US20130335703A1 - Ophthalmology - Google Patents
Ophthalmology Download PDFInfo
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- US20130335703A1 US20130335703A1 US13/978,849 US201113978849A US2013335703A1 US 20130335703 A1 US20130335703 A1 US 20130335703A1 US 201113978849 A US201113978849 A US 201113978849A US 2013335703 A1 US2013335703 A1 US 2013335703A1
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- Prior art keywords
- illumination
- transfer device
- lens system
- retina
- focus point
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/1025—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for confocal scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
- G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
- G02B26/0816—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements
- G02B26/0833—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light by means of one or more reflecting elements the reflecting element being a micromechanical device, e.g. a MEMS mirror, DMD
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
- G02B26/08—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
- G02B26/10—Scanning systems
- G02B26/101—Scanning systems with both horizontal and vertical deflecting means, e.g. raster or XY scanners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00897—Scanning mechanisms or algorithms
Definitions
- the present invention relates to an apparatus and method for illuminating, imaging and treating the retina of a human eye.
- Imaging systems such as scanning laser ophthalmoscopes (SLOs) may comprise a large number of optical components, such as laser scanning elements, scan transfer mirrors, laser sources and detectors.
- the laser scanning arrangement consists of first and second orthogonal scanning elements, which typically include a high speed rotating polygonal mirror and a motor driven slow speed mirror. These elements are used to create a raster scan pattern of the human retina.
- the polygon mirror has a plurality of facets and typically provides the vertical scanning of the laser beam, and the slow speed mirror typically provides the horizontal scanning of the laser beam.
- the scan transfer mirror transfers the two dimensional laser scan pattern created by the scanning elements to the retina of the eye.
- an apparatus for illuminating the retina of an eye comprising:
- the lens system may include an apparent focus point located within the lens system.
- the lens system may comprise a plurality of lens elements.
- the apparent focus point may be located within an outermost lens element of the lens system.
- the apparent focus point and the apparent point source are coincident.
- the illumination device and the lens system combine to illuminate an area of the retina. That is, the illumination device and the lens system are capable of illuminating a two-dimensional portion of the retina.
- the pupillary point of the eye may be accommodated at the second focus of the illumination transfer device.
- the front nodal point of the eye may be accommodated at the second focus of the illumination transfer device.
- the illumination device and the lens system are arranged such that the apparent point source is stationary. This ensures that the maximum incident illumination is transferred into the eye at the pupillary point.
- the lens system may include a wide-angle lens.
- the wide-angle lens may have a field of view (FOV) of between 30 degrees and 180 degrees.
- FOV field of view
- the wide-angle lens has a FOV of between 90 degrees and 160 degrees. More preferably, the wide-angle lens has a FOV of 120 degrees.
- the lens system may comprise or consist of a fisheye lens.
- the lens system may comprise a plurality of lens elements.
- the lens system may comprise any number and/or type of lenses required to achieve the desired FOV and/or to achieve achromatism across the visible spectrum.
- the apparent point source may be located within any one of the plurality of lens elements. Preferably, the apparent point source is located in the outermost lens element facing the illumination transfer device.
- the illumination transfer device may comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system.
- the lens system is arranged to provide two foci.
- the apparatus may further comprise an illumination relay device.
- the illumination relay device may comprise two foci. One foci of the illumination relay device may be coincident with one foci of the illumination transfer device and the other foci of the illumination relay device may be coincident with the apparent point source of the illumination device and the lens system.
- the illumination relay device is placed between the illumination transfer device and the lens system.
- the illumination device and the lens system again combine to provide incident illumination from an apparent point source located within the lens system, the apparent point source is located at the first focus point of the illumination relay device and the second focus of the illumination relay device is coincident with the first focus of the illumination transfer device.
- the retina of the eye is again illuminated by the illumination transfer device transferring the illumination from its first focus point to the pupillary point of the eye at its second focus.
- the illumination relay device may comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system.
- the illumination transfer device comprises a lens system
- the lens system is arranged to provide two foci.
- the illumination relay device may have the same geometry as the illumination transfer device.
- the illumination relay device has a major axis, which lies on a line joining the two foci.
- the illumination transfer device also has a major axis, which lies on a line joining the two foci.
- the illumination transfer device and the illumination relay device may be arranged such that the major axis of each device are parallel and/or collinear. This arrangement corrects for distortions introduced by the illumination transfer device. Since the geometry of the illumination relay device is the same as the geometry of the illumination transfer device, the distortions can be cancelled out, or at least partially corrected for.
