US3376999A - Packaging, mixing and dispensing apparatus - Google Patents

Packaging, mixing and dispensing apparatus Download PDF

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Publication number
US3376999A
US3376999A US642507A US64250767A US3376999A US 3376999 A US3376999 A US 3376999A US 642507 A US642507 A US 642507A US 64250767 A US64250767 A US 64250767A US 3376999 A US3376999 A US 3376999A
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United States
Prior art keywords
syringe
tube
barrel assembly
mixing
impeller
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Expired - Lifetime
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US642507A
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Hart Larry L De
Spencer J Speer
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General Dynamics Corp
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General Dynamics Corp
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Priority to US642507A priority Critical patent/US3376999A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B29/00—Packaging of materials presenting special problems
    • B65B29/10—Packaging two or more different substances isolated from one another in the package but capable of being mixed without opening the package, e.g. forming packages containing a resin and hardener isolated by a frangible partition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B01F35/7137—Piercing, perforating or melting membranes or closures which seal the compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7161—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00553—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with means allowing the stock of material to consist of at least two different components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/32005—Type of drive
    • B01F35/3202—Hand driven
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/01—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with manually mechanically or electrically actuated piston or the like

Definitions

  • a further object of the invention is to provide an apparatus for packaging a two-part compound, mixing the parts in fixed ratios, and dispensing the mixture in measured amounts.
  • Another object of the invention is to provide a packaging, mixing and dispensing apparatus wherein the material is mixed by manipulating an impeller, and the mixture is dispensed through an aperture created by the removal of the impeller manipulating means.
  • the primary components of the embodiment of the invention illustrated in the drawings comprises a dasher or actuator rod 10, a mixer or agitator impeller 11 threadedly or otherwise removably secured to rod 10, a secondary syringe-tube or barrel assembly 12, a primary syringe-tube or barrel assembly 13, a blow-out seal assembly 14 for syringe-tube 13, a secondary plunger retainer ferrel 15, a primary syringe plunger 16, and a primary plunger retainer ferrel 17, said primary syringe-tube 13 functioning as the plunger for the secondary syringe-tube 12.
  • Dasher or actuator rod 10 is provided with a knob or handle 18 which is theraded thereon to assist in turning of the impeller 11.
  • impeller means includes a tapered portion configured to cooperate with said tapered portion of said first barrel assembly, whereby contact between said tapered impeller portion and said tapered first barrel assembly portion produces a frictional retaining effect on said impeller means sufficient to allow said rod-like means to be removed therefrom.

