US20170079673A1 - Device for positioning an ultrasound transducer inside a mr scanner - Google Patents
Device for positioning an ultrasound transducer inside a mr scanner Download PDFInfo
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- US20170079673A1 US20170079673A1 US15/367,508 US201615367508A US2017079673A1 US 20170079673 A1 US20170079673 A1 US 20170079673A1 US 201615367508 A US201615367508 A US 201615367508A US 2017079673 A1 US2017079673 A1 US 2017079673A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
- A61B17/2255—Means for positioning patient, shock wave apparatus or locating means, e.g. mechanical aspects, patient beds, support arms, aiming means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A61B5/0555—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4416—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
- A61N7/022—Localised ultrasound hyperthermia intracavitary
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00115—Electrical control of surgical instruments with audible or visual output
- A61B2017/00128—Electrical control of surgical instruments with audible or visual output related to intensity or progress of surgical action
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00199—Electrical control of surgical instruments with a console, e.g. a control panel with a display
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- A—HUMAN NECESSITIES
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- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00902—Material properties transparent or translucent
- A61B2017/00911—Material properties transparent or translucent for fields applied by a magnetic resonance imaging system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2051—Electromagnetic tracking systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/374—NMR or MRI
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B34/70—Manipulators specially adapted for use in surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
Definitions
- the following relates to medical imaging systems. It finds particular application to facilitating the positioning of an ultrasound transducer inside a Magnetic Resonance (MR) scanner, but is also applicable to other medical imaging modalities.
- MR Magnetic Resonance
- High intensity focused ultrasound is used to treat tumors, especially uterine fibroids.
- the treatment is based on warming tissue in and/or near the focus of the ultrasound beam. Sufficient warming causes cell death and subsequently a lesion in the treated volume, which often includes the tumor and some margin of healthy tissue immediately adjacent. The body then slowly absorbs the lesion, leaving the treated area tumor-free.
- the ultrasound transducer needs to be able to be moved in a manner that focuses the beam at a desired location on the subject while avoiding exposing organs.
- at least two translational and two angular degrees of freedom are needed. Controlling the location and extent of the warming can be facilitated via feedback from a device that can visualize both the anatomy of the treatment area and the temperature profile generated.
- a MR scanner can perform both functions by running dedicated sequences.
- the temperature profile is obtained by locally measuring the magnetic resonance frequency of the protons in the subject.
- the frequency has a temperature factor that is relatively small being only one millionth of one percent per degree Celsius.
- the mechanisms for moving the transducer therefore are made of materials that are non-magnetic. Small amounts of any metal can be used, however, plastics and/or ceramics are mainly used.
- the motors for powering the movements typically are placed about one meter away or more. At the same time the precision of the system is about 0.5 mm or better. This makes the system critical with respect to mechanical slack and bending.
- the transducer typically is held by a structure shaped similar to a fork that is rotated about a central axis. As a consequence, one side of the transducer is lifted while the other side of the transducer is lowered. This swiveling about the axis when lifting one side of the transducer during focusing creates problems when the transducer is to be placed relatively close to the subject, and such close positioning is often crucial when treating different size patients with tumors located at different depths. In order to make the fork stiff translation in the up-down direction is typically sacrificed, limiting the range of movements.
- a device that positions an ultrasound transducer for ultrasound therapy to focus a treatment beam emitted by the ultrasound transducer at tissue of interest.
- the device includes at least three anchors which support the ultrasound transducer and at least three extendable structures, each with a coupling that supports a corresponding one of the at least three anchors.
- a drive mechanism independently drives each of the at least three extendable structures towards or away from a subject to move the ultrasound transducer within at least three degrees of freedom.
- One advantage includes facilitating positioning an ultrasound transducer for a high intensity focused ultrasound treatment.
- Another advantage lies in freely translating the ultrasound transducer in all directions and independently inclined around two directions.
- Another advantage includes translating and inclining members with minimum length relative to the amplitudes of the movements, and these members are mechanically stressed only in the lengthwise directions to minimize the amount of transducer displacement caused by elastic deformation in its suspension.
- translating and inclining members are made using a small amount of material to minimize their influence on the magnetic field inside the subject and on a temperature measurement.
- Another advantage resides in using medical imaging to facilitate focusing the beam of the ultrasound transducer at a region of interest.
- FIG. 1 illustrates a medical treatment system for treating portions of a subject/object with high intensity focused ultrasound (HIFU).
- HIFU high intensity focused ultrasound
- FIG. 2 illustrates a receptacle used to position an ultrasound transducer in a retracted position away from a subject.
- FIG. 3 illustrates a technique in which the receptacle holding the ultrasound transducer translates to re-focus the HIFU beam.
- FIG. 4 illustrates a technique in which the receptacle holding the ultrasound transducer translates and rotates to re-focus the HIFU beam.
- FIG. 5 illustrates an exemplary device for moving the receptacle holding the ultrasound transducer to suitably focus the HIFU beam.
- FIG. 6 illustrate an exemplary location of the receptacle within the device holding the ultrasound transducer.
- FIG. 7 illustrate an exemplary axial motion mechanism for controlling an axial position of the receptacle holding the ultrasound transducer.
- FIG. 8 illustrate an exemplary longitudinal motion mechanism for controlling a longitudinal position of the receptacle holding the ultrasound transducer.
- FIGS. 9, 10 and 11 illustrate an exemplary arm and wheel mechanism for driving the receptacle towards and away from the subject.
- FIG. 12 illustrates a method for positioning an ultrasound transducer used to treat portions of a subject/object with high intensity focused ultrasound (HIFU).
- HIFU high intensity focused ultrasound
- FIG. 1 illustrates a medical treatment system 10 for treating a subject/object with high intensity focused ultrasound (HIFU).
- a HIFU beam 12 is used to treat a region of interest within and/or the subject.
- the region of interest includes undesired tissue such as a tumor and some margin of healthy tissue.