- the illumination device may include a light source.
- the light source may provide collimated light.
- the light source may include a laser, a light emitting diode (LED), a Vertical Cavity Surface Emitting Laser (VCSEL), a super luminescent diode (SLD), a diode laser, a collimated incandescent lamp, a flash or illumination device or a digital light processing (DLP) projection device.
- LED light emitting diode
- VCSEL Vertical Cavity Surface Emitting Laser
- SLD super luminescent diode
- diode laser a collimated incandescent lamp
- DLP digital light processing
- the light source may provide illumination at one or more differing wavelengths.
- the light source may provide red light illumination (approximately 650 nm) and/or green light illumination (approximately 510 nm).
- the light source may be adapted to provide light at a wavelength between 450 nm and 1000 nm.
- the light source may be adapted to provide light at a wavelength between 488 nm and 700 nm. More preferably, the light source provides light at a wavelength of between 515 nm and 650 nm.
- the light source may be adapted to provide light at a power of between 500 nWatt and 1 W.
- the light source may include one or more light sources of differing wavelengths.
- the light source may be configured such that the wavelength of light provided is variable.
- the light source may be configured such that the power of light provided is variable.
- the illumination device may include a two-dimensional scanning device for scanning the retina of the eye with collimated light.
- the illumination device and the lens system combine to provide a two-dimensional collimated light scan from the apparent point source located within the lens system.
- the two-dimensional scanning device may comprise a first scanning element and a second scanning element.
- the first and second scanning elements may comprise an oscillating mechanism.
- the oscillating mechanism may be a resonant scanner.
- the first and second scanning elements may comprise an oscillating plane mirror.
- the oscillating plane mirror may be a galvanometer mirror.
- the first and second scanning elements may comprise a rotating mechanism.
- the rotating mechanism may be a rotating polygon mirror.
- the first and second scanning elements may comprise a line scanning element.
- the line scanning element may comprise a laser line scanner.
- the laser line may be generated by a diffractive optical element, cylindrical lens, or other known means of creating a laser line.
- the first and second scanning elements may comprise a combination of oscillating mechanisms, rotating mechanisms or line scanning elements, as described above.
- the two-dimensional scanning device may be a microelectromechanical system (MEMS) scanning element having two axes of rotation.
- MEMS microelectromechanical system
- the two-dimensional scanning device may be any suitable device which is capable of rotating in at least two axes, which are preferably orthogonal.
- the scanning device should preferably be capable of operating at high speed (i.e. above 5 kHz) and provide a high amplitude of scan (i.e. up to 180 degrees or more).
- the illumination device may further comprise one or more detectors for detecting the reflected light from the retina.
- the reflected light from the retina may be used to form an image of the retina.
- the light detector may include fast photo detectors, such as avalanche photo diodes (APDs), PIN diodes, photomultiplier tubes (PMT), silicon photo multipliers (SPM), or similar single point detectors.
- fast photo detectors such as avalanche photo diodes (APDs), PIN diodes, photomultiplier tubes (PMT), silicon photo multipliers (SPM), or similar single point detectors.
- the apparatus may further comprise one or more data processing devices for displaying, storing and/or combining the obtained images of the retina.
- the apparatus may be pivotable between a first position, in which the apparatus may be used to illuminate the first retina of a first eye, and a second position, in which the apparatus may be used to illuminate the second retina of a second eye.
- a system for illuminating the retina of each eye of a patient comprising two apparatuses according to the first aspect of the invention, wherein each apparatus may be capable of illuminating the retina of one eye.
- a method of illuminating the retina of an eye comprising the steps of:
- the lens system may include an apparent focus point located within the lens system.
- the lens system may comprise a plurality of lens elements.
- the apparent focus point may be located within an outermost lens element of the lens system.
- the apparent focus point and the apparent point source are coincident.
- the illumination device and the lens system combine to illuminate an area of the retina. That is, the illumination device and the lens system are capable of illuminating a two-dimensional portion of the retina.
- the pupillary point of the eye may be accommodated at the second focus of the illumination transfer device.
- the front nodal point of the eye may be accommodated at the second focus of the illumination transfer device.
- the illumination device and the lens system are arranged such that the apparent point source is stationary. This ensures that the maximum incident illumination is transferred into the eye at the pupillary point.
- the lens system may include a wide-angle lens.
- the wide-angle lens may have a field of view (FOV) of between 30 degrees and 180 degrees.
