US3729568A - Acne treatment - Google Patents

Acne treatment Download PDF

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Publication number
US3729568A
US3729568A US00860296A US3729568DA US3729568A US 3729568 A US3729568 A US 3729568A US 00860296 A US00860296 A US 00860296A US 3729568D A US3729568D A US 3729568DA US 3729568 A US3729568 A US 3729568A
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Prior art keywords
vitamin
acid
acne
glycol
treatment
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Expired - Lifetime
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US00860296A
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English (en)
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A Kligman
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Johnson and Johnson
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Johnson and Johnson
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • Acne is a dermatological disorder which is more prevalent in adolescence and is found mainly within the age group of about to 22. As it occurs primarily in the face and trunk are'as, affecting the appearance of the patient, it probably causes more mental pain and anguish to those afiiicted than many other diseases which, from a physical standpoint, may be much more severe.
  • the basic lesion of acne is the comedo or blackhead of a pilosebaceous follicle. The condition may be mild and transient with only a few blackheads which can readily be ejected by pressure and are of little concern, or may be severe, persistent, and very disfiguring with the more serious cases frequently leaving permanent scarring.
  • Vitamin A Its Effects on Acne, Northwest Med., 42; 219-225, August 1943
  • other investigators 3,729,568 Patented Apr. 24, 1973 have felt it to be ineffective
  • Easterson, J. A. D. et al. Vitamin A in Acne Vulgaris, Brit. Med. J., 2: 294-296, August 1963
  • Lynch, F. W. et al. Acne Vulgaris Treated With Vitamin A, Arch Derm., 55: 355, 357, March 1947, and Mitchell, G. H. et al., Results of Treatment of Acne Vulgaris by Intramuscular Injections of Vitamin A, Arch. Derm., 64: 428430, October 1951).
  • Vitamin A acid has been applied topically, Beer (Beer, Von P., Informen iiber diecode der Vitamin A-Sure, Dermatologica, 124: 192-l95, March 1962) and Stiittgen (Stiittgen, G., Zur Lokal opposition von Keratosen mit Vitamin A-Saure, Dermatologica, 124: 6580, February 1962) achieving good results in those hyperkeratotic disorders which are responsive to high oral doses of vitamin A. Among those treated by Beer and Stiittgen were patients with acne; however, these investigators reported no eifective results on this disorder. British Patent 906,000 discloses a cosmetic preparation containing vitamin A acid for regulation of the cornification processes of human skin.
  • Vitamin A acid is used in the present specification and claims refers to a composition in which the terminal methylene group of vitamin A has been replaced by a carboxyl group. It is also known as retinoic acid.
  • the vitamin A acid is preferably applied in a liquid solvent.
  • a composition found to be particularly effective is vitamin A acid dispersed in small amounts in a watermiscible (substantially oiland fat-free) liquid carrier made up of hydrophylic liquids having a high solvating action.
  • a particularly suitable solvent carrier in this regard consists essentially of a combination of (A) from about 25 to about by weight, of ethyl alcohol or isopropyl alcohol, preferably the former, and (B) the balance essentially a liquid glycol above ethylene glycol or a liquid glycol above ethylene glycol and a liquid ethylene glycol mono methyl or mono ethyl ether.
  • the balance is essentially a combination of a liquid glycol and a liquid ethylene glycol mono ether
  • the former will usually predominate; that is to say, the liquid glycol will be present in an amount, by weight, greater than the liquid ethylene glycol mono ether.
  • suitable glycols are liquid polyethylene glycols, such as polyethylene glycol 400, propylene glycol and liquid polypropylene glycols. Of these the polyethylene glycols and propylene glycol are preferred.