- the HIFU beam 12 is generated and emitted by an ultrasound transducer 14 , which is suitably positioned to focus the beam 12 at the region of interest 14 by a device 16 that moves the ultrasound transducer 14 through at least five degrees of freedom, at least three degrees of freedom in a direction towards and away from the subject and at least two degrees of freedom in axial and longitudinal directions with respect to the subject.
- the device 16 includes a receptacle or frame 18 , which supports the ultrasound transducer 14 .
- the receptacle 18 has anchors 20 1 , 20 2 , . . . , 20 N (collectively referred to herein as anchors 20 ), wherein N is a positive integer.
- Each of the anchors 20 1 , 20 2 , . . . , 20 N is respectively supported by couplings 22 1 , 22 2 , . . . , 22 N (collectively referred to herein as couplings 22 ).
- Each of the couplings 22 1 , 22 2 , . . . , 22 N respectively reside at an end of extendible structures 24 1 , 24 2 , . . .
- extendible structures 24 are moveably attached to a support plate 26 and extend and retract from the subject along a first axis 28 .
- the couplings 22 allow the anchors 20 to translate and/or rotate therein when one or more of the extendible structures 24 extends or retracts.
- the receptacle 18 translates and/or rotates towards or away from the subject and, hence, the transducer 14 translates and/or rotates towards or away from the subject.
- FIG. 2 illustrates the receptacle 18 in a retracted position away from the subject.
- there are three (i.e., N 3) extendible structures 24 , the extendible structure 24 1 , the extendible structure 24 2 , and an extendible structure 24 3 .
- the extendible structures 24 are respectively associated with the couplings 22 1 , 22 2 , and 22 3 .
- the couplings 22 are ball joints or the like and the anchors 20 1 , 20 2 , and 20 3 run through the holes in the ball joints, and the extendible structures 24 are pushrods.
- the extendible structures 24 (or pushrods) can be mounted to and actuated by lead screws 30 and corresponding lead screw nuts 32 or the like.
- the lead screw nuts 32 can be fixed on and rotatible about the first axis 28 .
- Driving mechanisms X (described in detail below in connection with FIGS. 9, 10 and 11 ) are used to independently turn each of the lead screw nuts 32 , which independently drives each lead screw 30 and extendible structure 24 along the first axis 28 .
- the anchors 20 are positioned about 60 degrees apart from one another.
- various other configurations can be used.
- two of the anchors 20 are positioned about 180 degrees apart and the third anchor is positioned about 90 degrees apart from the first two anchors.
- other extendible structures are contemplated, such as air or other fluid cylinders.
- the lead screws 30 are simultaneously driven at the same rate towards the subjects, which drives the extendible structures 24 in the same direction (towards the subject) at the same rate.
- the receptacle 18 and the ultrasound transducer 14 translate along the first axis 28 towards the subject.
- FIG. 4 only the lead screw 30 associated with the extendible structure 24 3 is driven towards the subject. The other lead screws 30 remain in a static position.
- the extendible structure 24 3 extends towards the subject, the anchor 20 3 translates through the coupling 20 3 , and the anchor 20 1 and 20 2 rotate (and slide a minute distance) within their respective couplings 22 1 and 22 2 (as illustrated at 34 and 36 ), which causes the receptacle 18 to rotate or tilt about the couplings 22 1 and 22 2 .
- the rotation of the receptacle 18 in turn rotates the ultrasound transducer 14 , which moves the focus point of the HIFU beam 12 .
- the support plate 26 is also attached to a first end 38 of an axial motion mechanism 40 , which provides translational movement of the support plate 26 along a second or transverse axis 42 in a transverse axial direction (side-to-side) with respect to the subject.
- a second end 44 of the axial motion mechanism 40 is attached to a longitudinal motion mechanism 46 , which provides translational movement of the support plate 26 along a third or longitudinal axis 48 in a longitudinal direction with respect to the subject.
- the combination of the translational movements along the axes 28 , 42 and 48 , and the rotational movements at 34 and 36 (as illustrated in FIG. 4 ) provides up to five degrees of freedom in which to position the receptacle 18 to suitably focus the ultrasound beam 12 .
- the receptacle 18 , the anchors 20 , the couplings 22 , the extendible structures 24 , the support plate 26 , the axial motion mechanism 40 and the longitudinal motion mechanism 46 reside within a cavity of a container or shell 50 .
- Controls 52 are used to drive the extendible structures 24 , the axial motion mechanism 40 and the longitudinal motion mechanism 46 in order to focus the ultrasound beam 12 .
- the controls 52 can include mechanical components for manually focusing the beam 12 and/or electrical components for electrically focusing the beam 12 .
- the device 16 is used in conjunction with a scanning system 54 or other device that is capable of providing information about tissue and/or temperature profiles associated with the treatment area. Such information is used to facilitate positioning the receptacle 18 to focus the ultrasound beam 12 .
- the scanning system 54 can be an open Magnetic Resonance (MR) scanner.
- MR Magnetic Resonance
- the scanning system 54 includes two main magnets 56 (e.g., permanent or resistive) separated by an imaging region 58 in an open configuration.
- a support mechanism 60 is used to position the subject within the imaging region 58 .
- the device 16 resides within the support mechanism 60 .
- the positioning of the two main magnets 56 is such that the magnets generate a magnetic field (B 0 ) in the subject.
- Magnetic field gradient coils (not shown, typically housed in or adjacent the main magnets) are arranged to superimpose selected magnetic field gradients on B 0 .
- Such gradients include orthogonal magnetic field gradients such as x, y and/or z gradients defined within a Cartesian plane.
- One or more radio frequency coils (not shown, typically disposed between the gradient coils and the subject) inject radio frequency excitation pulses (B 1 ) into and/or receive resonance signals from the imaging region 58 .
- a console 62 and a display 64 are used to plan patient procedures (e.g., selecting imaging protocol(s), set imaging parameters, etc.), commence scanning, present reconstructed images, as well as various other features.
