US3826364B1 - - Google Patents
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- Publication number
- US3826364B1 US3826364B1 US25544372A US3826364B1 US 3826364 B1 US3826364 B1 US 3826364B1 US 25544372 A US25544372 A US 25544372A US 3826364 B1 US3826364 B1 US 3826364B1
- Authority
- US
- United States
- Prior art keywords
- cells
- drops
- nozzle
- stream
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 abstract 5
- 239000012530 fluid Substances 0.000 abstract 2
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000005286 illumination Methods 0.000 abstract 1
- 238000007689 inspection Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 230000001360 synchronised effect Effects 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/34—Sorting according to other particular properties
- B07C5/342—Sorting according to other particular properties according to optical properties, e.g. colour
- B07C5/3425—Sorting according to other particular properties according to optical properties, e.g. colour of granular material, e.g. ore particles, grain
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/36—Sorting apparatus characterised by the means used for distribution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G01N15/149—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
- G01N2015/1406—Control of droplet point
Abstract
A particle sorting method and apparatus for separating minute particles incorporated in a liquid stream in accordance with selected particle parameters. Particles such as biological cells to be separated are incorporated in the inner or central portion of a confined coaxial flow stream which includes an outer cell-free fluid sheath portion. This coaxial flow stream is released through a vibrating nozzle for inspection by one or more cell sensing means for sensing cells in the jet stream immediately downstream of the nozzle. Beam illumination and/or observation of the jet stream for particle sensing is effected outside of the nozzle. Vibration of the nozzle breaks the coaxial jet stream into a series of uniform drops downstream of the cell sensing means, and signals from said means are used to initiate delayed charging pulses applied to preselected cell-containing drops as they break from the vibrating fluid jet. Nozzle vibration is synchronized with the charging pulse to prevent separation of drops from the stream during the drop charging pulse on and off transition times, thereby preventing undesired drop charging. The drops pass between charged deflection plates where the charged drops are deflected into appropriate receptacles. By using a plurality of sensing means such that all cells are sensed by one sensor, and only certain cells, i.e. cells characterized by a particular parameter value, are sensed by another sensor, drops containing both cells characterized by a particular parameter and cells not characterized by that parameter can be sorted away from the receptacle for cells characterized by that particular parameter.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00255443A US3826364A (en) | 1972-05-22 | 1972-05-22 | Particle sorting method and apparatus |
DE2246380A DE2246380C2 (en) | 1972-05-22 | 1972-09-21 | Device for separating or sorting particles |
CA152,527A CA974193A (en) | 1972-05-22 | 1972-09-26 | Chopped stream fluidized particle sensor charger and deflector |
JP48044234A JPS49109093A (en) | 1972-05-22 | 1973-04-20 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00255443A US3826364A (en) | 1972-05-22 | 1972-05-22 | Particle sorting method and apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
US3826364A US3826364A (en) | 1974-07-30 |
US3826364B1 true US3826364B1 (en) | 1984-09-25 |
Family
ID=22968350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00255443A Expired - Lifetime US3826364A (en) | 1972-05-22 | 1972-05-22 | Particle sorting method and apparatus |
Country Status (4)
Country | Link |
---|---|
US (1) | US3826364A (en) |
JP (1) | JPS49109093A (en) |
CA (1) | CA974193A (en) |
DE (1) | DE2246380C2 (en) |
Cited By (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3963606A (en) * | 1974-06-03 | 1976-06-15 | Coulter Electronics, Inc. | Semi-automatic adjusting delay for an electronic particle separator |
US3976197A (en) * | 1974-11-22 | 1976-08-24 | Bhattacharya Bhairab C | Thermal convection counter streaming sedimentation method and apparatus for controlling the sex of mammalian offspring |
US4097373A (en) * | 1977-03-23 | 1978-06-27 | John Caldwell Allred | High speed particle sorter using a field emission electrode |
FR2397634A1 (en) * | 1977-07-16 | 1979-02-09 | Deutsches Krebsforsch | METHOD AND DEVICE FOR ANALYSIS OF THE FLUORESCENCE OF COLORED PARTICLES, IN PARTICULAR OF BIOLOGICAL CELLS |
US4148718A (en) * | 1976-06-10 | 1979-04-10 | Coulter Electronics, Inc. | Single drop separator |
US4175662A (en) * | 1977-04-12 | 1979-11-27 | Tibor Zold | Method and device for sorting particles suspended in an electrolyte |
US4230558A (en) * | 1978-10-02 | 1980-10-28 | Coulter Electronics, Inc. | Single drop separator |
US4279345A (en) * | 1979-08-03 | 1981-07-21 | Allred John C | High speed particle sorter using a field emission electrode |
US4317520A (en) * | 1979-08-20 | 1982-03-02 | Ortho Diagnostics, Inc. | Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus |
US4318483A (en) * | 1979-08-20 | 1982-03-09 | Ortho Diagnostics, Inc. | Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system |
US4318482A (en) * | 1979-08-20 | 1982-03-09 | Ortho Diagnostics, Inc. | Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system |