- FOV field of view
- the wide-angle lens has a FOV of between 90 degrees and 160 degrees. More preferably, the wide-angle lens has a FOV of 120 degrees.
- the lens system may comprise or consist of a fisheye lens.
- the lens system may comprise a plurality of lens elements.
- the apparent point source may be located within any one of the plurality of lens elements. Preferably, the apparent point source is located in the outermost lens element facing the illumination transfer device.
- the illumination transfer device may comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system.
- the lens system is arranged to provide two foci.
- the method may comprise the further step of providing an illumination relay device comprising two foci.
- One foci of the illumination relay device may be coincident with one foci of the illumination transfer device and the other foci of the illumination relay device may be coincident with the apparent point source of the illumination device and the lens system.
- the illumination relay device is placed between the illumination transfer device and the lens system.
- the illumination device and the lens system again combine to provide incident illumination from an apparent point source located within the lens system, the apparent point source is located at the first focus point of the illumination relay device and the second focus of the illumination relay device is coincident with the first focus of the illumination transfer device.
- the retina of the eye is again illuminated by the illumination transfer device transferring the illumination from its first focus point to the pupillary point of the eye at its second focus.
- the illumination relay device may comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system.
- the illumination transfer device comprises a lens system
- the lens system is arranged to provide two foci.
- the illumination relay device may have the same geometry as the illumination transfer device.
- the illumination relay device has a major axis, which lies on a line joining the two foci.
- the illumination transfer device also has a major axis, which lies on a line joining the two foci.
- the illumination transfer device and the illumination relay device may be arranged such that the major axes of each device are parallel and/or collinear. This arrangement corrects for distortions introduced by the illumination transfer device. Since the geometry of the illumination relay device is the same as the geometry of the illumination transfer device, the distortions can be cancelled out, or at least partially corrected for.
- the illumination device may include a light source.
- the light source may provide collimated light.
- the light source may include a laser, a light emitting diode (LED), a Vertical Cavity Surface Emitting Laser (VCSEL), a super luminescent diode (SLD), a diode laser, a collimated incandescent lamp, a flash or illumination device or a digital light processing (DLP) projection device.
- LED light emitting diode
- VCSEL Vertical Cavity Surface Emitting Laser
- SLD super luminescent diode
- diode laser a collimated incandescent lamp
- DLP digital light processing
- the light source may provide illumination at one or more differing wavelengths.
- the light source may provide red light illumination (approximately 650 nm) and/or green light illumination (approximately 510 nm).
- the light source may be adapted to provide light at a wavelength between 450 nm and 1000 nm.
- the light source may be adapted to provide light at a wavelength between 488 nm and 700 nm. More preferably, the light source provides light at a wavelength of between 515 nm and 650 nm.
- the light source may be adapted to provide light at a power of between 500 nWatt and 1 W.
- the light source may include one or more light sources of differing wavelengths.
- the light source may be configured such that the wavelength of light provided is variable.
- the light source may be configured such that the power of light provided is variable.
- the illumination device may include a two-dimensional scanning device for scanning the retina of the eye with collimated light.
- the illumination device and the lens system combine to provide a two-dimensional collimated light scan from the apparent point source located within the lens system.
- the two-dimensional scanning device may comprise a first scanning element and a second scanning element.
- the first and second scanning elements may comprise an oscillating mechanism.
- the oscillating mechanism may be a resonant scanner.
- the first and second scanning elements may comprise an oscillating plane mirror.
- the oscillating plane mirror may be a galvanometer mirror.
- the first and second scanning elements may comprise a rotating mechanism.
- the rotating mechanism may be a rotating polygon mirror.
- the first and second scanning elements may comprise a line scanning element.
- the line scanning element may comprise a laser line scanner.
- the laser line may be generated by a diffractive optical element, cylindrical lens, or other known means of creating a laser line.
- the first and second scanning elements may comprise a combination of oscillating mechanisms, rotating mechanisms or line scanning elements, as described above.
- the two-dimensional scanning device may be a microelectromechanical system (MEMS) scanning element having two axes of rotation.
- MEMS microelectromechanical system
- the two-dimensional scanning device may be any suitable device which is capable of rotating in at least two axes, which are preferably orthogonal.
- the scanning device should preferably be capable of operating at high speed (i.e. above 5 kHz) and provide a high amplitude of scan (i.e. up to 180 degrees or more).
- the method may comprise the further step of providing one or more light detectors and using the one or more light detectors to detect reflected light from the retina to form an image of the retina.
- the method performs the steps of illuminating the retina and obtaining an image of the retina.