- the console 62 provides instructions to a scanner controller 66 that controls a gradient controller 68 , a radio frequency (RF) source 70 , and a receiver 72 .
- the gradient controller 68 controls the magnetic field gradient coils to spatially encode the resulting magnetic resonances.
- the RF source 70 generates and provides the radio frequency excitation pulses (B 1 ) to the one or more radio frequency coils.
- detection circuitry detects the magnetic resonance signals, and the receiver 72 receives the spatially encoded magnetic resonances.
- the acquired spatially encoded magnetic resonances are stored in a storage component 74 and/or provided to a processing component 76 , which reconstructs one or more images from the data.
- Raw and/or processed data e.g., images
- the acquired data and/or resulting images are used to focus the beam 12 on at the region of interest, which is optionally controlled from the console 62 through transducer beam power and control electronics 63 and/or motor power and control electronics 65 .
- the data and/or images provide numerical and/or graphical information about the region of interest such as the images of the treatment tissue and temperature profiles associated therewith.
- the data allows the operator to see the area that is being exposed to the beam 12 .
- the operator can then, if needed, use the console 62 to control the electronics 63 and/or 65 to drive the controls 52 to reposition the receptacle 18 via one or more of the five degrees of freedom described herein to move the transducer 14 and refine the focus position of the beam 12 .
- the ultrasound beam and/or its focal spot are superimposed on the displayed image, e.g. in phantom, with a color change or shift, or the like. This provides the operator with visual feedback as the transducer is positioned.
- the superimposed images can provide assurance that the focal spot is centered in the target tumor and that no vital or sensitive organs lie in the ultra sound beam.
- the device 16 includes the container 50 with a cavity 78 in which the receptacle 18 and associated supporting and moving members are situated.
- the cavity 78 is filled with material (e.g., water) that is a substantially non-attenuating to the beam 12 .
- the container 50 includes an ultrasound transmissive window 80 through which the beam 12 is directed.
- the window 80 is illustrated as rectangular in shaped; however, it is to be appreciated that the window 80 can be variously shaped.
- the window 80 can alternatively be square, circular, triangular, irregular, etc. in shape.
- the container 50 can simply sit within the patient support 60 and/or be mounted therein through screws, clamps, VelcroTM, and the like.
- the container 50 is illustrated as semi-transparent in order highlight the position of the receptacle 18 and its associated supporting and moving members within the container 50 .
- FIGS. 7 and 8 illustrate exemplary transverse and longitudinal motion mechanisms 40 and 46 , respectively.
- the axial motion mechanism 40 which includes a rail 82 and a carriage 84 , is highlighted.
- the support 26 (and thus the transducer 14 ) is coupled to a side 86 of the carriage 84 and moves with the carriage 84 along the axis 42 .
- the rail 82 is mounted at ends 88 and 90 to a first carriage 92 and a second carriage 94 of the longitudinal motion mechanism 46 .
- the first and second carriages 92 and 94 are more clearly illustrated in FIG. 8 .
- the first carriage 92 is slidably mounted to a rail 96 , which is mounted the container 50
- the second carriage 94 is slidably mounted to a rail 98 , which is also mounted to the container 50 .
- Both rails 96 and 98 typically are rigidly mounted to the container 50 .
- the first and second carriages 92 and 94 are respectively mounted to the rail 82 , and the rail 82 moves with the first and second carriages 92 and 94 along the rails 96 and 98 .
- Various drives such as rack and pinion, belt, lead screw, and the like to provide transverse and longitudinal movement along the axes 42 and 48 .
- FIGS. 9, 10 and 11 illustrate an exemplary mechanism 100 that can be used to drive the extendible structures 24 .
- each extendible structure 24 can be extended and/or retracted through a lead screw assembly that includes the lead screw 30 and the lead screw nut 32 .
- the nut 32 is fixed on and rotatible about the first axis 28 at a first end 102 of a first arm 104 .
- a second end 106 of the first arm 104 is coupled to a first end 108 of a second arm 110 , and a second end 112 of the second arm 110 is attached to a control device 114 .
- Gears or wheels 116 , 118 , 120 and 122 are connected to each of the ends 102 , 106 , 108 , and 112 .
- a belt 124 is used in conjunction with the wheels 116 and 120
- a belt 126 is used in conjunction with the wheels 118 and 122 .
- the belts 124 and 126 are attached such that rotation of the wheel 116 translates to a corresponding rotation of the wheel 120 (and vice versa) and rotation of the wheel 118 translates to a corresponding rotation of the wheel 122 (and vice versa).
- the belts 124 and 126 can be toothed (as depicted), smooth, etc. and constructed from various non-magnetic materials including KevlarTM, rubber, NylonTM, etc.
- the rotational translation from wheel to wheel depends upon factors such as the diameter of each wheel, belt slippage, tooth cogging, hysteresis, etc.
- a rack and pinion type system can be used.
- the first and second arms 104 and 110 are coupled together on a similar axis 128 .
- movement of the support 26 , and, hence, the ultrasound transducer 14 , along one or both the axes 42 and 48 can be tracked in the plane of the wheels 116 - 122 (within the reach of the arms) while maintaining an measurable angle of the wheels 116 - 122 .
- the control device 114 turns the wheel 122 , which turns the belt 124 of arm 110 , which in turn causes the wheel 120 to rotate.
- the wheels 120 and 118 are coupled such that rotating either wheel will cause the other wheel to rotate.
- FIG. 9 only shows one arm/wheel/belt assembly, similar assemblies can be used to control each of the other extendible structures 24 .
- the components of the device 26 can be designed for use inside a MR or other type of medical imaging scanner.
- the components can be constructed from available or readily manufactured from non-magnetic materials.
- FIG. 12 illustrates a method for positioning an ultrasound transducer used to treat portions of a subject/object with high intensity focused ultrasound (HIFU).
