US20160199323A1 - Cancer treatment - Google Patents
Cancer treatment Download PDFInfo
- Publication number
- US20160199323A1 US20160199323A1 US14/912,077 US201414912077A US2016199323A1 US 20160199323 A1 US20160199323 A1 US 20160199323A1 US 201414912077 A US201414912077 A US 201414912077A US 2016199323 A1 US2016199323 A1 US 2016199323A1
- Authority
- US
- United States
- Prior art keywords
- cancer
- individual
- day
- aurka
- tsa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- RTKIYFITIVXBLE-QEQCGCAPSA-N CC(/C=C/C(=O)NO)=C\[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 Chemical compound CC(/C=C/C(=O)NO)=C\[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Definitions
- Histone deacetylase (HDAC) inhibitors have been investigated for their use in cancer therapies due to their ability to inhibit tumor cell growth with comparatively little toxicity.
- HDAC inhibitors include, for example, rocilinostat (ACY-1215), Zolinza (vorinostat), abexinostat hydrochloride (PCI-24781), suberoylanilide hydroxamic acid (SAHA), valporic acid (VPA), Pracinostat (SB939), PCI-24781 (CRA-024781), JNJ-26481585, Mocetinostat (MGCD0103, MG0103), Droxinostat, MC1568, Givinostat (ITF2357), Tubastatin A HCl, PCI-34051, Tacedinaline (CI994), and Panobiostat (LBH589, NVP-LBH589).
- rocilinostat ACY-1215
- Zolinza vorinostat
- PCI-24781 abexino
- Aurora Kinase A is one member of a serine and threonine kinase family known to be important in maintaining normal mitotic chromosomal segregation. Its protein localizes in the centrosomes of interphase cells and in the spindle of mitotic cells. AURKA overexpression has been linked with carcinogenesis in humans and has been detected in tumors of the breast, gastric tissues, colorectal tissue, bladder, pancreas, ovaries, prostate, and lung. It is possible, however, for any cancer to overexpress AURKA, which may be determined, for example, by testing a tumor for AURKA overexpression. Inhibition of AURKA expression has been shown to reduce cell invasion in vivo.
- AURKA is a cancer treatment target, typically through small molecule inhibition.
- Known AURKA inhibitors include, for example, VE465, tozasertib (VX-680), MK-0457, MK-5108, Alisertib (MLN8237).
- HDAC inhibitors and AURKA inhibitors Due to the efficacy of HDAC inhibitors and AURKA inhibitors in blocking cancer progression on their own, studies have evaluated the effect of their combined administration in non-human cancer models. For example, Li et al. found that co-treatment with VPA and VE465 induced more apoptosis than either compound did alone. Similarly, Okabe et al. found a synergistic inhibitory effect on the proliferation of cancer cells through the administration of either vorinostat or pracinostat in combination with tozasertib. The studies leading to the discovery of the present invention were undertaken since even though the dual HDAC and AURKA blocking effect was desirable in the treatment of cancer, no single entity is generally known to have this dual effect.
- One embodiment of the invention provides a method of treating cancer in an individual, the method comprising: administering to the individual an effective amount of trichostatin A (TSA).
- TSA trichostatin A
- TSA trichostatin A
- AURKA primary aurora kinase A
- the invention provides a method of treating a cancer in an individual, the method comprising: determining, from a tumor sample obtained from the individual's body, a level of aurora kinase A (AURKA) expression; and in the case that the level of AURKA expression is indicative of overexpression, administering to the individual an effective amount of trichostatin A (TSA).
- AURKA aurora kinase A
- treatment with TSA is combined with one or more other cancer treatments.
- Such other treatments may include, for example, small molecule AURKA inhibition.
- Such a combined treatment may, in some cases, decrease the
- Trichostatin A (TSA or 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide), is an antifungal antibiotic and a known class I and II HDAC inhibitor.
- TSA Trichostatin A
- the structure of TSA is shown in Formula I below.
- TSA although previously known as an HDAC inhibitor, is also capable of inhibiting AURKA expression.
- TSA may be used as the primary or sole AURKA inhibitor in the treatment of cancers.
- Cancers that may be treated according to embodiments of the invention include, for example, breast cancer, gastric cancer, colon cancer, rectal cancer, bladder cancer, pancreatic cancer, ovarian cancer, prostate cancer, lung cancer, hematological cancer, skin cancer, and malignancies.
