WO2008003045A3 (en) * | 2006-06-28 | 2008-12-11 | Hospira Inc | Medical fluid container |
US20090235619A1 (en) * | 2004-12-23 | 2009-09-24 | Hospira, Inc. | Medical fluid container |
US20150069008A1 (en) * | 2012-05-09 | 2015-03-12 | B. Braun Melsungern Ag | Closure cap |
EP3210670A1 (de) * | 2010-11-22 | 2017-08-30 | Corning Incorporated | Verschlussanordnung für eine zellkulturvorrichtung |
USD823115S1 (en) * | 2017-02-02 | 2018-07-17 | Simcro Limited | Dispensing top for a bottle |
ES2789151A1 (es) * | 2020-04-23 | 2020-10-23 | Pujolasos S L | Tapón reciclable para envases |
ES2935303A1 (es) * | 2021-11-02 | 2023-03-03 | Pujolasos S L | Tapón biodegradable para envases |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4211333A (en) * | 1978-06-05 | 1980-07-08 | Merck & Co., Inc. | Tamperproof container |
JPS5664961A (en) * | 1979-11-01 | 1981-06-02 | Fujisawa Pharmaceutical Co | Plug body for vial |
JPS6196684A (ja) * | 1984-10-16 | 1986-05-15 | 株式会社小糸製作所 | ランプソケツトならびにその成形方法 |
JPS61194285U (de) * | 1985-05-23 | 1986-12-03 | ||
JPH0319240Y2 (de) * | 1985-12-20 | 1991-04-23 | ||
CN102874487B (zh) * | 2011-07-12 | 2015-01-07 | 苏州伟睿达机械科技有限公司 | 瓶塞 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US360131A (en) * | 1887-03-29 | Fruit-jar | ||
US1010285A (en) * | 1911-02-06 | 1911-11-28 | Francis J Mackin | Jar-closure. |
US2072853A (en) * | 1934-12-01 | 1937-03-09 | Donald E Baxter | Closure |
US2097149A (en) * | 1932-06-04 | 1937-10-26 | Anchor Cap & Closure Corp | Closure cap and method of making the same |
US2665024A (en) * | 1951-01-15 | 1954-01-05 | Baxter Don Inc | Pharmaceutical closure |
US2757831A (en) * | 1952-12-30 | 1956-08-07 | Crown Cork & Scal Company Inc | Pouring spout |
US2969158A (en) * | 1959-03-02 | 1961-01-24 | Baxter Laboratories Inc | Parenteral solution equipment |
US3067898A (en) * | 1959-05-18 | 1962-12-11 | Baxter Laboratories Inc | Parenteral solution equipment |
US3792794A (en) * | 1971-10-04 | 1974-02-19 | Cutter Lab | Closure for containers |
-
0
- BE BE794248D patent/BE794248A/xx not_active IP Right Cessation
-
1972
- 1972-02-22 US US228027A patent/US3904059A/en not_active Expired - Lifetime
-
1973
- 1973-01-16 CA CA161,373A patent/CA975323A/en not_active Expired
- 1973-01-19 ZA ZA730399A patent/ZA73399B/xx unknown
- 1973-01-22 AU AU51337/73A patent/AU474871B2/en not_active Expired
- 1973-01-30 JP JP1280373A patent/JPS572584B2/ja not_active Expired
- 1973-02-09 IT IT20238/73A patent/IT987012B/it active
- 1973-02-13 ES ES1973188693U patent/ES188693Y/es not_active Expired
- 1973-02-20 DE DE19732308205 patent/DE2308205A1/de not_active Ceased
- 1973-02-20 GB GB826173A patent/GB1406776A/en not_active Expired
- 1973-02-21 NO NO699/73A patent/NO135355C/no unknown
- 1973-02-21 FR FR7306034A patent/FR2173082B1/fr not_active Expired
- 1973-02-21 DK DK93173*#A patent/DK132861C/da not_active IP Right Cessation
- 1973-02-21 IE IE269/73A patent/IE37394B1/xx unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US360131A (en) * | 1887-03-29 | Fruit-jar | ||
US1010285A (en) * | 1911-02-06 | 1911-11-28 | Francis J Mackin | Jar-closure. |
US2097149A (en) * | 1932-06-04 | 1937-10-26 | Anchor Cap & Closure Corp | Closure cap and method of making the same |