- the method includes using a device (e.g., the device 16 ) that provides at least three degrees of freedom for moving an ultrasound transducer (e.g., the transducer 14 ) towards or away from a subject through a translation and/or two rotational motions in connection with a medial imaging system (e.g., the MR scanner 54 ).
- the device also provides at least two degrees for moving the ultrasound transducer axially and longitudinally with respect to the subject.
- the device 16 suitably positions the ultrasound transducer 14 to an initial position for treating a particular region in the subject.
- the ultrasound transducer 14 is activated and an ultrasound beam 12 is directed into the subject.
- the imaging system 54 is used to collect data representative of tissue in the treatment region and a temperature profile of the treatment region.
- the temperature profiles are superimposed on the displayed image, e.g. by temperature depending shading.
- the operator determines from the data whether the position of the ultrasound transducer should be refined to further focus the beam at the treatment area.
- the operator uses the controls 52 to extend or retract one or more of the extendible structures 24 , as describe above, for example, through the arm and wheel system 100 .
- Such movement results in translation and/or rotational movement of the beam to move the focus depth of the beam.
- the operator uses the controls 52 to move the support 26 in a transverse and/or longitudinal direction with respect to the patient to move the beam to move a different transverse and/or longitudinal location.
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Abstract
Description
- This application is a continuation of U.S. application Ser. No. 12/296,769 filed Oct. 10, 2008, now U.S. Pat. No. ______, which is a US National Stage Entry of PCT/US2007/064184 filed Mar. 16, 2007, which claims the benefit of U.S. Provisional Application Ser. No. 60/744,605 filed Apr. 11, 2006.
- The following relates to medical imaging systems. It finds particular application to facilitating the positioning of an ultrasound transducer inside a Magnetic Resonance (MR) scanner, but is also applicable to other medical imaging modalities.
- High intensity focused ultrasound (HIFU) is used to treat tumors, especially uterine fibroids. The treatment is based on warming tissue in and/or near the focus of the ultrasound beam. Sufficient warming causes cell death and subsequently a lesion in the treated volume, which often includes the tumor and some margin of healthy tissue immediately adjacent. The body then slowly absorbs the lesion, leaving the treated area tumor-free.
- To achieve the foregoing, the ultrasound transducer needs to be able to be moved in a manner that focuses the beam at a desired location on the subject while avoiding exposing organs. For suitable movement, at least two translational and two angular degrees of freedom are needed. Controlling the location and extent of the warming can be facilitated via feedback from a device that can visualize both the anatomy of the treatment area and the temperature profile generated. A MR scanner can perform both functions by running dedicated sequences.
- The temperature profile is obtained by locally measuring the magnetic resonance frequency of the protons in the subject. The frequency has a temperature factor that is relatively small being only one millionth of one percent per degree Celsius. The mechanisms for moving the transducer therefore are made of materials that are non-magnetic. Small amounts of any metal can be used, however, plastics and/or ceramics are mainly used. In addition the motors for powering the movements typically are placed about one meter away or more. At the same time the precision of the system is about 0.5 mm or better. This makes the system critical with respect to mechanical slack and bending.
- Conventional treatment systems use positioning devices that focus the high intensity ultrasound on tissue to be treated. The transducer typically is held by a structure shaped similar to a fork that is rotated about a central axis. As a consequence, one side of the transducer is lifted while the other side of the transducer is lowered. This swiveling about the axis when lifting one side of the transducer during focusing creates problems when the transducer is to be placed relatively close to the subject, and such close positioning is often crucial when treating different size patients with tumors located at different depths. In order to make the fork stiff translation in the up-down direction is typically sacrificed, limiting the range of movements.
- In one aspect, a device that positions an ultrasound transducer for ultrasound therapy to focus a treatment beam emitted by the ultrasound transducer at tissue of interest is illustrated. The device includes at least three anchors which support the ultrasound transducer and at least three extendable structures, each with a coupling that supports a corresponding one of the at least three anchors. A drive mechanism independently drives each of the at least three extendable structures towards or away from a subject to move the ultrasound transducer within at least three degrees of freedom.
- One advantage includes facilitating positioning an ultrasound transducer for a high intensity focused ultrasound treatment.
- Another advantage lies in freely translating the ultrasound transducer in all directions and independently inclined around two directions.
- Another advantage includes translating and inclining members with minimum length relative to the amplitudes of the movements, and these members are mechanically stressed only in the lengthwise directions to minimize the amount of transducer displacement caused by elastic deformation in its suspension.
- Another advantage is the translating and inclining members are made using a small amount of material to minimize their influence on the magnetic field inside the subject and on a temperature measurement.
- Another advantage resides in using medical imaging to facilitate focusing the beam of the ultrasound transducer at a region of interest.
- Still further advantages will become apparent to those of ordinary skill in the art upon reading and understanding the detailed description of the preferred embodiments.
- The drawings are only for purposes of illustrating embodiments and are not to be construed as limiting the claims.