- a human retinal pigment epithelial cell line was treated with trichostatin or vehicle for 24 hours and gene expression for 22,238 probe sets covering 12,490 genes was generated using an Affymetrix instrument.
- the effect of trichostatin A on AURKA expression is shown below in Table 1, and indicates a clear more than ten-fold downregulation of AURKA expression.
- an individual may be treated for cancer by administering to the individual an effective amount of TSA, wherein the effective amount is an amount sufficient to inhibit expression of AURKA in the individual. Such an amount may also be sufficient to inhibit HDAC activity in the individual.
- the effective amount is between about 0.1 mg/kg/day and about 10 mg/kg/day, e.g., between about 0.5 mg/kg/day and about 5 mg/kg/day.
- treating the individual may further comprise determining, from a tumor sample obtained from the individual's body, a level of AURKA expression.
- determining may include any known or later-developed method or technique, including, for example, quantitative antigen-antibody interactions, the use of labeled nucleotide probes, etc.
- TSA may be administered to the individual to be treated in the form of a pharmaceutical composition.
- Pharmaceutical compositions to be used according to various embodiments of the invention comprise a therapeutically effective amount of TSA or an active metabolite of TSA, or a pharmaceutically acceptable salt or other form (e.g., a solvate) thereof, together with one or more pharmaceutically acceptable excipients or carriers.
- pharmaceutical composition refers to a composition suitable for administration in medical use. It should be appreciated that the determinations of proper dosage forms, dosage amounts, and routes of administration for a particular patient are within the level of ordinary skill in the pharmaceutical and medical arts.
- Administration may be oral but other routes of administration may also be employed, e.g., parenteral, nasal, buccal, transdermal, sublingual, intramuscular, intravenous, rectal, vaginal, etc.
- Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules.
- the compound is admixed with at least one inert pharmaceutically-acceptable excipient such as (a) fillers or extenders, as for example, starches, lactose, sucrose, glucose, mannitol, and silicic acid, (b) binders, as for example, carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidone, sucrose, and acacia, (c) humectants, as for example, glycerol, (d) disintegrating agents, as for example, agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain complex silicates, and sodium carbonate, (e) solution retarders, as for example paraffin, (f) absorption accelerators, as for example, quaternary ammonium compounds, (g) wetting agents, as for example, cetyl alcohol, and glycerol monostearate, (h) adsorbents, as for example,
- the dosage forms may also comprise buffering agents.
- Solid dosage forms such as tablets, drages, capsules, pills, and granules also can be prepared with coatings and shells, such as enteric coatings and others well known in the art.
- the solid dosage form also may contain opacifying agents, and can also be of such composition that they release the active compound or compounds in a certain part of the intestinal tract in a delayed manner. Examples of embedding compositions which can be used are polymeric substances and waxes.
- the active compounds can also be in micro-encapsulated form, if appropriate, with one or more of the above-mentioned excipients.
- Such solid dosage forms may generally contain from 1% to 95% (w/w) of the active compound. In certain embodiments, the active compound ranges from 5% to 70% (w/w).
- Solid compositions for oral administration can be formulated in a unit dosage form, each dosage containing from about 1 mg to about 500 mg of active ingredient.
- unit dosage form refers to physically discrete units suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active ingredient calculated to produce the desired effect over the course of a treatment period, in association with the required pharmaceutical carrier.
- TSA can be formulated, e.g., in a unit dosage form that is a capsule having 1-500 mg of active in addition to excipients.
- Liquid dosage forms for oral administration include pharmaceutically-acceptable emulsions, solutions, suspensions, syrups, and elixirs.
- the liquid dosage forms may contain inert diluents commonly used in the art, such as water or other solvents, solubilizing agents and emulsifiers, as for example, ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propyleneglycol, 1,3-butyleneglycol, dimethylformamide, oils, in particular, cottonseed oil, groundnut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol, tetrahydrofurfuryl alcohol, polyethyleneglycols and fatty acid esters of sorbitan or mixtures of these substances.