US2072853A (en) * | 1934-12-01 | 1937-03-09 | Donald E Baxter | Closure |
US2665024A (en) * | 1951-01-15 | 1954-01-05 | Baxter Don Inc | Pharmaceutical closure |
US2757831A (en) * | 1952-12-30 | 1956-08-07 | Crown Cork & Scal Company Inc | Pouring spout |
US2969158A (en) * | 1959-03-02 | 1961-01-24 | Baxter Laboratories Inc | Parenteral solution equipment |
US3067898A (en) * | 1959-05-18 | 1962-12-11 | Baxter Laboratories Inc | Parenteral solution equipment |
US3792794A (en) * | 1971-10-04 | 1974-02-19 | Cutter Lab | Closure for containers |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4163500A (en) * | 1978-01-23 | 1979-08-07 | Siemens Aktiengesellschaft | Bottle seal |
US4243150A (en) * | 1978-01-23 | 1981-01-06 | Siemens Aktiengesellschaft | Bottle seal |
US4265364A (en) * | 1978-08-25 | 1981-05-05 | Zenyu Kinzoku Co., Ltd. | Bottle cap |
US4484916A (en) * | 1982-01-20 | 1984-11-27 | American Hospital Supply Corporation | Medical solution container and port construction |
WO1984000530A1 (en) * | 1982-07-21 | 1984-02-16 | Schubert & Co A S | A closure for a container, such as an infusion bottle |
US4501372A (en) * | 1983-03-22 | 1985-02-26 | Gerhard Hansen | Tear-open closure for a container |
US4589879A (en) * | 1983-11-04 | 1986-05-20 | Baxter Travenol Laboratories, Inc. | Cannula assembly having closed, pressure-removable piercing tip |
US4717668A (en) * | 1986-12-12 | 1988-01-05 | Baxter Travenol Laboratories, Inc. | Plastic roller bottle for suspension cultures |
US6193697B1 (en) | 1987-03-17 | 2001-02-27 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US6261266B1 (en) | 1988-01-25 | 2001-07-17 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US6605076B1 (en) | 1988-01-25 | 2003-08-12 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US6569125B2 (en) | 1988-01-25 | 2003-05-27 | Baxter International Inc | Pre-slit injection site and tapered cannula |
US6447498B1 (en) | 1988-01-25 | 2002-09-10 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US6217568B1 (en) | 1988-01-25 | 2001-04-17 | Edwards Lifesciences Corporation | Preslit injection site and tapered cannula for blood sampling |
US5658260A (en) * | 1988-01-25 | 1997-08-19 | Baxter International Inc. | Bayonet lock cannula for pre-slit y-site |
US6213996B1 (en) | 1988-01-25 | 2001-04-10 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US5797897A (en) * | 1988-01-25 | 1998-08-25 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US5871500A (en) * | 1988-01-25 | 1999-02-16 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
US5016770A (en) * | 1988-04-18 | 1991-05-21 | Napoleone Rizzardi | Sealing cap especially for antibiotic, infusion and transfusion bottles |
US5332113A (en) * | 1989-11-30 | 1994-07-26 | Elan Pharmaceutical Research Corporation | Cap assembly |
US5016771A (en) * | 1990-09-04 | 1991-05-21 | J. G. Finneran Associates | Cap closure and liner |
US5776125A (en) * | 1991-07-30 | 1998-07-07 | Baxter International Inc. | Needleless vial access device |
US5421469A (en) * | 1993-03-02 | 1995-06-06 | Morihiro Sudo | Synthetic resin sealing cap for a fluid bottle |
US5755269A (en) * | 1993-12-09 | 1998-05-26 | Ciba Corning Diagnostics Corp. | Fluid delivery system |
US5588547A (en) * | 1993-12-09 | 1996-12-31 | Carl Freudenberg | Covering developed for infusion bottle |