Description

April 9, 1968 L. DE HART ETAL 3,376,999
PACKAGING, MIXING AND DISPENSING APPARATUS Filed May 51, 1967 ii/vebfras.
l/zxay 1/. $517527; SP N ER el. 51 E542.
- 3,376,999 PACKAGING, MIXING ANSD DISPENSING I APPARATU Larry L. De Hart, Pomona, and Spencer J. Speer, Ontario,
Callf., assignors to General Dynamics Corporation, a
corporation of Delaware Filed May 31, 1967, Ser. No. 642,507
. Claims. (Cl. 222135) ABSTRACT OF THE DISCLOSURE The disclosure is directed to a syringe-like construction which is adapted to serve as a package and also serve for mixing and dispensing two separate materials which must be mixed in fixed ratios and dispensed in measured amounts. Generally the syringe-like apparatus comprises a dual chamber and plunger construction wherein one of the syringe-like unit s acts as a plunger for the second syringe-like unit, and wherein one of the syringe-like units contains a mixer connected to a manipulating rod. Each of the plungers is provided with a ferrule for preventing depression until actually desired. In addition, the wall between the chambers of the syringe-like units is provided with a rupturable or blow out seal. In use, when the ingredients are merged, the impeller is manipulated by the actuator rod so as to intimately mix the substances, whereupon the rod may be unthreaded from the impeller so as to provide an exit for the mixture.
Background of the invention This invention relates to packaging, mixing and dispensing apparatus, and more particularly to such an apparatus wherein two materials are separately packaged, mixed together in fixed ratios, and the mixture dispensed in measured amounts.
Much prior effort has been directed to apparatus or injectors wherein a powder and a diluent are separately packaged in the required amounts, with the mixture being accomplished by injecting the diluent into the powder, and the mixture ejected as needed. Such prior efforts are exemplified by US. Patents 2,869,543 and 3,052,239. Also, as exemplified by US. Patent-3,197,067, prior efforts have been directed to providing a mixer assembly which can be inserted in a container for mixing the material therein, whereafter the mixture is ejected as desired. However, none of the known prior efforts have been directed to providing a packaging, mixing and dispensing apparatus wherein various ratios of two materials can be selectively mixed and dispensed in measured amounts.
Summary of the invention This invention provides such a needed packaging, mixing and dispensing apparatus wherein the individual packaging sections are provided with ferrules for preventing inadvertent dispensing, and the mixing is accomplished by an impeller manipulated by a removable rod, which upon'removal provides a discharge passage for the mixture.
' Therefore, it is an object of this invention to provide a packaging, mixing and dispensing apparatus. g
A further object of the invention is to provide an apparatus for packaging a two-part compound, mixing the parts in fixed ratios, and dispensing the mixture in measured amounts.
Another objectof the invention is to provide a syringelike apparatus adapted toserve as a package and also serve for mixing and dispensing two separate materials which 3,376,999 Patented Apr. 9, 1968 2 t may be mixed in various ratios and dispensed in measured amounts.
Another object of the invention is to provide a packaging, mixing and dispensing apparatus wherein the material is mixed by manipulating an impeller, and the mixture is dispensed through an aperture created by the removal of the impeller manipulating means.
Other objects of the invention will become readily apparent from the following description and accompanying drawings wherein:
Brief description of the drawings FIG. 1 is a partially exploded view of an embodiment of the invention; and
FIG. 2 is an assembled view of the FIG. 1 device with portions cut-away to illustrate various components thereof.
Description 0 the embodiment The primary components of the embodiment of the invention illustrated in the drawings comprises a dasher or actuator rod 10, a mixer or agitator impeller 11 threadedly or otherwise removably secured to rod 10, a secondary syringe-tube or barrel assembly 12, a primary syringe-tube or barrel assembly 13, a blow-out seal assembly 14 for syringe-tube 13, a secondary plunger retainer ferrel 15, a primary syringe plunger 16, and a primary plunger retainer ferrel 17, said primary syringe-tube 13 functioning as the plunger for the secondary syringe-tube 12. Dasher or actuator rod 10 is provided with a knob or handle 18 which is theraded thereon to assist in turning of the impeller 11. Mixer impeller 11 is provided with a tapering or conical portion 19 which is configured similar to a conical or tapering end portion 20 of secondary syringe-tube 12 and coacts with tube portion 20 such that it is held thereby to allow the dasher rod 10 to be unscrewed therefrom for discharge of the material from syringe-tube 12 via a discharge nozzle 21 thereof. Secondary syringe-tube 12 is additionally provided with a flange portion 22 which functions to assist the discharge operation thereof as known in the art. Primary syringe-tube 13 is provided with a flanged portion 23 at the rearward end thereof and a tapering portion 24 at the forward end which terminates in a discharge nozzle 25. Seal assembly 14 includes an end cap 26 which maybe constructed of rubber or other suitable material and which is constructed for a snug fit over' the discharge nozzle 25 of syringe-tube 13, and a piston 27 secured to end cap 26 by a rod 28. Secondary plunger retainer ferrel 15 includes a flange portion 29 and is of the removable reusable typev and may include a slot (not shown) extending longitudinally thereof or other like means whereby the ferrel may be expanded for removal from or replacement over the primary syringe-tube 13. Primary syringe plunger 16 is provided with a tapered forward end portion 30, a body portion composed of a plurality of ribs 31 and a flanged rear portion 32, with a Wiper seal member 33 positioned to the rear of tapered end portion 30. Primary plunger retainer ferrel 17 includes a-flange portion 34 and may be constructed as described above with respect to ferrel 15. Primary syringe-tube 13 is provided with a wiper seal 35 adjacent the end 24 thereof. Seals 33 and 35 may be constructed from neoprene or other suitable material. i
As pointed out above, this invention is particularly applicable for packaging, mixing and dispensing a two-part compound which must be mixed in fixed ratios of one part to the other and dispensed in measured amounts.
With, for example, primary syringe-tube 13 containing compound A and secondary syringe-tube 12 containing compound B, and with ferrels 15 and 17 and the impeller- 3 dasher rod (11-10) positioned as shown in FIG. operational sequencev is as follows:
(1) Ferrel 17 is removed from about primary syringe plunger 16.
(2) Actuate plunger 16 by moving same to the left as shown in the drawings which applies pressure to compound A in syringe-tube 13 and the thus applied pressure acts against piston 27 of the blow-out seal assembly 14 which in turn forces the end cap 26 from about nozzle 25 and compound A is injected into syringe-tube 12.
(3) Manipulate mixer impeller 11 by reciprocating and/ or rotating actuator or dasher rod until the required mix consistency of compounds A and B with syringe-tube 12 is obtained.
(4) Withdraw the rod 10 such that impeller 11 contacts and is frictionally held by conical portion of syringe-tube 12, and unscrew the rod from the impeller.
(5) Remove ferrel 15 from about the primary syringetube 13, which frees the syringe-tube 13 to act as a plunger for the secondary syringe-tube 12.
