US3748101A - Centrifuge fluid container - Google Patents
Centrifuge fluid container Download PDFInfo
- Publication number
- US3748101A US3748101A US00221530A US3748101DA US3748101A US 3748101 A US3748101 A US 3748101A US 00221530 A US00221530 A US 00221530A US 3748101D A US3748101D A US 3748101DA US 3748101 A US3748101 A US 3748101A
- Authority
- US
- United States
- Prior art keywords
- container
- bag
- periphery
- tube
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
- B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
Definitions
- FIG. 2 A. L. JONES ETAL CENTRIFUGE FLUID CONTAINER Filed Jan. 28, 1972 FIG. 2
- a fluid container particularly useful in a system for processing blood is generally annular or toroidal in shape, with a central hub portion which communicates with the annular portion via a plurality of radial channels, and is preferably formed from two circular pieces of plastic material, sealed at the periphery, and in centrally-located segments to provide the desired configuration.
- a central hub provides one fluid entrance and exit.
- a peripherally-located output tube, appropriately sealed, is located opposite a slitted flap, to provide means for suspending the container from a support and draining the container by gravity through the outlet tube.
- a sampling tube may also be provided, connected to the periphery of the bag.
- a copending patent application, Ser. No. 211,194 filed on Dec. 23, 1971 discloses and claims a blood processing system in which thawed frozen blood is washed to remove glycerol or other cryopreservative agents.
- This system requires a blood container which is circular in shape and has a centrally-located fluid inlet/outlet tube.
- the present invention provides an improved fluid container for use in the referenced blood processing system.
- a specific object of the invention is to provide an improved fluid container for processing thawed blood including a centrifuging step.
- a further object of the invention is to provide an improved blood container for centrifuging incorporating radial fluid channels to exclude the blood mixture from the low G force area near the center of rotation.
- the fluid container provided by this invention is an annular or toroidal-shaped container when filled with fluid. It is preferably formed by sealing two identical circular pieces of suitable flexible elastic material, such as medical-grade polyvinylchloride, at the periphery thereof to provide an enclosed volume. A plurality of sector-shaped areas, centrally located, are formed by sealing the two sides of the bag together. This provides a central or hub portion which communicates with the annular outer portion by a plurality of radial channels. A fluid inlet/outlet tube is located on the axis of the bag, to permit entrance and exit of fluid via the radial channels. (The radial channels confine the major volume of the blood to the outer portions of the bag, where higher G forces are available, and centrifuging time is accordingly reduced.)
- a sealed outlet tube is provided at the periphery of the bag, and a hanger opening is provided diametrically opposite the outlet tube, so that the bag can be suspended from a suitable support and drained by gravity via tubing attached to the bag by way of the outlet tube.
- a sampling tube may also be provided, having one end connected to the bag at the periphery thereof.
- FIG. 1 is a diagrammatic plan view of a fluid container comprising a preferred embodiment of the invention
- the fluid container is circular in general shape as manifest in FIGS. 1 and 3.
- Two circular pieces 3a and 3b of suitable dimensions, of material suited to the purpose, such as medical-grade polyvinylchloride, are sealed together at their periphery, as by application of suitable heat and pressure.
- a plurality of sectorshaped areas 5 of the two sides 3a and 3b are further sealed together to be liquid tight. It is apparent that this configuration will then provide a plurality of radial channels 7 extending outwardly from the center of the bag.
- a fluid inlet/ outlet hub 11 Located on the central axis of the bag is a fluid inlet/ outlet hub 11. Insertion of a suitable tubing connector provided with a rotating seal, not shown, permits fluid to be supplied to or withdrawn from the bag during centrifuging.
- an outlet tube 15 can be provided at the periphery of the bag.
- This tube can be of semi-rigid plastic material, entering the bag radially as shown, and appropriately sealed in place.
- An inner cap 17 and an outer cap 19 are shown.
- Inner cap 17 prevents exit of the bag contents during processing while cap 19 protects the sterility of the interior of the outlet tube.
- the outer cap 19 would be removed, and the stabber or cannula of a suitable tubing set would be thrust into tube 15, the end of the cannula forcing off the cap 17 to permit outward flow of the bag contents.
