US2062285A - Syringe - Google Patents

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US2062285A
US2062285A US723437A US72343734A US2062285A US 2062285 A US2062285 A US 2062285A US 723437 A US723437 A US 723437A US 72343734 A US72343734 A US 72343734A US 2062285 A US2062285 A US 2062285A
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port
valve
sleeve
piston
barrel
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US723437A
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Bergman Sam
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/60Containers for suction drainage, adapted to be used with an external suction source
    • A61M1/63Containers for suction drainage, adapted to be used with an external suction source with means for emptying the suction container, e.g. by interrupting suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus

Definitions

  • This invention relates to syringes particularly adapted for use in blood transfusion though capable of use for many other purposes, and it has lfor its objects the control ofthe ow of blood y from donor to syringe and then out of the syringe into the recipient entirely automatically, yet With the certainty offered by a positively actuated valve; the elimination of the possibility and danger of injection of blood into the donor and ""aspiration of blood from the recipient; the uti lization of citrate solution as an anti-coagulant within the valve joint space to prevent clotting of blood there with the consequent gumming up of the valve action While not permitting the cit- "-ratesolution to mix with the blood transfused;
  • the invention provides a pump sys- O-ftem in which an accurately fitting piston slidesv within a chamber formed in a cylindrical sleevev line III-III of Fig. 1;
  • Fig. 4 is a, fragmentary longitudinal section of the outer end of a modified form showing a detail of an air valve;
  • Fig. 5 is a fragmentary longitudinal section of an inner end of a modification;
  • Fig. 6 is a transverse section on the line VI-VI of Fig. 5;
  • Fig. 7 is a transverse section on the line VII-VII of Fig. 5;
  • Fig. 11 is a transverse section through am valve controlled port;
  • Fig. 12 is a longitudinal section through amodication providinghaddi-A tional channels for saline solution;
  • Fig. 14 is a transverse section 'onthe line'V XIV-XIV of Fig. 12;l Fig.
  • FIG. 15 is al longitudinal section of a modification showing a different channel arrangement from that of Fig. 12; ⁇ Fig.:1(ilV 16 'f" is a transverse section on the line XVIL--XVIgjofv Fig. 15; Fig. 17 isl a fragmentary longitudinalj,v section of a mo-dification vproviding ,anI outletV portat the outer end of the pump; Fig. 18""is'a fragmentary longitudinal section of amodific'aeql tion-in whichthe outer end is provided withanr outlet and inlet port; Fig. 19 is a transversefr section on the line XIX- XIX of Fig.
  • Fig. 18j Fig.v 20"; ⁇ is a view similar to Fig. 16 but having a' different arrangement vof tubes connected'with the nip# ples;
  • Fig. 21 is a .diagrammatic transverse section of'a modification having a chamber for an anti-coagulant solution;
  • Fig. 22 is a longitudinal' section through a modification providing transy Y parent portions in the valve Vand'cyllnder, and
  • Fig. 23 is a longitudinal section of a modification having two pistons operating in a double- ⁇ ended valve.
  • the outer barrel or cylinder is provided 355 with ports 2' and 3 in the same longitudinal' plane'gl and with ports 4 and 5 in a longitudinal plane* substantially at right angles'to that of the ports 2 and 3, though it win be understood that the angle between the planes is a matter of choice.
  • Slidably androtatably mountedwithin the; cyl-A inder I is a sleeve valve 6 formed asa cylinder open at both ends and separated by a partition 'l yinto two chambers Sand 9'.
  • a cylindrical ⁇ pistonl is slidably fitted vvithinthe chamber 8 461i and provided with a handle II.
  • the outer surface of the sleeve 6 has formed therein agroove or channel I2 for the reception of a study I3'A carried by a ring I4 which is mounted on the outer surface of the cylinder il, the stud extend-V 453 ing' through a slot I5 in the cylinder.
  • This slot is of a length which permits the ring to be turned through substantially ninety degrees, thev angle between the planes of the ports, the ends of the slot acting as stops'to engage the vstud I3 and ⁇ 563 thereby accurately position the sleeve valve in its angular relations in the cylinder, whilethe channel I2 allowslongitudinal sliding movement"l ofthe valve and is of a length such that'the stud lslwiu remainin the ohanneithrough the1-55f" entire travel of the valve.
  • the outer periphery of the sleeve valve for at least a substantial portion of its length is formed to engage the inner periphery of the cylinder with a ground and liquid-tight joint, and the piston I engages within the ⁇ cylindrical inner periphery of the sleeve valve 6 with a similar joint.
  • the inner end of the sleeve may be out of contact with the inside of the cylinder at a distance from the ports.
  • a plug or cap I6 shown as in screw-threaded engagement with the end of the cylinder I and as centrally perforated for the passage of the handle II, acts as a stop to limit the inward sliding movement of the piston and of the valve,"
  • ThisA plug l1 isprovided with an opening I8 for which an air valve I9 having an air passage 20 may furnish a c'onvenient means for closing the chamber between the plug II and the partition 1.
  • a passage 2l extends through the wall of the sleeve valve 6, the length of the valve being such that when it is at the inner end of its movement with its inner lend in contact with the plug I6, the outer end of the passage 2
  • the ring I4 may be turned to slide the stud
  • Fig. l is especially adapted for blood transfusion, a tube leading from the nipple 22 being provided with a hypodermic needle inserted within the vein of a donor of blood, and a tube leading from nipple 23 being provided with a hypodermic needle inserted within the vein of a recipient of the blood.
  • simple reciprocation lof the piston will obviously withdraw blood from the donor through the port 2 and will inject it into the vein of the recipient through the port 3.
  • This operation does not require more technical skill or knowledge than is required for a venipuncture and operation of the ordinary hypodermic syringe, and during its use, the surgeons attention is not required for the operation of valveswhile he has the assurance that blood. can be vaspirated only from the donor and injected only into the recipient.
  • a solution of citrate of sodium or of potassium will be drawn into the chamber 9 whence it may penetrate by capillary action into the joint between the cylinder and the sleeve, thus preventing the intrusion of blood in the space, or, if any should penetrate into the space, mixing with it to prevent its coagulation.
  • the sleeve After pumping a sucient quantity of the washing solution into the Valve chamber until the washing liquid shows clear, the sleeve will be rotated back to the original angular setting to permit the transfusion ⁇ to be continued.
  • the opening I8V in the plug I1 is shown as screw-threaded to receive a threaded valve member I9 having a transverse passage soon.
  • the expansion-- of the air will slide the sleeve back to cause automatic closing of the port 3 or 5.
  • the valve IS-is closed when the sleeve is at the outer positiontagainst the plug I1 inward sliding of the valve I-will cause a partial vacuum in the chamber 9,- and release of the handle I I will allow thel sleeve to 'slide outward, automatically closing the port ⁇ 2.0114. If the sleeve is slid to a mid position with-the.