  • suitable liquid ethylene glycol ethers are the mono-, diand triethylene glycol monomethyl ethers and the mono-, diand triethylene glycol monoethyl ethers. Of these the monoand diethylene glycol monoethers are preferred.
  • Small amounts of other materials which do not materially alter the advantageous characteristics of the composition may be included. For example, a small amount of polyethylene glycol 4000 may be included to thicken the composition. Likewise, a small amount of an antioxidant, like butylated hydroxytoluene, may be included as a stabilizer to increase shelf life.
  • Typical such solvent carriers are as follows (percent being by weight):
  • the concentration of the vitamin A acid in the topically-applied composition is generally in the order of about 0.1%, by weight, of the applied composition.
  • the vitamin A acid concentration in the applied composition may range from 0.20% to 0.5%, by weight, with a concentration in the range of from about 0.05 to about 0.25% being preferred.
  • the vitamin A acid composition is applied daily until the desired relief is obtained, and this may require one or two (or possibly three) applications each day, depending upon the particular individual. Normally the treatment requires at least a month. Thus, acne in its mildest form (only a small number of comed'ones) may be substantially cleared in four to six weeks. However, more severe cases may require two to three months or longer.
  • the vitamin A acid appears to have an effect substantially diiferent from the irritants generally employed. Its effect is twofold: it causes an intercellular edema of the epithelium lining the comedo which thereby becomes porous allowing products within the comedo to leak into the tissue. This incites the inflammation which converts the comedones. Secondly, it increases the rate of reproduction of epithelial cells so that the horny cells stream out more rapidly carrying the impaction with them. This is illustrated, for example, in the drawings wherein the several tfigures show the progressive stages of expulsion of the comedo, inflammatory in one case, increased keratinization in other. Not infrequently, new pustules and papules suddenly appear during the initial period of therapy.
  • FIG. 1 shows an open comedo (blackhead) before treatment.
  • FIG. 2 Shows the inflammatory reaction, caused by the present treatment, destroying epith'elia lining with consequent unseating of the comedo which will soon be exfoliated.
  • FIG. 3 shows extrusion of the comedo as a result of speeding up of keratinization. Horny cells are being produced at an accelerated rate, and the comedo is being swept out by this stream of cells.
  • FIG. 4 shows normal sebaceous follicles of the face. These follicles are the sites in which cornedones form.
  • FIG. 5 shows the filling of the follicle with horny material, the intermediate stage of comedo formation.
  • the method of treating acne comprising applying vitamin A acid topically to the aflected area in a concentration eflective for the treatment of acne and repeating such applications daily, whereby said applications result in the peeling and diffuse redness of the skin treated, and continuing said treatment until the acne has subsided.
  • said carrier consists essentially of (A) from about 25 to 75%, by weight, of an alcohol selected from the group consisting of ethyl and isopropyl, alcohol and 5 (B) the balance being essentially a liquid selected from the group consisting of (a) a liquid glycol above ethylene glycol, and (b) a mixture of a liquid glycol above ethylene glycol and a liquid lower alkyl ether of an ethylene glycol selected from the group consisting of the monomethyl and monoethyl ethers.
  • said alcohol is ethyl alcohol
  • said liquid glycol is a liquid polyethylene 10 glycol
  • said liquid ethylene glycol mono ether is selected from the group consisting of monoethylene glycol monomethyl ether, monoethylene glycol monoethyl ether, diethyleneglycol monomethyl ether and diethyleneglycol monoethyl ether.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US00860296A 1969-09-23 1969-09-23 Acne treatment Expired - Lifetime US3729568A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86029669A 1969-09-23 1969-09-23