- outlet tube 15 Opposite the outlet tube 15, the rim of the bag 'is slit as shown at 21, to permit the bag to be suspended from a suitable support when draining through outlet tube 15.
- a sampling tube 25 may also be provided, one end of which is attached to the periphery of the bag, and the other end of which is closed, as by heating sealing.
- a portion of the bag contents may be expressed into the coupling tube, and then the tube may be cut off and sealed near its connection to the bag, so that the contents of the sampling tube can be used for tests.
- the present invention provides an improved fluid container, particularly suited for centrifuging of blood, which is economi i cal to manufacture, maximizes exposure to G force, thereby reducing time of centrifugation, and is adapted to dispense the contained blood or other fluid in conventional manner.
- a flexible collapsible blood processing container comprising,
- a central hub portion having an axially-aligned inlet/ outlet tube connection, a plurality of radial channels integrally formed and extending radially from said hub portion to said outer portion,
- a container as claimed in claim 1 in which said container is fomed from two circular pieces of material, sealed together at the periphery thereof, and sealed together at selected sector-shaped central portions to form said central hub portion and said channels.
- a container as claimed in claim 1 in which a sampling tube is provided, having one end thereof sealed in theperiphery of said container and communicating with the interior of the container.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Centrifugal Separators (AREA)
- External Artificial Organs (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22153072A | 1972-01-28 | 1972-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3748101A true US3748101A (en) | 1973-07-24 |
Family
ID=22828197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00221530A Expired - Lifetime US3748101A (en) | 1972-01-28 | 1972-01-28 | Centrifuge fluid container |
Country Status (13)
Country | Link |
---|---|
US (1) | US3748101A (nl) |
JP (1) | JPS554270B2 (nl) |
AU (1) | AU469904B2 (nl) |
BE (1) | BE794220A (nl) |
BR (1) | BR7300608D0 (nl) |
CA (1) | CA971143A (nl) |
CH (1) | CH542106A (nl) |
DE (1) | DE2262856C3 (nl) |
FR (1) | FR2175400A5 (nl) |
GB (1) | GB1374050A (nl) |
IT (1) | IT971834B (nl) |
NL (1) | NL167613C (nl) |
ZA (1) | ZA73285B (nl) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4007871A (en) * | 1975-11-13 | 1977-02-15 | International Business Machines Corporation | Centrifuge fluid container |
US4010894A (en) * | 1975-11-21 | 1977-03-08 | International Business Machines Corporation | Centrifuge fluid container |
US4052165A (en) * | 1975-11-26 | 1977-10-04 | Compur-Electronic Gesellschaft Mit Beschrankter Haftung | Apparatus for centrifugal separation of test samples |
US4052164A (en) * | 1972-11-26 | 1977-10-04 | Compur-Electronic Gesellschaft Mit Beschrankter Haftung | Apparatus for centrifugal separation and measurement of samples |
US4076169A (en) * | 1974-10-09 | 1978-02-28 | Schlutz Charles A | Centrifuge separation and washing device and method |
US4278202A (en) * | 1978-07-25 | 1981-07-14 | Separek Teknik Ab | Centrifuge rotor and collapsible separation container for use therewith |
US4409820A (en) * | 1981-06-17 | 1983-10-18 | Irwin Nash | Apparatus and method for use in quantitative analysis of a fluid suspension |
US4482342A (en) * | 1982-06-17 | 1984-11-13 | Haemonetics Corporation | Blood processing system for cell washing |
FR2590023A1 (fr) * | 1985-11-14 | 1987-05-15 | Tiyoda Seisakusho Kk | Cellule utilisee pour le depot de substances solides sur une lame porte-objet sous l'action d'une force centrifuge |
US4934995A (en) * | 1977-08-12 | 1990-06-19 | Baxter International Inc. | Blood component centrifuge having collapsible inner liner |
US4939087A (en) * | 1987-05-12 | 1990-07-03 | Washington State University Research Foundation, Inc. | Method for continuous centrifugal bioprocessing |