  • valve member IS-open and the passage 2ll.-is'.then closed the pressure in the chamber 9k on the outward stroke and the partial vacuum on the inward stroke will be sufficient in either caseto cause the sleeve to recede from its eX-.
  • a spring 25 is shown as seated withina recess in the end of the valve 5, or the spring may be on the outside of the sleeve as shown at 21 in Fig. 9, the function in each case beingto'press the sleeve away from contact with the end member engaged by the spring, and thus to slide the sleeve valve port out of registration withthe inlet or outlet ports.
  • Such springs may be used'in cases where it is not desirable to have theV chamber 9 closed by a member I9.
  • FIG. 5 Another embodiment of the invention is illustrated in Figs. 5, 6, and '1, in which the piston III! has a non-circular handle II' slidable through an aperture of similar cross section in aadisc 28 mounted for rotation on a shoulder 23formed. in the enlarged inner end of the cylin'der. Il, the disc being held in place by a plug I6? having. an aperture-permitting the rotation offthe'handle Il.
  • the disc 23 has a guide portion. 30'. provided with a groove or channel I2 parallel with the axis of the cylinder.
  • a sleeve valve 6" has aprojection I3 extending intothe channel I2! which is of a length to be engaged byy the projection I3- during the entire travel .e
  • the friction between the piston and the sleeve may be made greater than the friction between the sleeve and the cylinder by forming slits or slots 3
  • a piston ring 32 set within a groove in the piston wall will not only act to increase friction but will tend to prevent the ingress of blood b-etween the piston and the valve wall.
  • Fig. 1 a modification of the construction of Fig. 1 is shown in Figs. 12, 13, and .14, in which the inlet opening 33 for the saline solution is substantially opposite the inlet opening 34 for blood; in which the sleeve Valve is provided with channels 35, 31, and 38 in its periphery for passage of the saline solution; and in which the cylinder has a channel 3B formed in its inner periphery.
  • the channel 35 is shown in Figs.
  • Nipples will be provided at each port for the' ⁇ usual tubing.
  • Nipple 40 at port 34 will be connected by a tube with the vein of the donor.
  • Nipple 4I at port 42 will be connected by a tubewith the vein lof the recipient.
  • Nipple 43 at outlet port 44 will be connected with a receptacle for washings.
  • the piston I6" is shown rin Fig. 12 at the inner end of its stroke with the passage 2
  • saline solution into the vein of the recipient supplementary to the transfusion of blood from the vein of the donor. This infusion may be continued at will as long as the piston is held at the inner end of its stroke, the pressure on the saline solution being made sufficient to provide a continuous flow.
  • valve 45 in the inlet port 33 as shown in Fig. 11, the flow of saline solution may be made greater or less or may be entirely cut off from either the donor or the recipient or both, While an independent passage 46 without a valve may be used instead of the channel 3B to permit a free flow of the solution for washing.
  • Figs. 15 and 16 The modication shown in Figs. 15 and 16 is substantially the same as the structure just described with the addition of an inlet port 41 and nipple 48 and the omission of the channel 3B, which enables the .operator to use a T 49 connected by tube 55 to a source of saline solution, connected by tube 5
  • A11 adjustable clamp 53 regulates the pressure of solution entering the port 33 for passage either to the donor or to the recipient while: the open tube 5
  • This Construction also permits the two tubes 5
  • FIG. 18 and 19 A still further modication is illustrated in Figs. 18 and 19 in which the nipples 43 and 48 of Fig. 15 have been omitted and a longitudinal channel 54 has been formed in the Wall of the cylinder to register with the passage 2l when it has been turned ninety degrees away from registration with the ports 34 and 42.
  • the cap l1' may have a nipple 55 at the opening I8 through which a saline or citrate washing solution may be drawn and discharged.
  • a pressure cup 55 (shown in Fig. 21 as attached to the cylinder on the side opposite the ports 51 and 58, which may correspond with any of the ports 2, 3, 4, 5, 33, 34, or 42), can be provided as an addition to any of the modications already described.
  • the cup 56 has a chamber 59 formed with an outlet passage 60 and has a cap 6I in screw-threaded engagement with the outer periphery of the upper end of the cup, the cap being formed with a pis-l ton portion 62 sliding with a ground and liquidtight joint in the cylindrical interior of the cup.
  • the cap Before use of the device, the cap is removed, a quantity of citrate solution is poured into the chamber 59, and the cap is replaced, the piston portion 62 acting to force some of the solution through the passage 60 into the space between the valve and the cylinder. At intervals during the process of transfusion, the cap 6
  • a modication shown in Fig. 17 provides an inlet port 4 for saline washing solution and a channel 63 in line with the port 4 to discharge washings from the chamber 8 into the chamber 9 from which they escape through a port 64 in a nipple 55 on the end plug, this nipple being held while in use at the top of the plug 66 and being connected by a tube 61 with an open-mouthed funnel 68 leading to a receptacle 69 for washings.
  • the devices described thus far may be made of any suitable material, a non-corrosive, nonrusting metal being entirely satisfactory for most purposes, but since many operators desire visibility of the blood chamber, glass may be used for the center of the device as illustrated in Fig. 22.
  • the central part 10 of the cylinder is indicated as a glass tube attached at its ends to metal portions 1l and 12, and the central portion 14 of the valve is indicated as a glass tube attached at its endsto metal portions 15 and 16. It will be evident that the contents of the valve element 14 will be visible throughout the entire range of its movement within the cylinder element 1D.
  • the length of the channel 2Ig is necessarily greater than that of the channel 2l of Fig.
  • the chambers 9 and 9 respectively are shown as having an inlet port 11 or 11 formed in the wall of the cylinder while the end plug 18 or 18 is imperforate.
  • the end of the cylinder With the valve in its outermost position, the end of the cylinder may be immersed beneath the surface of a citrate solution and some of the liquid may be drawn into the chamber by sliding the valve inward as a means by which a limited amount of the solution will be available to penetrate into the valve joint by capillarity.
  • the port 11 or 11' will be carried on the upper surface of the cylinder as it is held in place for use so that the liquid cannot escape.
  • the modification shown in Fig.' 23 is a doubleacting pump having ahandle 19 connected at its ends by cross arms 80 to theshafts 8l of thepis- ⁇ tons 82 and 83 sliding within chambers 84 and 85 of a valve member 86 consisting of a cylindrical sleeve having a partition 81 separating the chambers 8'4 and 85.
  • the sleeve valve is limited in its longitudinal sliding movements by the end caps 89 and 90 of the cylinder 88 and there is an intake port 9
  • the chamber 85 has a passage 93 adjacent to the partition 81, the outer end of this passage being in registration with the intake port 9i at one end of its stroke and in registration with the discharge ,port 92 at the other end of -its stroke.