(6) Depress the syringe-tube 13 (move to the left as shown) to dispense the mixed compounds A and B from syringe-tube 12 via discharge nozzle 21.
While not shown, the primary syringe-tube 13 and the secondary syringe-tube 12 may be provided with calibrations to indicate the amount of the compound or mixture ejected from or remaining therein. While the apparatus has been illustrated as cylindrical, the components thereof may have other cooperative configurations and the flanged portions thereof may be configured to serve as a pistol grip for actuating same. Also, each of the syringe-tubes 12 and 13 may be refilled through the open rearward end thereof with the desired compounds or other material to be separately packaged, mixed and dispensed. Also, it is readily apparent that the inventive kit or apparatus can be prefilled in required amounts and utilized for one-shot type applications, and the kit or apparatus discarded thereafter. In addition, a needle assembly may be attached to the discharge nozzle of the secondary syringe-tube if desired, while the primary syringe-tube may have a blunt or flat closed end with a passageway therethrough which serves as the discharge nozzle therefor.
While not shown, it is within the scope of this invention to modify the primary syringe-tube or barrel assembly 13 by replacing the blow-out seal assembly 14 with a rupturable disc or diaphragm type seal which extends across the discharge nozzle of syringe-tube 13, and by modifying the actuator rod 10 such that it extends through the agitator impeller internal end thereof, such as by tapering, so as to serve as a means for rupturing the disc or diaphragm of the syringe-tube 13 upon movement of either, the tube 13 or the rod 10 toward one another. Also, the rupturable 2, the
disc may be of the type which can be ruptured by the force on the compound within the primary chamber created by the movement of the plunger therein.
It has thus been shown that the present invention provides an effective apparatus for packaging, mixing, and dispensing a two-part compound or material which must be mixed in fixed ratios of one to the other, and dispensed in measured amounts.
Although a particular embodiment of the invention has been illustrated and described, modifications and changes will become apparent to those skilled in the art, and it is intended to cover in the appended claims all such modifications and changes as may come within the true spirit and scope of the invention.
What we claim is:
1. An apparatus for packaging, mixing and dispensing material comprising: a first barrel assembly being open at one end, said barrel assembly having at the end opposite said one end a discharge nozzle-like portion, a second barrel assembly being open at one end, said second barrel assembly being slidably disposed within said 11 and is configured at the first barrel assembly and positionable so as to form a -chamber within said first barrel assembly designed to contain a material, a seal assembly mounted on said second barrel assembly and adapted to open communication between said chamber and the interior of said second barrel assembly, a plunger assembly slidably disposed within said second barrel assembly and positionable therein to form a second chamber designed to contain a material whereby upon movement by at least two of said assemblies with respect to one another causes said seal assembly to be forcibly opened thereby providing communication between said chambers and allowing material contained in said second chamber to be injected into said first-mentioned chamber, means movably positioned in said first-mentioned chamber and having a portion thereof extending outwardly through said nozzle-like portion of said first barrel assembly for agitating material contained therein, said outwardly extending portion of said agitating means being removable so as to provide open communication through said nozzle-like portion between said first-mentioned chamber and the exterior of said first barrel assembly, said second barrel assembly serving as a plunger member movable into said first barrel assembly to eject material from said first-mentioned chamber through said nozzle-like portion of said first barrel assembly.
2. The apparatus defined in claim 1, wherein each of said first and second barrel assemblies and said plunger assembly are substantially cylindrical, wherein said opposite end of said first barrel assembly includes a tapered portion, and wherein said agitating means includes an impeller means, said outwardly extending portion of said agitating means comprises a rod-like means removably secured to said impeller means.
3. The apparatus defined in claim 2, wherein impeller means includes a tapered portion configured to cooperate with said tapered portion of said first barrel assembly, whereby contact between said tapered impeller portion and said tapered first barrel assembly portion produces a frictional retaining effect on said impeller means sufficient to allow said rod-like means to be removed therefrom.
4. The apparatus defined in claim 1, wherein each of said second barrel assembly and said plunger assembly is provided with a wiper seal assembly.
5. The apparatus defined in claim 1, wherein said seal assembly is of the blow-out type and comprises an end cap portion, a piston-like portion, and a rod-like portion interconnecting said end cap and piston-like portions, said end cap portion being positioned and adapted for covering at least the terminal end of said nozzle-like portion of said second barrel assembly, said rod-like portion extending through and movable in said second barrel assembly nozzle-like portion, and said piston-like portion being located within said second chamber.
6. The apparatus defined in claim 1, additionally including a pair of removable plunger retaining means, one of said retaining means being positioned about said second barrel assembly and the other of said retaining means being positioned about said plunger assembly, thereby preventing movement of said plunger assembly into said second barrel assembly and preventing movement of said second barrel assembly into said first barrel assembly.
7. The apparatus defined in claim 1, wherein each of said first and second barrel assemblies includes an outwardly extending flange portion adjacent the open end thereof.
8. The apparatus defined in claim 1, wherein said agitating means comprises an impeller member, and said outwardly extending portion of said agitating means comprises a rod means removably attached to said impeller member.
9. The apparatus defined in claim 8, wherein said impeller member is provided with a threaded portion, wherein said rod means is provided with a threaded portion designed to threadedly cooperate with the threaded por- References Cited tion of said impeller member, and wherein said rod UNITED STATES PATENTS means is provided with a handle-like portion.
10. The apparatus defined in claim 1, wherein said 2841'145 7/1958 EPPS, 128-218 first barrel assembly includes a tapered portion at said 5 2,869,543 1/1959 Ratchff et a1 128 218 opposite end, and wherein said agitating means includes 2939459 6/1960 a at 128 218 a portion configured to cooperate with said tapered bar- 3,013,697 12/1961 m 222-135 rel portion, whereby contact between said tapered bar- 3,052,240 9/1962 Silver et 128 218 rel portion and said configured agitating means portion 310821914 3/1963 G111 222-435 produces a frictional retaining force on said agitating 10 3,197,067 7/1965 Rataczak 222-130 means such that said outwardly extending portion of said agitating means can be readily removed therefrom. SAMUEL COLEMAN Primary Examiner
US642507A 1967-05-31 1967-05-31 Packaging, mixing and dispensing apparatus Expired - Lifetime US3376999A (en)

