US3807235A - Micropipetting apparatus - Google Patents
Micropipetting apparatus Download PDFInfo
- Publication number
- US3807235A US3807235A US00295646A US29564672A US3807235A US 3807235 A US3807235 A US 3807235A US 00295646 A US00295646 A US 00295646A US 29564672 A US29564672 A US 29564672A US 3807235 A US3807235 A US 3807235A
- Authority
- US
- United States
- Prior art keywords
- plate
- liquid
- cannula
- pump membrane
- opening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
Definitions
- MICROPIPETTING APPARATUS [ Apr. 30, 1974 MICROPIPETTING APPARATUS [75] Inventors: Ivan Lefkovits, Bettingen; Otto Kamber, Basel, both of Switzerland [73] Assignee: Hoffmann-La Roche Inc., Nutley,
- ABSTRACT Apparatus for withdrawing minute quantities of a liquid medium into a liquid collecting apparatus.
- the soobtained liquid medium is then transferred from the liquid collecting apparatus into a vessel containing another medium which interacts with the liquid medium collected to give information about the latter.
- the present invention relates to a micropipetting apparatus. More particularly, it relates to a micropipetting apparatus adapted to simultaneously withdraw from a liquid containing vessel, very small samplings of a liquid, which samplings are substantially all of equal volume and are of a very small magnitude, i.e., of the order of a microliter.
- Pipetting apparatuses which are capable of simultaneously withdrawing a plurality of samples of liquid to be pipetted are known. Such known apparatuses, however, are generally suitable for withdrawing amounts of liquid in excess of 25 microliters. In many instances, 25 microliters is much more than the amount needed and, thus, more liquid is withdrawn from the liquidcontaining medium than is needed for an intended purpose. Hence, waste of liquid and inefficiency result. I
- micropipetting apparatus provided by the present invention which comprises a number of cannulas fastened to a carrier plate and a pump membrane fitted over the carrier plate, the pump membrane being in communication with a suction chamber by means of a perforated plate provided with indentations which are disposed in such a way that they each register with a cannula and determine the volume of the liquid which is to be pipetted.
- FIG. 1 is a sectional view of the cannula plate
- FIG. 2 is a sectional view of a part of a cannula plate
- FIG. 3 is a complete view of the micropipetting apparatus.
- the micropipetting apparatus comprises a cannula plate shown in FIG. 1 made of stainless steel material which consists of a carrier plate 2 having 60 cannulas 1 secured thereto.
- the cannulas are all of equal dimensions and are disposed on plate 2 in staggered relationship in six rows, each containing 10 cannulas.
- a flat pump membrane 3 which is made, for example, of rubber or of any suitable elastic synthetic material.
- the membrane 3 is supported on a plate 4 having 60 indentations 6.
- the transverse axis of each indentation 6 and the longitudinal axis of each of the cannulas are disposed along substantially the same line.
- Opening 7 is disposed between pump membrane 3 and suction chamber 5.
- the indentations 6 are all of the same volume, i.e., of the order of magnitude of a microliter.
- Fastening means is utilized to secure membrane 3 between plates 2 and 4 and section chamber 5 to plates 2 and 4 as shown in FIG. 1. Any suitable securing means of the type shown in FIG. 3 may be utilized as the fastening means.
- the suction chamber 5 In order to withdraw samples, the suction chamber 5 is placed under vacuum in a conventional manner, whereby an adjacent portion of the membrane is sucked into each indentation 6. An aliquot of liquid, which corresponds to the volume of an indentation 6 is withdrawn from a liquid containing vessel into each cannula.
- FIG. 3 is a view of a preferred embodiment of the micropipetting apparatus provided by the present invention.
- the micropipetting apparatus shown in FIG. 3 can be operated as follows:
- the microtitration plate 12 which has 6O recesses filled with culture media, is placed on a carrier plate 13.
- the cannulas 1 of the cannula plate are then lowered until they are each immersed in the culture media.
- the suction chamber 5 is placed under vacuum and 60 samplings are drawn into each of the respective cannulas.
- the microtitration plate 12 is removed and an agar plate or a plate having another nutrient medium thereon, is placed under the cannula plate 10.
- the vacuum condition which have been imparted to the suction chamber 5 is removed, whereby the liquid in the cannulas is discharged under the influence of gravity onto an agar plate or the like.