- the light detector may include fast photo detectors, such as avalanche photo diodes (APDs), PIN diodes, photomultiplier tubes (PMT), silicon photo multipliers (SPM), or similar single point detectors.
- fast photo detectors such as avalanche photo diodes (APDs), PIN diodes, photomultiplier tubes (PMT), silicon photo multipliers (SPM), or similar single point detectors.
- the method may comprise the further step of pivoting the illumination device, lens system and illumination transfer device between a first position, in which illumination of the first retina of a first eye is performed, and a second position, in which illumination of the second retina of a second eye is performed.
- an apparatus for imaging the retina of an eye comprising:
- a method of imaging the retina of an eye comprising the steps of:
- an apparatus for treating the retina of an eye with collimated light comprising:
- Treatment of the retina is interpreted here to include photodynamic therapy, photo-ablation, photoporation, photoactivation or other methods where the interaction of the light is used to alter the state or structure of the retina or to alter the state of chemicals within the retinal structure.
- a seventh aspect of the present invention there is provided a method of treating the retina of an eye with collimated light comprising the steps of:
- Treatment of the retina is interpreted here to include photodynamic therapy, photo-ablation, photoporation, photoactivation or other methods where the interaction of the light is used to alter the state or structure of the retina or to alter the state of chemicals within the retinal structure.
- FIG. 1 is a schematic side view of an apparatus for illuminating, imaging and treating the retina of an eye according to the present invention
- FIG. 2 is a schematic side view of an alternative apparatus for illuminating, imaging and treating the retina of an eye
- FIG. 3 is a flowchart diagram detailing a method of illuminating, imaging and treating the retina of an eye according to the present invention.
- FIG. 1 illustrates an apparatus 10 for illuminating the retina 12 of an eye 14 .
- the apparatus 10 includes an illumination device 16 , a lens system 18 and an illumination transfer device 20 .
- the lens system 18 is arranged to include an apparent focus point 23 located within the lens system 18 .
- the illumination device 16 and the lens system 18 are arranged such that they combine to provide incident illumination 22 from an apparent point source 24 located within the lens system 18 .
- the apparent focus point 23 of the lens system 18 is coincident with the apparent point source 24 of the lens system 18 .
- the focus point 23 and point source 24 are termed “apparent” because when the illumination device 16 illuminates the lens system 18 it appears that the incident illumination 22 emanates from an actual, or “real”, point located within the system. That is, if the incident illumination 22 were traced back into the lens system 18 without any refraction, it would appear as if it were emanating from a single point.
- the apparent point source 24 is stationary with respect to the lens system 18 . This ensures that the incident illumination 22 emanates from the apparent point source 24 without translation.
- the incident illumination 22 generated by the illumination device 16 and the lens system 18 is two-dimensional and therefore illuminates an area of the retina 12 (see below).
- the incident illumination 22 in the embodiment illustrated and described here provides a “flood illumination”, i.e. the illumination device 16 simultaneously illuminates the area of the retina.
- the illumination device 16 includes a light source 26 .
- the light source 26 may provide collimated light.
- the light source 26 may include a laser, a light emitting diode (LED), a Vertical Cavity Surface Emitting Laser (VCSEL), a super luminescent diode (SLD), a diode laser, a collimated incandescent lamp, a flash or illumination device or a digital light processing (DLP) projection device.
- LED light emitting diode
- VCSEL Vertical Cavity Surface Emitting Laser
- SLD super luminescent diode
- DLP digital light processing
- the light source 26 is capable of providing illumination at one or more differing wavelengths.
- the light source 26 may provide red light illumination (approximately 650 nm) and/or green light illumination (approximately 510 nm).
- the light source 26 is capable of providing light at a power of between 500 nWatt and 1 W.
- the wavelength and power of the light from the light source 26 may both be variable.
- the lens system 18 includes an incident optical path 28 and a return optical path 30 .
- the incident optical path 28 and a return optical path 30 are split by a beam splitter 32 .
- the beam splitter 32 illustrated and described here is 80:20 transmission/reflection. However, it should be appreciated that other types of beam splitters could be used if required.
- the incident optical path 28 includes a first focussing lens 34 and the return optical path 30 includes second and third focussing lenses 38 , 40 and a combined focussing lens and aperture 46 .
- the return optical path 30 also includes a second (dichroic) beam splitter 48 which splits the returned reflected light from the retina 12 to a first detector 50 and a second detector 52 .