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172457A (en) * 1977-10-06 1979-10-30 American Hospital Supply Corporation Plural component mixing system and method
WO2005053776A1 (en) * 2003-12-03 2005-06-16 Btg International Limited Apparatus for delivering foam
US20060089655A1 (en) * 2002-08-07 2006-04-27 Watkins Neil D Instrument for preparing a bone cement material
US20090292290A1 (en) * 2008-04-21 2009-11-26 Dfine, Inc. Bone treatment systems and methods
US20100091606A1 (en) * 2008-10-13 2010-04-15 Dfine, Inc. System for use in bone cement preparation and delivery
US20100241085A1 (en) * 2006-08-03 2010-09-23 Medrad, Inc. Blow-molded syringe for use with injectors
US20100262152A1 (en) * 2009-04-14 2010-10-14 Dfine, Inc. Medical system and method of use
AU2010101255B4 (en) * 2010-11-15 2011-09-22 Lumsden, Andrew A prefilled syringe for administering buffered lignocaine
US20130070555A1 (en) * 2010-05-31 2013-03-21 Ge Healthcare Bio-Sciences Ab Adjustable volume mixer chamber and method of use
US8469924B2 (en) 2006-04-04 2013-06-25 Covidien Lp Method and apparatus for generating vascular treatment foam
US9180416B2 (en) 2008-04-21 2015-11-10 Dfine, Inc. System for use in bone cement preparation and delivery
US20160106584A1 (en) * 2013-06-03 2016-04-21 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
US9572613B2 (en) 2005-08-22 2017-02-21 Dfine, Inc. Bone treatment systems and methods
US9636253B1 (en) 2013-05-03 2017-05-02 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
US9931330B2 (en) 2012-11-08 2018-04-03 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
US9956114B2 (en) 2014-06-20 2018-05-01 Clearside Biomedical, Inc. Variable diameter cannula and methods for controlling insertion depth for medicament delivery
US10328208B2 (en) 2013-11-01 2019-06-25 Bayer Healthcare Llc Blow-molded syringe for use with an injector
US10390901B2 (en) 2016-02-10 2019-08-27 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
US10952894B2 (en) 2010-10-15 2021-03-23 Clearside Biomedical, Inc. Device for ocular access
US10973681B2 (en) 2016-08-12 2021-04-13 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
US11596545B2 (en) 2016-05-02 2023-03-07 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
US11752101B2 (en) 2006-02-22 2023-09-12 Clearside Biomedical, Inc. Ocular injector and methods for accessing suprachoroidal space of the eye