- a micropipetting apparatus for pipetting a liquid comprising a liquid receiving cannula secured to a carrier plate and extending downwardly from the underside thereof, the upper end of said cannula extending to the upperside of the carrier plate, a pump membrane disposed over the upperside of said carrier plate, a second plate provided with an opening overlying the pump membrane, said opening being in registry with said upper end of said cannula, said opening being provided by an indentation and a bore in a second plate in axial alignment and in communication with each other, said indentation extending from the surface of the side of said second plate overlying the pump membrane to a point between the last mentioned surface and the surface of the upperside of the second plate, said bore extending from the surface of the upper.
- the diameter of the portion of the bore at the surface of the upper side of the second plate being less than the diameter of the portion of the indentation at the surface of the side of the second plate overlying the pump membrane, means for moving the pump membrane so that a portion thereof is drawn into said indentation in the second plate whereby withdrawal of a predetermined amount of said liquid into said cannula occurs.
- a micropipetting apparatus as defined in claim I which comprises a plurality of cannulas and openings whereby a plurality of substantially equal amounts of said liquid is withdrawn from said vessel containing said liquid.
- a micropipetting apparatus as defined in claim 2 wherein the means for moving the pump membrane is provided by a suction chamber overlying the pump membrane.
- a micropipetting apparatus for pipetting a liquid comprising a liquid receiving cannula secured to a carrier plate and extending downwardly from the underside thereof, the upper end of said cannula extending to the upperside of the carrier plate, a pump membrane disposed over the upperside of said carrier plate, a second plate provided with an opening overlying the pump membrane, said opening being in registry with said upper end of said cannula, means for moving the pump membrane so that a portion thereof is drawn into said opening in the second plate whereby withdrawal of a predetermined amount of said liquid from a vessel containing said liquid into said cannula occurs and wherein the opening in the second plate comprise a large opening in the side of the plate adjacent the pump membrane and a smaller opening extending therefrom, the upper end of said smaller opening being in communication with a suction chamber.
Landscapes
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1490771A CH543306A (de) | 1971-10-13 | 1971-10-13 | Mikropipettiergerät |
Publications (1)
Publication Number | Publication Date |
---|---|
US3807235A true US3807235A (en) | 1974-04-30 |
Family
ID=4404739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00295646A Expired - Lifetime US3807235A (en) | 1971-10-13 | 1972-10-06 | Micropipetting apparatus |
Country Status (7)
Country | Link |
---|---|
US (1) | US3807235A (de) |
JP (1) | JPS4847891A (de) |
CH (1) | CH543306A (de) |
DE (1) | DE2244968A1 (de) |
FR (1) | FR2157473A5 (de) |
GB (1) | GB1363540A (de) |
NL (1) | NL7211704A (de) |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3982438A (en) * | 1975-06-23 | 1976-09-28 | The Salk Institute For Biological Studies | Multiple sample pipetting apparatus |
US4047438A (en) * | 1975-04-04 | 1977-09-13 | Teruaki Sekine | Liquid quantitative dispensing apparatus |
US4158035A (en) * | 1978-03-15 | 1979-06-12 | Byrd William J | Multiple sample micropipette |
EP0135985A2 (de) * | 1983-08-29 | 1985-04-03 | Becton Dickinson and Company | Flüssigkeitsabgabevorrichtung |
US4511534A (en) * | 1982-05-26 | 1985-04-16 | John T. Bennett | Liquid transfer device |
US4532805A (en) * | 1984-05-29 | 1985-08-06 | Flesher Robert W | Pipette system |
US4626509A (en) * | 1983-07-11 | 1986-12-02 | Data Packaging Corp. | Culture media transfer assembly |
