US3661158A - Atrio-ventricular demand pacer with atrial stimuli discrimination - Google Patents
Atrio-ventricular demand pacer with atrial stimuli discrimination Download PDFInfo
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- US3661158A US3661158A US884825A US3661158DA US3661158A US 3661158 A US3661158 A US 3661158A US 884825 A US884825 A US 884825A US 3661158D A US3661158D A US 3661158DA US 3661158 A US3661158 A US 3661158A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
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- the demand pacer of the present invention provides atrial stimulation and also pro- [52]
- U.S. Cl ..l28/4l9 P was agaInst Ventricular asystoki In PIIIeIIts WIIII aIIIaI [51 1 Int. Cl. ..A6ln 1/36 bradycardia but n m AV conduction.
- ATRIO-VENTRICULAR DEMAND PACER WITH ATRIAL STIMULI DISCRIMINATION This invention relates to pacers, and more particularly to demand pacers for use with patients exhibiting symptomatic atrial bradycardia and unpredictable AV block.
- the electrical activity of a normal heart begins with a nerve impulse generated by a bundle of fibers located in the sinoatrial node.
- the impulse spreads across the two atria while they contract and speed the flow of blood into the ventricles underneath them.
- the atrial activity of the heart corresponds to the P wave in an electrocardiogram trace.
- the electrical impulse continues to spread across the atrioventricular (AV) node, which in turn stimulates the left and right ventricles.
- AV atrioventricular
- an interval of approximately 120-160 milliseconds elapses between atrial and ventricular stimulation.
- the ventricular activity corresponds to the QRS portion of the electrocardiogram, and typically has a duration of 80 milliseconds.
- the ventricular muscles repolarize, and this portion of the electrical activity of the heart corresponds to the T wave in the electrocardiogram.
- the ventricular is far more important than the atrial.
- the atrial contractions cause the ventricular contractions to be more efficient; the ventricular contractions are more effective if the ventricles are first filled with blood. While a patient can survive without proper atrial action, he cannot survive without ventricular contractions.
- an AV block that is, an AV node which is open-circulated, life cannot be sustained (unless the ventricles somehow beat on their own without AV stimulation, and even in such a case the heartbeat rate is generally far too slow).
- AV block that is, an AV node which is open-circulated
- life cannot be sustained (unless the ventricles somehow beat on their own without AV stimulation, and even in such a case the heartbeat rate is generally far too slow).
- AV block that is, an AV node which is open-circulated, life cannot be sustained (unless the ventricles somehow beat on their own without AV stimulation, and even in such a case the heartbeat rate is generally far too slow).
- AV block that
- the demand pacer was introduced.
- electrical heart-stimulating impulses are provided only in the absence of natural heartbeats. If only a single natural heartbeat is absent, only a single electrical impulse is generated. If more than one natural heartbeat is missing, the pacer fills in beats at the pacer rate as long as the natural beats fail to occur. No matter how many electrical stimuli are generated, they occur at essentially the same time spacing from each other and from previous natural heartbeats as would be the case if they were all natural heartbeats. The result is an overall integrated operation, i.e., a mutually exclusive cooperation of natural heartbeats and stimulating impulses.
- the demand pacer of this type is disclosed in my U.S. Pat. No. 3,345,990 issued on Oct. I0, 1967.
- a demand pacer is primed to generate an impulse at a predetermined time after the last natural heartbeat. If another natural heartbeat occurs during the timing interval of the pacer, an impulse is not generated and the timing period starts all over again. On the other hand, if a natural heartbeat does not take place by the end of the timing period a stimulating impulse is generated.
- the pacer circuitry must determine if a natural heartbeat has occurred. The largest magnitude electrical signal generated by the heart activity is the QRS complex corresponding to ventricular contraction.
- an electrode is generally coupled to a ventricle. Since in most cases ventricular stimulation is required, the same electrode can be usedfor both stimulating the ventricles and detecting a natural heartbeat, as disclosed in my aforesaid patent.
- an improved demand pacer in the presence of'noise the pacertiming period is not interrupted. Continuous stimulating impulses are generated, even if they are not required. It is better to provide an impulse even if it is not required than it is not to provide an impulse if it is required.
- Ventricular pacer stimulation has been, used in the past to treat this disorder.
- atrial stimulation it would be better to, provide atrial stimulation to thus control both the atrial and ventricular rates, with the additional benefit of the natural atrioventricular sequence. But such atrial stimulation would leave the patient unprotected from unpredictable AV block. Thus, provision should also be made for ventricular stimulation if it becomes necessary.
- a demand pacer for atrial as well as ventricular stimulation is disclosed in my co-pending application Ser. No. 810,519 filed on Mar. 26, 1969, now U.S. Pat. No. 3,595,242.
- the first function of the pacer is to generate an atrial stimulating impulse. After a predetermined timeinterval, the pacer functions to generate a ventricular stimulating impulse.
- Three electrodes are provided a neutral electrode, an electrode for atrial stimulation and an electrode for ventricular stimulation.
- the ventricular electrode also serves to detect the occurrence of a ventricular contraction.
- the pacer exhibits two timing or escape. intervals.
- the ventricular escape interval is -250 milliseconds longer than the atrial escape interval.
- the ventricular escape interval is greater than the normal interval between two heartbeats (as in a typical demand pacemaker).
- the atrial escape interval is greater than the normal interval between ventricular and atrial beats (R to P), but less than the normal inter-beat interval (R to R). Both timing periods begin with the generation of the last heartbeat (natural or stimulated). If another ventricular contraction does not occur within the atrial timing period, that is, in the absence of a premature ventricular contraction, the atrial stimulating impulse is generated. The atria contract and fill the ventricles with blood.
- the detected ECG signal on the ventricular electrode resets both timing circuits and the ventricular impulse is not generated.
- a ventricular-impulse is generated at the end of the ventricular timing interval.
- the atrial stimulating pulse is large in magnitude, in the order of 5 volts, and causes an electrical signal to appear on the ventricular electrode. If this signal is treated as one which results from a ventricular contraction, the ventricular timing circuit will be reset and a ventricular stimulating pulse will not be generated even if a ventricular contraction does not occur following the atrial contraction. For this reason it is necessary to prevent the pacer from misinterpreting a signal on the ventricular electrode at the time of an atrial electrical stimulus as representing a ventricular contraction. In the pacer disclosed in my co-pending application Ser. No. 810,519, now U.S. Pat. No. 3,595,242 the pacer heartbeat detecting circuit is inhibited from operating for a short refractory period following the generation of each atrial stimulating pulse.
- the atrial stimulating pulse has a duration of 2 milliseconds, and the heartbeat detecting circuitry is inhibited from operating for 8 milliseconds starting with the leading portion of the atrial stimulating pulse. In this manner, the ventricular timing circuit cannot be reset when the atrial stimulating pulse is generated. The ventricular timing sequence continues in its ordinary course, and if the ventricular contraction does not occur on schedule a ventricular stimulating pulse is generated.
- a ventricular contraction coincides with an atrial contraction, or follows it within 8 milliseconds.