- the composition can also include adjuvants, such as we
- TSA is provided in a liquid form and administered to an individual intravenously.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/912,077 US20160199323A1 (en) | 2013-08-22 | 2014-08-22 | Cancer treatment |
US15/980,644 US10265282B2 (en) | 2013-08-22 | 2018-05-15 | Cancer treatment |
US16/357,249 US11078289B2 (en) | 2013-08-22 | 2019-03-18 | Cancer treatment |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361869039P | 2013-08-22 | 2013-08-22 | |
US14/912,077 US20160199323A1 (en) | 2013-08-22 | 2014-08-22 | Cancer treatment |
PCT/US2014/052209 WO2015027121A2 (en) | 2013-08-22 | 2014-08-22 | Cancer treatment |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/052209 A-371-Of-International WO2015027121A2 (en) | 2013-08-22 | 2014-08-22 | Cancer treatment |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/980,644 Continuation US10265282B2 (en) | 2013-08-22 | 2018-05-15 | Cancer treatment |
US15/980,664 Continuation US20190040145A1 (en) | 2006-03-27 | 2018-05-15 | Antibody molecule for human gm-csf receptor alpha |
Publications (1)
Publication Number | Publication Date |
---|---|
US20160199323A1 true US20160199323A1 (en) | 2016-07-14 |
Family
ID=51794948
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/912,077 Abandoned US20160199323A1 (en) | 2013-08-22 | 2014-08-22 | Cancer treatment |
US15/980,644 Active US10265282B2 (en) | 2013-08-22 | 2018-05-15 | Cancer treatment |
US16/357,249 Active 2034-09-05 US11078289B2 (en) | 2013-08-22 | 2019-03-18 | Cancer treatment |
US17/359,986 Active 2034-09-17 US11667718B2 (en) | 2013-08-22 | 2021-06-28 | Cancer treatment |
US18/306,601 Pending US20230257471A1 (en) | 2013-08-22 | 2023-04-25 | Cancer treatment |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/980,644 Active US10265282B2 (en) | 2013-08-22 | 2018-05-15 | Cancer treatment |
US16/357,249 Active 2034-09-05 US11078289B2 (en) | 2013-08-22 | 2019-03-18 | Cancer treatment |
US17/359,986 Active 2034-09-17 US11667718B2 (en) | 2013-08-22 | 2021-06-28 | Cancer treatment |
US18/306,601 Pending US20230257471A1 (en) | 2013-08-22 | 2023-04-25 | Cancer treatment |
Country Status (12)
Country | Link |
---|---|
US (5) | US20160199323A1 (es) |
EP (2) | EP3036007B1 (es) |
JP (4) | JP2016528297A (es) |
KR (5) | KR20210127821A (es) |
CN (2) | CN105579101A (es) |
AU (4) | AU2014308700A1 (es) |
CA (1) | CA2921036A1 (es) |
CL (1) | CL2016000397A1 (es) |
EA (1) | EA037667B1 (es) |
ES (1) | ES2755983T3 (es) |
MX (1) | MX2016002307A (es) |
WO (1) | WO2015027121A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105579101A (zh) * | 2013-08-22 | 2016-05-11 | 万达制药公司 | 癌症的治疗 |
WO2021016203A1 (en) * | 2019-07-19 | 2021-01-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Pdlim2 as a biomarker for cancer and as an anti-cancer treatment target |
WO2023168201A1 (en) * | 2022-03-01 | 2023-09-07 | Vanda Pharmaceuticals Inc. | Trichostatin a (tsa) sensitivity in the treatment of tumors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4218478A (en) * | 1979-01-05 | 1980-08-19 | Ruiko Oiwa | Trichostatin as an antiprotozoal agent |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1265431A (en) | 1985-01-08 | 1990-02-06 | Roderick John Macdonald | Electrode device for flare stack ignitor |
JPS61176523A (ja) * | 1985-01-30 | 1986-08-08 | Teruhiko Beppu | 制癌剤 |
US20020183388A1 (en) * | 2001-02-01 | 2002-12-05 | Gudas Lorraine J. | Use of retinoids plus histone deacetylase inhibitors to inhibit the growth of solid tumors |