US5006103A (en) * | 1977-08-12 | 1991-04-09 | Baxter International Inc. | Disposable container for a centrifuge |
US5217427A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Centrifuge assembly |
US5217426A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Combination disposable plastic blood receiving container and blood component centrifuge |
US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
US5362291A (en) * | 1991-12-23 | 1994-11-08 | Baxter International Inc. | Centrifugal processing system with direct access drawer |
US5370802A (en) * | 1987-01-30 | 1994-12-06 | Baxter International Inc. | Enhanced yield platelet collection systems and methods |
US5427695A (en) * | 1993-07-26 | 1995-06-27 | Baxter International Inc. | Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate |
US5549834A (en) * | 1991-12-23 | 1996-08-27 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
US5571068A (en) * | 1977-08-12 | 1996-11-05 | Baxter International Inc. | Centrifuge assembly |
US5573678A (en) * | 1987-01-30 | 1996-11-12 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cells |
US5628915A (en) * | 1987-01-30 | 1997-05-13 | Baxter International Inc. | Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions |
US5632893A (en) * | 1987-01-30 | 1997-05-27 | Baxter Internatinoal Inc. | Enhanced yield blood processing systems with angled interface control surface |
US5641414A (en) * | 1987-01-30 | 1997-06-24 | Baxter International Inc. | Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields |
US5690835A (en) * | 1991-12-23 | 1997-11-25 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US5961842A (en) * | 1995-06-07 | 1999-10-05 | Baxter International Inc. | Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit |
US5980760A (en) * | 1997-07-01 | 1999-11-09 | Baxter International Inc. | System and methods for harvesting mononuclear cells by recirculation of packed red blood cells |
US5993370A (en) * | 1987-01-30 | 1999-11-30 | Baxter International Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
US6007725A (en) * | 1991-12-23 | 1999-12-28 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US6027657A (en) * | 1997-07-01 | 2000-02-22 | Baxter International Inc. | Systems and methods for collecting diluted mononuclear cells |
US6511411B1 (en) | 1987-01-30 | 2003-01-28 | Baxter International Inc. | Compact enhanced yield blood processing systems |
US6582349B1 (en) | 1997-07-01 | 2003-06-24 | Baxter International Inc. | Blood processing system |
US6736768B2 (en) | 2000-11-02 | 2004-05-18 | Gambro Inc | Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach |
US20050113237A1 (en) * | 2003-11-25 | 2005-05-26 | Keith Rosiello | Integral seal for centrifuge chamber |
US20080215029A1 (en) * | 1993-01-22 | 2008-09-04 | I-Flow Corporation | Platen pump |
US20130130382A1 (en) * | 2010-08-03 | 2013-05-23 | Sapporo Medical University | Autoserum-containing bone marrow cell culture system, autoserum-containing bone marrow cell culture method, and method for producing medicinal composition comprising autoserum-containing cultured bone marrow cells as active ingredient |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1097942A (en) * | 1976-06-09 | 1981-03-24 | Frederick C. Bullock | Disposable cuvette array |
DE4226974C2 (de) * | 1992-08-14 | 1994-08-11 | Fresenius Ag | Verfahren und Vorrichtung zur kontinuierlichen Aufbereitung einer Zellsuspension |
DE19802321C2 (de) | 1998-01-23 | 2000-05-11 | Fresenius Ag | Verfahren und Vorrichtung zur Aufbereitung von intra- oder postoperativen Blutverlusten für die Autotransfusion |
CN105501675A (zh) * | 2016-02-14 | 2016-04-20 | 宗士香 | 一种感染科用运送架 |
-
0
- BE BE794220D patent/BE794220A/xx not_active IP Right Cessation
-
1972
- 1972-01-28 US US00221530A patent/US3748101A/en not_active Expired - Lifetime
- 1972-12-14 IT IT32869/72A patent/IT971834B/it active
- 1972-12-15 AU AU50171/72A patent/AU469904B2/en not_active Expired
- 1972-12-22 DE DE2262856A patent/DE2262856C3/de not_active Expired
- 1972-12-29 NL NL7217784A patent/NL167613C/nl not_active IP Right Cessation
- 1972-12-29 GB GB6015572A patent/GB1374050A/en not_active Expired