- a ventricular contraction cannot be detected because the ventricular contraction detecting circuitry is inhibited from operating during and immediately following the generation of each atrial stimulus. If a ventricular contraction does occur during the refractory period, the ventricular timing circuit does not reset and a ventricular stimulating pulse is generated at the end of the timing period even though a ventricular contraction has already occurred.
- the design of the pacer is predicated on an analysis of the signal frequencies contained in various waveforms, including an atrial stimulating pulse and the QRS waveform (the electrical signal on the ventricular electrode corresponding to a ventricular contraction).
- the atrial and ventricular stimulating circuits are isolated from each other by the use of a different pair of electrodes for each function, as contrasted with the use of three electrodes (one of which is shared) for the two functions. This isolation cuts down the magnitude of the electrical signal on the ventricular electrode resulting from the generation of an atrial stimulus.
- the signal is not sufficiently small in magnitude to prevent the pacer detecting circuitry from treating it as representing a ventricular contraction.
- Additional circuits are provided for discriminating between the two events based upon the different frequency contents of the two respective signals which appear on the ventricular electrode. In this manner, there is no need to inhibit the operation of the detecting circuitry following the generation of an atrial stimulus, and if a ventricular contraction does occur during or immediately following atrial stimulation the event can be detected.
- FIG. 1 depicts the illustrative demand pacer disclosed in my copending application Ser. No. 810,519, now U.S. Pat. No. 3,595,242;
- FIG. 2 depicts a typical electrocardiogram
- FIG. 3 is a timing diagram which will be helpful in understanding the operation of the pacer of FIG. 1;
- FIG. 4 depicts the illustrative embodiment of the present invention.
- electrode E2 is a neutral electrode (conductor 9 is grounded)
- electrode E1 is the ventricular stimulating electrode
- electrode E3 is the atrial stimulating electrode.
- the ventricular timing and stimulating circuit is contained in the drawing between switch S and electrodes E1 and E2.
- Capacitor 65 is initially charged by current flowing from batteries 3, 5 and 7 through resistor 59, terminals El and E2, and the patients heart in a time much shorter than the interval between successive heartbeats.
- the magnitude of resistor 59 is low enough to permit rapid charging of capacitor 65. but high enough to prevent significant attenuation of the signal detected across terminal El and E2, these terminals being connected to the implanted electrodes.
- transistor T9 When transistor T9 is triggered to conduction, the capacitor discharges through it, current flowing from the capacitor through the collector-emitter circuit of the transistor, tenninal E2, a cable to one electrode, the heart itself, the other electrode, and
- capacitor 65 is not involved with the various timing sequences used to control the selective generation of impulses.
- the capacitor always charges to the peak battery voltage. Because it discharges through an essentially short-circuited transistor switch, the magnitudes of the impulses do not vary as the battery impedance increases with aging. Nor is there any waste of energy between manufacture and implantation although transistor T9 is gated on during each cycle, as long as the electrodes are open-circuited capacitor 65 cannot discharge.
- the capacitor charges, as well as discharges, through the heart so that the net DC current through the electrodesfrom the pacemaker is zero. Otherwise, electrolytic processes in the heart cells could dissolve the electrodes.
- Transistors T7 and T8, connected as shown, are the equivalent of a conventional silicon controlled rectifier. Both are normally non-conducting. When the emitter electrode of transistor T7 goes sufficiently positive, the transistors conduct and current flows through the emitter circuit of transistor T8. Current continues to flow until the potential at the emitter of transistor T7 drops below a predetermined value.
- Transistor T9 is a simple current amplifier which is normally non-conducting. When transistor T8 conducts. however, the emitter current flowing through resistors 61 and 63 causes the potential at the base of transistor T9 to increase. At such a time transistor T9 is biased to conduction and capacitor 65 can discharge through it as described above.
- the apparatus can be used in a free-running mode, that is, an impulse can be generated at a 72-pulse-per-minute rate, for example, independent of the occurrence of natural heartbeats.
- switch S is closed and the base of transistor T6 is connected to the negative terminal of battery 3.
- Transistor T6 therefore remains in a cut-off condition. Pulses transmitted through capacitor 53 (to be described below) are shorted through the switch away from the transistor. Initially, capacitor 57 is discharged and transistors T7 and T8 are non-conducting. Current flows from batteries 3, 5 and 7 through resistors 35 and 37, capacitor 57, and resistors 61 and 63. The current through resistors 61 and 63 is insufficient to turn on transistor T9.
- Capacitor 57 discharges through resistor 37 and these two transistors. At the same time current flows from batteries 3 and 5 through the collectoremitter circuit of transistor T8, and resistors 61 and 63. Transistor T9 conducts and capacitor 65 discharges through it to provide an impulse to the ventricles. As soon as capacitor 57 has discharged sufficiently and the potential of the emitter of transistor T7 has dropped to a low enough value, all of transistors T7, T8 and T9 turn off and the impulse is terminated. Capacitor 65 immediately recharges, and capacitor 57 starts charging once again in preparation for the next impulse.
- the charging period of capacitor 57 is determined by the magnitude of the capacitor, and the magnitudes of resistors 35, 37, 61 and 63.
- Resistors 37, 61 and 63 are very small in comparison to the magnitude of resistor 35. Consequently, it is the magnitude of resistor 35 which determines the inter-pulse interval. As the magnitude of resistor 35 is adjusted the rate of the impulses vanes.
- Capacitor 57 discharges through resistor 37 and transistors T7 and T8.
- the width of the impulse delivered by capacitor 65 is determined by the discharge time of capacitor 57, that is, the time period during which transistors T7 and T8 conduct and thereby turn on transistor T9.
- the width of each impulse can be adjusted. In the case of an implantable pacer, the magnitudes of resistors 35 and 37 would be adjusted prior to implanting the apparatus in the patient.
- switch S When switch S is opened, i.e., in the case of a pacer required to operate in the demand mode, the same type of free-running operation would take place were there no input to the base of transistor T6 through capacitor 53. Transistor T6 would remain non-conducting and would not affect the charging of capacitor 57. However, with switch S open, pulses transmitted through capacitor 53 are not shorted through the switch away from the base-emitter circuit of transistor T6. With the switch open, each pulse transmitted through capacitor 53 to the base of transistor T6 causes the transistor to conduct. Capacitor 57 discharges through the collector-emitter circuit of the transistor.
- each ventricular contraction causes a pulse to be transmitted through capacitor 53 to turn on transistor T6.
- Transistor T6 conducts to discharge capacitor 57 just prior to the time when capacitor 57 would trigger, and discharge through, transistors T7 and T8 to control the generation of an impulse.
- the transistor After capacitor 57 has discharged through transistor T6, the transistor turns off. The capacitor then starts charging once again. The new cycle begins immediately after the occurrence of the last ventricular contraction so that the next impulse, if needed, will be generated immediately after the next natural heartbeat should have been detected were the heart functioning properly.
- a similar circuit is provided for generating an atrial stimulating pulse.
- the various elements to the right of electrodes E1 and E2 are designated by the same numerals as the equivalent elements in the atrial timing circuit with the addition of prime symbols. Except for component magnitudes, the atrial timing circuit is the same as the ventricular timing circuit.
