US3664341A - Vaginal capsule - Google Patents
Vaginal capsule Download PDFInfo
- Publication number
- US3664341A US3664341A US101285A US3664341DA US3664341A US 3664341 A US3664341 A US 3664341A US 101285 A US101285 A US 101285A US 3664341D A US3664341D A US 3664341DA US 3664341 A US3664341 A US 3664341A
- Authority
- US
- United States
- Prior art keywords
- capsule
- diameter portion
- large diameter
- vaginal
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Definitions
- a water Soluble c ylmdncally shaped vagmal capsule 1s [58] FleldofSearch ..128/27l,272iZ/0?;726lli described comprising a Sealed elongated large diameter pop tion containing a medicament and an elongated small diameter portion located at the distal end of the large diameter por- [56] References cued tion.
- This capsule is useful in treating vaginal infections such UNITED STATES PATENTS as vaginal moniliasis in pediatric patients 298,720 5/ 1984 Anderson 128/270 3 Claims, 2 Drawing figures PATENTEDMAY23 I972 3. 664, 841
- This invention relates to a novel medicament containing vaginal capsule.
- the present invention provides a medicament containing water soluble capsule that is designed for use in treating vaginal infections without requiring rupture of the hymen.
- one aspect of the present invention is to provide a vaginal capsule containing a premeasured quantity of medicament for use in treatment of vaginal infections such as Candida albicans.
- Another aspect of the present invention is to provide a vaginal capsule that has deformable walls so that the medicament content may be squeezed from the capsule.
- a still further aspect of the present invention is to provide a vaginal capsule that is conveniently used in pregnant or gravid patients without the use of an applicator.
- An additional aspect of the present invention is to provide a vaginal capsule that contains the medicament candicidin.
- FIG. 1 is a perspective view of a capsule according to the present invention.
- FIG. 2 is a sectional view of the capsule of the present invention.
- FIG. 1 shows a vaginal capsule generally cylindrical in shape having an elongated deformable large diameter body portion 11, a large diameter hemisphere-shaped end portion 12 integrally connected to the proximal end of body portion 11 and an elongated deformable small diameter portion 13 connected at the distal end of large diameter portion 11 by an integrally formed slope portion 14 and having a small diameter hemisphere-shaped end portion 15. Both large diameter portion 11 and small diameter portion 13 contain medicament 16. The length of small diameter portion 13 is substantially less than that of large diameter portion 1 l.
- the vaginal capsule is dimensioned so that it can conveniently hold the desired quantity of medicament and be comfortably inserted in the vaginal tract.
- the dimensions of elongated small diameter portion 13 are such that this portion of the capsule can be inserted through the imperfections in the wall of the hymen located at the vagina orifice without damaging the hymen.
- the preferred outside circumference of small diameter portion 13 is about three sixteenths of an inch.
- the overall length of capsule 10 is about 2% inches with the large diameter portion having a length of about 2 inches.
- the vaginal capsule is preferably manufactured from a gelatin containing composition that is water soluble.
- the walls of the capsule are deformable so that medicament may be squeezed out after the hemisphere portion 15 of small diameter portion 13 is cut off.
- the capsule provides an air tight encasement for medicament l6 (e.g., 3 mg. of candicidin in a petrolatum base) which is necessary in order to maintain the potency and stability of this material during storage.
- medicament l6 e.g., 3 mg. of candicidin in a petrolatum base
- the vaginal capsule may be used either by inserting it in the vaginal area and permitting the capsule to dissolve or the medicament may be squeezed from the capsule as previously indicated. This latter technique is particularly desirable in the treatment of vaginal infections in pediatric patients who still retain their hymen.
- the following example describes the manufacture of the vaginal capsule of the present invention containing three mg. of candicidin in a petrolatum base which is used to treat infections caused by Candida albicans.
- Candicidin ointment (Petrolatum base) is-melted at 53 to 55 C. and evacuated in the fluid state. The ointment is then cooled to approximately 33 to 35 C. prior to encapsulation.
- the encapsulation procedure is carried out v at a temperature between 32 and 34 C.
- the foregoing capsule provides a unit does form which eliminates the use of an applicator.
- the medicament may be any material that is used locally to treat vaginal infections such as antifungal agents (e.g., nystatin, amphotericin B); antibacterial agents (e.g., 9 aminoacridine, nitrofurazone, oxytetracycline), etc.
- antifungal agents e.g., nystatin, amphotericin B
- antibacterial agents e.g., 9 aminoacridine, nitrofurazone, oxytetracycline
- a medicament containing water soluble capsule for use in treating vaginal infections said capsule being cylindrical in shape and having an elon-v gated deformable large diameter body portion containing a premeasured quantity of medicament useful in the treatment of vaginal infections, and an elongated deformable small diameter portion located at the distal end of said large diameter portion and integrally connected to said large diameter portion by a sloped portion, said small diameter portion being of substantially less length than said large diameter portion and the opposed ends of said capsule being hemispherical in shape.