US5092184A (en) * | 1989-12-22 | 1992-03-03 | Medical Research Institute Of The Mary Imogene Bassett Hospital | Cell staining system for flow cytometry |
US5343909A (en) * | 1992-12-17 | 1994-09-06 | Jack Goodman | Liquid transfer device |
WO1998026872A1 (en) * | 1996-12-18 | 1998-06-25 | Ansys, Inc. | Method for conducting assays and separations for components of interest in fluid samples |
US5920009A (en) * | 1996-12-20 | 1999-07-06 | Robert Bosch Gmbh | Method for generating a certain constant pressure in a test liquid of a test apparatus |
US6024925A (en) * | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
US6140053A (en) * | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
US6254826B1 (en) | 1997-11-14 | 2001-07-03 | Gen-Probe Incorporated | Assay work station |
US6268131B1 (en) | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
US6428955B1 (en) | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
US6468748B1 (en) | 1996-03-04 | 2002-10-22 | Sequenom, Inc. | Methods of screening nucleic acids using volatile salts in mass spectrometry |
US20030022225A1 (en) * | 1996-12-10 | 2003-01-30 | Monforte Joseph A. | Releasable nonvolatile mass-label molecules |
US6558902B1 (en) | 1998-05-07 | 2003-05-06 | Sequenom, Inc. | Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules |
US6566055B1 (en) | 1996-09-19 | 2003-05-20 | Sequenom, Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
US20030096258A1 (en) * | 1992-11-06 | 2003-05-22 | Dong-Jing Fu | Solid phase sequencing of double-stranded nucleic acids |
US6660229B2 (en) | 2000-06-13 | 2003-12-09 | The Trustees Of Boston University | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing |
US20040191924A1 (en) * | 1998-01-12 | 2004-09-30 | Massachusetts Institute Of Technology | Reformatted through-hole arrays |
US6818394B1 (en) | 1996-11-06 | 2004-11-16 | Sequenom, Inc. | High density immobilization of nucleic acids |
US20060024841A1 (en) * | 2000-10-30 | 2006-02-02 | Sequenom, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
US20060063193A1 (en) * | 1995-04-11 | 2006-03-23 | Dong-Jing Fu | Solid phase sequencing of double-stranded nucleic acids |
US20070016160A1 (en) * | 2005-07-07 | 2007-01-18 | Eisai Co., Ltd. | Recovery system |
US7198893B1 (en) | 1996-11-06 | 2007-04-03 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
US7285422B1 (en) | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
US20080156377A1 (en) * | 2006-12-29 | 2008-07-03 | Brad Mann | Recovery system |
US20090181463A1 (en) * | 2006-05-03 | 2009-07-16 | Ncl New Concept Lab Gmbh | Device and method for chemical, biochemical, biological and physical analysis, re-action, assay and more |
US7759065B2 (en) | 1995-03-17 | 2010-07-20 | Sequenom, Inc. | Mass spectrometric methods for detecting mutations in a target nucleic acid |
US7803529B1 (en) | 1995-04-11 | 2010-09-28 | Sequenom, Inc. | Solid phase sequencing of biopolymers |
US9068953B2 (en) | 2007-09-17 | 2015-06-30 | Agena Bioscience, Inc. | Integrated robotic sample transfer device |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5267389A (en) * | 1975-12-01 | 1977-06-03 | Kuraray Co | Method and apparatus for precise and separate taking of liquids of multi components system |
EP0110610B1 (de) * | 1982-11-20 | 1988-07-27 | The University Of Birmingham | Vorrichtung zum Abgeben von Flüssigkeiten und zum Registrieren von Reaktionen |
TWI428271B (zh) | 2004-06-09 | 2014-03-01 | Smithkline Beecham Corp | 生產藥物之裝置及方法 |
US8101244B2 (en) | 2004-06-09 | 2012-01-24 | Smithkline Beecham Corporation | Apparatus and method for producing or processing a product or sample |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3430628A (en) * | 1965-02-23 | 1969-03-04 | Reatha L Wiggins | Plurality of aspirators |
US3568735A (en) * | 1968-06-26 | 1971-03-09 | Cooke Eng Co | Laboratory microtitration dispensing apparatus |
US3572552A (en) * | 1969-07-25 | 1971-03-30 | Perry W Guinn | Diaphragm dispenser |
-
1971
- 1971-10-13 CH CH1490771A patent/CH543306A/de not_active IP Right Cessation