-
FIG. 1 illustrates a medical treatment system for treating portions of a subject/object with high intensity focused ultrasound (HIFU). -
FIG. 2 illustrates a receptacle used to position an ultrasound transducer in a retracted position away from a subject. -
FIG. 3 illustrates a technique in which the receptacle holding the ultrasound transducer translates to re-focus the HIFU beam. -
FIG. 4 illustrates a technique in which the receptacle holding the ultrasound transducer translates and rotates to re-focus the HIFU beam. -
FIG. 5 illustrates an exemplary device for moving the receptacle holding the ultrasound transducer to suitably focus the HIFU beam. -
FIG. 6 illustrate an exemplary location of the receptacle within the device holding the ultrasound transducer. -
FIG. 7 illustrate an exemplary axial motion mechanism for controlling an axial position of the receptacle holding the ultrasound transducer. -
FIG. 8 illustrate an exemplary longitudinal motion mechanism for controlling a longitudinal position of the receptacle holding the ultrasound transducer. -
FIGS. 9, 10 and 11 illustrate an exemplary arm and wheel mechanism for driving the receptacle towards and away from the subject. -
FIG. 12 illustrates a method for positioning an ultrasound transducer used to treat portions of a subject/object with high intensity focused ultrasound (HIFU). -
FIG. 1 illustrates amedical treatment system 10 for treating a subject/object with high intensity focused ultrasound (HIFU). AHIFU beam 12 is used to treat a region of interest within and/or the subject. The region of interest includes undesired tissue such as a tumor and some margin of healthy tissue. TheHIFU beam 12 is generated and emitted by anultrasound transducer 14, which is suitably positioned to focus thebeam 12 at the region ofinterest 14 by adevice 16 that moves theultrasound transducer 14 through at least five degrees of freedom, at least three degrees of freedom in a direction towards and away from the subject and at least two degrees of freedom in axial and longitudinal directions with respect to the subject. - The
device 16 includes a receptacle orframe 18, which supports theultrasound transducer 14. Thereceptacle 18 hasanchors anchors extendible structures extendible structures 24 are moveably attached to asupport plate 26 and extend and retract from the subject along afirst axis 28. The couplings 22 allow theanchors 20 to translate and/or rotate therein when one or more of theextendible structures 24 extends or retracts. As theanchors 20 translate and/or rotate within their respective couplings 22, thereceptacle 18 translates and/or rotates towards or away from the subject and, hence, thetransducer 14 translates and/or rotates towards or away from the subject. - By way of example,
FIG. 2 illustrates thereceptacle 18 in a retracted position away from the subject. In this example, there are three (i.e., N=3)extendible structures 24, theextendible structure 24 1, theextendible structure 24 2, and anextendible structure 24 3. Theextendible structures 24 are respectively associated with the couplings 22 1, 22 2, and 22 3. In one instance, the couplings 22 are ball joints or the like and theanchors extendible structures 24 are pushrods. As such, the extendible structures 24 (or pushrods) can be mounted to and actuated bylead screws 30 and correspondinglead screw nuts 32 or the like. Thelead screw nuts 32 can be fixed on and rotatible about thefirst axis 28. Driving mechanisms X (described in detail below in connection withFIGS. 9, 10 and 11 ) are used to independently turn each of thelead screw nuts 32, which independently drives eachlead screw 30 andextendible structure 24 along thefirst axis 28. In this example, theanchors 20 are positioned about 60 degrees apart from one another. However, in other embodiments, various other configurations can be used. For instance, in one alternative embodiment two of theanchors 20 are positioned about 180 degrees apart and the third anchor is positioned about 90 degrees apart from the first two anchors. Also, other extendible structures are contemplated, such as air or other fluid cylinders. - In the mode of motion illustrated in
FIG. 3 , the lead screws 30 are simultaneously driven at the same rate towards the subjects, which drives theextendible structures 24 in the same direction (towards the subject) at the same rate. As a result, thereceptacle 18 and theultrasound transducer 14 translate along thefirst axis 28 towards the subject. InFIG. 4 , only thelead screw 30 associated with theextendible structure 24 3 is driven towards the subject. The other lead screws 30 remain in a static position. As a result, theextendible structure 24 3 extends towards the subject, theanchor 20 3 translates through thecoupling 20 3, and theanchor receptacle 18 to rotate or tilt about the couplings 22 1 and 22 2. The rotation of thereceptacle 18 in turn rotates theultrasound transducer 14, which moves the focus point of theHIFU beam 12. - Returning to
FIG. 2 , by independently extending and/or retracting one or more of theextendible structures 24 to similar and/or different distances at similar and/or different rates, up to three degrees of freedom can be achieved and used to effectuate translational, rotational, or both translational and rotational movements of thereceptacle 18 in order to move theultrasound transducer 14 and the focal point of theultrasound beam 12. - Returning to
FIG. 1 , thesupport plate 26 is also attached to afirst end 38 of anaxial motion mechanism 40, which provides translational movement of thesupport plate 26 along a second ortransverse axis 42 in a transverse axial direction (side-to-side) with respect to the subject. Asecond end 44 of theaxial motion mechanism 40 is attached to alongitudinal motion mechanism 46, which provides translational movement of thesupport plate 26 along a third orlongitudinal axis 48 in a longitudinal direction with respect to the subject. The combination of the translational movements along theaxes FIG. 4 ) provides up to five degrees of freedom in which to position thereceptacle 18 to suitably focus theultrasound beam 12. - The