-
1973
- 1973-01-09 FR FR7301493A patent/FR2175400A5/fr not_active Expired
- 1973-01-11 JP JP561473A patent/JPS554270B2/ja not_active Expired
- 1973-01-15 ZA ZA730285A patent/ZA73285B/xx unknown
- 1973-01-22 CH CH84373A patent/CH542106A/de not_active IP Right Cessation
- 1973-01-24 CA CA162,350A patent/CA971143A/en not_active Expired
- 1973-01-26 BR BR73608A patent/BR7300608D0/pt unknown
Cited By (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4052164A (en) * | 1972-11-26 | 1977-10-04 | Compur-Electronic Gesellschaft Mit Beschrankter Haftung | Apparatus for centrifugal separation and measurement of samples |
US4076169A (en) * | 1974-10-09 | 1978-02-28 | Schlutz Charles A | Centrifuge separation and washing device and method |
US4007871A (en) * | 1975-11-13 | 1977-02-15 | International Business Machines Corporation | Centrifuge fluid container |
US4010894A (en) * | 1975-11-21 | 1977-03-08 | International Business Machines Corporation | Centrifuge fluid container |
US4052165A (en) * | 1975-11-26 | 1977-10-04 | Compur-Electronic Gesellschaft Mit Beschrankter Haftung | Apparatus for centrifugal separation of test samples |
US4934995A (en) * | 1977-08-12 | 1990-06-19 | Baxter International Inc. | Blood component centrifuge having collapsible inner liner |
US5571068A (en) * | 1977-08-12 | 1996-11-05 | Baxter International Inc. | Centrifuge assembly |
US5759147A (en) * | 1977-08-12 | 1998-06-02 | Baxter International Inc. | Blood separation chamber |
US5006103A (en) * | 1977-08-12 | 1991-04-09 | Baxter International Inc. | Disposable container for a centrifuge |
US5217427A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Centrifuge assembly |
US5217426A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Combination disposable plastic blood receiving container and blood component centrifuge |
US4278202A (en) * | 1978-07-25 | 1981-07-14 | Separek Teknik Ab | Centrifuge rotor and collapsible separation container for use therewith |
US4409820A (en) * | 1981-06-17 | 1983-10-18 | Irwin Nash | Apparatus and method for use in quantitative analysis of a fluid suspension |
US4482342A (en) * | 1982-06-17 | 1984-11-13 | Haemonetics Corporation | Blood processing system for cell washing |
FR2590023A1 (fr) * | 1985-11-14 | 1987-05-15 | Tiyoda Seisakusho Kk | Cellule utilisee pour le depot de substances solides sur une lame porte-objet sous l'action d'une force centrifuge |
US5641414A (en) * | 1987-01-30 | 1997-06-24 | Baxter International Inc. | Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields |
US5807492A (en) * | 1987-01-30 | 1998-09-15 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cell |
US6899666B2 (en) | 1987-01-30 | 2005-05-31 | Baxter International Inc. | Blood processing systems and methods |
US5529691A (en) * | 1987-01-30 | 1996-06-25 | Baxter International Inc. | Enhanced yield platelet collection systems and method |
US20030102272A1 (en) * | 1987-01-30 | 2003-06-05 | Baxter International Inc. | Blood processing systems and methods |
US6511411B1 (en) | 1987-01-30 | 2003-01-28 | Baxter International Inc. | Compact enhanced yield blood processing systems |
US5573678A (en) * | 1987-01-30 | 1996-11-12 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cells |
US5628915A (en) * | 1987-01-30 | 1997-05-13 | Baxter International Inc. | Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions |
US5632893A (en) * | 1987-01-30 | 1997-05-27 | Baxter Internatinoal Inc. | Enhanced yield blood processing systems with angled interface control surface |
US5370802A (en) * | 1987-01-30 | 1994-12-06 | Baxter International Inc. | Enhanced yield platelet collection systems and methods |
US5993370A (en) * | 1987-01-30 | 1999-11-30 | Baxter International Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
US5750039A (en) * | 1987-01-30 | 1998-05-12 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cells |
US4939087A (en) * | 1987-05-12 | 1990-07-03 | Washington State University Research Foundation, Inc. | Method for continuous centrifugal bioprocessing |
US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
