US2399736A - Dialkylaminopropanol esters of benzilic acid - Google Patents
Dialkylaminopropanol esters of benzilic acid Download PDFInfo
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- US2399736A US2399736A US437020A US43702042A US2399736A US 2399736 A US2399736 A US 2399736A US 437020 A US437020 A US 437020A US 43702042 A US43702042 A US 43702042A US 2399736 A US2399736 A US 2399736A
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- esters
- benzilate
- ether
- anesthetic
- dialkylaminopropanol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Definitions
- This invention relates to dialkylaminopropanol esters of benzilic acid.
- alkamine esters of the diarylhydroxyacetic acids are of very considerable commercial importance. The exact properties and consequently the uses to which they may be put depend upon the particular acids and the par-v ever, ***e has still remained the standard against which the new products are measured. Of the many different compounds which have been synthesized, relatively a very few have found commercial acceptance.
- the present invention is particularly concerned with the dialkylamino-n-propyl benzilates which may be represented by the formula alkyl
- dialkylamino-n-propyl benzilates which may be represented by the formula alkyl
- the present application is primarily. concerned with the y-dialkylaminopropyl esters in which the alkyl radicals are the same, each having 2 to 5 carbon atoms. Typical examples of these compounds are dipropylaminopropyl benzilate and dibutyl-aminopr'opyl benzilate.
- the present invention is not limited to any particular method of producing the desired compounds.
- the presence of the a-hydroxy radical precludes the use, at least on a commercial scale, of the more common methods of preparing esters such as by the reaction oi! a halide of the acid with the aminoalcohol or by direct esterification of the acid with the aminoalcohol.
- Our preferred method which produces excellent yields comprises forming an ester of the acid and a lower aliphatic alcohol such as methyl or ethyl alcohol and then carrying out a catalyzed ester interchange with the replaced alcohol as fast as it is set free.
- the dialkylaminopropyl benzilates are ingeneral oily compounds which are relatively insoluble in water. .Their action is mildly basic and salts such as the hydrochloride may be readily prepared by dissolving the base in cold anhydrous ether and bubbling dry hydrochloric acid gas therethrough,
- the hydrochlorides are in general white crystalline solids, generally soluble in water and insoluble in ether.
- the 7- dibutylaminopropyl benzilate hydrochloride for example, when purified by recrystallization from an acetone-ether solution occurs as long, silky, white needles melting sharply at 115 C.
- the hydrcchlorides of these bases are suitable for use as local anesthetics in aqueous solution.
- Example 2 'y-Diethylaminopropyl benzilate hydrochloride
- the product of Example 1 was collected and dissolved in anhydrous ether. Dry hydrogen chloride was passed into the cooled solution and the alkamine ester precipitated as the hydrochloride. In the last step an excess of hydrogen chloride was avoided, inasmuch as the hydrochloride is hygroscopic and free hydrogen chloride tends to aggravate this property.
- the product was filtered and crystallized from acetone. After two recrystallizations the compound melted consistently at 1i5-6 C.
- Example 3 1 part of sodium was dissolved in 415 parts of v-di-n-butylaminopropanol and mixed with 300 parts of ethyl benzilate. The mixture was heated for 48 hours in an oil bath at a temperature of 160 C. Ethanol boiled gently during the course of the alcoholysls. After cooling, the reaction mixture was diluted with ether and the aminoester and excess aminoalcohol extracted with dilute hydrochloric acid. The aqueous extract was made alkaline with an excess of sodium carbonate, the alkamine ester extracted with ether and washed twice with water. After drying the ethereal extract and removing the ether the residue was distilled at a pressure of 6mm.
- the dibutylaminopropanol distilled first at from 99- 105 C. and was recovered.
- the aminoester distilled from 205-280 C. This was redistilled at 5 mm. and the fraction distilling between 225 and 230 C. was collected.
- Example 4 Hydrochloride of 'y-di-n-bntylaminopropyl bcnziiatc
- the aminoester obtained in Example 3 was dissolved in anhydrous ether and the solution cooled in an ice bath. Dry hydrogen chloride gas was Passed over the surface of the ether while the solution was stirred. The hydrochloride precipitated as an oil which solidified after standing for a few hours in the cold. Recrystallization from an acetone-ether solution gave a pure prodnot in the form of long, silky, white needles that melted at C.