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US2841145A (en) * 1956-05-07 1958-07-01 John A Epps Syringe
US2869543A (en) * 1957-08-23 1959-01-20 Iowa Cooperative Ass Injector
US2939459A (en) * 1957-01-11 1960-06-07 Jorge A Lazarte Tandem syringe
US3013697A (en) * 1959-01-21 1961-12-19 Gill Wilbur Mixing and dispensing device
US3052240A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3082914A (en) * 1958-11-06 1963-03-26 Gill Wilbur Dispensing device
US3197067A (en) * 1963-02-07 1965-07-27 Interchem Corp Cartridge assembly

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Publication number Priority date Publication date Assignee Title
US2841145A (en) * 1956-05-07 1958-07-01 John A Epps Syringe
US2939459A (en) * 1957-01-11 1960-06-07 Jorge A Lazarte Tandem syringe
US2869543A (en) * 1957-08-23 1959-01-20 Iowa Cooperative Ass Injector
US3082914A (en) * 1958-11-06 1963-03-26 Gill Wilbur Dispensing device
US3013697A (en) * 1959-01-21 1961-12-19 Gill Wilbur Mixing and dispensing device
US3052240A (en) * 1959-01-29 1962-09-04 Silver Disposable hypodermic syringe
US3197067A (en) * 1963-02-07 1965-07-27 Interchem Corp Cartridge assembly

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243080A (en) * 1977-10-06 1981-01-06 American Hospital Supply Corporation Method of mixing plural components
US4172457A (en) * 1977-10-06 1979-10-30 American Hospital Supply Corporation Plural component mixing system and method
US20060089655A1 (en) * 2002-08-07 2006-04-27 Watkins Neil D Instrument for preparing a bone cement material
US9713679B2 (en) 2003-12-03 2017-07-25 Btg International Limited Apparatus for delivering foam
US20070112308A1 (en) * 2003-12-03 2007-05-17 Kay Stuart B W Apparatus for delivering foam
WO2005053776A1 (en) * 2003-12-03 2005-06-16 Btg International Limited Apparatus for delivering foam
US10278754B2 (en) 2005-08-22 2019-05-07 Dfine, Inc. Bone treatment systems and methods
US9572613B2 (en) 2005-08-22 2017-02-21 Dfine, Inc. Bone treatment systems and methods
US9592317B2 (en) 2005-08-22 2017-03-14 Dfine, Inc. Medical system and method of use
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