EP2238982B8 (en) * | 2003-06-27 | 2013-01-16 | Astellas Pharma Inc. | Therapeutic agent for soft tissue sarcoma |
EP2537942B1 (en) | 2004-05-21 | 2015-09-23 | The Board of Trustees of the University of Arkansas System | Use of gene expression profiling to predict survival in cancer patient |
WO2007067516A2 (en) * | 2005-12-06 | 2007-06-14 | Duke University | Multiple myeloma |
ZA200809956B (en) | 2006-05-26 | 2010-07-28 | Celgene Corp | Methods and compositions using Immunomodulatory compounds in combination therapy |
CA2574531C (en) * | 2007-01-19 | 2016-10-25 | The University Of British Columbia | Hat acetylation promoters and uses of compositions thereof in promoting immunogenicity |
US20120107304A1 (en) | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
US9296753B2 (en) * | 2012-06-04 | 2016-03-29 | Pharmacyclics Llc | Crystalline forms of a Bruton's tyrosine kinase inhibitor |
CN105579101A (zh) * | 2013-08-22 | 2016-05-11 | 万达制药公司 | 癌症的治疗 |
MX2016002308A (es) | 2013-08-22 | 2016-06-15 | Vanda Pharmaceuticals Inc | Tratamiento del mieloma multiple. |
-
2014
- 2014-08-22 CN CN201480046624.5A patent/CN105579101A/zh active Pending
- 2014-08-22 KR KR1020217033186A patent/KR20210127821A/ko not_active IP Right Cessation
- 2014-08-22 CN CN201910836673.3A patent/CN110585184A/zh active Pending
- 2014-08-22 EA EA201690445A patent/EA037667B1/ru unknown
- 2014-08-22 WO PCT/US2014/052209 patent/WO2015027121A2/en active Application Filing
- 2014-08-22 EP EP14789436.4A patent/EP3036007B1/en active Active
- 2014-08-22 ES ES14789436T patent/ES2755983T3/es active Active
- 2014-08-22 US US14/912,077 patent/US20160199323A1/en not_active Abandoned
- 2014-08-22 KR KR1020177032020A patent/KR20170126018A/ko not_active IP Right Cessation
- 2014-08-22 MX MX2016002307A patent/MX2016002307A/es unknown
- 2014-08-22 KR KR1020237010047A patent/KR20230047203A/ko not_active Application Discontinuation
- 2014-08-22 KR KR1020167004630A patent/KR20160033779A/ko active Application Filing
- 2014-08-22 AU AU2014308700A patent/AU2014308700A1/en not_active Abandoned
- 2014-08-22 EP EP19201777.0A patent/EP3616754A1/en active Pending
- 2014-08-22 JP JP2016536469A patent/JP2016528297A/ja active Pending
- 2014-08-22 KR KR1020217002758A patent/KR102315528B1/ko active IP Right Grant
- 2014-08-22 CA CA2921036A patent/CA2921036A1/en active Pending
-
2016
- 2016-02-22 CL CL2016000397A patent/CL2016000397A1/es unknown
-
2018
- 2018-05-15 US US15/980,644 patent/US10265282B2/en active Active
-
2019
- 2019-03-18 US US16/357,249 patent/US11078289B2/en active Active
- 2019-05-08 JP JP2019088425A patent/JP2019167351A/ja active Pending
- 2019-11-06 AU AU2019261718A patent/AU2019261718A1/en not_active Abandoned
-
2021
- 2021-03-16 JP JP2021042699A patent/JP2021105005A/ja active Pending
- 2021-06-28 US US17/359,986 patent/US11667718B2/en active Active
- 2021-11-03 AU AU2021261882A patent/AU2021261882B2/en active Active
-
2022
- 2022-03-30 AU AU2022202183A patent/AU2022202183B2/en active Active
-
2023
- 2023-03-22 JP JP2023045826A patent/JP2023088996A/ja active Pending
- 2023-04-25 US US18/306,601 patent/US20230257471A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4218478A (en) * | 1979-01-05 | 1980-08-19 | Ruiko Oiwa | Trichostatin as an antiprotozoal agent |
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Owner name: VANDA PHARMACEUTICALS, INC., DISTRICT OF COLUMBIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:POLYMEROPOULOS, MIHAEL H.;LICAMELE, LOUIS WILLIAM;LAVEDAN, CHRISTIAN;SIGNING DATES FROM 20160321 TO 20160324;REEL/FRAME:038167/0475 |
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