Publications (1)

Publication Number Publication Date
US3729568A true US3729568A (en) 1973-04-24

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US00860296A Expired - Lifetime US3729568A (en) 1969-09-23 1969-09-23 Acne treatment

Country Status (7)

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US (1) US3729568A (de)
CA (1) CA945069A (de)
DE (1) DE2046119C2 (de)
FR (1) FR2070083B1 (de)
GB (1) GB1325732A (de)
IT (1) IT1059655B (de)
ZA (1) ZA706459B (de)

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3882244A (en) * 1971-12-13 1975-05-06 Univ California Method of treating acne with a c{hd 20 {b acid
US3906108A (en) * 1973-10-12 1975-09-16 Johnson & Johnson Stabilized tretinoin cream emulsion
US3932665A (en) * 1974-04-05 1976-01-13 Scott Eugene J Van Process for the treatment of acne vulgaris utilizing retinal
US3934028A (en) * 1974-04-22 1976-01-20 The Regents Of The University Of California Acne and psoriasis treatment with retinoic acid analogs
DE2601489A1 (de) * 1975-01-17 1976-07-22 Johnson & Johnson Tretinoin enthaltende gelpraeparate
US4021573A (en) * 1974-04-22 1977-05-03 The Regents Of The University Of California Psoriasis treatment with retinoic acid analogs
US4034114A (en) * 1976-09-15 1977-07-05 Yu Ruey J Treatment of skin keratoses with retinal
US4055659A (en) * 1975-11-03 1977-10-25 Johnson & Johnson Retinoic acid derivatives
US4108880A (en) * 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
US4126697A (en) * 1975-11-03 1978-11-21 Johnson & Johnson Retinoic acid derivatives in the treatment of acne
US4170229A (en) * 1978-01-16 1979-10-09 Dominion Pharmacal, Inc. Method for improved health care of hair and scalp using a vitamin A aqueous emulsion
US4190594A (en) * 1975-11-03 1980-02-26 Johnson & Johnson Retinoic acid derivatives
US4200647A (en) * 1977-12-21 1980-04-29 Hoffmann-La Roche Inc. Vitamin A compositions to treat rheumatic disease
US4214000A (en) * 1978-10-30 1980-07-22 Johnson & Johnson Zinc salt of all-trans-retinoic acid for the treatment of acne
US4239781A (en) * 1979-05-03 1980-12-16 Roy Edwards Method for treating skin ailments
US4247547A (en) * 1979-03-19 1981-01-27 Johnson & Johnson Tretinoin in a gel vehicle for acne treatment
US4603146A (en) * 1984-05-16 1986-07-29 Kligman Albert M Methods for retarding the effects of aging of the skin
US4843096A (en) * 1985-06-26 1989-06-27 Stiefel Laboratories, Inc. Treatment of acne
US4877805A (en) * 1985-07-26 1989-10-31 Kligman Albert M Methods for treatment of sundamaged human skin with retinoids
US4889847A (en) * 1986-11-03 1989-12-26 Ortho Pharmaceutical Corporation Prevention of glucocorticoid-induced skin atrophy
WO1990014833A1 (en) * 1989-06-07 1990-12-13 Bazzano Gail S Slow release vehicles for minimizing skin irritancy of topical compositions
US4985235A (en) * 1988-08-02 1991-01-15 Kligman Albert M Treatment of periodontoclasia with retinoic acid
US5019569A (en) * 1986-11-03 1991-05-28 Ortho Pharmaceutical Corporation Reversal of glucocorticoid-induced skin atrophy
AU614643B2 (en) * 1988-08-02 1991-09-05 Albert M. Kligman Treatment of periodontoclasia with retinoic acid
US5051449A (en) * 1991-02-27 1991-09-24 Kligman Albert M Treatment of cellulite with retinoids
US5124313A (en) * 1989-06-02 1992-06-23 Schaeffer Hans A Methods of improved skin care and the treatment of dermatological conditions
US5183817A (en) * 1981-02-17 1993-02-02 Bazzano Gail S Combinations of retinoids and minoxidil-type compounds for hair growth
WO1993006086A1 (en) * 1991-09-24 1993-04-01 Pfizer Inc. Retinoids and their use in treating skin diseases and leukemia
US5273739A (en) * 1990-12-07 1993-12-28 Jim Baral Composition and treatment for darkening hair color
US5380764A (en) * 1989-06-08 1995-01-10 Herzog; Paul Composition of vitamin A, glucose and hydrogen peroxide for cosmetic or pharmaceutical use
US5459153A (en) * 1990-03-27 1995-10-17 Leung; Lit-Hung Composition and methods for treatment of acne vulgaris and for retardation of aging