  • the chamber' 84 has a passage 94 adjacent to the partition 81, the outer end of the passage communicating with two channels formed within the outer periphery of the sleeve valve, of which one channelis designated as 95 and this is in registration with the intake port 9! when the passage 93 is in registration with the discharge port 92, and the other channel, designated as 96, is in registration with the discharge port 92 when the passage 93 is-in registration with the intake port 9
  • a pump assembly comprising a cylin-der having two inlet ports in the same transverse plane and having two outlet ports in a transverse plane different from that of the inlet ports, each outlet port being in a longitudinal plane with an inlet port, a cylindrical sleeve valve within the cylinder, said sleeve having a transverse partition and being provided with a port formed in the wall of the sleeve adjacent to the partition, a piston slidable within the sleeve, and guiding means comprising elements on the cylinder and on the sleeve adapted for rotation whereby the port of the sleeve valve may be brought into alinement selectively with either of the longitudinal planes having an inlet and outlet port.
  • a pump assembly comprising a barrel having inlet and outlet ports, a sleeve valve having a port registrable with the inlet or the outlet port selectively, a piston slidable in the sleeve valve, and a port angularly spaced from the inlet port, the sleeve valve being provided with a channel arranged to connect the said angularly spaced port with the inlet port of the barrel when the valve port is in registration-with the outlet port of the barrel.
  • a pump assembly comprising a barrel having inlet and outlet ports, a sleeve valve within the barrel and having a port registrable with the inlet or the outlet port selectively, a piston slidable in the valve, the barrel being formed with separate inlet and outlet ports for a washing liquid, and means for rotating the sleeve valve andfor limiting its rotative movement to positions in which the port in the valve registers with either of the inlet ports at one end of its longitudinal movement and with either of the outlet ports at the other end of its longitudinal movement.
  • a pump assembly comprising abarrel having inlet and outlet ports formed therein for one iluid, and having a separate port formed therein for another fluid, a sleeve valve slidable within the barrel and providedwith a port formed within its wall for registration with the inlet or the outlet port of the barrel selectively, a piston yslidable Within the valve, and the sleeve valve being provided with a channel arranged to connect the said separate port for fluid with the outlet port of the barrel when the Valve port is in registration with the inlet port of the barrel.
  • a structure as in claim 5 in which the sleeve valve is provided with a channel arranged to connect the said separate port for iluid with the inlet port of the barrel when the valve port is in registration with the outlet port of the barrel.
  • a pump assembly comprising a barrel having inlet and outlet ports, a sleeve valve slidable within the barrel and having a passage formed in its wall for registration with the ports of the barrel, a piston in the sleeve, and a pressure cup secured to the barrel and communicating with the space between the barrel and the sleeve valve, whereby a liquid in the cup may be forced under pressure into said space.
  • a pump assembly comprising a barrel having spaced ports for use as inlet and outlet ports, a sleeve valve slidable longitudinally within the barrel and having a transverse partition and a port formed within the Wall of the valve adjacent to the partition for registration with the ports in the barrel, and a piston slidable within the sleeve valve and conforming to its interior dimensions whereby to expel substantially all fluid from the valve as the piston reaches the partition.
  • a pump assembly comprising a cylinder having two inlet ports and two outlet ports, a cylindrical hollow sleeve valve sli-dable longitudinally and rotatable within the cylinder, said sleeve valve being provided with a port formed in the wall of the sleeve, a piston operatively connected with the interior of the sleeve valve, and guiding means comprising elements on the cylinder and on the sleeve adapted for rotation whereby the port of the sleeve valve may be brought into alinement selectively with either inlet port or either outlet port.
  • a pump assembly comprising a barrel having inlet and outlet ports, a sliding hollow Valve having a port registrable with the inlet or the outlet port selectively and having a piston operatively connected with the hollow interior of the valve, the barrel having a port angularly spaced from the inlet port, and the sliding valve being provided With a channel arranged to connect the said angularly spaced port With the inlet port of the barrel when the valve port is in registration with the outlet port of the barrel.
  • a pump assembly comprising a barrel having inletI and outlet ports, a sleeve valve within the barrel and having a port registering selectively with either the inlet or the outlet port, a piston operatively connected with the interior of the sleeve valve, the barrel being formed with separate inlet and outlet ports for a washing liquid, and means for rotating the valve and for limiting the rotative movement to positions in which the port in the valve registers with either of the inlet ports at one end of its longitudinal movement and with either of the outlet ports at the other end of its longitudinal movement.
  • a pump assembly comprising a barrel having inlet and outlet ports formed therein for one fluid, and having a separate port formed therein for another fluid, a sleeve valve slidable within the barrel and provided With a port formed within its Wall for registration with inlet or the outlet port of the barrel selectively, a piston operatively connected with the interior of the sleeve valve, and the sleeve valve being provided with a channel arranged to connect the said separate port for fluid with the outlet port of the barrel when the valve port is in registration with the inlet port of the barrel.
  • a pump assembly comprising a barrel having inlet and outlet ports, a sleeve valve slidable within the barrel and having a passage formed ing inlet and outlet ports, a sleeve valve slidable longitudinally within the barrel and having a transverse partition and a port formed in the wall of the valve adjacent to the partition for registration with the ports in the barrel, a piston slidable within the valve between one end ofl the valve and the partition, and a closure for the end of the barrel remote from the piston to provide a liquid chamber within the barrel between said closure and the partition in said valve.

Description

Dec. l, 1936. 5 BERGMAN 2,062,285
SYRINGE -Filed May 2, 1934 2 Sheets-Sheet' 1 s. BERGMAN Dec. l, 1936.
SYRIN'GE 2 Sheets-Sheet 2 Filed `Maly 2, 1934 Patented Dec. 1, 1936 UNIT ED- STATES Ierfreut" oFFicEi 15 Claims.
This invention relates to syringes particularly adapted for use in blood transfusion though capable of use for many other purposes, and it has lfor its objects the control ofthe ow of blood y from donor to syringe and then out of the syringe into the recipient entirely automatically, yet With the certainty offered by a positively actuated valve; the elimination of the possibility and danger of injection of blood into the donor and ""aspiration of blood from the recipient; the uti lization of citrate solution as an anti-coagulant within the valve joint space to prevent clotting of blood there with the consequent gumming up of the valve action While not permitting the cit- "-ratesolution to mix with the blood transfused;
the elimination of broken, jointed or uneven surfaces between the syringe and the donor and recipient tubes, preventing stagnation areas so that there is no intermixing of blood fresh from the donor with residual blood before injection into the recipient; the provision for Washing out the syringe with saline or other solution in such manner that the washings are not thrown'back.
into the container for the solution but clean f solution only to be drawn'into the syringe; and
the achievement of these desirable results with' simplicity of construction and a minimum number of parts.