receptacle 18, theanchors 20, the couplings 22, theextendible structures 24, thesupport plate 26, theaxial motion mechanism 40 and thelongitudinal motion mechanism 46 reside within a cavity of a container orshell 50.Controls 52 are used to drive theextendible structures 24, theaxial motion mechanism 40 and thelongitudinal motion mechanism 46 in order to focus theultrasound beam 12. Thecontrols 52 can include mechanical components for manually focusing thebeam 12 and/or electrical components for electrically focusing thebeam 12. - The
device 16 is used in conjunction with ascanning system 54 or other device that is capable of providing information about tissue and/or temperature profiles associated with the treatment area. Such information is used to facilitate positioning thereceptacle 18 to focus theultrasound beam 12. As illustrated inFIG. 1 , thescanning system 54 can be an open Magnetic Resonance (MR) scanner. However, it is to be appreciated that other types of MR scanners and/or other imaging modalities are also contemplated herein. - In this example, the
scanning system 54 includes two main magnets 56 (e.g., permanent or resistive) separated by animaging region 58 in an open configuration. Asupport mechanism 60 is used to position the subject within theimaging region 58. As depicted, thedevice 16 resides within thesupport mechanism 60. The positioning of the twomain magnets 56 is such that the magnets generate a magnetic field (B0) in the subject. Magnetic field gradient coils (not shown, typically housed in or adjacent the main magnets) are arranged to superimpose selected magnetic field gradients on B0. Such gradients include orthogonal magnetic field gradients such as x, y and/or z gradients defined within a Cartesian plane. One or more radio frequency coils (not shown, typically disposed between the gradient coils and the subject) inject radio frequency excitation pulses (B1) into and/or receive resonance signals from theimaging region 58. - A
console 62 and adisplay 64 are used to plan patient procedures (e.g., selecting imaging protocol(s), set imaging parameters, etc.), commence scanning, present reconstructed images, as well as various other features. Theconsole 62 provides instructions to ascanner controller 66 that controls agradient controller 68, a radio frequency (RF)source 70, and areceiver 72. Thegradient controller 68 controls the magnetic field gradient coils to spatially encode the resulting magnetic resonances. TheRF source 70 generates and provides the radio frequency excitation pulses (B1) to the one or more radio frequency coils. During a readout phase, detection circuitry (not shown) detects the magnetic resonance signals, and thereceiver 72 receives the spatially encoded magnetic resonances. The acquired spatially encoded magnetic resonances are stored in astorage component 74 and/or provided to aprocessing component 76, which reconstructs one or more images from the data. Raw and/or processed data (e.g., images) are displayed at thedisplay 64, archived, filmed, conveyed for further processing, etc. - The acquired data and/or resulting images are used to focus the
beam 12 on at the region of interest, which is optionally controlled from theconsole 62 through transducer beam power andcontrol electronics 63 and/or motor power andcontrol electronics 65. For example, the data and/or images provide numerical and/or graphical information about the region of interest such as the images of the treatment tissue and temperature profiles associated therewith. Thus, the data allows the operator to see the area that is being exposed to thebeam 12. The operator can then, if needed, use theconsole 62 to control theelectronics 63 and/or 65 to drive thecontrols 52 to reposition thereceptacle 18 via one or more of the five degrees of freedom described herein to move thetransducer 14 and refine the focus position of thebeam 12. In one embodiment, the ultrasound beam and/or its focal spot are superimposed on the displayed image, e.g. in phantom, with a color change or shift, or the like. This provides the operator with visual feedback as the transducer is positioned. For example, the superimposed images can provide assurance that the focal spot is centered in the target tumor and that no vital or sensitive organs lie in the ultra sound beam. - Now referring to
FIG. 5 , an exemplary configuration of thedevice 16 is illustrated. Thedevice 16 includes thecontainer 50 with acavity 78 in which thereceptacle 18 and associated supporting and moving members are situated. Thecavity 78 is filled with material (e.g., water) that is a substantially non-attenuating to thebeam 12. Thecontainer 50 includes anultrasound transmissive window 80 through which thebeam 12 is directed. Thewindow 80 is illustrated as rectangular in shaped; however, it is to be appreciated that thewindow 80 can be variously shaped. For example, thewindow 80 can alternatively be square, circular, triangular, irregular, etc. in shape. Thecontainer 50 can simply sit within thepatient support 60 and/or be mounted therein through screws, clamps, Velcro™, and the like. InFIG. 6 , thecontainer 50 is illustrated as semi-transparent in order highlight the position of thereceptacle 18 and its associated supporting and moving members within thecontainer 50. -
FIGS. 7 and 8 illustrate exemplary transverse andlongitudinal motion mechanisms FIG. 7 , theaxial motion mechanism 40, which includes arail 82 and acarriage 84, is highlighted. The support 26 (and thus the transducer 14) is coupled to aside 86 of thecarriage 84 and moves with thecarriage 84 along theaxis 42. Therail 82 is mounted at ends 88 and 90 to afirst carriage 92 and asecond carriage 94 of thelongitudinal motion mechanism 46. The first andsecond carriages FIG. 8 . Continuing withFIG. 8 , thefirst carriage 92 is slidably mounted to arail 96, which is mounted thecontainer 50, and thesecond carriage 94 is slidably mounted to arail 98, which is also mounted to thecontainer 50. Both rails 96 and 98 typically are rigidly mounted to thecontainer 50. As discussed above, the first andsecond carriages rail 82, and therail 82 moves with the first andsecond carriages rails axes -