- the first detector 50 detects red light
- the second detector 52 detects green light. It should, however, be appreciated that the apparatus 10 may not necessarily need to include two separate colour detectors and that the apparatus 10 may function equally well with a single detector.
- the lens system 18 is a wide-angle lens system which may consist or comprise a fisheye lens.
- the lens system 18 is a wide-angle lens comprising a plurality of meniscus lens elements 18 a to 18 e .
- the wide-angle lens may have a field of view (FOV) of between 30 degrees and 180 degrees. Preferably, the FOV is around 120 degrees.
- FOV field of view
- the wide-angle lens may have a FOV at any suitable angle between the above-referenced range depending on the specific requirements of the apparatus 10 .
- the illumination device 16 and the lens system 18 are arranged such the incident illumination 22 emanates from the apparent point source 24 at an angle ⁇ . Angle ⁇ is around 120 degrees (see FIG. 1 ).
- the illumination transfer device 20 has two foci 20 a , 20 b .
- the illumination transfer device 20 is an ellipsoidal mirror.
- the illumination transfer device 20 may alternatively comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system.
- the illumination transfer device comprises a lens system
- the lens system is arranged to provide two foci.
- the illumination transfer device 20 and the lens system 18 are arranged such that the apparent point source 24 is provided at the first focus point 20 a of the illumination transfer device 20 and the eye 14 is accommodated at the second focus point 20 b of the illumination transfer device 20 . More specifically, the pupillary point 14 a of the eye 14 is positioned at the second focus point 20 b of the illumination transfer device 20 .
- the incident illumination 22 is conveyed to the subject's eye 14 via the illumination transfer device 20 .
- the incident illumination 22 provided at the apparent point source 24 by the illumination device 16 and the lens system 18 is coupled by the illumination transfer device 20 through the pupillary point 14 a of the subject's eye 14 , and thus onto the retina 12 .
- the apparatus 10 provides illumination of an area of the retina 12 .
- the incident illumination 22 emanates from the apparent point source 24 without translation, i.e. the apparent point source 24 is stationary during operation.
- the result of this is that the incident illumination 22 emerging at the second focus point 20 b of the illumination transfer device 20 is also stationary.
- the illumination transfer device 20 therefore provides “point-to-point” transfer of the incident illumination 22 without translation, or clipping, thereof. Since the illumination transfer device 20 provides point-to-point transfer of the incident illumination 22 , the incident illumination 22 emerging at the second focus point 20 b of the illumination transfer device 20 emanates therefrom with the same angle ⁇ that the incident illumination 22 emanates from the first focus point 20 a of the illumination transfer device 20 , i.e. at an angle of around 120 degrees.
- the incident illumination 22 enters the eye without being “clipped” by the iris, for example. This maximises the area of the retina 12 that can be illuminated by the apparatus 10 and allows ultra-wide illumination of the retina 12 to be performed.
- the incident illumination 22 enters the pupillary point 14 a of the subject's eye 14 at an angle of around 120 degrees.
- An angle of around 120 degrees at the pupillary point 14 a of the eye 14 equates to an angle of around 200 degrees when measured at the centre of the eye 14 . Therefore, the apparatus 10 can be considered as providing a 120 degree “external” angle of illumination and a 200 degree “internal” angle of illumination.
- the above-described properties of the illumination device 16 , the lens system 18 and the illumination transfer device 20 also ensures that reflected light from the retina is conveyed back through the same optical path of the apparatus 10 .
- the retina 12 of the eye 14 may be illuminated by (a) providing the illumination device 16 , (b) providing the lens system 18 , (c) using the illumination device 16 and the lens system 18 in combination to provide incident illumination from the apparent point source 24 located within the lens system 18 , (d) providing the illumination transfer device 20 having two foci 20 a , 20 b , (e) providing the apparent point source 24 at the first focus point 20 a of the illumination transfer device 20 and an eye 14 at the second focus point 20 b of the illumination transfer device 20 and (f) using the illumination transfer device 20 to transfer the incident illumination 22 from the apparent point source 24 into the eye 14 .
- the reflected light returned from the retina 12 is detected at the first and second detectors 50 , 52 .
- the reflected light returned from the retina 12 is used to produce an image of the subject's retina 12 in the known manner.
- the detectors 50 , 52 may include fast photo detectors, such as avalanche photo diodes (APDs), PIN diodes, photomultiplier tubes (PMTs), silicon photo multipliers (SPMs), or similar single point detectors.