- salts of the bases may be readily prepared.
- examples of such salts are the nitrate, sulfate, hydrobromide, phosphate, tartrate, citrate and the like.
- it may be desirable to form quaternary salts of the base such as the methlodide and ethobromide.
- These may be readily prepared, for example, by treating the base in an absolute alcohol solution with a compound such as methyl iodide or ethyl bromide.
- the quaternary salt may then be precipitated with absolute ether in an approximately quantitative yield.
- the quaternary compounds have the advantage that they are generally more soluble, than a corresponding salt such as the hydrochloride or hydrobromide. It is also an advantage of the quaternary compounds that in most cases the activity of the base as an anesthetic is increased.
- the well known p-diethylaminoethanol ester of diphenylacetic acid is active as an anesthetic but it is of relatively short duration, exceeding that of ***e in corresponding doses by only a few minutes either as a surface anesthetic or as a nerve block.
- Increasing the number of carbon atoms in the aminoalcohol residue of the diphenyiacetic acid esters causes a rapid decrease in their value as anesthetics and increases their toxicity.
- the alkamine radical is large enough so that the base hydrolyzes in solution before there is any perceptible anesthetic activity.
- increasing the number or carbon. atoms in the alkyl rexiimls of the di- 5 y-dihutyiaminopropyl benzilate hydrochloride itself is of especial interest as a local anesthetic because of its peculiar and unexpected properties. It is active both as a surface anesthetic and as a blocking anesthetic, its activity in either case be- 10 ing very long in duration and characterized y an extremely small minimal anesthetic dose. Its
- properties as compared with th0se.of ***e are one-hali-times that of ***e, so that coupled with itslonz Period of duration, it is particularly useful as a local anesthetic. Further it is no more irritating than ***e and is not habit-'iorming.
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Description
Patented May 7, 1946 DIALKYLAMINOPBOPANOL BENZILIC ACID ESTERS F 7 Roger B. Holmes, South River, N. 3., and Arthur J. Hill, New Haven, Coma, assignors to American Cyanamid Company, New York, N. Y., a
corporation of Maine No Drawing. Application March 31,1942,
' Serial No. 437,020
'7 Claims.
This invention relates to dialkylaminopropanol esters of benzilic acid.
Some of the alkamine esters of the diarylhydroxyacetic acids are of very considerable commercial importance. The exact properties and consequently the uses to which they may be put depend upon the particular acids and the par-v ever, ***e has still remained the standard against which the new products are measured. Of the many different compounds which have been synthesized, relatively a very few have found commercial acceptance.
In many cases a satisfactory localanesthetic of long duration is highly desirable. For example in cystoscopic work, extended anesthesia is especially desirable. Similarly inspinal anes- I thesia, long duration is particularly important since in many types of operation the effects of. the anesthetic begin to disappear before the operation has been completed. The hydrochloride of p-diethylaminoethyl p-aminobenzoic acid, for example, is very commonly used for spinal anesthesia and, as is well known, is of such comparatively short duration that in many cases repeated injections must be made. Another field in which long duration anesthetics are highly desirable is in connection with, treatments of the eye as for painful ulcerations.
The present invention is particularly concerned with the dialkylamino-n-propyl benzilates which may be represented by the formula alkyl Although it is feasible to prepare both the -5- and y-dialkylaminopropyl esters using the same or different alkyl'radicals, the present application is primarily. concerned with the y-dialkylaminopropyl esters in which the alkyl radicals are the same, each having 2 to 5 carbon atoms. Typical examples of these compounds are dipropylaminopropyl benzilate and dibutyl-aminopr'opyl benzilate.
The present invention is not limited to any particular method of producing the desired compounds. Unfortunately however, the presence of the a-hydroxy radical precludes the use, at least on a commercial scale, of the more common methods of preparing esters such as by the reaction oi! a halide of the acid with the aminoalcohol or by direct esterification of the acid with the aminoalcohol. Our preferred method which produces excellent yields comprises forming an ester of the acid and a lower aliphatic alcohol such as methyl or ethyl alcohol and then carrying out a catalyzed ester interchange with the replaced alcohol as fast as it is set free.