- Electrode E3 is implanted in the patients heart to stimulate his atria.
- Capacitor 57 charges through potentiometers 35 and 37. After a predetermined interval, when the capacitor voltage has reached the level required to control conduction of transistors T7 and T8, the two transistors conduct and forward bias the base-emitter junction of transistor T9. The charge on capacitor 65 flows through transistor T9 and electrodes E2 and E3.
- the width of each pulse is determined by the setting of potentiometer 37 which determines the time required for capacitor 57 to discharge through transistors T7 and T8.
- the inter-pulse interval is determined by the setting of potentiometer 35' which determines the time required for capacitor 57 to charge to the level which causes transistors T7 and T8 to conduct.
- FIG. 3 depicts a timing sequence which will be helpful in understanding the pacer operation.
- Two R waves are shown and represent two successive beats (ventricular contractions) of the patients heart. Typically, the time interval between them is less than 760 milliseconds.
- the P wave associated with the second R wave is shown occurring before it.
- Potentiometer 35 has a value such that capacitor 57 charges to the level required for the conduction of transistors T7 and T8 after 600 milliseconds have elapsed since the last capacitor discharge.
- the atrial stimulating pulse E3 is thus shown occurring 600 milliseconds after the first R wave.
- the atria are stimulated following the P wave during a normal heartbeat. Actually, if a P wave has been generated it is an indication that the atria have contracted and an atrial stimulating impulse on electrode E3 is not required. However, if such an impulse is generated following the atrial contraction, that is, during the refractory interval of the atria, it has no effect on the beating action of the patients heart. (The generation of an atrial stimulating impulse prior to the natural atrial contraction can induce an atrial premature beat which is not desirable.)
- Potentiometer 35 in FIG. 1 has a value such that the timing interval for the ventricular stimulation is 800 milliseconds.
- the pulse designated E1 in FIG. 5' is shown occurring 800 milliseconds after the first R wave, which is slightly after the second R wave should it be present. If the second R wave is detected on electrode El, both timing circuits are reset and an impulse is not generated on electrode El. This is the desired demand-type operation. If a natural heartbeat does not occur within 800 milliseconds after the last heartbeat, an impulse is generated on electrode E1 to stimulate the ventricular contraction. It should be noted that if the heartbeats naturally, there will be no ventricular stimulation by the pacer.
- the 600 millisecond atrial timing interval is less than the natural interpulse interval. But in the event a natural atrial contraction does not take place, the atrial stimulation is required in order that the heart function more efficiently.
- the ventricular stimulation is provided to correct any AV block. A nor mal ventricular contraction can occur approximately milliseconds after the atrial stimulation.
- the ventricular timing period is 200 milliseconds longer than the atrial timing period; sufficient time is allowed for a natural ventricular contraction before a ventricular stimulating impulse is generated. In general, the ventricular timing period should exceed the atrial timing period by 160-250 milliseconds.
- the operation of the atrial timing circuit is keyed to the detection of a ventricular contraction on electrode El. It is highly desirable to key the atrial timing circuit to the beating of the patients heart were a freerunning generator provided to stimulate the atria, the timing of the beating of the patients heart might be seriously affected. While the natural timing might change, the circuitry timing would be invariant. For this reason, capacitor 57 is discharged following any beating of the patients heart. Theoretically, it might be possible to detect an atrial contraction, that is, to detect the P wave, and to discharge capacitor 57 before its timing period is completed so that an atrial stimulating impulse would not be generated if it is not required. However, it is exceedingly difficult to detect the?
- the natural beating action of the heart produces electrical signals which are characteristic of successive steps in the occurrence of each heartbeat.
- a heart beating in normal or sinus rhythm produces electrical signals conventionally identified as P, Q, R, S and T waves as shown in FIG. 2.
- the QRS complex in an electrocardiogram is the cellular electrogram in the vicinity of the electrodes which is important, not the skin electrocardiogram, since the pacer responds to the electrical signals generated by the cells in the vicinity of the electrodes.
- the cellular electrogram is generally considerably different from the skin electrocardiogram.
- the latter is the integral of all the cellular electrograms generated by a beating action of the heart. Because the various cells generate their signals at different times during each heartbeat, the integral (electrocardiogram) is in many respects dissimilar from an individual cellular electrogram.
- the R peak comprises frequency components primarily in the 2030 Hz region.
- the P and T waves comprise for the most part lower frequency components.
- various filters are provided in the circuit to filter out frequencies below 20 Hz.
- Such filters are incorporated in the pacer depicted in FIG. 1, although it has been found that such filters are not totally effective in preventing the triggering of transistor T6 by 60-Hz stray signals.
- a rate dis crimination circuit including transistors T3, T4 and T5, resistors 45 and 47, and capacitors 49 and 53
- This rate discrimination circuit will be described below after the frequency discrimination circuit is first considered.
- Transistor T1 is normally conducting, the emitter terminal of the transistor being connected through resistor 19 and conductor 9 to the negative terminal of battery 3, and the base of the transistor being connected through resistor 15 and conductor 13 to the positive terminal of the battery.
- the electrical signals picked up by the electrodes implanted in the patient's heart are coupled across capacitor 17 and resistor 15 in the base circuit of transistor T1. Signals of either polarity are amplified by transistor T1.
- the transistor is biased for class A operation because the polarity of the detected signal may be of either type depending on the manner in which the eIectrodes are implanted.
- Zener diodes 67 and 67 respectively bridge electrodes E1 and E2, and electrodes E3 and E2. It is possible that very high voltages can appear across the electrodes. For example, if defibrillation equipment is used, a very high voltage may be applied to the patient's heart. To avoid damage to the pacer circuitry, the large voltage signals are short-circuited through the Zener diodes. Each diode conducts in the forward direction (for voltages above a few tenths of a volt) as well as for voltages in the reverse direction which are above the breakdown potential of volts.
- Capacitor l7 and resistor emphasize the step function in the cellular electrogram. These two elements comprise a differentiator which emphasizes the frequency components above approximately 20 Hz. For such signals, the voltage drop across resistor 15 is appreciable and the input to transistor T1 is relatively large. For lower frequency signals, however, the
- Resistor l9 and capacitor 21 in the emitter circuit of transistor T1 serve a similar function.
- the impedance of the parallel circuit increases as the frequency decreases.
- the emitter impedance provides negative feedback for the transistor, and the overall gain of the transistor decreases as the frequency decreases.
- the amplified signal at the collector of transistor T1 is applied across the base-emitter junction of transistor T2, this transistor also being biased for class A operation.
- Transistor T2 further amplifies the detected signals.
- Capacitor 25 and resistor 27 in the emitter circuit of transistor T2 serve the same function as resistor 19 and capacitor 21 in the emitter circuit of transistor TI. This third differentiator further limits the low-frequency response of the detecting circuit to discriminate against the P and T waves and any other frequencies well below 20 Hz.
- Resistor 29 and capacitor 23 serve as an integrator to reduce high-frequency noise components well above 30 Hz.
- Resistor 31 and capacitor 43 in the collector circuit of transistor T2 serve the same function. Actually, these four elements serve to attenuate frequencies well above 60 Hz and have little effect on 60 Hz signals. In the illustrative embodiment of the invention the rate discrimination stage distinguishes 60-H2 stray signals from desired signals.