FIGS. 9, 10 and 11 illustrate anexemplary mechanism 100 that can be used to drive theextendible structures 24. As described in connection withFIG. 2 above, eachextendible structure 24 can be extended and/or retracted through a lead screw assembly that includes thelead screw 30 and thelead screw nut 32. Thenut 32 is fixed on and rotatible about thefirst axis 28 at afirst end 102 of afirst arm 104. Asecond end 106 of thefirst arm 104 is coupled to afirst end 108 of asecond arm 110, and asecond end 112 of thesecond arm 110 is attached to acontrol device 114. Gears orwheels ends - As illustrated in
FIGS. 10 and 11 , abelt 124 is used in conjunction with thewheels belt 126 is used in conjunction with thewheels belts wheel 116 translates to a corresponding rotation of the wheel 120 (and vice versa) and rotation of thewheel 118 translates to a corresponding rotation of the wheel 122 (and vice versa). Thebelts - Returning to
FIG. 9 , the first andsecond arms similar axis 128. With this configuration, movement of thesupport 26, and, hence, theultrasound transducer 14, along one or both theaxes control device 114 turns thewheel 122, which turns thebelt 124 ofarm 110, which in turn causes thewheel 120 to rotate. Thewheels wheel 118 turns thebelt 126 ofarm 104, which in turn causes thewheel 116 to rotate. The rotation of thewheel 116 turns thelead screw nut 32, which drives thelead screw 30 andextendible structure 24 along theaxis 28 towards or away from the subject. AlthoughFIG. 9 only shows one arm/wheel/belt assembly, similar assemblies can be used to control each of the otherextendible structures 24. - It is to be appreciated that the components of the
device 26 can be designed for use inside a MR or other type of medical imaging scanner. In addition, the components can be constructed from available or readily manufactured from non-magnetic materials. -
FIG. 12 illustrates a method for positioning an ultrasound transducer used to treat portions of a subject/object with high intensity focused ultrasound (HIFU). The method includes using a device (e.g., the device 16) that provides at least three degrees of freedom for moving an ultrasound transducer (e.g., the transducer 14) towards or away from a subject through a translation and/or two rotational motions in connection with a medial imaging system (e.g., the MR scanner 54). The device also provides at least two degrees for moving the ultrasound transducer axially and longitudinally with respect to the subject. - At
reference numeral 130, thedevice 16 suitably positions theultrasound transducer 14 to an initial position for treating a particular region in the subject. Theultrasound transducer 14 is activated and anultrasound beam 12 is directed into the subject. At 132, theimaging system 54 is used to collect data representative of tissue in the treatment region and a temperature profile of the treatment region. Optionally, the temperature profiles are superimposed on the displayed image, e.g. by temperature depending shading. At 134, the operator determines from the data whether the position of the ultrasound transducer should be refined to further focus the beam at the treatment area. Assuming the operator desires to refine the position of the ultrasound transducer, at 136, the operator uses thecontrols 52 to extend or retract one or more of theextendible structures 24, as describe above, for example, through the arm andwheel system 100. Such movement results in translation and/or rotational movement of the beam to move the focus depth of the beam. Optionally, the operator uses thecontrols 52 to move thesupport 26 in a transverse and/or longitudinal direction with respect to the patient to move the beam to move a different transverse and/or longitudinal location. - The invention has been described with reference to the preferred embodiments. Modifications and alterations may occur to others upon reading and understanding the preceding detailed description. It is intended that the invention be constructed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (15)
Priority Applications (1)
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US15/367,508 US20170079673A1 (en) | 2006-04-11 | 2016-12-02 | Device for positioning an ultrasound transducer inside a mr scanner |
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PCT/US2007/064184 WO2008048708A2 (en) | 2006-04-11 | 2007-03-16 | A device for positioning an ultrasound transducer inside a mr scanner |
US29676908A | 2008-10-10 | 2008-10-10 | |
US15/367,508 US20170079673A1 (en) | 2006-04-11 | 2016-12-02 | Device for positioning an ultrasound transducer inside a mr scanner |
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US12/296,769 Continuation US9526515B2 (en) | 2006-04-11 | 2007-03-16 | Device for positioning an ultrasound transducer inside a MR scanner |
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Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100574829C (en) * | 2006-08-24 | 2009-12-30 | 重庆融海超声医学工程研究中心有限公司 | A kind of high-strength focus supersonic therapeutic system of image documentation equipment guiding |
JP5887137B2 (en) * | 2008-09-09 | 2016-03-16 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Treatment system to administer energy |
CA2743158C (en) | 2008-11-17 | 2016-04-05 | Sunnybrook Health Sciences Centre | Focused ultrasound system |
EP2437852B1 (en) * | 2009-06-02 | 2017-03-29 | Koninklijke Philips N.V. | Mr imaging guided therapy |
CN102573992B (en) * | 2009-09-24 | 2016-04-27 | 皇家飞利浦电子股份有限公司 | High intensity focused ultrasound positioning mechanism |
EP2386248B1 (en) | 2010-05-14 | 2018-06-27 | Samsung Medison Co., Ltd. | Ultrasonic diagnostic apparatus |
KR20140039418A (en) * | 2012-09-21 | 2014-04-02 | 삼성전자주식회사 | Medical robot system |
KR102478907B1 (en) * | 2014-08-15 | 2022-12-19 | 인튜어티브 서지컬 오퍼레이션즈 인코포레이티드 | A surgical system with variable entry guide configurations |
EP3090695A4 (en) | 2015-03-06 | 2017-11-22 | Murakumo Corporation | Ultrasonic oscillation device |
US11551028B2 (en) | 2017-04-04 | 2023-01-10 | Hailo Technologies Ltd. | Structured weight based sparsity in an artificial neural network |
US11238334B2 (en) | 2017-04-04 | 2022-02-01 | Hailo Technologies Ltd. | System and method of input alignment for efficient vector operations in an artificial neural network |
US10387298B2 (en) | 2017-04-04 | 2019-08-20 | Hailo Technologies Ltd | Artificial neural network incorporating emphasis and focus techniques |