In general, the invention provides a pump sys- O-ftem in which an accurately fitting piston slidesv within a chamber formed in a cylindrical sleevev line III-III of Fig. 1; Fig. 4 is a, fragmentary longitudinal section of the outer end of a modified form showing a detail of an air valve; Fig. 5 is a fragmentary longitudinal section of an inner end of a modification; Fig. 6 is a transverse section on the line VI-VI of Fig. 5; Fig. 7 is a transverse section on the line VII-VII of Fig. 5; Fig. 8
is a fragmentary longitudinal section of a` centering 'spring within the outer end of a modification; Fig. 9 is a fragmentary longitudinal sectional detail'of a centering spring within the inner end 1of` am'odication; Fig. 10 is a longitudinal sec= tion through a piston provided with frictionde'- vices; Fig. 11 is a transverse section through am valve controlled port; Fig. 12 is a longitudinal section through amodication providinghaddi-A tional channels for saline solution; Fig. 13`isra1 5** transverse section'on the line XIII-XIII' of Fig." 12; Fig. 14 is a transverse section 'onthe line'V XIV-XIV of Fig. 12;l Fig. 15 is al longitudinal section of a modification showing a different channel arrangement from that of Fig. 12;`Fig.:1(ilV 16 'f" is a transverse section on the line XVIL--XVIgjofv Fig. 15; Fig. 17 isl a fragmentary longitudinalj,v section of a mo-dification vproviding ,anI outletV portat the outer end of the pump; Fig. 18""is'a fragmentary longitudinal section of amodific'aeql tion-in whichthe outer end is provided withanr outlet and inlet port; Fig. 19 is a transversefr section on the line XIX- XIX of Fig. 18j Fig.v 20";` is a view similar to Fig. 16 but having a' different arrangement vof tubes connected'with the nip# ples; Fig. 21 is a .diagrammatic transverse section of'a modification having a chamber for an anti-coagulant solution; Fig. 22 is a longitudinal' section through a modification providing transy Y parent portions in the valve Vand'cyllnder, and Fig. 23 is a longitudinal section of a modification having two pistons operating in a double-` ended valve. y e l In theembodiment of the invention illustrated A in Fig. 1, the outer barrel or cylinder is provided 355 with ports 2' and 3 in the same longitudinal' plane'gl and with ports 4 and 5 in a longitudinal plane* substantially at right angles'to that of the ports 2 and 3, though it win be understood that the angle between the planes is a matter of choice. Slidably androtatably mountedwithin the; cyl-A inder I is a sleeve valve 6 formed asa cylinder open at both ends and separated by a partition 'l yinto two chambers Sand 9'. A cylindrical `pistonl is slidably fitted vvithinthe chamber 8 461i and provided with a handle II. The outer surface of the sleeve 6 has formed therein agroove or channel I2 for the reception of a study I3'A carried by a ring I4 which is mounted on the outer surface of the cylinder il, the stud extend-V 453 ing' through a slot I5 in the cylinder. This slot is of a length which permits the ring to be turned through substantially ninety degrees, thev angle between the planes of the ports, the ends of the slot acting as stops'to engage the vstud I3 and`563 thereby accurately position the sleeve valve in its angular relations in the cylinder, whilethe channel I2 allowslongitudinal sliding movement"l ofthe valve and is of a length such that'the stud lslwiu remainin the ohanneithrough the1-55f" entire travel of the valve. The outer periphery of the sleeve valve for at least a substantial portion of its length is formed to engage the inner periphery of the cylinder with a ground and liquid-tight joint, and the piston I engages within the `cylindrical inner periphery of the sleeve valve 6 with a similar joint. To lessen friction, the inner end of the sleeve may be out of contact with the inside of the cylinder at a distance from the ports.
A plug or cap I6, shown as in screw-threaded engagement with the end of the cylinder I and as centrally perforated for the passage of the handle II, acts as a stop to limit the inward sliding movement of the piston and of the valve,"
and a plug or cap Il at the other end of the cylinder acts as a stop to limit the outward sliding movement of the valve. ThisA plug l1 isprovided with an opening I8 for which an air valve I9 having an air passage 20 may furnish a c'onvenient means for closing the chamber between the plug II and the partition 1. At the bottom of the chamber 8, adjacent to the partition 1, a passage 2l extends through the wall of the sleeve valve 6, the length of the valve being such that when it is at the inner end of its movement with its inner lend in contact with the plug I6, the outer end of the passage 2| will be in the same transverse plane as the ports 2 and 4, and when the sleeve is at the outer end of its longitudinal movement, the outer end of the channel 2| will be in the same transverse plane as the ports 3 and 5.
' Starting in the position of parts shown in Fig. 1, and assuming that a liquid is in the chamber 8 between the piston I8 and the partition 1, pressure applied to the handle tending to force the piston into the chamber 8 will be transmitted to the partition I and will cause the valve to slide within the cylinder. The area of the partition vis so much greater than the area of the passage 2| that the pressure on the partition will be su'icient to overcome any friction between the valve and the cylinder, especially in view of the fact that there is always a film of liquid in the joint v `between the valve and the cylinder, and a very -plug l1, at which position of the valve, the passhort movement of the valve will carry the end of the passage 2| out of registry with the port 2. Continued pressure will cause the sleeve to move until its outer end comes into contact with the sage 2| will be in registry with the port 3. Further movement of the piston toward the partition I will force liquid in the chamber 8 out through 4the port 3, the partition acting as a stop to limit the outward movement of the piston.
Abrought to a stop, force applied to the handle It will be obvious that the movement of the piston can be controlled by the operator to give a full stroke or to pause at any point in the outward movement. When the piston has been to move the piston in a reverse or inward direction will cause the valve 6 to slide inward carrying the passage 2| out Aof registration with the port 3. The sleeve 6 is made to slide at least "as freely within the cylinder as the piston slides within the sleeve, and as subsequently explained, there will usually be a greater friction between the piston and the sleeve than between the sleeve andthe cylinder. Thus a pull exerted on the 'handle of the piston will, because of this fricact to create a partial vacuum within the chanii ber 8, whereupon air pressure on the outer surface of the partition 'I will act to push the sleeve after the piston until the inner end of the sleeve comes into contact with the plug I6, the passage 2l then being in registration with the inlet port 2. Further inward movement of the piston will tend to create a vacuum within the chamber 8 and this will cause inward suction at the port 2. At the ports 2, 3, 4, and are nipples 22, 23, 24, and 25 respectively to which rubber tubing may be attached as is familiar in the art, such tubing being indicated in Figs. 16, 17, and 20.