- transistors T3 and T4 require a signal of approximately 1 volt to conduct, and the maximum gain of stages T1 and T2 is above 50, it is apparent that 20-mv signals in the 20-30 Hz region at the electrodes can trigger transistors T3 and T4 to conduction.
- the 2030 Hz components in the electrical signal generated by the beating of the heart in the vicinity of the electrodes is typically above 20 mv.
- the frequency components characteristic of the P and T waves are not only one to two times smaller in magnitude than those characteristic of the R wave, but since the gain of stages T1 and T2 in the region around 5 Hz is only a fraction of the maximum gain, these signals do not trigger transistors T3 and T4 to conduction.
- the rate discriminator stage includes three transistors T3, T4 and T5 which collectively comprise a bi-phase switch having two functions.
- the switch serves to provide unipolar current pulses to charge capacitor 49.
- the switch is not a true rectifier because of its second function.
- This function is to provide unipolar pulses of constant magnitude independent of the amplitude of input signals above a threshold value. Any signal through capacitor 41, either positive or negative, which exceeds a threshold value (typically, 1 volt) results in a unipolar current pulse of predetermined magnitude being fed through resistor 45 to charge capacitor 49.
- the emitter of transistor T4 is connected to the positive terminal of battery 5, while the base of the transistor is connected through bias resistor 39 to the same potential.
- Transistor T4 is normally non-conducting. However, when a negative signal is transmitted through capacitor 41 the transistor turns on and current flows from battery 5 through the emitter-collector circuit of the transistor, resistor 45, and the parallel combination of resistor 47 and capacitor 49. The capacitor thus charges toward a maximum voltage determined by batteries 3 and 5, the drop across transistor T4, and resistors 45 and 47. If the emitter-collector circuit of the transistor is considered to have negligible impedance, the charging current is detennined solely by the magnitude of the batteries, and the magnitudes of elements 45, 47 and 49. The magnitude of the negative input signal is of no moment. As long as it is above the threshold value necessary for controlling the conduction of transistor T4, a current pulse of predetermined magnitude will be delivered to charge capacitor 49.
- a positive signal transmitted through capacitor 41 has no effect on transistor T4. However, it does cause transistor T3 to conduct, current flowing from battery 7 through resistor 33 and the collector-emitter circuit of transistor T3. It is necessary that the positive signal transmitted through capacitor 41 also result in a unipolar pulse of the same polarity to charge capacitor 49.
- the collector output of transistor T3 cannot be used for this purpose because it drops in potential when transistor T3 conducts. For this reason, phase inverter T5 is provided. While the emitter of this transistor is connected to the negative terminal of battery 7, the base of the transistor is connected to the junction of resistors 51 and 69. Normally the transistor is non-conducting. However, when transistor T3 conducts and the collector voltage drops, so does the base potential of transistor T5.
- transistor T5 conducts, current flowing from the positive terminal of battery 5 through the emitter-collector circuit of transistor T5 to resistor 45. It is thus seen that any changing signal transmitted through capacitor 41 above a threshold value causes a unipolar pulse to be delivered to the charging circuit.
- the capacitor will then recharge to the maximum voltage, after which it will fully discharge once again.
- the potential across capacitor 49 is AC- coupled through capacitor 53 to the base of transistor T6 and the base of transistor T6. Each charging pulse increases the potential across capacitor 49 from zero to the maximum voltage. The positive step is sufficient to cause transistors T6 and T6 to conduct, thereby discharging capacitors 57 and 57' and inhibiting the next impulses which would otherwise have been generated.
- each charging pulse charges capacitor 49 to the maximum voltage.
- the capacitor then starts to discharge through resistor 47 but before the discharge is complete another charging pulse occurs.
- the capacitor immediately charges to the maximum voltage and then starts to discharge once again.
- the capacitor never fully discharges, but the minimum voltage across it (that at the end of the discharge cycle when the next charging pulse is received) is low enough such that the increase in the capacitor voltage with the occurrence of each charging pulse is still sufficient to trigger transistors T6 and T6. Consequently, each charging pulse which results from a natural heartbeat resets both timing circuits.
- steps of negligible magnitude are transmitted through capacitor 53 to the base of transistor T6 and the base of transistor T6.
- Each transistor requires a signal of approximately 0.5 volts for conduction, and the step functions delivered through capacitor 53 are well below this value as the result of unipolar pulses occurring at a rate of 120 per second.
- transistors T3 or T4 are sufficient to prevent appreciable discharge of capacitor 49 and the triggering of transistor T6. It will be seen that should any 60-l-lz signals, or signals of any higher frequency, be present in the circuit, step functions of insufficient magnitude to trigger transistors T6 and T6 are transmitted through capacitor 53. Transistors T6 and T6 remain non-conducting and the pacer operates in its free-running mode. Even if there are natural heartbeats at this time, they have no effect. Each natural heartbeat causes a charging pulse to be delivered to capacitor 49, but it has no effect since the capacitor is at all times charged to almost its peak value.
- the pacer operates in its freerunning mode along with the natural beating of the patients heart. This may be disadvantageous, but it is far better than allowing the pacer to cease functioning at all a disastrous condition if at the particular time the patients heart has stopped functioning.
- single pulses of very narrow width can cause either of transistors T3 or T4 to conduct and a charging pulse to be delivered to capacitor 49. If capacitor 49 is discharged at this time (as it would be before the end of each cycle) the positive step across capacitor 49 can falsely trigger transistors T6 and T6. T0 preclude this possibility, resistor 45 is provided. Although each charging pulse causes a rapid rise in potential across capacitor 49, the rise is not a perfect step function because resistor 45 increases the charging time constant. With a very narrow pulse, by the time capacitor 49 has begun to charge appreciably, the pulse terminates. Consequently, capacitor 49 does not charge sufficiently to trigger transistors T6 and T6.
- Transistors T1 and T2 serve a different function than transistors T3, T4 and T5.
- the bi-phase switch delivers a current pulse of predetermined magnitude to the capacitor charging circuit, it is the rate discrimination circuit which prevents cancellation of the pacer stimuli by competitive sine wave interference or any other interference from signals occuring at a rate greater than a minimum value. In the pacer of FIG. 1, intereference is prevented for all signals occurring at a rate greater than 40 per second.
- Atrial stimulating pulse will produce an electrical signal on electrode El which after amplification will cause the two timing circuits to be reset.
- FET switch 92 is inserted in conductor 11 between electrode El and capacitor 17 in the base circuit of transistor T1.
- the switch is normally conducting due to its connection through resistor 94 to ground conductor 9.
- the negative pulse generated at electrode E3 is transmitted over conductor 84 and through diode 95 to capacitor 93.
- the capacitor charges and turns off the FET switch.
- capacitor 93 discharges through resistor 94.
- the time constant of the capacitor-resistor combination is such that the FET switch remains off for approximately an additional 6 milliseconds to prevent erroneous detection of a ventricular contraction for a few additional milliseconds until after all transients have died down. In this manner, the heartbeat detection circuit is disabled during each atrial stimulation and for a short interval thereafter.