US11615297B2 (en) | 2017-04-04 | 2023-03-28 | Hailo Technologies Ltd. | Structured weight based sparsity in an artificial neural network compiler |
US11544545B2 (en) | 2017-04-04 | 2023-01-03 | Hailo Technologies Ltd. | Structured activation based sparsity in an artificial neural network |
EP3793683A4 (en) * | 2018-05-16 | 2022-01-26 | Profound Medical Inc. | Apparatus and method for directing energy from a multi-element source |
CN110179527B (en) * | 2019-05-17 | 2021-11-16 | 鑫高益医疗设备股份有限公司 | Nuclear magnetic resonance ultrasonic knife control device and nuclear magnetic resonance medical bed |
CN113633899B (en) * | 2021-08-04 | 2023-12-08 | 四川泰猷科技有限公司 | Continuous zooming low-intensity focusing ultrasonic transducer |
EP4226874A1 (en) * | 2022-02-09 | 2023-08-16 | Storz Medical AG | Ultrasound and/or shock wave device with hexapod platform mounted source |
EP4226875A1 (en) * | 2022-02-09 | 2023-08-16 | Storz Medical AG | Shock wave device having a source self aligning with an x-ray device |
EP4226877A1 (en) * | 2022-02-09 | 2023-08-16 | Storz Medical AG | Shock wave device with integrated ultrasound probe |
EP4226876A1 (en) * | 2022-02-09 | 2023-08-16 | Storz Medical AG | Shock wave device having improved acoustic coupling |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5443068A (en) * | 1994-09-26 | 1995-08-22 | General Electric Company | Mechanical positioner for magnetic resonance guided ultrasound therapy |
US5722411A (en) * | 1993-03-12 | 1998-03-03 | Kabushiki Kaisha Toshiba | Ultrasound medical treatment apparatus with reduction of noise due to treatment ultrasound irradiation at ultrasound imaging device |
US5740699A (en) * | 1995-04-06 | 1998-04-21 | Spar Aerospace Limited | Wrist joint which is longitudinally extendible |
US20060033253A1 (en) * | 2001-06-22 | 2006-02-16 | Mccormick Peter E | Electrically driven tool |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4356577A (en) * | 1980-03-31 | 1982-11-02 | Taylor Gene E | Multipositional medical bed |
US4435116A (en) * | 1982-05-27 | 1984-03-06 | Deberg Walter H | Robotic manipulator |
US4567780A (en) * | 1984-03-12 | 1986-02-04 | American Hospital Supply Corporation | Hand-held pipette with disposable capillary |
JPS62159869A (en) | 1985-12-30 | 1987-07-15 | Yamatake Honeywell Co Ltd | Low-noise valve |
EP0265742A1 (en) | 1986-10-23 | 1988-05-04 | Siemens Aktiengesellschaft | Lithotripter with a locating device |
US4957099A (en) * | 1988-02-10 | 1990-09-18 | Siemens Aktiengesellschaft | Shock wave source for extracorporeal lithotripsy |
US4951653A (en) * | 1988-03-02 | 1990-08-28 | Laboratory Equipment, Corp. | Ultrasound brain lesioning system |
US5626595A (en) * | 1992-02-14 | 1997-05-06 | Automated Medical Instruments, Inc. | Automated surgical instrument |
US5275165A (en) * | 1992-11-06 | 1994-01-04 | General Electric Company | Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space |
US5492122A (en) * | 1994-04-15 | 1996-02-20 | Northrop Grumman Corporation | Magnetic resonance guided hyperthermia |
US20030195410A1 (en) * | 1995-08-10 | 2003-10-16 | James Winter | Method of treatment using magnetic resonance and apparatus therefor |
AU9036098A (en) * | 1997-08-28 | 1999-03-16 | Microdexterity Systems | Parallel mechanism |
CN1058905C (en) * | 1998-01-25 | 2000-11-29 | 重庆海扶(Hifu)技术有限公司 | High-intensity focus supersonic tumor scanning therapy system |
US5999839A (en) * | 1998-01-30 | 1999-12-07 | General Electric Company | Arterial MRI with chemical-shift nulling |
US6675037B1 (en) * | 1999-09-29 | 2004-01-06 | Regents Of The University Of Minnesota | MRI-guided interventional mammary procedures |
SE518763C2 (en) * | 2000-07-17 | 2002-11-19 | Ultrazonix Dnt Ab | Device for non-invasive ultrasound treatment of disk disease |
US6506171B1 (en) * | 2000-07-27 | 2003-01-14 | Insightec-Txsonics, Ltd | System and methods for controlling distribution of acoustic energy around a focal point using a focused ultrasound system |
US6582381B1 (en) * | 2000-07-31 | 2003-06-24 | Txsonics Ltd. | Mechanical positioner for MRI guided ultrasound therapy system |
JP2002360600A (en) * | 2001-06-11 | 2002-12-17 | Toshiba Corp | Ultrasonic treatment equipment |
CN1169588C (en) * | 2001-11-05 | 2004-10-06 | 北京源德生物医学工程股份有限公司 | Extenal high-energy focusing ultrasonic treating apparatus |
US7128711B2 (en) * | 2002-03-25 | 2006-10-31 | Insightec, Ltd. | Positioning systems and methods for guided ultrasound therapy systems |
FR2869547B1 (en) | 2004-04-29 | 2007-03-30 | Centre Nat Rech Scient Cnrse | DEVICE FOR POSITIONING ENERGY GENERATING MEANS OF AN ASSEMBLY FOR THE THERMAL TREATMENT OF BIOLOGICAL TISSUES |
-
2007
- 2007-03-16 JP JP2009505527A patent/JP5081227B2/en active Active
- 2007-03-16 RU RU2008144406/14A patent/RU2471448C2/en active
- 2007-03-16 EP EP07863334A patent/EP2007305B1/en active Active
- 2007-03-16 CN CN2007800128408A patent/CN101484084B/en active Active
- 2007-03-16 WO PCT/US2007/064184 patent/WO2008048708A2/en active Application Filing
- 2007-03-16 US US12/296,769 patent/US9526515B2/en active Active
-
2016
- 2016-12-02 US US15/367,508 patent/US20170079673A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5722411A (en) * | 1993-03-12 | 1998-03-03 | Kabushiki Kaisha Toshiba | Ultrasound medical treatment apparatus with reduction of noise due to treatment ultrasound irradiation at ultrasound imaging device |
US5443068A (en) * | 1994-09-26 | 1995-08-22 | General Electric Company | Mechanical positioner for magnetic resonance guided ultrasound therapy |
US5740699A (en) * | 1995-04-06 | 1998-04-21 | Spar Aerospace Limited | Wrist joint which is longitudinally extendible |
US20060033253A1 (en) * | 2001-06-22 | 2006-02-16 | Mccormick Peter E | Electrically driven tool |
Also Published As
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JP2009533162A (en) | 2009-09-17 |
EP2007305A2 (en) | 2008-12-31 |
JP5081227B2 (en) | 2012-11-28 |
CN101484084B (en) | 2012-08-29 |
CN101484084A (en) | 2009-07-15 |
WO2008048708A2 (en) | 2008-04-24 |
WO2008048708A9 (en) | 2008-07-10 |
EP2007305B1 (en) | 2012-05-16 |
US20090069667A1 (en) | 2009-03-12 |
US9526515B2 (en) | 2016-12-27 |
RU2008144406A (en) | 2010-05-20 |
WO2008048708A3 (en) | 2008-11-27 |
RU2471448C2 (en) | 2013-01-10 |
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