At any point in the range of longitudinal travel of the valve, the ring I4 may be turned to slide the stud |3 along the slot I5, and when the stud engages the end of the slot, the valve will be in the exact angular adjustment to cause the valve passage 2| to register with the plane in which lie an inlet and an outlet port. Longitudinal movement of the piston and of the valve without change of angular adjustment will act to cause inward suction at port 2 and expulsion at port 3 when the stud is at one end of the slot, and inward suction at port 4 and expulsion at port 5 when the stud is at the other end of the slot. However it is clear that after inward suction at port 2 or port 4, the Valve may be turned to discharge at the outlet port in the other plane. Thus the same piston may be made to draw a. liquid from either of two sources and may discharge it at either of two outlets in accordance with the adjustment of the ring I4.
'Ihe device illustrated in Fig. l is especially adapted for blood transfusion, a tube leading from the nipple 22 being provided with a hypodermic needle inserted within the vein of a donor of blood, and a tube leading from nipple 23 being provided with a hypodermic needle inserted within the vein of a recipient of the blood. With the valve properly positioned, simple reciprocation lof the piston will obviously withdraw blood from the donor through the port 2 and will inject it into the vein of the recipient through the port 3. This operation does not require more technical skill or knowledge than is required for a venipuncture and operation of the ordinary hypodermic syringe, and during its use, the surgeons attention is not required for the operation of valveswhile he has the assurance that blood. can be vaspirated only from the donor and injected only into the recipient.
Whenever the operator desires to cleanse the pump without disturbing the connections from donor to recipient, he may rotate the sleeve by turning the ring I4 to the other limit of its angular adjustment, and reciprocation of the piston will then act to draw in a saline or citrate washing solution through a tube connected to the nipple of the port 4 and to discharge it through the port 5 from which a tube maylead to any receptacle for the washings.
As a further precaution against clotting of the blood, before beginning transfusion, a solution of citrate of sodium or of potassium will be drawn into the chamber 9 whence it may penetrate by capillary action into the joint between the cylinder and the sleeve, thus preventing the intrusion of blood in the space, or, if any should penetrate into the space, mixing with it to prevent its coagulation. After pumping a sucient quantity of the washing solution into the Valve chamber until the washing liquid shows clear, the sleeve will be rotated back to the original angular setting to permit the transfusion `to be continued. v Y Y In Fig; 4,' the opening I8V in the plug I1 is shown as screw-threaded to receive a threaded valve member I9 having a transverse passage soon. as the handle II is released, the expansion-- of the air will slide the sleeve back to cause automatic closing of the port 3 or 5. If the valve IS-is closed when the sleeve is at the outer positiontagainst the plug I1, inward sliding of the valve I-will cause a partial vacuum in the chamber 9,- and release of the handle I I will allow thel sleeve to 'slide outward, automatically closing the port` 2.0114. If the sleeve is slid to a mid position with-the. valve member IS-open and the passage 2ll.-is'.then closed, the pressure in the chamber 9k on the outward stroke and the partial vacuum on the inward stroke will be sufficient in either caseto cause the sleeve to recede from its eX-.
treme positions to a central position in which bothdnlet and outlet ports will be closed.
In Fig. 8, a spring 25 is shown as seated withina recess in the end of the valve 5, or the spring may be on the outside of the sleeve as shown at 21 in Fig. 9, the function in each case beingto'press the sleeve away from contact with the end member engaged by the spring, and thus to slide the sleeve valve port out of registration withthe inlet or outlet ports. Such springs may be used'in cases where it is not desirable to have theV chamber 9 closed by a member I9.
Another embodiment of the invention is illustrated in Figs. 5, 6, and '1, in which the piston III! has a non-circular handle II' slidable through an aperture of similar cross section in aadisc 28 mounted for rotation on a shoulder 23formed. in the enlarged inner end of the cylin'der. Il, the disc being held in place by a plug I6? having. an aperture-permitting the rotation offthe'handle Il. The disc 23 has a guide portion. 30'. provided with a groove or channel I2 parallel with the axis of the cylinder. A sleeve valve 6" has aprojection I3 extending intothe channel I2! which is of a length to be engaged byy the projection I3- during the entire travel .e
Rotation of the handle il of`the sleeve valve. will, cause rotation of the disc 28 and hence of theehannel vand the sleeve Valve, wherever the valve may be in its longitudinal movement. The
shoulder 29`is provided with a slot I5' throughV Whicnextends a pointer I3, the ends of the slot` I5' acting as stops to engage the pointer to determine the limiting positions of the sleeve valve in the same manner as the corresponding slot; I5` in Fig. 2 and for the same purpose. This disc 28, inside the cylinder and rotated by the handle, takes the place and has the function of the ring I'4'of Figs. l and 2. It is more easil)r removed than theV ring and there is nothing on the. outside of the 'cylinder to render cleaning or sterilization more diflcult. The pointer I3" ad- `jacent to the outer surface of the cylinder at its expanded endmay serve to indicate to the operator the angularposition occupied by the valve.
merely sliding and rotating'the handle and has no need to let go of the handle to manipulate a ring.
Since the longitudinal movement of the valve is necessary to cause registration of the passage ZI rst with port 2 or 4 4at the intake end of the stroke and then with port 3 or 5 at the outlet end ofthe stroke, the friction between the piston and the sleeve may be made greater than the friction between the sleeve and the cylinder by forming slits or slots 3| in the 4open inner end of the piston as is shown in Fig. 1U, to permit the metal portions between them to be expanded slightly to act as spring fingers. A piston ring 32 set within a groove in the piston wall will not only act to increase friction but will tend to prevent the ingress of blood b-etween the piston and the valve wall.
In giving a transfusion of blood, it may be desirable to give the donor an infusion of 4saline solution, and it may also bedeemed desirable to supplement the transfusion of blood by giving the recipient an infusion of saline solution. For the facile accomplishment of this purpose, a modification of the construction of Fig. 1 is shown in Figs. 12, 13, and .14, in which the inlet opening 33 for the saline solution is substantially opposite the inlet opening 34 for blood; in which the sleeve Valve is provided with channels 35, 31, and 38 in its periphery for passage of the saline solution; and in which the cylinder has a channel 3B formed in its inner periphery. The channel 35 is shown in Figs. 12 and 14 as extending around the outer periphery of the sleeve valve '6" for a little more than 180 and the .channel31, separated from the channel 35 by a distance longitudinally twice that travelled by the sleeve, lies on the same side of the sleeve and has the same length. These two transverse or semicircumferential channels are connected at one end by a the present'invention it has not been illustrated.
Those familiar with the art will recognize as suit-y abler sources such familiarA equivalent devices as a suspended container, a hand operated piston, or a closed tank charged with compressed air and the solution.