- Capacitor 91 is provided to short high-frequency transients, arising from the FET switching, to conductor 9.
- a true ventricular contraction is not detected because the signal on electrode E1 is not transmitted through the switch and capacitor 17 to the base of transistor T1. It is desirable that the ventricular contraction be detected in order to reset the ventricular timing circuit.
- the atrial timing circuit re-starts anyway inasmuch as capacitor 57' discharges in order to generate the atrial pulse in the first place. But capacitor 57 continues to charge if transistor T6 is not turned on with the occurrence of the ventricular contraction.
- the pacer of FIG. 4 is similar to that of FIG. 1 except that the inhibiting circuit including FET switch 92 is omitted.
- the ventricular timing circuit in the pacer of FIG. 4 can be reset if a ventricular contraction occurs during or immediately after the generation of an atrial stimulating pulse. At the same time, in the absence of such a ventricular contraction, the atrial stimulating pulse does not cause transistor T6 to turn on thus resetting the ventricular timing circuit.
- the circuit of FIG. 4 is different from the circuit of FIG. 1 in a number of respects.
- the collector circuit of transistor T9 in FIG. 4 is different from that of FIG. 1.
- a parallel connection of resistor 38 and diode 42 is provided in the circuit of FIG. 4.
- Fourth, the arrangement of switch S is slightly different in the circuit of FIG. 4, and two separate capacitors 53 and 54 are provided instead of the single capacitor 53 of FIG. 1.
- the atrial stimulating pulse on electrode E3 can cause a significant signal on ventricular-contraction detecting electrode E1. This is due to the fact that ground electrode E2 is shared by the two other electrodes. Each of electrodes El and E3 is connected through the heart to electrode E2. Electrode E2 has some impedance and it is apparent that when an atrial stimulating pulse is generated and current flows between electrodes E3 and E2, the potential on electrode E2 rises due to the voltage drop across it. The increased potential is in turn extended through the heart to electrode El.
- the pacer of FIG. 4 In order to eliminate the atrial refractory period of the pacer, as a first step it is desirable to attenuate the signal on electrode E] which results from the generation of an atrial stimulating pulse. This is achieved in the pacer of FIG. 4 by providing a separate pair of electrodes E3 and E4 for the atrial stimulating circuit. When an atrial pulse is generated, current flows between electrodes E3 and E4. Because electrode E2 is not shared by electrodes El and E3, a significant rise in potential is not extended to electrode E1.
- Capacitor 65' is no longer used to store charge preparatory to the generation of each atrial stimulating pulse. Instead, the conduction of transistor T9 causes a pulse to be transmitted through transformer 44 to electrodes E3 and E4. When the transistor turns on, current flows from batteries 3, 5 and 7 through the primary winding of transformer 44 and the collector-emitter circuit of transistor T9 to ground conductor 9. The current pulse through the primary winding of transformer 44 causes a voltage pulse to appear across the secondary winding of the transformer. This pulse is transmitted through capacitor 48. Electrode E3 goes positive with respect to electrode E4 and current flows through the atrium to which the electrodes are connected.
- Capacitor 48 is provided to prevent the flow of direct current in the event the electrodes become polarized.
- Zener diode 52 is provided in place of Zener diode 67 in FIG. 1. The diode is poled such that it is reverse biased when the current stimulating pulse is generated. However, in the event of an excessive signal appearing across the electrodes resulting from an external source, the diode conducts in the forward direction if the signal exceeds a few tenths of a volt and it conducts in the reverse direction if the signal exceeds 10 volts. In either case, the magnitude of the pulse extended in the reverse direction through transformer 44 to the collector circuit of transistor T9 can cause no damage.
- Diode 46 is provided to allow the current through the primary winding of the transformer to dissipate when transistor T9 turns off at the end of each pulse. The current continues to flow in the same direction through the primary winding but it now flows through diode 46 instead of transistor T9. The diode is reverse biased when transistor T9 conducts so that during the generation of the current pulse it has no effect on the circuit operation. The use of the diode in this manner allows the rapid disappearance of the magnetic field produced by the current flow through the primary winding at the end of the atrial stimulating pulse.
- the pacemaker of FIG. 4 includes additional circuitry for preventing resetting of the ventricular timing circuit.
- the atrial stimulating pulse has a typical duration of 2 milliseconds. Due to its short width, the pulse is characterized primarily by relatively high-frequency components.
- electrode E1 is connected through FET switch 92 directly to capacitor 17. If the FET switch is omitted, it is apparent that electrode E1 is coupled directly to the base of transistor T1 through the capacitor.
- electrode E1 is coupled through resistor 32 to capacitor 17. One end of the resistor is connected through capacitor 91 to ground conductor 9.
- Capacitor 91 in the pacer of FIG. 1 serves to short high-frequency switching transients of FET switch 92 to ground. In the pacer of FIG.
- resistor 32 and capacitor 91 comprise a low-pass filter which reduces the spike transmitted through capacitor 17 to the base of transistor T1 when an atrial stimulating pulse is generated.
- the cut-off frequency of the low-pass filter comprising resistor 32 and capacitor 91 is 15 Hz.
- the filter has little effect on the QRS signal which is detected at electrode E1 because the QRS waveform is characterized primarily by frequencies above 15 Hz. But the low-pass filter does attenuate the relatively high-frequency signal on conductor 11 which appears when the atrial stimulating pulse is generated.
- the base bias potential for transistor T1 is derived by the connection of conductor 13 from the junction of batteries 3 and to resistor 15. Although ideally the batteries have no source impedance, as a practical matter the batteries do exhibit some impedance. When the atrial stimulating pulse is generated, the current which flows through the batteries does cause a change in the potential exhibited across each battery. Thus even though the use of an isolated pair of electrodes in the atrial stimulating circuit and the incorporation of an additional low-pass filter do cut down the magnitude of the spike transmitted through capacitor 17 to the base of transistor T1 when an atrial stimulating pulse is generated, the change in the voltage across battery 3 when the atrial stimulating current flows can cause the base potential of transistor T1 to change.
- the resistor and capacitor form another low-pass filter.
- the atrial stimulating current pulse which flows through battery 3 causes a 2-millisecond voltage spike to appear across the battery terminals.
- the pulse is characterized by relatively high frequencies and they are attenuated by the low-pass filter so that the resultingspike transmitted through resistor to the base of transistor T1 is minimal.
- the cut-off frequency of the low-pass filter comprising resistor 36 and capacitor 34 can be much higher than the l5-Hz cut-off frequency of the low-pass filter comprising resistor 32 and capacitor 91.
- the latter filter should not attenuate the frequencies which characterize the QRS waveform and consequently the cut-off frequency is only 15 Hz.
- resistor 36 and capacitor 34 can attenuate even the higher frequencies characteristic of the QRS waveform. For this reason the cutoff frequency of the low-pass filter inserted in conductor 13 can be orders of magnitude higher than the cut-off frequency of the low-pass filter inserted in conductor 11.
- the short-duration (2-millisecond) atrial stimulating pulse even if it causes one of transistors T4 and T5 to conduct,
- short-duration 'pulse is similar to an RF spike for which the circuit including resistor 45, resistor 47 and capacitor 49 is designed to attenuate.