EP0699439A2 (de) 1994-08-31 1996-03-06 Pfizer Inc. Behandlung von durch Talgdrüse verursachten Erkrankungen mit Inhibitoren der Acyl CoA Cholesterin Acyltransferase
US5514672A (en) * 1981-02-17 1996-05-07 Bazzano; Gail S. Use of retinoids and compositions containing same for hair growth
US5643584A (en) * 1992-04-16 1997-07-01 Ortho Pharmaceutical Corporation Aqueous gel retinoid dosage form
US5661141A (en) * 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
US5670547A (en) * 1989-04-17 1997-09-23 Dow Pharmaceutical Sciences Moisturizing vehicle for topical application of vitamin A acid
US5698593A (en) * 1988-04-26 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Method for treating acne
WO1998050023A1 (en) * 1997-05-09 1998-11-12 Kligman Douglas E Use of high dose retinoids for the treatment of skin disorders
USRE36068E (en) * 1981-08-28 1999-01-26 Kligman; Albert M. Methods for treatment of sundamaged human skin with retinoids
US5998395A (en) * 1992-02-07 1999-12-07 Kligman; Albert M. Methods of treating inflammatory dermatosis
US6028105A (en) * 1989-04-06 2000-02-22 Nigra; Thomas P. Topical drug delivery composition and method
US6063817A (en) * 1997-02-21 2000-05-16 Bristol-Myers Squibb Company Use of substituted (5,6) dihydronaphthalenyl compounds having retinoid-like activity to prevent or reduce ischemic injury
WO2000033877A1 (en) * 1998-12-04 2000-06-15 Johnson And Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US6169110B1 (en) 1995-11-21 2001-01-02 Vivant Pharmaceuticals Rejuvenating the skin using a combination of vitamin A and alphahydroxy acids
US6248763B1 (en) 1998-05-19 2001-06-19 Scivoletto Rosemarie Composition for treating skin conditions
EP1159956A2 (de) * 2000-05-01 2001-12-05 Johnson & Johnson Consumer Companies, Inc. Wasserfreie topische Zubereitungen für die Haut
US6344448B1 (en) 1992-09-11 2002-02-05 Stb Family Limited Partnership Composition for the treatment of hair loss
US6429218B1 (en) 1997-05-19 2002-08-06 Joseph Scivoletto Method of controlling niacin concentration in lotion
US20040157936A1 (en) * 1998-12-04 2004-08-12 Johnson And Johnson Consumer Companies Inc. Anhydrous topical skin preparations
US20050159485A1 (en) * 2002-01-04 2005-07-21 Jost-Price Edward R. Combinations for the treatment of immunoinflammatory disorders and proliferative skin diseases
US20050255130A1 (en) * 2004-05-11 2005-11-17 Mohan Vishnupad Retinoid solutions and formulations made therefrom
US20060014834A1 (en) * 2004-05-11 2006-01-19 Mohan Vishnupad Retinoid solutions and formulations made therefrom
US20060100181A1 (en) * 2002-05-03 2006-05-11 Jost-Price Edward R Combinations for the treatment of inflammatory skin disorders
US20060122282A1 (en) * 2004-12-03 2006-06-08 Todd Leonard Method for treating skin disorders with xanthophylls
US20060172955A1 (en) * 2000-12-12 2006-08-03 Mohan Vishnupad Antibiotic/benzoyl peroxide dispenser
US20060189552A1 (en) * 2000-12-12 2006-08-24 Mohan Vishnupad Dispenser for dispensing three or more actives
EP1714640A1 (de) * 1992-07-13 2006-10-25 Shiseido Company, Ltd. Retinolenthaltige stabilisierte Hautpflegemittel zur äusserlichen Anwendung
US20070141015A1 (en) * 2005-12-16 2007-06-21 Shane Malek Topical administration carrier composition and therapeutic formulations comprising same
US20080139518A1 (en) * 2006-12-04 2008-06-12 Concert, Llc Topical compositions for treatment of skin conditions
US20090264527A1 (en) * 2008-04-14 2009-10-22 Skinvisible Pharmaceuticals, Inc. Method for stabilizing retinoic acid, retinoic acid containing composition, and method of using a retinoic acid containing composition
CN104382798A (zh) * 2014-11-28 2015-03-04 李正梅 一种面膜及其制备方法
US20150094351A1 (en) * 2008-01-23 2015-04-02 Thesan Pharmaceuticals, Inc. Composition for topical use
US9962444B2 (en) 2016-09-27 2018-05-08 Shane Malek Pharmacokinetically extended action topical hair growth formulation, and administration method