Nipples will be provided at each port for the'` usual tubing. Nipple 40 at port 34 will be connected by a tube with the vein of the donor. Nipple 4I at port 42 will be connected by a tubewith the vein lof the recipient. Nipple 43 at outlet port 44 will be connected with a receptacle for washings. The piston I6" is shown rin Fig. 12 at the inner end of its stroke with the passage 2| opposite the port 34 as -'it would be justl after draw-- ing inblood from the donor. Pressure on the handle IIv will cause the valve 6" to slide longitudinally until the passage 2l" registers with the port 42 and the channel 31 will then form acornmunicating passage betweenthe port 33 andV the port 34.- While the piston is forcing blood outat the port 42, salinesolution maybe passed 'l through-.the channel=31to the veiniof thedonorl longitudinal channel 38, shown in Figs. 1 2 and 13 to prevent stasis of blood in the connecting tube, thus preventing coagulation of blood in the tube. On the intake stroke, the sleeve slides to the position shown in Fig. 12 and the channel 35 and half of the channel 38 form a passage for the saline solution from the inlet port 33 to the port 42 permitting an infusion of. saline solution into the vein of the recipient supplementary to the transfusion of blood from the vein of the donor. This infusion may be continued at will as long as the piston is held at the inner end of its stroke, the pressure on the saline solution being made sufficient to provide a continuous flow.
Rotation of the sleeve Valve through counterclockwise in Figs. 13 and 14 will bring the passage 2| in the same longitudinal plane with the end of the channel 33 and the outlet port 44, whereupon reciprocation of the piston will draw saline solution into the valve chamber through the channel 3G from the port 33 and will force it out at the port 44 into the receptacle for waste. After washing out the valve by this operation, a charge of saline solution, if desired, may be drawn into the valve and after ro-tating it ninety degrees, the Charge may be sent into the vein of the recipient. Thus it will be seen that saline solution may be given both to the donor and to the recipient of blood during a transfusion. The channel 38 registers with the port 33 during the entire reciprocation of the piston in the normal angular setting and the pressure on the saline solution aids in causing the liquid to interpose itself between the valve and the cylinder.
By the provision of a valve 45 in the inlet port 33 as shown in Fig. 11, the flow of saline solution may be made greater or less or may be entirely cut off from either the donor or the recipient or both, While an independent passage 46 without a valve may be used instead of the channel 3B to permit a free flow of the solution for washing.
The modication shown in Figs. 15 and 16 is substantially the same as the structure just described with the addition of an inlet port 41 and nipple 48 and the omission of the channel 3B, which enables the .operator to use a T 49 connected by tube 55 to a source of saline solution, connected by tube 5| with the nipple 43 and connected by tube 52 with the nipple 39. A11 adjustable clamp 53 regulates the pressure of solution entering the port 33 for passage either to the donor or to the recipient while: the open tube 5| permits the unobstructed flow at full pressure of solution .into the port 41 for use in washing out the valve chamber.
This Construction also permits the two tubes 5| and 52 to be used independently as indicated in Fig. 20, in which the tube 52 may be used for connection with a source of saline solution and the tube 5l may be used to connect the apparatus with a source of citrate solution for washing out the chamber when an anti-coagulant is desired.
A still further modication is illustrated in Figs. 18 and 19 in which the nipples 43 and 48 of Fig. 15 have been omitted and a longitudinal channel 54 has been formed in the Wall of the cylinder to register with the passage 2l when it has been turned ninety degrees away from registration with the ports 34 and 42. The cap l1' may have a nipple 55 at the opening I8 through which a saline or citrate washing solution may be drawn and discharged.
It will be seen that with this arrangement, the recipient of blood may still receive an infusion of saline solution through the channel 35 though no provision is made for giving the donor an infusion. It will be noted that the channel 54 for the washing solution does not communicate with the channel 35', which however will be kept free from blood during the intake stroke of the piston by the saline solution entering at port 33.
The use of a solution of citrate of soda orv citrate of potassium to prevent coagulation of blood in the joints between the sleeve valve and the cylinder is so desirable that a pressure cup 55, (shown in Fig. 21 as attached to the cylinder on the side opposite the ports 51 and 58, which may correspond with any of the ports 2, 3, 4, 5, 33, 34, or 42), can be provided as an addition to any of the modications already described. The cup 56 has a chamber 59 formed with an outlet passage 60 and has a cap 6I in screw-threaded engagement with the outer periphery of the upper end of the cup, the cap being formed with a pis-l ton portion 62 sliding with a ground and liquidtight joint in the cylindrical interior of the cup.
Before use of the device, the cap is removed, a quantity of citrate solution is poured into the chamber 59, and the cap is replaced, the piston portion 62 acting to force some of the solution through the passage 60 into the space between the valve and the cylinder. At intervals during the process of transfusion, the cap 6| may be turned enough to force additional citrate solution into the valve joint, the surplus escaping at some of the ports and leaving the joint lled with clean solution.
A modication shown in Fig. 17 provides an inlet port 4 for saline washing solution and a channel 63 in line with the port 4 to discharge washings from the chamber 8 into the chamber 9 from which they escape through a port 64 in a nipple 55 on the end plug, this nipple being held while in use at the top of the plug 66 and being connected by a tube 61 with an open-mouthed funnel 68 leading to a receptacle 69 for washings.
This does not permit return of the washings from the receptacle 69 back to the chamber 9.
The devices described thus far may be made of any suitable material, a non-corrosive, nonrusting metal being entirely satisfactory for most purposes, but since many operators desire visibility of the blood chamber, glass may be used for the center of the device as illustrated in Fig. 22. The central part 10 of the cylinder is indicated as a glass tube attached at its ends to metal portions 1l and 12, and the central portion 14 of the valve is indicated as a glass tube attached at its endsto metal portions 15 and 16. It will be evident that the contents of the valve element 14 will be visible throughout the entire range of its movement within the cylinder element 1D. With this arrangement in which the intake and outletnipples are not in the .glass portion but within a metal portion, the length of the channel 2Ig is necessarily greater than that of the channel 2l of Fig. 1 and the partition 1 will be of greater thickness than that of partition 1. In Figs. 12 and 22, the chambers 9 and 9 respectively are shown as having an inlet port 11 or 11 formed in the wall of the cylinder while the end plug 18 or 18 is imperforate. With the valve in its outermost position, the end of the cylinder may be immersed beneath the surface of a citrate solution and some of the liquid may be drawn into the chamber by sliding the valve inward as a means by which a limited amount of the solution will be available to penetrate into the valve joint by capillarity. The port 11 or 11' will be carried on the upper surface of the cylinder as it is held in place for use so that the liquid cannot escape.