Abstract
A water soluble cylindrically shaped vaginal capsule is described comprising a sealed elongated large diameter portion containing a medicament and an elongated small diameter portion located at the distal end of the large diameter portion. This capsule is useful in treating vaginal infections such as vaginal moniliasis in pediatric patients.
Description
United States Patent Gordon [4 May 23, 1972 [54] VAGINAL CAPSULE 2,722,218 11 1955 Mittleman ..128/261 [72] Inventor: Harry W. GOI'dOll, BIOIIX, N.Y. FOREIGN PATENTS OR APPLICATIONS [731 Sigma Julius schmid New Yuk, 513,175 5/1955 Canada 128/261 [22] Filed: Dec. 24, 1970 Primary Examiner-L. W. Trapp [21] Appl. No.: 101,285 Atmmey Darby & Dal-by [52] U.S. CL... ..128/271, 424 14 ABSTRACT [51] Int. Cl. ..A6lf 15/00 A water Soluble c ylmdncally shaped vagmal capsule 1s [58] FleldofSearch ..128/27l,272iZ/0?;726lli described comprising a Sealed elongated large diameter pop tion containing a medicament and an elongated small diameter portion located at the distal end of the large diameter por- [56] References cued tion. This capsule is useful in treating vaginal infections such UNITED STATES PATENTS as vaginal moniliasis in pediatric patients 298,720 5/ 1984 Anderson 128/270 3 Claims, 2 Drawing figures PATENTEDMAY23 I972 3. 664, 841
VENTOR. HA Y W. GORDON F .a, z 19.
ATTORNEYS VAGINAL CAPSULE This invention relates to a novel medicament containing vaginal capsule.
ln pediatric patients who not infrequently incur vaginal infections such as caused by Candida albicans, it has been difficult to effectively treat such infections where the patient retains her hymen. This membrane acts as a barrier against the passage of the medicament to the situs of the infection. Therefore, in many instances it is necessary to rupture the hymen to treat the patient.
The present invention provides a medicament containing water soluble capsule that is designed for use in treating vaginal infections without requiring rupture of the hymen.
Accordingly, one aspect of the present invention is to provide a vaginal capsule containing a premeasured quantity of medicament for use in treatment of vaginal infections such as Candida albicans.
Another aspect of the present invention is to provide a vaginal capsule that has deformable walls so that the medicament content may be squeezed from the capsule.
A still further aspect of the present invention is to provide a vaginal capsule that is conveniently used in pregnant or gravid patients without the use of an applicator.
An additional aspect of the present invention is to provide a vaginal capsule that contains the medicament candicidin.
These and other aspects of the present invention will be apparent from the following description and drawings in which FIG. 1 is a perspective view of a capsule according to the present invention; and
- FIG. 2 is a sectional view of the capsule of the present invention.
Turning now to the drawings, FIG. 1 shows a vaginal capsule generally cylindrical in shape having an elongated deformable large diameter body portion 11, a large diameter hemisphere-shaped end portion 12 integrally connected to the proximal end of body portion 11 and an elongated deformable small diameter portion 13 connected at the distal end of large diameter portion 11 by an integrally formed slope portion 14 and having a small diameter hemisphere-shaped end portion 15. Both large diameter portion 11 and small diameter portion 13 contain medicament 16. The length of small diameter portion 13 is substantially less than that of large diameter portion 1 l.
The vaginal capsule is dimensioned so that it can conveniently hold the desired quantity of medicament and be comfortably inserted in the vaginal tract. The dimensions of elongated small diameter portion 13 are such that this portion of the capsule can be inserted through the imperfections in the wall of the hymen located at the vagina orifice without damaging the hymen. The preferred outside circumference of small diameter portion 13 is about three sixteenths of an inch. The overall length of capsule 10 is about 2% inches with the large diameter portion having a length of about 2 inches.
The vaginal capsule is preferably manufactured from a gelatin containing composition that is water soluble.
The walls of the capsule are deformable so that medicament may be squeezed out after the hemisphere portion 15 of small diameter portion 13 is cut off.
The capsule provides an air tight encasement for medicament l6 (e.g., 3 mg. of candicidin in a petrolatum base) which is necessary in order to maintain the potency and stability of this material during storage.
The vaginal capsule may be used either by inserting it in the vaginal area and permitting the capsule to dissolve or the medicament may be squeezed from the capsule as previously indicated. This latter technique is particularly desirable in the treatment of vaginal infections in pediatric patients who still retain their hymen.
The following example describes the manufacture of the vaginal capsule of the present invention containing three mg. of candicidin in a petrolatum base which is used to treat infections caused by Candida albicans.
Candicidin ointment (Petrolatum base) is-melted at 53 to 55 C. and evacuated in the fluid state. The ointment is then cooled to approximately 33 to 35 C. prior to encapsulation.
3 mg. candicidin. The encapsulation procedure is carried out v at a temperature between 32 and 34 C.
The foregoing capsule provides a unit does form which eliminates the use of an applicator. The medicament may be any material that is used locally to treat vaginal infections such as antifungal agents (e.g., nystatin, amphotericin B); antibacterial agents (e.g., 9 aminoacridine, nitrofurazone, oxytetracycline), etc.