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7612936L (sv) * 1976-11-19 1978-05-20 Pharmacia Ab Hygienisk-kosmetiska kompositioner

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL257621A (de) * 1959-11-23
GB901659A (en) * 1959-11-25 1962-07-25 Carolina Julia Cornelia Vintge Ointment for the treatment of acne vulgaris
CA945068A (en) * 1967-10-25 1974-04-09 Albert M. Kligman Composition and method of treating acne

Cited By (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3882244A (en) * 1971-12-13 1975-05-06 Univ California Method of treating acne with a c{hd 20 {b acid
US3906108A (en) * 1973-10-12 1975-09-16 Johnson & Johnson Stabilized tretinoin cream emulsion
US3932665A (en) * 1974-04-05 1976-01-13 Scott Eugene J Van Process for the treatment of acne vulgaris utilizing retinal
US3934028A (en) * 1974-04-22 1976-01-20 The Regents Of The University Of California Acne and psoriasis treatment with retinoic acid analogs
US4021573A (en) * 1974-04-22 1977-05-03 The Regents Of The University Of California Psoriasis treatment with retinoic acid analogs
DE2601489A1 (de) * 1975-01-17 1976-07-22 Johnson & Johnson Tretinoin enthaltende gelpraeparate
US4108880A (en) * 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
US4055659A (en) * 1975-11-03 1977-10-25 Johnson & Johnson Retinoic acid derivatives
US4126697A (en) * 1975-11-03 1978-11-21 Johnson & Johnson Retinoic acid derivatives in the treatment of acne
US4190594A (en) * 1975-11-03 1980-02-26 Johnson & Johnson Retinoic acid derivatives
US4034114A (en) * 1976-09-15 1977-07-05 Yu Ruey J Treatment of skin keratoses with retinal
US4200647A (en) * 1977-12-21 1980-04-29 Hoffmann-La Roche Inc. Vitamin A compositions to treat rheumatic disease
US4170229A (en) * 1978-01-16 1979-10-09 Dominion Pharmacal, Inc. Method for improved health care of hair and scalp using a vitamin A aqueous emulsion
US4214000A (en) * 1978-10-30 1980-07-22 Johnson & Johnson Zinc salt of all-trans-retinoic acid for the treatment of acne
US4247547A (en) * 1979-03-19 1981-01-27 Johnson & Johnson Tretinoin in a gel vehicle for acne treatment
US4239781A (en) * 1979-05-03 1980-12-16 Roy Edwards Method for treating skin ailments
US5514672A (en) * 1981-02-17 1996-05-07 Bazzano; Gail S. Use of retinoids and compositions containing same for hair growth
US5183817A (en) * 1981-02-17 1993-02-02 Bazzano Gail S Combinations of retinoids and minoxidil-type compounds for hair growth
USRE36068E (en) * 1981-08-28 1999-01-26 Kligman; Albert M. Methods for treatment of sundamaged human skin with retinoids
US4603146A (en) * 1984-05-16 1986-07-29 Kligman Albert M Methods for retarding the effects of aging of the skin
US4843096A (en) * 1985-06-26 1989-06-27 Stiefel Laboratories, Inc. Treatment of acne
US4877805A (en) * 1985-07-26 1989-10-31 Kligman Albert M Methods for treatment of sundamaged human skin with retinoids
US4889847A (en) * 1986-11-03 1989-12-26 Ortho Pharmaceutical Corporation Prevention of glucocorticoid-induced skin atrophy
US5019569A (en) * 1986-11-03 1991-05-28 Ortho Pharmaceutical Corporation Reversal of glucocorticoid-induced skin atrophy
US5698593A (en) * 1988-04-26 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Method for treating acne
US4985235A (en) * 1988-08-02 1991-01-15 Kligman Albert M Treatment of periodontoclasia with retinoic acid
AU614643B2 (en) * 1988-08-02 1991-09-05 Albert M. Kligman Treatment of periodontoclasia with retinoic acid
US6586473B1 (en) * 1989-04-06 2003-07-01 Medicis Pharmaceutical Corporation Topical drug delivery composition and method
US6028105A (en) * 1989-04-06 2000-02-22 Nigra; Thomas P. Topical drug delivery composition and method