The modification shown in Fig.' 23 is a doubleacting pump having ahandle 19 connected at its ends by cross arms 80 to theshafts 8l of thepis- ` tons 82 and 83 sliding within chambers 84 and 85 of a valve member 86 consisting of a cylindrical sleeve having a partition 81 separating the chambers 8'4 and 85. The sleeve valve is limited in its longitudinal sliding movements by the end caps 89 and 90 of the cylinder 88 and there is an intake port 9| and a discharge port 92 separated from each other by a distance equal to the amount of Sliding movement of the sleeve in the cylinder. The chamber 85 has a passage 93 adjacent to the partition 81, the outer end of this passage being in registration with the intake port 9i at one end of its stroke and in registration with the discharge ,port 92 at the other end of -its stroke. The chamber' 84 has a passage 94 adjacent to the partition 81, the outer end of the passage communicating with two channels formed within the outer periphery of the sleeve valve, of which one channelis designated as 95 and this is in registration with the intake port 9! when the passage 93 is in registration with the discharge port 92, and the other channel, designated as 96, is in registration with the discharge port 92 when the passage 93 is-in registration with the intake port 9|.
Starting with the p-arts in the position shown in Fig. 23, with'the piston 82 in contact with the partition 81 and the piston 83 in contact With the plug 90, longitudinal movement of the handle 19 will cause the valve 86 to slide along the interior of the cylinder 88 until the plug 89 stops its further sliding movement with the passage 93 in registration With the port 92. Continued movement of the handle will cause both pistons to slide in the sleeve valve, piston 83 forcing' any contents of the chamber 85 out through the passage 93 and port 92 while piston 82 creates a suction to draw liquid into chamber 84 through the passage 95 and port 9L It will be obvious that a reverse movement will act to slide the valve to the plug 90 followed by expulsion of liquid from chamber 84 through passage 94 and channel 96 to the outlet port 92, and simultaneous inward suction into chamber 85 through port 9! and passage 93.
It will be evident that the invention is not limited to the exact details of construction of the specic elements chosen for illustration as preferred embodiments of the device since obviously many changes in formation and arrangement of parts may be made without departure from the essential mode of operation and without loss of its many advantages, While it is also clear that such a pump assembly is adapted for many other uses than those set forth.
I claim:
1. A pump assembly comprising a cylin-der having two inlet ports in the same transverse plane and having two outlet ports in a transverse plane different from that of the inlet ports, each outlet port being in a longitudinal plane with an inlet port, a cylindrical sleeve valve within the cylinder, said sleeve having a transverse partition and being provided with a port formed in the wall of the sleeve adjacent to the partition, a piston slidable within the sleeve, and guiding means comprising elements on the cylinder and on the sleeve adapted for rotation whereby the port of the sleeve valve may be brought into alinement selectively with either of the longitudinal planes having an inlet and outlet port.
2. A structure as in claim l in which the guiding means on the cylinder and on the sleeve are interengaged during the entire longitudinal movement of the valve.
8. A pump assembly comprising a barrel having inlet and outlet ports, a sleeve valve having a port registrable with the inlet or the outlet port selectively, a piston slidable in the sleeve valve, and a port angularly spaced from the inlet port, the sleeve valve being provided with a channel arranged to connect the said angularly spaced port with the inlet port of the barrel when the valve port is in registration-with the outlet port of the barrel.
4. A pump assembly comprisinga barrel having inlet and outlet ports, a sleeve valve within the barrel and having a port registrable with the inlet or the outlet port selectively, a piston slidable in the valve, the barrel being formed with separate inlet and outlet ports for a washing liquid, and means for rotating the sleeve valve andfor limiting its rotative movement to positions in which the port in the valve registers with either of the inlet ports at one end of its longitudinal movement and with either of the outlet ports at the other end of its longitudinal movement.
5. A pump assembly comprising abarrel having inlet and outlet ports formed therein for one iluid, and having a separate port formed therein for another fluid, a sleeve valve slidable within the barrel and providedwith a port formed within its wall for registration with the inlet or the outlet port of the barrel selectively, a piston yslidable Within the valve, and the sleeve valve being provided with a channel arranged to connect the said separate port for fluid with the outlet port of the barrel when the Valve port is in registration with the inlet port of the barrel.
6. A structure as in claim 5 in which the sleeve valve is provided with a channel arranged to connect the said separate port for iluid with the inlet port of the barrel when the valve port is in registration with the outlet port of the barrel.
7. A pump assembly comprising a barrel having inlet and outlet ports, a sleeve valve slidable within the barrel and having a passage formed in its wall for registration with the ports of the barrel, a piston in the sleeve, and a pressure cup secured to the barrel and communicating with the space between the barrel and the sleeve valve, whereby a liquid in the cup may be forced under pressure into said space.
8. A pump assembly comprising a barrel having spaced ports for use as inlet and outlet ports, a sleeve valve slidable longitudinally within the barrel and having a transverse partition and a port formed within the Wall of the valve adjacent to the partition for registration with the ports in the barrel, and a piston slidable within the sleeve valve and conforming to its interior dimensions whereby to expel substantially all fluid from the valve as the piston reaches the partition.
9. A pump assembly comprising a cylinder having two inlet ports and two outlet ports, a cylindrical hollow sleeve valve sli-dable longitudinally and rotatable within the cylinder, said sleeve valve being provided with a port formed in the wall of the sleeve, a piston operatively connected with the interior of the sleeve valve, and guiding means comprising elements on the cylinder and on the sleeve adapted for rotation whereby the port of the sleeve valve may be brought into alinement selectively with either inlet port or either outlet port.
10. A pump assembly comprising a barrel having inlet and outlet ports, a sliding hollow Valve having a port registrable with the inlet or the outlet port selectively and having a piston operatively connected with the hollow interior of the valve, the barrel having a port angularly spaced from the inlet port, and the sliding valve being provided With a channel arranged to connect the said angularly spaced port With the inlet port of the barrel when the valve port is in registration with the outlet port of the barrel.
11. A pump assembly comprising a barrel having inletI and outlet ports, a sleeve valve within the barrel and having a port registering selectively with either the inlet or the outlet port, a piston operatively connected with the interior of the sleeve valve, the barrel being formed with separate inlet and outlet ports for a washing liquid, and means for rotating the valve and for limiting the rotative movement to positions in which the port in the valve registers with either of the inlet ports at one end of its longitudinal movement and with either of the outlet ports at the other end of its longitudinal movement.
12. A pump assembly comprising a barrel having inlet and outlet ports formed therein for one fluid, and having a separate port formed therein for another fluid, a sleeve valve slidable within the barrel and provided With a port formed within its Wall for registration with inlet or the outlet port of the barrel selectively, a piston operatively connected with the interior of the sleeve valve, and the sleeve valve being provided with a channel arranged to connect the said separate port for fluid with the outlet port of the barrel when the valve port is in registration with the inlet port of the barrel.