. process is more fully set forth in our copending application, Serial No. 431,822, filed February 21, 1942, of which the present invention is a continuation in part. i
The dialkylaminopropyl benzilates are ingeneral oily compounds which are relatively insoluble in water. .Their action is mildly basic and salts such as the hydrochloride may be readily prepared by dissolving the base in cold anhydrous ether and bubbling dry hydrochloric acid gas therethrough, The hydrochlorides are in general white crystalline solids, generally soluble in water and insoluble in ether. The 7- dibutylaminopropyl benzilate hydrochloride, for example, when purified by recrystallization from an acetone-ether solution occurs as long, silky, white needles melting sharply at 115 C. The hydrcchlorides of these bases are suitable for use as local anesthetics in aqueous solution.
The invention willbe described in greater detail in conjunction with the following specific examples, which are meant to be merely illustrative and do not in any way limit the invention. The parts are by weight unless otherwise noted.
Example 1 -Diethyiominopropyl benzilate HO- -C-OCH:CH:CH:N
1 part of sodium was dissolved in 170 parts of y-diethylaminopropyl alcohol and the solution added to 150 parts of ethyl benzilate. The reaction mixture was heated for a period of about 40 hours in an oil bath at 150 C. and then distilled until the temperature reached 200 C. to remove the ethanol and the unreacted aminoalcohol. The residue was dissolved in ether and washed with water to efl'ect a removal of any remaining aminoalcohol, and its sodium salt. The ethereal solution was dried over sodium sulfate. After drying the ether was removed and the residue, consisting of ethyl benz ilate and y-diethylaminopropyl benzilate, distilled at a pressure of mm. The fraction distilling between 160 and 210 C. was collected.
CiHl
Example 2 'y-Diethylaminopropyl benzilate hydrochloride The product of Example 1 was collected and dissolved in anhydrous ether. Dry hydrogen chloride was passed into the cooled solution and the alkamine ester precipitated as the hydrochloride. In the last step an excess of hydrogen chloride was avoided, inasmuch as the hydrochloride is hygroscopic and free hydrogen chloride tends to aggravate this property. The product was filtered and crystallized from acetone. After two recrystallizations the compound melted consistently at 1i5-6 C.
Example 3 1 part of sodium was dissolved in 415 parts of v-di-n-butylaminopropanol and mixed with 300 parts of ethyl benzilate. The mixture was heated for 48 hours in an oil bath at a temperature of 160 C. Ethanol boiled gently during the course of the alcoholysls. After cooling, the reaction mixture was diluted with ether and the aminoester and excess aminoalcohol extracted with dilute hydrochloric acid. The aqueous extract was made alkaline with an excess of sodium carbonate, the alkamine ester extracted with ether and washed twice with water. After drying the ethereal extract and removing the ether the residue was distilled at a pressure of 6mm. The dibutylaminopropanol distilled first at from 99- 105 C. and was recovered. The aminoester distilled from 205-280 C. This was redistilled at 5 mm. and the fraction distilling between 225 and 230 C. was collected.
Example 4 Hydrochloride of 'y-di-n-bntylaminopropyl bcnziiatc The aminoester obtained in Example 3 was dissolved in anhydrous ether and the solution cooled in an ice bath. Dry hydrogen chloride gas was Passed over the surface of the ether while the solution was stirred. The hydrochloride precipitated as an oil which solidified after standing for a few hours in the cold. Recrystallization from an acetone-ether solution gave a pure prodnot in the form of long, silky, white needles that melted at C.
If it is desired to do so, other salts of the bases may be readily prepared. Examples of such salts are the nitrate, sulfate, hydrobromide, phosphate, tartrate, citrate and the like. In some cases it may be desirable to form quaternary salts of the base such as the methlodide and ethobromide. These may be readily prepared, for example, by treating the base in an absolute alcohol solution with a compound such as methyl iodide or ethyl bromide. The quaternary salt may then be precipitated with absolute ether in an approximately quantitative yield. The quaternary compounds have the advantage that they are generally more soluble, than a corresponding salt such as the hydrochloride or hydrobromide. It is also an advantage of the quaternary compounds that in most cases the activity of the base as an anesthetic is increased.