US5804079A (en) * | 1991-12-23 | 1998-09-08 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
US5690835A (en) * | 1991-12-23 | 1997-11-25 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US6007725A (en) * | 1991-12-23 | 1999-12-28 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US6071421A (en) * | 1991-12-23 | 2000-06-06 | Baxter International Inc. | Systems and methods for obtaining a platelet suspension having a reduced number of leukocytes |
US5362291A (en) * | 1991-12-23 | 1994-11-08 | Baxter International Inc. | Centrifugal processing system with direct access drawer |
US5549834A (en) * | 1991-12-23 | 1996-08-27 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
US20080215029A1 (en) * | 1993-01-22 | 2008-09-04 | I-Flow Corporation | Platen pump |
US5427695A (en) * | 1993-07-26 | 1995-06-27 | Baxter International Inc. | Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate |
US5961842A (en) * | 1995-06-07 | 1999-10-05 | Baxter International Inc. | Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit |
US20030211927A1 (en) * | 1997-07-01 | 2003-11-13 | Baxter International Inc. | Blood processing chamber counter-balanced with blood-free liquid |
US6582349B1 (en) | 1997-07-01 | 2003-06-24 | Baxter International Inc. | Blood processing system |
US6027657A (en) * | 1997-07-01 | 2000-02-22 | Baxter International Inc. | Systems and methods for collecting diluted mononuclear cells |
US5980760A (en) * | 1997-07-01 | 1999-11-09 | Baxter International Inc. | System and methods for harvesting mononuclear cells by recirculation of packed red blood cells |
US6736768B2 (en) | 2000-11-02 | 2004-05-18 | Gambro Inc | Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach |
US6773389B2 (en) | 2000-11-02 | 2004-08-10 | Gambro Inc | Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced configuration |
US7094197B2 (en) | 2000-11-02 | 2006-08-22 | Gambro, Inc. | Method for fluid separation devices using a fluid pressure balanced configuration |
US7094196B2 (en) | 2000-11-02 | 2006-08-22 | Gambro Inc. | Fluid separation methods using a fluid pressure driven and/or balanced approach |
US20050113237A1 (en) * | 2003-11-25 | 2005-05-26 | Keith Rosiello | Integral seal for centrifuge chamber |
US20130130382A1 (en) * | 2010-08-03 | 2013-05-23 | Sapporo Medical University | Autoserum-containing bone marrow cell culture system, autoserum-containing bone marrow cell culture method, and method for producing medicinal composition comprising autoserum-containing cultured bone marrow cells as active ingredient |
US9683214B2 (en) * | 2010-08-03 | 2017-06-20 | Sapporo Medical University | Autoserum-containing bone marrow cell culture system, autoserum-containing bone marrow cell culture method, and method for producing medicinal composition comprising autoserum-containing cultured bone marrow cells as active ingredient |
US10563173B2 (en) | 2010-08-03 | 2020-02-18 | Nipro Corporation | Autoserum-containing bone marrow cell culture system, autoserum-containing bone marrow cell culture method, and method for producing medicinal composition comprising autoserum-containing cultured bone marrow cells as active ingredient |
Also Published As
Publication number | Publication date |
---|---|
NL167613B (nl) | 1981-08-17 |
GB1374050A (en) | 1974-11-13 |
JPS4884078A (nl) | 1973-11-08 |
BR7300608D0 (pt) | 1973-10-25 |
CA971143A (en) | 1975-07-15 |
CH542106A (de) | 1973-09-30 |
FR2175400A5 (nl) | 1973-10-19 |
NL7217784A (nl) | 1973-07-31 |
NL167613C (nl) | 1982-01-18 |
AU469904B2 (en) | 1976-02-26 |
ZA73285B (en) | 1974-08-28 |
DE2262856A1 (de) | 1973-08-16 |
JPS554270B2 (nl) | 1980-01-29 |
DE2262856B2 (de) | 1979-03-22 |
IT971834B (it) | 1974-05-10 |
DE2262856C3 (de) | 1979-11-15 |
AU5017172A (en) | 1974-06-20 |
BE794220A (fr) | 1973-05-16 |
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Owner name: COBE LABORATORIES, INC., 1201 OAK STREET, LAKEWOOD Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:INTERNATIONAL BUSINESS MACHINES CORPORATION, A CORP. OF NEW YORK;REEL/FRAME:004528/0945 Effective date: 19860225 |