13. A structure as in claim 12 in which the sleeve valve is provided with a channel adapted to connect the said separate port for fluid with the inlet port of the barrel when the valve port is in registration with the outlet port of the barrel.
14. A pump assembly comprising a barrel having inlet and outlet ports, a sleeve valve slidable within the barrel and having a passage formed ing inlet and outlet ports, a sleeve valve slidable longitudinally within the barrel and having a transverse partition and a port formed in the wall of the valve adjacent to the partition for registration with the ports in the barrel, a piston slidable within the valve between one end ofl the valve and the partition, and a closure for the end of the barrel remote from the piston to provide a liquid chamber within the barrel between said closure and the partition in said valve.
SAM BERGMAN.
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Cited By (17)

* Cited by examiner, † Cited by third party
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US3859985A (en) * 1973-06-27 1975-01-14 Becton Dickinson Co Angiography valve
US20040133146A1 (en) * 2000-11-17 2004-07-08 Broek Arjan Jacob Device for treating a fluid-like sample such as a whole blood, with treatment fluid, use of such a device and kit containing such a device
US6884231B1 (en) 2002-10-17 2005-04-26 Hamilton Company Dual chambered fluid displacement apparatus
US20110002802A1 (en) * 2007-12-10 2011-01-06 Medrad, Inc. Continuous fluid delivery system
US20110046604A1 (en) * 2009-08-21 2011-02-24 Becton Dickinson France S.A.S. Syringe Assembly with Inverse Delivery
WO2013043868A1 (en) 2011-09-21 2013-03-28 Medrad, Inc. Continuous multi-fluid delivery system and method
USRE45717E1 (en) 2007-10-30 2015-10-06 Bayer Medical Care Inc. System and method for proportional mixing and continuous delivery of fluids
US9433730B2 (en) 2013-03-14 2016-09-06 Bayer Healthcare Llc Fluid mixing control device for a multi-fluid delivery system
US9861742B2 (en) 2008-11-05 2018-01-09 Bayer Healthcare Llc Fluid mixing control device for a multi-fluid delivery system
US10507319B2 (en) 2015-01-09 2019-12-17 Bayer Healthcare Llc Multiple fluid delivery system with multi-use disposable set and features thereof
US11340104B2 (en) 2020-07-07 2022-05-24 Matthew Moers Syringe with a valve in a housing for measuring chemicals
US11547793B2 (en) 2016-10-17 2023-01-10 Bayer Healthcare Llc Fluid injector with syringe engagement mechanism
US11717614B2 (en) 2014-04-25 2023-08-08 Bayer Healthcare Llc Syringe with rolling diaphragm
US11826541B2 (en) * 2017-09-13 2023-11-28 Bayer Healthcare Llc Sliding syringe cap for separate filling and delivery
US11839751B2 (en) 2020-06-18 2023-12-12 Bayer Healthcare Llc In-line air bubble suspension apparatus for angiography injector fluid paths
US11938093B2 (en) 2020-02-21 2024-03-26 Bayer Healthcare Llc Fluid path connectors for medical fluid delivery
US11975172B2 (en) 2016-10-17 2024-05-07 Bayer Healthcare Llc Fluid injector with syringe engagement mechanism

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859985A (en) * 1973-06-27 1975-01-14 Becton Dickinson Co Angiography valve
US7144382B2 (en) * 2000-11-17 2006-12-05 Best Quality B.V. Device for treating a fluid-like sample such as a whole blood, with treatment fluid, use of such a device and kit containing such a device
US20040133146A1 (en) * 2000-11-17 2004-07-08 Broek Arjan Jacob Device for treating a fluid-like sample such as a whole blood, with treatment fluid, use of such a device and kit containing such a device
US6884231B1 (en) 2002-10-17 2005-04-26 Hamilton Company Dual chambered fluid displacement apparatus
USRE45717E1 (en) 2007-10-30 2015-10-06 Bayer Medical Care Inc. System and method for proportional mixing and continuous delivery of fluids
US20110002802A1 (en) * 2007-12-10 2011-01-06 Medrad, Inc. Continuous fluid delivery system
US9057363B2 (en) 2007-12-10 2015-06-16 Bayer Medical Care, Inc. Continuous fluid delivery system
US9861742B2 (en) 2008-11-05 2018-01-09 Bayer Healthcare Llc Fluid mixing control device for a multi-fluid delivery system
US10441716B2 (en) 2008-11-05 2019-10-15 Bayer Healthcare Llc Fluid mixing control device for a multi-fluid delivery system
US11491279B2 (en) 2009-08-21 2022-11-08 Becton Dickinson France Syringe assembly with inverse delivery
US20110046604A1 (en) * 2009-08-21 2011-02-24 Becton Dickinson France S.A.S. Syringe Assembly with Inverse Delivery
US9352096B2 (en) 2009-08-21 2016-05-31 Becton Dickinson France Syringe assembly with inverse delivery
US11724038B2 (en) 2009-08-21 2023-08-15 Becton Dickinson France Syringe assembly with inverse delivery
US10507288B2 (en) 2009-08-21 2019-12-17 Becton Dickinson France Syringe assembly with inverse delivery
WO2013043868A1 (en) 2011-09-21 2013-03-28 Medrad, Inc. Continuous multi-fluid delivery system and method
US9433730B2 (en) 2013-03-14 2016-09-06 Bayer Healthcare Llc Fluid mixing control device for a multi-fluid delivery system
US11717614B2 (en) 2014-04-25 2023-08-08 Bayer Healthcare Llc Syringe with rolling diaphragm
US10507319B2 (en) 2015-01-09 2019-12-17 Bayer Healthcare Llc Multiple fluid delivery system with multi-use disposable set and features thereof
US11491318B2 (en) 2015-01-09 2022-11-08 Bayer Healthcare Llc Multiple fluid delivery system with multi-use disposable set and features thereof
US11547793B2 (en) 2016-10-17 2023-01-10 Bayer Healthcare Llc Fluid injector with syringe engagement mechanism
US11975172B2 (en) 2016-10-17 2024-05-07 Bayer Healthcare Llc Fluid injector with syringe engagement mechanism
US11826541B2 (en) * 2017-09-13 2023-11-28 Bayer Healthcare Llc Sliding syringe cap for separate filling and delivery
US11938093B2 (en) 2020-02-21 2024-03-26 Bayer Healthcare Llc Fluid path connectors for medical fluid delivery
US11839751B2 (en) 2020-06-18 2023-12-12 Bayer Healthcare Llc In-line air bubble suspension apparatus for angiography injector fluid paths
US11340104B2 (en) 2020-07-07 2022-05-24 Matthew Moers Syringe with a valve in a housing for measuring chemicals

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