-
1972
- 1972-08-15 GB GB3804872A patent/GB1363540A/en not_active Expired
- 1972-08-28 NL NL7211704A patent/NL7211704A/xx not_active Application Discontinuation
- 1972-09-13 DE DE2244968A patent/DE2244968A1/de active Pending
- 1972-10-04 JP JP47099723A patent/JPS4847891A/ja active Pending
- 1972-10-06 US US00295646A patent/US3807235A/en not_active Expired - Lifetime
- 1972-10-13 FR FR7236327A patent/FR2157473A5/fr not_active Expired
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3430628A (en) * | 1965-02-23 | 1969-03-04 | Reatha L Wiggins | Plurality of aspirators |
US3568735A (en) * | 1968-06-26 | 1971-03-09 | Cooke Eng Co | Laboratory microtitration dispensing apparatus |
US3572552A (en) * | 1969-07-25 | 1971-03-30 | Perry W Guinn | Diaphragm dispenser |
Cited By (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4047438A (en) * | 1975-04-04 | 1977-09-13 | Teruaki Sekine | Liquid quantitative dispensing apparatus |
US3982438A (en) * | 1975-06-23 | 1976-09-28 | The Salk Institute For Biological Studies | Multiple sample pipetting apparatus |
US4158035A (en) * | 1978-03-15 | 1979-06-12 | Byrd William J | Multiple sample micropipette |
US4511534A (en) * | 1982-05-26 | 1985-04-16 | John T. Bennett | Liquid transfer device |
US4626509A (en) * | 1983-07-11 | 1986-12-02 | Data Packaging Corp. | Culture media transfer assembly |
EP0135985A2 (de) * | 1983-08-29 | 1985-04-03 | Becton Dickinson and Company | Flüssigkeitsabgabevorrichtung |
US4537231A (en) * | 1983-08-29 | 1985-08-27 | Becton, Dickinson And Company | Dispenser apparatus for simultaneously dispensing predetermined equal volumes of liquid including a disposable dispenser module |
EP0135985A3 (de) * | 1983-08-29 | 1986-03-05 | Becton Dickinson and Company | Flüssigkeitsabgabevorrichtung |
US4532805A (en) * | 1984-05-29 | 1985-08-06 | Flesher Robert W | Pipette system |
US5092184A (en) * | 1989-12-22 | 1992-03-03 | Medical Research Institute Of The Mary Imogene Bassett Hospital | Cell staining system for flow cytometry |
US20030096258A1 (en) * | 1992-11-06 | 2003-05-22 | Dong-Jing Fu | Solid phase sequencing of double-stranded nucleic acids |
US6991903B2 (en) | 1992-11-06 | 2006-01-31 | Sequenom, Inc. | Solid phase sequencing of double-stranded nucleic acids |
US5343909A (en) * | 1992-12-17 | 1994-09-06 | Jack Goodman | Liquid transfer device |
WO1995000392A1 (en) * | 1993-06-25 | 1995-01-05 | Jack Goodman | Liquid transfer device |
US7759065B2 (en) | 1995-03-17 | 2010-07-20 | Sequenom, Inc. | Mass spectrometric methods for detecting mutations in a target nucleic acid |
US6428955B1 (en) | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
US20060063193A1 (en) * | 1995-04-11 | 2006-03-23 | Dong-Jing Fu | Solid phase sequencing of double-stranded nucleic acids |
US8758995B2 (en) | 1995-04-11 | 2014-06-24 | Sequenom, Inc. | Solid phase sequencing of biopolymers |
US20110172111A1 (en) * | 1995-04-11 | 2011-07-14 | Sequenom, Inc. | Solid phase sequencing of biopolymers |
US7803529B1 (en) | 1995-04-11 | 2010-09-28 | Sequenom, Inc. | Solid phase sequencing of biopolymers |
US20030113745A1 (en) * | 1996-03-04 | 2003-06-19 | Monforte Joseph A. | Methods of screening nucleic acids using mass spectrometry |
US6468748B1 (en) | 1996-03-04 | 2002-10-22 | Sequenom, Inc. | Methods of screening nucleic acids using volatile salts in mass spectrometry |
US6566055B1 (en) | 1996-09-19 | 2003-05-20 | Sequenom, Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
US20090023150A1 (en) * | 1996-11-06 | 2009-01-22 | Sequenom, Inc. | DNA Diagnostics Based on Mass Spectrometry |
US7198893B1 (en) | 1996-11-06 | 2007-04-03 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
US7501251B2 (en) | 1996-11-06 | 2009-03-10 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
US6140053A (en) * | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
US6818394B1 (en) | 1996-11-06 | 2004-11-16 | Sequenom, Inc. | High density immobilization of nucleic acids |
US8486623B2 (en) | 1996-12-10 | 2013-07-16 | Sequenom, Inc. | Releasable nonvolatile mass-label molecules |