- Resistor 45 is included in the circuit so that capacitor 49 charges slowly with respect to the width of an RF spike. Only a relatively wide spike, such as that produced with the detection of a QRS waveform signal on electrode E1, results in the charging of capacitor 49 to a suffi cient level for triggering transistor T6.
- resistor 45 can be increased in magnitude. With a sufficiently large resistor, capacitor 49 can be prevented from charging sufficiently from a 2-millisecond spike to trigger the transistor.
- resistor 45 is increased in magnitude even a spike resulting from the detection of a QRS waveform signal may not charge capacitor 49 suffi: ciently to trigger transistor T6. This is due to the fact that resistor 45 and resistor 47 form a voltage divider, and the larger resistor 45 the smaller the source potential for charging capacitor 49. Even a spike resulting from the detection of a QRS waveform may not charge capacitor 49 sufficiently to trigger transistor T6 if resistor 45 is increased greatly in magnitude.
- resistor 38 delays the charging of capacitor 49 so that the relatively narrow spike resulting from the generation of an atrial stimulating pulse does not charge capacitor 49 sufficiently to trigger transistor T6, the relatively wide spike resulting from the detection of a ventricular contraction does cause capacitor 49 to charge sufficiently to trigger the transistor.
- resistor 38 affects the operation of the circuit in yet another manner. It will be recalled that the spike resulting from each QRS waveform charges capacitor 49 in FIG. 1, the capacitor thereafter discharging through resistor 47. The capacitor must discharge sufficiently during the interbeat interval in order that the spike resulting from each QRS waveform be capable of increasing the voltage across the capacitor. If the capacitor does not discharge sufficiently, the rise in potential across the capacitor with the conduction of transistor T4 or T5 will not be sufficient for turning on transistor T6. In fact, the rate discrimination circuit operatesv in such a manner that pulses at too rapid a rate do not permit the capacitor to discharge sufficiently each pulse charges the capacitor only slightly and transistor T6 does not turn on. With resistor 38 included in the circuit of FIG. 4, it is apparent that the discharge path now includes this resistor as well as resistor 47. The increased time constant of the discharge circuit may not permit capacitor 49 to discharge sufficiently between beats; transistor T6 may not conduct when each QRS waveform is detected.
- diode 42 is included in the circuit.
- the diode conducts current only when capacitor 49 is discharging and current flows in the forward direction through the diode.
- resistor 38 is effectively short-circuited by the diode whose impedance is negligable. Consequently the discharge circuit in the pacer of FIG. 4 is basically the same as that in the pacer of FIG. 1 since resistor 38 is effectively removed from the circuit.
- the resistor is effective only during the charging cycle of capacitor 49 since when current flows from one of transistors T4 and T5, it flows through resistor 38 from left to right and diode 42 is reverse biased.
- diode 42 in the circuit allows resistor 38 to be used to increase the charging time constant of the rate discrimination circuit, without affecting the discharge time constant.
- the circuit can be adjusted, for example, such that one of transistors T4 and T must conduct for at least milliseconds (at intervals corresponding to the normal heartbeat rate) in order for the voltage rise across capacitor 49 to be sufficient to turn on transistor T6.
- the atrial stimulating pulse which is only 2 milliseconds in width, even if it causes one of transistors T4 and T5 to conduct, will now allow capacitor 49 to charge sufficiently to turn on transistor T6.
- the potential at the junction of capacitor 53 and resistor 55' (the base of transistor T6) cannot rise instantaneously when the potential at the junction of resistors 55 and 61 rises with the generation of the atrial stimulating pulse.
- the atrial stimulating pulse is sufficiently short in duration such that the voltage at the base of transistor T6 does not rise sufficiently to turn the transistor on by the time the atrial stimulating pulse is terminated.
- capacitor 54 is greater in magnitude than capacitor 53 so that the pulse transmitted through capacitor 53 to the base of transistor T6 is even further reduced in magnitude to prevent conduction of transistor T6.
- the use of an additional capacitor 54 in this manner further isolates the two timing circuits from each other.
- switch S in the pacer of FIG. 4 is connected in series with the base of transistor T6 rather than in parallel with it as in the circuit of FIG. 1.
- the base of transistor T6 and the base of transistor T6 are shorted to ground and both pulse generating circuits operate in the continuous mode.
- both pulse generating circuits function in the demand mode.
- switch S is placed in series with the base of transistor T6.
- the ventricular timing circuit operates in the continuous mode since no pulses are transmitted through capacitor 53 to trigger transistor T6 and discharge capacitor 57.
- the switch is closed, on the other hand, the ventricular timing circuit operates in the demand mode.
- the atrial timing circuit As for the atrial timing circuit, it operates in the demand mode at all times. Even with switch S open and the ventricular stimulating circuit operating in the continuous mode, each ventricular contraction is detected and causes a pulse to be extended through capacitor 54 to reset transistor T6. The atrial timing period thus starts over again with each ventricular contraction. This arrangement is most satisfactory because it allows the two timing circuits to be synchronized to each other even when the ventricular timing circuit operates in the continuous mode.
- An atrial and ventricular pacer comprising a first pair of terminals for connection to a patients heart for atrial stimulation, a second pair of terminals for connection to said patients heart for ventricular stimulation, means coupled to said second pair of terminals for detecting an electrical signal thereon resulting from the beating of said patients heart, means for generating electrical stimuli on said fist and second pairs of terminals in accordance with the time at which the beating of said patients heart is detected, and means for preventing the operation of said detecting means responsive to the appearance on said second pair of terminals of an electrical signal resulting from the generation of an electrical stimulus on said first pair of terminals.
- An atrial and ventricular pacer in accordance with claim 1 wherein stimuli are generated on said first pair of tenninals at intervals which are shorter than the normal interval between successive R waves in the electrocardiographic waveform of said patient and are longer than the normal interval between an R wave and the next P wave in the electrocardiographic waveform of said patient, and stimuli are generated on said second pair of terminals at intervals which are longer than the normal interval between successive R waves in the electrocardiographic waveform of said patient.
- An atrial and ventricular pacer in accordance with claim 4 further including means responsive to the operation of said detecting means at a rate greater than a predetermined rate for controlling the generation of stimuli on said second pair of terminals at a rate independent of the detection of the beating of said patients heart, said controlling means including a capacitor, first resistance means connected in series with said capacitor, means responsive to the operation of said detecting means for applying a current pulse to said first resistance means for charging said capacitor, second resistance means connected between said first resistance means and said capacitor for discharging said capacitor between applications thereto of successive current pulses, said electrical stimuli generating means operating in accordance with an instantaneous rise in potential greater than a predetermined value across said capacitor with the application of one of said current pulses, and means for reducing the discharge time constant of said capacitor.
- An atrial and ventricular pacer in accordance with claim 1 wherein said electrical stimuli generating means includes a pulse generating circuit and transformer means for coupling said pulse generating circuit to said first pair of terminals.