US5670547A (en) * 1989-04-17 1997-09-23 Dow Pharmaceutical Sciences Moisturizing vehicle for topical application of vitamin A acid
US5124313A (en) * 1989-06-02 1992-06-23 Schaeffer Hans A Methods of improved skin care and the treatment of dermatological conditions
USRE41134E1 (en) 1989-06-07 2010-02-16 Alyzan, Inc. Slow release vehicles for minimizing skin irritancy of topical compositions
US5721275A (en) * 1989-06-07 1998-02-24 Bazzano; Gail S. Slow release vehicles for minimizing skin irritancy of topical compositions
WO1990014833A1 (en) * 1989-06-07 1990-12-13 Bazzano Gail S Slow release vehicles for minimizing skin irritancy of topical compositions
US5380764A (en) * 1989-06-08 1995-01-10 Herzog; Paul Composition of vitamin A, glucose and hydrogen peroxide for cosmetic or pharmaceutical use
US5459153A (en) * 1990-03-27 1995-10-17 Leung; Lit-Hung Composition and methods for treatment of acne vulgaris and for retardation of aging
US5273739A (en) * 1990-12-07 1993-12-28 Jim Baral Composition and treatment for darkening hair color
WO1992015293A1 (en) 1991-02-27 1992-09-17 Kligman Albert M Treatment of cellulite with retinoids
US5051449A (en) * 1991-02-27 1991-09-24 Kligman Albert M Treatment of cellulite with retinoids
WO1993006086A1 (en) * 1991-09-24 1993-04-01 Pfizer Inc. Retinoids and their use in treating skin diseases and leukemia
US5998395A (en) * 1992-02-07 1999-12-07 Kligman; Albert M. Methods of treating inflammatory dermatosis
US5643584A (en) * 1992-04-16 1997-07-01 Ortho Pharmaceutical Corporation Aqueous gel retinoid dosage form
EP1714640A1 (de) * 1992-07-13 2006-10-25 Shiseido Company, Ltd. Retinolenthaltige stabilisierte Hautpflegemittel zur äusserlichen Anwendung
US6344448B1 (en) 1992-09-11 2002-02-05 Stb Family Limited Partnership Composition for the treatment of hair loss
EP0699439A2 (de) 1994-08-31 1996-03-06 Pfizer Inc. Behandlung von durch Talgdrüse verursachten Erkrankungen mit Inhibitoren der Acyl CoA Cholesterin Acyltransferase
US5661141A (en) * 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
US6169110B1 (en) 1995-11-21 2001-01-02 Vivant Pharmaceuticals Rejuvenating the skin using a combination of vitamin A and alphahydroxy acids
US6063817A (en) * 1997-02-21 2000-05-16 Bristol-Myers Squibb Company Use of substituted (5,6) dihydronaphthalenyl compounds having retinoid-like activity to prevent or reduce ischemic injury
WO1998050023A1 (en) * 1997-05-09 1998-11-12 Kligman Douglas E Use of high dose retinoids for the treatment of skin disorders
US6008254A (en) * 1997-05-09 1999-12-28 Kligman; Douglas E. Method of treating skin disorders with high-strength tretinoin
US6228887B1 (en) 1997-05-09 2001-05-08 Douglas E. Kligman Method of treating skin disorders with high-strength retinoids
US6429218B1 (en) 1997-05-19 2002-08-06 Joseph Scivoletto Method of controlling niacin concentration in lotion
US6248763B1 (en) 1998-05-19 2001-06-19 Scivoletto Rosemarie Composition for treating skin conditions
US7179475B1 (en) 1998-12-04 2007-02-20 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US6238683B1 (en) 1998-12-04 2001-05-29 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US20040157936A1 (en) * 1998-12-04 2004-08-12 Johnson And Johnson Consumer Companies Inc. Anhydrous topical skin preparations
AU778524B2 (en) * 1998-12-04 2004-12-09 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
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CA945069A (en) 1974-04-09
ZA706459B (en) 1972-04-26
FR2070083B1 (de) 1974-05-24
DE2046119C2 (de) 1984-05-30
IT1059655B (it) 1982-06-21
GB1325732A (en) 1973-08-08
DE2046119A1 (de) 1971-04-22
FR2070083A1 (de) 1971-09-10

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