US6635452B1 (en) | 1996-12-10 | 2003-10-21 | Sequenom Inc. | Releasable nonvolatile mass label molecules |
US20030022225A1 (en) * | 1996-12-10 | 2003-01-30 | Monforte Joseph A. | Releasable nonvolatile mass-label molecules |
US7132519B2 (en) | 1996-12-10 | 2006-11-07 | Sequenom, Inc. | Releasable nonvolatile mass-label molecules |
WO1998026872A1 (en) * | 1996-12-18 | 1998-06-25 | Ansys, Inc. | Method for conducting assays and separations for components of interest in fluid samples |
US5920009A (en) * | 1996-12-20 | 1999-07-06 | Robert Bosch Gmbh | Method for generating a certain constant pressure in a test liquid of a test apparatus |
US20080248968A1 (en) * | 1997-01-23 | 2008-10-09 | Sequenom, Inc. | Matrix-assisted laser desorption ionization mass spectrometry substrates having low volume matrix array elements |
US7285422B1 (en) | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
US8821816B2 (en) | 1997-01-23 | 2014-09-02 | Agena Biosciences, Inc. | Matrix-assisted laser desorption ionization mass spectrometry substrates having low volume matrix array elements |
US6024925A (en) * | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
US6569385B1 (en) | 1997-01-23 | 2003-05-27 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
US6254826B1 (en) | 1997-11-14 | 2001-07-03 | Gen-Probe Incorporated | Assay work station |
US6852283B2 (en) | 1997-11-14 | 2005-02-08 | Gen-Probe Incorporated | Substance transfer device |
US6846456B2 (en) | 1997-11-14 | 2005-01-25 | Gen-Probe Incorporated | Assay work station |
US20050025673A1 (en) * | 1997-11-14 | 2005-02-03 | Gen-Probe Incorporated | Substance transfer device |
US20010016178A1 (en) * | 1997-11-14 | 2001-08-23 | Acosta Galo F. | Assay work station |
US6268131B1 (en) | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
US20040191924A1 (en) * | 1998-01-12 | 2004-09-30 | Massachusetts Institute Of Technology | Reformatted through-hole arrays |
US6706530B2 (en) | 1998-05-07 | 2004-03-16 | Sequenom, Inc. | IR-MALDI mass spectrometry of nucleic acids using liquid matrices |
US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
US6558902B1 (en) | 1998-05-07 | 2003-05-06 | Sequenom, Inc. | Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules |
US6660229B2 (en) | 2000-06-13 | 2003-12-09 | The Trustees Of Boston University | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing |
US20040077004A1 (en) * | 2000-06-13 | 2004-04-22 | Cantor Charles R. | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and highly multiplexed nucleic acid sequencing |
US8999266B2 (en) | 2000-10-30 | 2015-04-07 | Agena Bioscience, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
US20060024841A1 (en) * | 2000-10-30 | 2006-02-02 | Sequenom, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
US9669376B2 (en) | 2000-10-30 | 2017-06-06 | Agena Bioscience, Inc. | Method and apparatus for delivery of submicroliter volumes onto a substrate |
US7815621B2 (en) * | 2005-07-07 | 2010-10-19 | Eisai R & D Management Co. Ltd. | Recovery system |
US20070016160A1 (en) * | 2005-07-07 | 2007-01-18 | Eisai Co., Ltd. | Recovery system |
US20090181463A1 (en) * | 2006-05-03 | 2009-07-16 | Ncl New Concept Lab Gmbh | Device and method for chemical, biochemical, biological and physical analysis, re-action, assay and more |
US10105705B2 (en) * | 2006-05-03 | 2018-10-23 | Ncl New Concept Lab Gmbh | Device and method for chemical, biochemical, biological and physical analysis, re-action, assay and more |
US20080156377A1 (en) * | 2006-12-29 | 2008-07-03 | Brad Mann | Recovery system |
US9068953B2 (en) | 2007-09-17 | 2015-06-30 | Agena Bioscience, Inc. | Integrated robotic sample transfer device |
Also Published As
Publication number | Publication date |
---|---|
DE2244968A1 (de) | 1973-04-19 |
NL7211704A (de) | 1973-04-17 |
CH543306A (de) | 1973-10-31 |
FR2157473A5 (de) | 1973-06-01 |
GB1363540A (en) | 1974-08-14 |
JPS4847891A (de) | 1973-07-06 |
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