- An atrial and ventricular pacer in accordance with claim 8 further including means responsive to the operation of said detecting means at a rate greater than a predetermined rate for controlling the generation of stimuli on said second pair of terminals at a rate independent of the detection of the beating of said patients heart, said controlling means including a capacitor, first resistance means connected in series with said capacitor, means responsive to the operation of said detecting means for applying a current pulse to said first resistance means for charging said capacitor, second resistance means connected between said first resistance means and said capacitor for discharging said capacitor between applications thereto of successive current pulses, said electrical stimuli generating means operating in accordance with an instantaneous rise in potential greater than a predetermined value across said capacitor with the application of one of said current pulses, and means for reducing the discharge time constant of said capacitor.
- said discharge time constant reducing means includes a diode connected across said first resistance means poled in the direction of the flow of discharge current from said capacitor.
- An atrial and ventricular pacer in accordance with claim 1 wherein the electrical stimuli generated on said first pair of terminals are much narrower than the width of a normal QRS waveform and said preventing means includes a low-pass filter for attenuating the relatively high-frequency signal components contained in the electrical signal appearing on said second pair of terminals resulting from the generation of an electrical stimulus on said first pair of terminals.
- An atrial and ventricular pacer in accordance with claim 11 further including means responsive to the operation of said detecting means at a rate greater than a predetermined rate for controlling the generation of stimuli on said second pair of terminals at a rate independent of the detection of the beating of said patients heart, said controlling means including a capacitor, first resistance means connected in series with said capacitor, means responsive to the operation of said detecting means for applying a current pulse to said first resistance means for charging said capacitor, second resistance means connected between said first resistance means and said capacitor for discharging said capacitor between applications thereto of successive current pulses, said electrical stimuli generating means operating in accordance with an instantaneous rise in potential greater than a predetermined value across said capacitor with the application of one of said current pulses, and means for reducing the discharge time constant of said capacitor.
- An atrial and ventricular pacer comprising terminal means for connection to a patients heart for atrial stimulation, terminal means for connection to said patients heart for ventricular stimulation, a first timing circuit connected to said atrial terminal means for generating an electrical impulse on said atrial terminal means, a second timing circuit connected to said ventricular terminal means for generating an electrical impulse on said first and said ventricular terminal means, means continuously operative for detecting a signal on said ventricular terminal means corresponding to a ventricular contraction of said patients heart, means responsive to the operation of said detecting means for resetting said second timing circuit, and means for preventing the operation of said resetting means responsive to the operation of said detecting means when a signal appears on said ventricular terminal means as a result of the generation of an electrical impulse on said atrial terminal means.
- An atrial and ventricular pacer in accordance with claim 15 further including means responsive to the operation of said detecting means at a rate greater than a predetermined rate for controlling the generation of electrical impulses on said ventricular terminal means at a rate independent of the detection of signals on said ventricular terminal means corresponding to ventricular contractions of said patients heart, said controlling means including a capacitor, first resistance means connected in series with said capacitor, means responsive to the operation of said detecting means for applying a current pulse to said first resistance means for charging said capacitor, second resistance means connected between said first resistance means and said capacitor for discharging said capacitor between applications thereto of successive current pulses, said second timing means operating in accordance with an instantaneous rise in potential greater than a predetermined value across said capacitor with the application of one of said current pulses, and means for reducing the discharge time constant of said capacitor.
- An atrial and ventricular pacer in accordance with claim 14 further including means responsive to the operation of said detecting means at a rate greater than a predeterminedrate for controlling the generation of electrical impulses on said ventricular terminal means at a rate independent of the detection of signals on said ventricular terminal means corresponding to ventricular contractions of said patients heart, said controlling means including a capacitor, first resistance means connected in series with said capacitor, means responsive to the operation of said detecting means for charging said capacitor, second resistance means connected between said first resistance means and said capacitor for discharging said capacitor between applications thereto of successive current pulses, said second timing means operating in accordance with an instantaneous rise in potential greater than a predetermined value across said capacitor with the application of one of said current pulses, and means for reducing the discharge time constant of said capacitor.
- An atrial and ventricular pacer comprising terminal means for connection to a patients heart for atrial stimulation, terminal means for connection to said patients heart for ventricular stimulation, a first timing circuit connected to said atrial terminal means for generating an electrical impulse on said atrial terminal means, a second timing circuit connected to said ventricular terminal means for generating an electrical impulse on said ventricular terminal means, means for detecting a signal corresponding to a ventricular contraction of said patients heart, means responsive to the operation of saiddetecting means for resetting said first and second timing circuits, and switch means for preventing the resetting of only 20 wherein said detecting means includes means for providing continuous operation of said detecting means.
- a pacer comprising terminal means for connection to a' patients heart for atrium and ventricle stimulation, means for detecting electrical signals on said terminal means resulting from beating of said ventricle, and means controlled by operation of said detecting means for generating electrical stimulii on said terminal means for stimulating said atrium and said ventricle in a predetermined timing sequence.
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- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88482569A | 1969-12-15 | 1969-12-15 |
Publications (1)
Publication Number | Publication Date |
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US3661158A true US3661158A (en) | 1972-05-09 |
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ID=25385487
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US884825A Expired - Lifetime US3661158A (en) | 1969-12-15 | 1969-12-15 | Atrio-ventricular demand pacer with atrial stimuli discrimination |