US4318481A (en) * | 1979-08-20 | 1982-03-09 | Ortho Diagnostics, Inc. | Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter |
US4318480A (en) * | 1979-08-20 | 1982-03-09 | Ortho Diagnostics, Inc. | Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device |
US4325483A (en) * | 1979-08-20 | 1982-04-20 | Ortho Diagnostics, Inc. | Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus |
US4347935A (en) * | 1979-05-16 | 1982-09-07 | The United States Of America As Represented By The United States Department Of Energy | Method and apparatus for electrostatically sorting biological cells |
US4367043A (en) * | 1980-05-05 | 1983-01-04 | Leland Stanford Junior University | Method and means for delivering liquid samples to a sample scanning device |
US4395397A (en) * | 1981-09-17 | 1983-07-26 | Sidney Farber Cancer Institute, Inc. | Apparatus and method for killing unwanted cells |
FR2543298A1 (en) * | 1983-03-24 | 1984-09-28 | Coulter Corp | DEVICE FOR ANALYZING AND SORTING PARTICLES |
US4487320A (en) * | 1980-11-03 | 1984-12-11 | Coulter Corporation | Method of and apparatus for detecting change in the breakoff point in a droplet generation system |
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US4499052A (en) * | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
FR2557977A1 (en) * | 1984-01-06 | 1985-07-12 | Us Energy | APPARATUS FOR REMOVING BACKGROUND NOISE INTERFERENCE IN FLUORESCENCE MEASUREMENTS |
US4538733A (en) * | 1983-10-14 | 1985-09-03 | Becton, Dickinson And Company | Particle sorter with neutralized collection wells and method of using same |
US4545677A (en) * | 1984-03-05 | 1985-10-08 | Becton, Dickinson And Company | Prismatic beam expander for light beam shaping in a flow cytometry apparatus |
US4599307A (en) * | 1983-07-18 | 1986-07-08 | Becton, Dickinson And Company | Method for elimination of selected cell populations in analytic cytology |
EP0210343A1 (en) * | 1985-07-29 | 1987-02-04 | Becton, Dickinson and Company | Flow cytometry apparatus with improved light beam adjustment |
US4663522A (en) * | 1984-10-05 | 1987-05-05 | Spandrel Establishment | Integrating sphere device for measuring transmission of light in objects |
US4667830A (en) * | 1981-06-15 | 1987-05-26 | The Board Of Trustees Of The Leland Stanford Junior University | Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like |
US4691829A (en) * | 1980-11-03 | 1987-09-08 | Coulter Corporation | Method of and apparatus for detecting change in the breakoff point in a droplet generation system |
US4701664A (en) * | 1986-01-09 | 1987-10-20 | Becton, Dickinson And Company | Mercury arc lamp suitable for inclusion in a flow cytometry apparatus |
US4710635A (en) * | 1986-04-14 | 1987-12-01 | Becton, Dickinson And Company | Dual laser excitation from single laser source |
US4745285A (en) * | 1986-08-21 | 1988-05-17 | Becton Dickinson And Company | Multi-color fluorescence analysis with single wavelength excitation |
US4781459A (en) * | 1985-05-17 | 1988-11-01 | Horiba, Ltd. | Apparatus for measuring the amount of minute particles contained in liquid |
WO1989000894A1 (en) * | 1987-08-05 | 1989-02-09 | The Board Of Trustees Of The Leland Stanford Junio | Apparatus and method for multidimensional characterization of objects in real time |
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US5047321A (en) * | 1988-06-15 | 1991-09-10 | Becton Dickinson & Co. | Method for analysis of cellular components of a fluid |
US5057413A (en) * | 1988-06-13 | 1991-10-15 | Becton, Dickinson And Company | Method for discriminating between intact and damaged cells in a sample |
US5064616A (en) * | 1987-11-30 | 1991-11-12 | Becton Dickinson And Company | Kit for analysis of subsets of subpopulations of leukocytes |
EP0455867A2 (en) * | 1990-05-07 | 1991-11-13 | Esm International, Inc. | Sorting machine incorporating photo site processing |
EP0461618A2 (en) * | 1990-06-13 | 1991-12-18 | Becton, Dickinson and Company | Cleaning cycle for flow cytometers |
US5076472A (en) * | 1990-06-13 | 1991-12-31 | Becton, Dickinson And Company | Cleaning cycle for flow cytometers |
US5089384A (en) * | 1988-11-04 | 1992-02-18 | Amoco Corporation | Method and apparatus for selective cell destruction using amplified immunofluorescence |
US5098849A (en) * | 1988-07-13 | 1992-03-24 | Becton Dickinson And Company | Material and method to reduce non-specific binding of a labelled material |
US5108904A (en) * | 1990-03-26 | 1992-04-28 | Alan Landay | CD44 as a marker for HIV infection |
US5123731A (en) * | 1988-02-01 | 1992-06-23 | Canon Kabushiki Kaisha | Particle measuring device |
US5156951A (en) * | 1989-07-13 | 1992-10-20 | Becton Dickinson And Company | Detecting immunological changes in HIV infected patient samples |
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US5199576A (en) * | 1991-04-05 | 1993-04-06 | University Of Rochester | System for flexibly sorting particles |
US5224058A (en) * | 1990-05-01 | 1993-06-29 | Becton, Dickinson And Company | Method for data transformation |
US5232828A (en) * | 1992-03-09 | 1993-08-03 | Becton, Dickinson And Company | Coating agents for cell recovery |
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Also Published As
Publication number | Publication date |
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US3826364A (en) | 1974-07-30 |
CA974193A (en) | 1975-09-09 |
JPS49109093A (en) | 1974-10-17 |
DE2246380C2 (en) | 1982-11-04 |
DE2246380A1 (en) | 1973-12-20 |
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