- APDs avalanche photo diodes
- PMTs photomultiplier tubes
- SPMs silicon photo multipliers
- the apparatus 10 also comprises a data processing device for displaying, processing, storing, and/or combining the obtained images of the retina 12 .
- the apparatus 10 may also comprise a distortion correction device, which may be part of the data processing device, for correcting distortions introduced by the illumination transfer device 20 .
- the apparatus 10 may also include on or more filed flattener elements which correct for focal aberrations in the system.
- FIG. 2 illustrates an alternative embodiment of the apparatus 10 .
- the only difference between the apparatus 10 of FIG. 1 and the apparatus 100 of FIG. 2 is that an illumination relay device 200 has been placed between the lens system 18 and the illumination transfer device 20 .
- the illumination relay device 200 has the same geometry as the illumination transfer device 20 .
- the illumination relay device 200 has two foci 200 a , 200 b .
- the illumination relay device 200 is an ellipsoidal mirror.
- the illumination relay device 200 may alternatively comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system.
- the illumination transfer device comprises a lens system
- the lens system is arranged to provide two foci.
- the illumination relay device 200 , the illumination transfer device 20 and the lens system 18 are arranged such that the apparent point source 24 is provided at the first focus point 200 a of the illumination relay device 200 and the second focus point 200 b of the illumination relay device 200 is coincident with the first focus point 20 a of the illumination transfer device 20 .
- the subject's eye 14 is accommodated at the second focus point 20 b of the illumination transfer device 20 as before.
- the incident illumination 22 is conveyed to the subject's eye 14 via the illumination relay device 200 and the illumination transfer device 20 .
- the incident illumination 22 provided at the apparent point source 24 by the illumination device 16 and the lens system 18 is coupled by the illumination relay device 200 to the illumination transfer device 20 , which, in turn, couples the incident illumination 22 through the pupillary point 14 a of the subject's eye 14 to the retina 12 , as before.
- the illumination relay device 200 Given that the illumination relay device 200 has the same geometry as the illumination transfer device 20 , the illumination relay device 200 therefore also provides point-to-point transfer of the incident illumination 22 without translation, or clipping, thereof. Therefore, the incident illumination 22 emerging at the second focus point 200 b of the illumination relay device 200 emanates therefrom with the same angle ⁇ that the incident illumination emanates from the first focus point 200 a of the illumination relay device 200 . It therefore follows that the incident illumination 22 emanating from the first focus point 20 a of the illumination transfer device 20 (or second focus point 200 b of the illumination relay device 200 ) emanates with the same angle ⁇ as the incident illumination 22 emanating from the second focus point 20 b of the illumination transfer device 20 into the eye 14 , as before. The incident illumination 22 therefore again enters the eye 14 without being clipped, thus maximising the area of the retina 12 that can be illuminated by the apparatus 10 .
- the apparatus 100 again provides a 120 degree external angle (200 degree internal angle) of illumination of the retina, as before.
- the illumination relay device 200 has a major axis, which lies on a line joining the two foci ( 200 a , 200 b ).
- the illumination transfer device 20 also has a major axis, which lies on a line joining the two foci ( 20 a , 20 b ).
- the illumination transfer device 20 and the illumination relay device 200 may be arranged such that the major axes of each device are parallel and/or collinear.
- the purpose of the illumination relay device 200 is to correct for distortions introduced by the illumination transfer device 20 . Since the geometry of the illumination relay device 200 is the same as the geometry of the illumination transfer device 20 the distortions can be cancelled out, or at least partially corrected for.
- the arrangement of the illumination relay device 200 and the illumination transfer device 20 is such that the major axis (i.e. the line joining the two foci of the device) of the illumination relay device 200 is parallel and collinear to the major axis of the illumination transfer device 20 . In this arrangement the distortions are cancelled by symmetry.
- the apparatus 10 may also comprise a distortion correction device, which may be part of the data processing device, for correcting distortions introduced by the illumination transfer device 20 .
- the reflected light returned from the retina 12 is detected in the same manner as described above in relation to the apparatus 10 of FIG. 1 .
- the apparatus 100 is therefore capable of imaging the retina 12 of the eye 14 in the same manner as described above in relation to apparatus 10 .
- the apparatus 10 , 100 may be pivotable between a first position, in which the apparatus 10 , 100 may be used to illuminate and image the first retina of a first eye, and a second position, in which the apparatus 10 , 100 may be used to illuminate and image the second retina of a second eye.
- the apparatus 10 , 100 may be used to illuminate and image both eyes of a subject without the need to move the subject.