Country Status (5)
Country | Link |
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US (1) | US3661158A (de) |
JP (1) | JPS5145912B1 (de) |
DE (1) | DE2061182A1 (de) |
GB (2) | GB1335679A (de) |
NL (1) | NL7016859A (de) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3999556A (en) * | 1974-12-16 | 1976-12-28 | Medtronic, Inc. | Demand cardiac pacemaker with input circuit portion of increased sensitivity |
DE2701104A1 (de) * | 1977-01-12 | 1978-07-13 | Medtronic France S A | Herzschrittmacher |
US4328807A (en) * | 1980-04-07 | 1982-05-11 | Medtronic, Inc. | Output pulse artifact rejection in demand pacemakers |
US4333470A (en) * | 1980-04-07 | 1982-06-08 | Medtronic, Inc. | Output pulse artifact rejection in demand pacemakers |
US4386610A (en) * | 1980-05-27 | 1983-06-07 | Cordis Corporation | Ventricular-inhibited cardiac pacer |
US4401119A (en) * | 1981-02-17 | 1983-08-30 | Medtronic, Inc. | Prolongation of timing intervals in response to ectopic heart beats in atrial and ventricular pacemakers |
US4407287A (en) * | 1981-02-17 | 1983-10-04 | Medtronic, Inc. | Atrial and ventricular-only pacemaker responsive to premature ventricular contractions |
US4421114A (en) * | 1978-10-30 | 1983-12-20 | Berkovits Barouh V | Tachycardia treatment |
EP0160801A2 (de) * | 1981-02-17 | 1985-11-13 | Medtronic, Inc. | Anzeiger des Erschöpfungszustandes der Speisequelle einpflanzbarer medizinischer Geräte |
USRE32378E (en) * | 1980-04-07 | 1987-03-24 | Medtronic, Inc. | Output pulse artifact rejection in demand pacemakers and sensing circuits employed in conjunction therewith |
US6198968B1 (en) | 1998-01-23 | 2001-03-06 | Intermedics Inc. | Implantable cardiac stimulator with safe noise mode |
US20060212064A1 (en) * | 2002-09-12 | 2006-09-21 | Shah Tilak M | Dip-molded polymeric medical devices with reverse thickness gradient, and methood of making same |
US20080009910A1 (en) * | 2006-07-10 | 2008-01-10 | Hannes Kraetschmer | Cardiac pacemaker |
US20100312095A1 (en) * | 2009-06-08 | 2010-12-09 | Jenkins Kimble L | Mri-guided surgical systems with proximity alerts |
US8369930B2 (en) | 2009-06-16 | 2013-02-05 | MRI Interventions, Inc. | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3814106A (en) * | 1972-04-14 | 1974-06-04 | American Optical Corp | Atrial and ventricular pacer having independent rate controls and means to maintain a constant av delay |
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US3241556A (en) * | 1962-05-17 | 1966-03-22 | Cotelec Soc Fr D Etudes Et De | Cardiac stimulators |
US3433228A (en) * | 1966-05-06 | 1969-03-18 | Cordis Corp | Multimode cardiac pacer |
US3454012A (en) * | 1966-11-17 | 1969-07-08 | Esb Inc | Rechargeable heart stimulator |
US3523539A (en) * | 1968-02-26 | 1970-08-11 | Hewlett Packard Co | Demand cardiac pacemaker and method |
-
1969
- 1969-12-15 US US884825A patent/US3661158A/en not_active Expired - Lifetime
-
1970
- 1970-11-18 NL NL7016859A patent/NL7016859A/xx unknown
- 1970-12-11 JP JP45109643A patent/JPS5145912B1/ja active Pending
- 1970-12-11 DE DE19702061182 patent/DE2061182A1/de active Pending
- 1970-12-15 GB GB5943570A patent/GB1335679A/en not_active Expired
- 1970-12-15 GB GB193373A patent/GB1335680A/en not_active Expired
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US3241556A (en) * | 1962-05-17 | 1966-03-22 | Cotelec Soc Fr D Etudes Et De | Cardiac stimulators |
US3433228A (en) * | 1966-05-06 | 1969-03-18 | Cordis Corp | Multimode cardiac pacer |
US3454012A (en) * | 1966-11-17 | 1969-07-08 | Esb Inc | Rechargeable heart stimulator |
US3523539A (en) * | 1968-02-26 | 1970-08-11 | Hewlett Packard Co | Demand cardiac pacemaker and method |
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Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3999556A (en) * | 1974-12-16 | 1976-12-28 | Medtronic, Inc. | Demand cardiac pacemaker with input circuit portion of increased sensitivity |
DE2701104A1 (de) * | 1977-01-12 | 1978-07-13 | Medtronic France S A | Herzschrittmacher |
US4421114A (en) * | 1978-10-30 | 1983-12-20 | Berkovits Barouh V | Tachycardia treatment |
US4328807A (en) * | 1980-04-07 | 1982-05-11 | Medtronic, Inc. | Output pulse artifact rejection in demand pacemakers |
US4333470A (en) * | 1980-04-07 | 1982-06-08 | Medtronic, Inc. | Output pulse artifact rejection in demand pacemakers |
USRE32378E (en) * | 1980-04-07 | 1987-03-24 | Medtronic, Inc. | Output pulse artifact rejection in demand pacemakers and sensing circuits employed in conjunction therewith |
US4386610A (en) * | 1980-05-27 | 1983-06-07 | Cordis Corporation | Ventricular-inhibited cardiac pacer |
US4401119A (en) * | 1981-02-17 | 1983-08-30 | Medtronic, Inc. | Prolongation of timing intervals in response to ectopic heart beats in atrial and ventricular pacemakers |
EP0160801A2 (de) * | 1981-02-17 | 1985-11-13 | Medtronic, Inc. | Anzeiger des Erschöpfungszustandes der Speisequelle einpflanzbarer medizinischer Geräte |
EP0160801A3 (en) * | 1981-02-17 | 1986-05-28 | Medtronic, Inc. | Implantable medical device power source depletion indicators |
US4407287A (en) * | 1981-02-17 | 1983-10-04 | Medtronic, Inc. | Atrial and ventricular-only pacemaker responsive to premature ventricular contractions |
US6198968B1 (en) | 1998-01-23 | 2001-03-06 | Intermedics Inc. | Implantable cardiac stimulator with safe noise mode |
US20060212064A1 (en) * | 2002-09-12 | 2006-09-21 | Shah Tilak M | Dip-molded polymeric medical devices with reverse thickness gradient, and methood of making same |
US7697986B2 (en) * | 2006-07-10 | 2010-04-13 | Biotronik Crm Patent Ag | Cardiac pacemaker |
US20080009910A1 (en) * | 2006-07-10 | 2008-01-10 | Hannes Kraetschmer | Cardiac pacemaker |
US20100312095A1 (en) * | 2009-06-08 | 2010-12-09 | Jenkins Kimble L | Mri-guided surgical systems with proximity alerts |
US9259290B2 (en) | 2009-06-08 | 2016-02-16 | MRI Interventions, Inc. | MRI-guided surgical systems with proximity alerts |
US9439735B2 (en) | 2009-06-08 | 2016-09-13 | MRI Interventions, Inc. | MRI-guided interventional systems that can track and generate dynamic visualizations of flexible intrabody devices in near real time |
US8369930B2 (en) | 2009-06-16 | 2013-02-05 | MRI Interventions, Inc. | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
US8396532B2 (en) | 2009-06-16 | 2013-03-12 | MRI Interventions, Inc. | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
US8768433B2 (en) | 2009-06-16 | 2014-07-01 | MRI Interventions, Inc. | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
US8825133B2 (en) | 2009-06-16 | 2014-09-02 | MRI Interventions, Inc. | MRI-guided catheters |
US8886288B2 (en) | 2009-06-16 | 2014-11-11 | MRI Interventions, Inc. | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
Also Published As
Publication number | Publication date |
---|---|
NL7016859A (de) | 1971-06-17 |
GB1335679A (en) | 1973-10-31 |
JPS5145912B1 (de) | 1976-12-06 |
DE2061182A1 (de) | 1971-06-24 |
GB1335680A (en) | 1973-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: COOK PACEMAKER CORPORATION, INDIANA Free format text: LICENSE;ASSIGNOR:ATLANTIC RICHFIELD COMPANY;REEL/FRAME:003852/0285 Effective date: 19810327 Owner name: COOK PACEMAKER CORPORATION, P.O. BOX 99, BLOOMINGT Free format text: LICENSE;ASSIGNOR:ATLANTIC RICHFIELD COMPANY;REEL/FRAME:003852/0285 Effective date: 19810327 |
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AS | Assignment |
Owner name: TELECTRONICS PTY. LIMITED Free format text: CONFIRMS THE GRANTING OF LICENSE AGREEMENT DATED JULY 1, 1973 SUBJECT TO CONDITIONS IN AGREEMENT DATED JANUARY 16, 1984;ASSIGNOR:HONEYWELL MEDICAL ELECTRONICS B.V.;REEL/FRAME:004436/0297 Effective date: 19850306 |