That the dialkylaminopropyl benzilates should have this property of producing local anesthesia or long duration particularly in the case of the y-=dibutylpropanol ester was wholly unexpected. The well known p-diethylaminoethanol ester of diphenylacetic acid is active as an anesthetic but it is of relatively short duration, exceeding that of ***e in corresponding doses by only a few minutes either as a surface anesthetic or as a nerve block. Increasing the number of carbon atoms in the aminoalcohol residue of the diphenyiacetic acid esters causes a rapid decrease in their value as anesthetics and increases their toxicity. Further, in the fl-dibutylaminoethyl ester of diphenylacetic acid the alkamine radical is large enough so that the base hydrolyzes in solution before there is any perceptible anesthetic activity. On the contrary, increasing the number or carbon. atoms in the alkyl rexiimls of the di- 5 y-dihutyiaminopropyl benzilate hydrochloride itself is of especial interest as a local anesthetic because of its peculiar and unexpected properties. It is active both as a surface anesthetic and as a blocking anesthetic, its activity in either case be- 10 ing very long in duration and characterized y an extremely small minimal anesthetic dose. Its
properties as compared with th0se.of ***e are one-hali-times that of ***e, so that coupled with itslonz Period of duration, it is particularly useful as a local anesthetic. Further it is no more irritating than ***e and is not habit-'iorming.
We claim:
1. As a new chemical compound, a member se lected from the group consisting oi the gammadial'kylamino-n-propyl bcnzilates and the water soluble salts thereof, the alkyl groups being identical and each being a. straight chain contain ing from two to tour carbon atoms.
2. Gamma di n butylamino-n-propyl benshown in the following table: j zilate.
. I Q i Rabbit cornea Frog urostyle Index of anesthetic potenc 22 5? Dura' Structural iormula Migiiflon 1m 1825- D Do8 M. 115.16 I). Tormm m lion Gor- Uro- Cor- Uroanssthesis taanustion (mouse 1 thstic (its tion thetic M. a. p. 5 mm: m5... dose 2pc:- dose perit.)
cont) Mm. Mm. Mm. PM P 1 amt Min. prom Min. gram pram CBIOOC.HG CH CHI 0.5 m 0.01 30 @c'mi its.
0,11. 0.125 62 gconooocmcmcn It will be seen that although 'y-di-butylaminopropyl benzilate is very slightly more toxic than ***e it is a much more active compound. For 4 :it is'over four times as active as is ***e and 5 the duration 0! its minimal anesthetic dose is six times that of ***e. Because of its high activity its therapeutic ratio is nearly three and 3. Water-soluble salts oi! gamma-di-n-butylamino-n-propyl benzilate.
4. Gamma-di-n-propylamino n propyl benz ilate.
5. Water-soluble salts or gamma-di-n-propyl amino-n-propyl benzilate.
6. Gamma-di-ethylamino-n-propyl benziiate,
7. Water-soluble salts of gamma di ethylamino-n-propyl benzilate.
ROGER B. HOLMES.
ARTHUR-J. HILL.