- the apparatus 10 , 100 may not necessarily need to produce an image of the retina 12 . That is, the apparatus 10 , 100 may be used to simply illuminate the retina 12 without acquiring an image, i.e. not detecting the reflected light from the retina 12 . The apparatus 10 , 100 may therefore be used to treat the retina 12 of the eye 14 by illuminating the retina 12 with light.
- the apparatus 10 , 100 of the present invention can be manufactured at a lower cost than known retinal imaging apparatuses, such as scanning laser ophthalmoscopes (SLOs), as the apparatus 10 , 100 does not require conventional separated laser scanning elements (i.e. two separate one-dimensional scanning elements separated in space from one another, such as a horizontal scanning polygon mirror and a vertical scanning galvanometer scanner). Although, as described above, the apparatus 10 , 100 may use such scanning elements.
- the apparatus 10 , 100 can be made more compact than known retinal imaging apparatuses, since the apparatus 10 , 100 uses a smaller number of components.
- the apparatus 10 , 100 of the present invention also includes a smaller number of optical surfaces, which increases the optical efficiency of the apparatus 10 , 100 .
- the total power at the imaging detector is higher than known methods.
- Providing a wide-angle lens system 18 in combination with an illumination transfer device 20 allows the incident illumination 22 to be provided indirectly to the pupillary point 14 a of the eye 14 .
- the apparatus 10 , 100 of the present invention thus avoids the need for physical contact with the eye 14 . This is advantageous, as patients often find physical contact with retinal illumination apparatuses extremely difficult.
- the illumination device 16 has been described above as including a light source 26 which provides a “flood illumination” to the retina, i.e. the illumination device 16 simultaneously illuminates the area of the retina 12
- the illumination device 16 may include a two-dimensional scanning device for scanning the retina 12 of the eye 14 with collimated light.
- the illumination device 16 and the lens system 18 combine to provide a two-dimensional collimated light scan from the apparent point source 24 located within the lens system 18 .
- the two-dimensional scanning device may comprise a first scanning element and a second scanning element.
- the first and second scanning elements may comprise an oscillating mechanism.
- the oscillating mechanism may be a resonant scanner.
- the first and second scanning elements may comprise an oscillating plane mirror.
- the oscillating plane mirror may be a galvanometer mirror.
- the first and second scanning elements may comprise a rotating mechanism.
- the rotating mechanism may be a rotating polygon mirror.
- the first and second scanning elements may comprise a line scanning element.
- the line scanning element may comprise a laser line scanner.
- the laser line may be generated by a diffractive optical element, cylindrical lens, or other known means of creating a laser line.
- the first and second scanning elements may comprise a combination of oscillating mechanisms, rotating mechanisms or line scanning elements, as described above.
- the two-dimensional scanning device may be a microelectromechanical system (MEMS) scanning element having two axes of rotation.
- MEMS microelectromechanical system
- the two-dimensional scanning device may be any suitable device which is capable of rotating in at least two axes, which are preferably orthogonal.
- the scanning device should preferably be capable of operating at high speed (i.e. above 5 kHz) and provide a high amplitude of scan (i.e. up to 180 degrees or more).
- the apparatus 10 , 100 would illuminate the retina 12 of the eye 14 by scanning the collimated light across the retina.
- the wavelength and power levels and variability of the collimated light from the scanning device may be the same as described for the flood illumination device.
- the reflected collimated light may be detected in the manner described above to produce an image of the retina 12 .
- the apparatus 10 , 100 has been illustrated and described above as comprising one illumination device 16 , it should be appreciated that the apparatus 10 , 100 may comprise one or more illumination devices, which may include one or more light sources and/or one or more two-dimensional scanning devices.
- apparent focus point 23 and apparent point source 24 have been illustrated and described above as being located within the outermost lens element 18 a of the lens system 18 , it should be appreciated that, depending on the arrangement of the lens system 18 , the apparent focus point 23 and apparent point source 24 could be located in one of the other lens elements 18 b to 18 e.
- the FOV of the lens system 18 has been described above as being around 120 degrees, it should be appreciated that the FOV of the lens system 18 could be any suitable angle between 30 and 180 degrees, for example: 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160 or 170, or any value in between these angles.
- the apparatus 100 has been illustrated and described above with the illumination relay device 200 being positioned between the lens system 18 and the illumination transfer device 20 , it should be appreciated that, since the illumination relay device 200 is essentially identical to the illumination transfer device 20 , the apparatus 100 may be considered has having an illumination relay device 200 being positioned between the illumination transfer device 20 and the eye 14 .