What is claimed is:
1. As an article of manufacture a medicament containing water soluble capsule for use in treating vaginal infections, said capsule being cylindrical in shape and having an elon-v gated deformable large diameter body portion containing a premeasured quantity of medicament useful in the treatment of vaginal infections, and an elongated deformable small diameter portion located at the distal end of said large diameter portion and integrally connected to said large diameter portion by a sloped portion, said small diameter portion being of substantially less length than said large diameter portion and the opposed ends of said capsule being hemispherical in shape.
2. An article of manufacture according to claim 1 wherein said medicament is candicidin.
3. An article of manufacture according to claim 2 wherein said large diameter portion and said small diameter portions are composed of gelatin.
Claims (3)
1. As an article of manufacture a medicament containing water soluble capsule for use in treating vaginal infections, said capsule being cylindrical in shape and having an elongated deformable large diameter body portion containing a premeasured quantity of medicament useful in the treatment of vaginal infections, and an elongated deformable small diameter portion located at the distal end of said large diameter portion and integrally connected to said large diameter portion by a sloped portion, said small diameter portion being of substantially less length than said large diameter portion and the opposed ends of said capsule being hemispherical in shape.
2. An article of manufacture according to claim 1 wherein said medicament is candicidin.
3. An article of manufacture according to claim 2 wherein said large diameter portion and said small diameter portions are composed of gelatin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10128570A | 1970-12-24 | 1970-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3664341A true US3664341A (en) | 1972-05-23 |
Family
ID=22283844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US101285A Expired - Lifetime US3664341A (en) | 1970-12-24 | 1970-12-24 | Vaginal capsule |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US3664341A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3971376A (en) * | 1973-02-26 | 1976-07-27 | Ceskoslovenska Akademie Ved | Method and apparatus for introducing fluids into the body |
| US4027670A (en) * | 1976-10-15 | 1977-06-07 | Bronner Emanuel H | Contraceptive device |
| DE19922537A1 (en) * | 1999-05-10 | 2000-11-16 | Roland Bodmeier | Dosage form for application in body openings |
| GB2417231A (en) * | 2004-08-19 | 2006-02-22 | Lrc Products | Lubricant-containing capsules |
| US20070281008A1 (en) * | 2006-06-05 | 2007-12-06 | Lin Shun Y | Personal lubricant compositions and kits for providing personal lubrication |
| US20100100035A1 (en) * | 2007-03-15 | 2010-04-22 | Om Kataria | Uterine stimulant sticks |
| USD801518S1 (en) * | 2012-11-21 | 2017-10-31 | Therapeuticsmd, Inc. | Pharmaceutical capsule |
| USD914867S1 (en) | 2019-10-31 | 2021-03-30 | R.P. Scherer Technologies, Llc | Suppository |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US298720A (en) * | 1884-05-20 | Capsule | ||
| CA513175A (en) * | 1955-05-24 | Senff Karl | Pile ointment tubes | |
| US2722218A (en) * | 1952-07-12 | 1955-11-01 | Mittleman Myron Budd | Dispenser |
-
1970
- 1970-12-24 US US101285A patent/US3664341A/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US298720A (en) * | 1884-05-20 | Capsule | ||
| CA513175A (en) * | 1955-05-24 | Senff Karl | Pile ointment tubes | |
| US2722218A (en) * | 1952-07-12 | 1955-11-01 | Mittleman Myron Budd | Dispenser |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3971376A (en) * | 1973-02-26 | 1976-07-27 | Ceskoslovenska Akademie Ved | Method and apparatus for introducing fluids into the body |
| US4027670A (en) * | 1976-10-15 | 1977-06-07 | Bronner Emanuel H | Contraceptive device |
| DE19922537A1 (en) * | 1999-05-10 | 2000-11-16 | Roland Bodmeier | Dosage form for application in body openings |
| GB2417231A (en) * | 2004-08-19 | 2006-02-22 | Lrc Products | Lubricant-containing capsules |
| GB2417231B (en) * | 2004-08-19 | 2009-09-16 | Lrc Products | Lubricant delivery |
| US20070281008A1 (en) * | 2006-06-05 | 2007-12-06 | Lin Shun Y | Personal lubricant compositions and kits for providing personal lubrication |
| EP1864652A1 (en) * | 2006-06-05 | 2007-12-12 | McNeil-PPC, Inc. | Personal lubricant compositions and kits for providing personal lubrication |
| US20100100035A1 (en) * | 2007-03-15 | 2010-04-22 | Om Kataria | Uterine stimulant sticks |
| US8894599B2 (en) * | 2007-03-15 | 2014-11-25 | Om Kataria | Uterine stimulant sticks |
| USD801518S1 (en) * | 2012-11-21 | 2017-10-31 | Therapeuticsmd, Inc. | Pharmaceutical capsule |
| USD914867S1 (en) | 2019-10-31 | 2021-03-30 | R.P. Scherer Technologies, Llc | Suppository |
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