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Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2511835A (en) * | 1948-07-23 | 1950-06-20 | Sterling Drug Inc | Alkylaminoalkylmercaptoalkyl esters of benzilic acid |
US2533084A (en) * | 1946-08-17 | 1950-12-05 | Univ Michigan | Aminoalkyl esters of dithienyl aliphatic acids |
US2570181A (en) * | 1949-04-15 | 1951-10-09 | Allied Lab Inc | Diethylaminoethyl alkoxybenzilates |
US2595735A (en) * | 1949-04-28 | 1952-05-06 | Schieffelin & Co | Basic esters of 2, 3-di (4-alkoxyphenyl)-2-hydroxypropanoic acid |
US2598542A (en) * | 1947-01-23 | 1952-05-27 | Wander Ag Dr A | Process for the manufacture of basic esters of alpha, alpha-diaryl-alpha-alkoxy-acetic acids |
US2752385A (en) * | 1953-01-15 | 1956-06-26 | Searle & Co | Quaternary ammonium salts of alkyl (hydroxyalkyl) aminoalkyl benzilates and esters thereof |
US2770646A (en) * | 1951-04-18 | 1956-11-13 | Schieffelin & Co | Quaternary ammonium compounds of basic esters of 2-aryl-2-(1-hydroxycyclohexyl) ethanoic acids |
US2770647A (en) * | 1951-04-18 | 1956-11-13 | Schieffelin & Co | Quaternary ammonium compounds of basic esters of 2-aryl-2-(1-hydroxycyclopentyl) ethanoic acids |
DE959277C (en) * | 1952-07-23 | 1957-03-07 | Hoechst Ag | Process for the preparation of benzilic acid [1-alkyl-piperidyl- (4)] - esters |
US2788365A (en) * | 1953-01-15 | 1957-04-09 | Searle & Co | Quaternary ammonium salts of dialkylaminoalkyl esters of 9, 10-dihydroanthracene-9-carboxylic acid and the preparation thereof |
US2788364A (en) * | 1953-01-15 | 1957-04-09 | Searle & Co | Quaternary ammonium salts of dialkylaminoalkyl fluorene-9-carboxylates and the preparation thereof |
US2928843A (en) * | 1956-12-07 | 1960-03-15 | Beecham Res Lab | Basic esters and salts thereof |
US3198825A (en) * | 1955-03-19 | 1965-08-03 | Boehringer Sohn Ingelheim | Quaternary ammonium salts of organic carboxylic acid esters of 1-dialkyl-aminoethanols-2 |
US4645853A (en) * | 1985-08-30 | 1987-02-24 | Ici Americas Inc. | Hindered phenolic oxamide compounds and stabilized compositions |
-
1942
- 1942-03-31 US US437020A patent/US2399736A/en not_active Expired - Lifetime
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2533084A (en) * | 1946-08-17 | 1950-12-05 | Univ Michigan | Aminoalkyl esters of dithienyl aliphatic acids |
US2598542A (en) * | 1947-01-23 | 1952-05-27 | Wander Ag Dr A | Process for the manufacture of basic esters of alpha, alpha-diaryl-alpha-alkoxy-acetic acids |
US2511835A (en) * | 1948-07-23 | 1950-06-20 | Sterling Drug Inc | Alkylaminoalkylmercaptoalkyl esters of benzilic acid |
US2570181A (en) * | 1949-04-15 | 1951-10-09 | Allied Lab Inc | Diethylaminoethyl alkoxybenzilates |
US2595735A (en) * | 1949-04-28 | 1952-05-06 | Schieffelin & Co | Basic esters of 2, 3-di (4-alkoxyphenyl)-2-hydroxypropanoic acid |
US2770646A (en) * | 1951-04-18 | 1956-11-13 | Schieffelin & Co | Quaternary ammonium compounds of basic esters of 2-aryl-2-(1-hydroxycyclohexyl) ethanoic acids |
US2770647A (en) * | 1951-04-18 | 1956-11-13 | Schieffelin & Co | Quaternary ammonium compounds of basic esters of 2-aryl-2-(1-hydroxycyclopentyl) ethanoic acids |
DE959277C (en) * | 1952-07-23 | 1957-03-07 | Hoechst Ag | Process for the preparation of benzilic acid [1-alkyl-piperidyl- (4)] - esters |
US2752385A (en) * | 1953-01-15 | 1956-06-26 | Searle & Co | Quaternary ammonium salts of alkyl (hydroxyalkyl) aminoalkyl benzilates and esters thereof |
US2788365A (en) * | 1953-01-15 | 1957-04-09 | Searle & Co | Quaternary ammonium salts of dialkylaminoalkyl esters of 9, 10-dihydroanthracene-9-carboxylic acid and the preparation thereof |
US2788364A (en) * | 1953-01-15 | 1957-04-09 | Searle & Co | Quaternary ammonium salts of dialkylaminoalkyl fluorene-9-carboxylates and the preparation thereof |
US3198825A (en) * | 1955-03-19 | 1965-08-03 | Boehringer Sohn Ingelheim | Quaternary ammonium salts of organic carboxylic acid esters of 1-dialkyl-aminoethanols-2 |
US2928843A (en) * | 1956-12-07 | 1960-03-15 | Beecham Res Lab | Basic esters and salts thereof |
US4645853A (en) * | 1985-08-30 | 1987-02-24 | Ici Americas Inc. | Hindered phenolic oxamide compounds and stabilized compositions |
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