US5586673A (en) * | 1993-12-09 | 1996-12-24 | Ciba Corning Diagnostics Corp. | Cap assembly for fluid delivery system |
US5586590A (en) * | 1993-12-09 | 1996-12-24 | Ciba Corning Diagnostics Corp. | Coupler for fluid delivery system |
US5573046A (en) * | 1993-12-09 | 1996-11-12 | Ciba Corning Diagnostics Corp. | Value housing for a fluid delivery system |
US5555988A (en) * | 1994-05-04 | 1996-09-17 | Hoechst Aktiengesellschaft | Closure with tamper-indicating cap for injecton and infusion bottles |
US20050115917A1 (en) * | 2002-04-22 | 2005-06-02 | Tetra Laval Holdings & Finance S.A. | Sealing device, receptacle fitted with one such device and method for the production |
US20090235619A1 (en) * | 2004-12-23 | 2009-09-24 | Hospira, Inc. | Medical fluid container |
US7530974B2 (en) * | 2004-12-23 | 2009-05-12 | Hospira, Inc. | Port closure system for intravenous fluid container |
US20090192484A1 (en) * | 2004-12-23 | 2009-07-30 | Hospira, Inc. | Port closure system for intravenous fluid container |
US20090209934A1 (en) * | 2004-12-23 | 2009-08-20 | Hospira, Inc. | Port closure system for intravenous fluid container |
US20060138070A1 (en) * | 2004-12-23 | 2006-06-29 | John Domkowski | Port closure system for intravenous fluid container |
US8034042B2 (en) | 2004-12-23 | 2011-10-11 | Hospira, Inc. | Port closure system for intravenous fluid container |
US8034041B2 (en) | 2004-12-23 | 2011-10-11 | Hospira, Inc. | Port closure system for intravenous fluid container |
US8136330B2 (en) | 2004-12-23 | 2012-03-20 | Hospira, Inc. | Medical fluid container |
WO2008003045A3 (en) * | 2006-06-28 | 2008-12-11 | Hospira Inc | Medical fluid container |
US10100273B2 (en) | 2010-11-22 | 2018-10-16 | Corning Incorporated | Closure assembly for cell culture apparatus |
EP3210670A1 (de) * | 2010-11-22 | 2017-08-30 | Corning Incorporated | Verschlussanordnung für eine zellkulturvorrichtung |
US10626362B2 (en) | 2010-11-22 | 2020-04-21 | Corning Incorporated | Closure assembly for cell culture apparatus |
US9731872B2 (en) * | 2012-05-09 | 2017-08-15 | B. Braun Melsungern Ag | Closure cap |
US20150069008A1 (en) * | 2012-05-09 | 2015-03-12 | B. Braun Melsungern Ag | Closure cap |
USD823115S1 (en) * | 2017-02-02 | 2018-07-17 | Simcro Limited | Dispensing top for a bottle |
ES2789151A1 (es) * | 2020-04-23 | 2020-10-23 | Pujolasos S L | Tapón reciclable para envases |
ES2935303A1 (es) * | 2021-11-02 | 2023-03-03 | Pujolasos S L | Tapón biodegradable para envases |
Also Published As
Publication number | Publication date |
---|---|
CA975323A (en) | 1975-09-30 |
FR2173082B1 (de) | 1977-04-22 |
IE37394L (en) | 1973-08-22 |
ES188693Y (es) | 1974-09-16 |
DK132861B (da) | 1976-02-23 |
NO135355C (no) | 1977-03-30 |
ZA73399B (en) | 1973-10-31 |
DK132861C (da) | 1976-07-26 |
AU5133773A (en) | 1974-07-25 |
IE37394B1 (en) | 1977-07-20 |
JPS4897681A (de) | 1973-12-12 |
FR2173082A1 (de) | 1973-10-05 |
NO135355B (de) | 1976-12-20 |
DE2308205A1 (de) | 1973-08-30 |
ES188693U (es) | 1974-02-16 |
JPS572584B2 (de) | 1982-01-18 |
IT987012B (it) | 1975-02-20 |
GB1406776A (en) | 1975-09-17 |
AU474871B2 (en) | 1976-08-05 |
BE794248A (fr) | 1973-05-16 |
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