- the apparatus 10 , 100 has been described above as being used to illuminate and/or image the retina 12 of the eye 14 , it should be appreciated that the apparatus 10 , 100 could be used to treat the retina of the eye by illuminating the retina with collimated light.
- the illumination device 16 would include a source of collimated light which may be operated to produce a laser beam of variable wavelength and/or power.
- the source of collimated light may be operated to produce a number of differing wavelengths, if required. This allows the apparatus 10 , 100 to treat retinal diseases.
- the light source 26 would be polarised and the return optical path 30 would include a polariser either before or after the aperture 46 , or alternatively, two separate polarisers before the first and second detectors 50 , 52 . In this arrangement the polarisers would block the light directly reflected from the lens system 18 that is not randomly polarised.
- the lens system 18 and/or the illumination transfer device 20 , 200 may be moveable. That is, the lens system 18 and/or the illumination transfer device 20 , 200 may be moveable relative to one another to compensate for movement in the location of the apparent focus point 23 and apparent point source 24 in the lens system 18 when illuminating and/or imaging the retina 12 at different FOV angles.
- the apparent focus point 23 and apparent point source 24 in the lens system 18 may move slightly depending on the FOV angle.
- Arranging the lens system 18 and/or the illumination transfer device 20 , 200 such that they may be moveable with respect to one another ensures that the apparent focus point 23 and apparent point source 24 of the lens system 18 are always accommodated at the first focus point 20 a , 200 a of the illumination transfer device 20 , 200 . As described above, this prevents the incident illumination 22 being clipped by the iris when entering the eye.
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Abstract
Apparatus for illuminating the retina of an eye. The apparatus comprising an illumination device, a lens system, wherein the illumination device and the lens system combine to provide incident illumination from an apparent point source located within the lens system. The apparatus further comprising an illumination transfer device, wherein the illumination transfer device has two foci and the apparent point source of the lens system is provided at a first focus point of the illumination transfer device and an eye is accommodated at a second focus point of the illumination transfer device, and wherein the illumination transfer device transfers the incident illumination from the apparent point source into the eye to illuminate the retina.
Description
- The present invention relates to an apparatus and method for illuminating, imaging and treating the retina of a human eye.
- Imaging systems, such as scanning laser ophthalmoscopes (SLOs), may comprise a large number of optical components, such as laser scanning elements, scan transfer mirrors, laser sources and detectors. The laser scanning arrangement consists of first and second orthogonal scanning elements, which typically include a high speed rotating polygonal mirror and a motor driven slow speed mirror. These elements are used to create a raster scan pattern of the human retina. The polygon mirror has a plurality of facets and typically provides the vertical scanning of the laser beam, and the slow speed mirror typically provides the horizontal scanning of the laser beam. The scan transfer mirror transfers the two dimensional laser scan pattern created by the scanning elements to the retina of the eye.
- While such imaging systems provide acceptable images of the retina of the eye, they are limited in that they are expensive to manufacture (the laser scanning elements and scan transfer mirror are particularly expensive components), large in size and, due to the large number of optical components, have low optical efficiency.
- According to a first aspect of the present invention there is provided an apparatus for illuminating the retina of an eye comprising:
-
- an illumination device;
- a lens system,
wherein the illumination device and the lens system combine to provide incident illumination from an apparent point source located within the lens system; and - an illumination transfer device, wherein the illumination transfer device has two foci and the apparent point source of the lens system is provided at a first focus point of the illumination transfer device and an eye is accommodated at a second focus point of the illumination transfer device, and wherein the illumination transfer device transfers the incident illumination from the apparent point source into the eye to illuminate the retina.
- The lens system may include an apparent focus point located within the lens system. The lens system may comprise a plurality of lens elements. The apparent focus point may be located within an outermost lens element of the lens system. The apparent focus point and the apparent point source are coincident.
- The illumination device and the lens system combine to illuminate an area of the retina. That is, the illumination device and the lens system are capable of illuminating a two-dimensional portion of the retina.
- The pupillary point of the eye may be accommodated at the second focus of the illumination transfer device.
- The front nodal point of the eye may be accommodated at the second focus of the illumination transfer device.
- The illumination device and the lens system are arranged such that the apparent point source is stationary. This ensures that the maximum incident illumination is transferred into the eye at the pupillary point.
- The lens system may include a wide-angle lens. The wide-angle lens may have a field of view (FOV) of between 30 degrees and 180 degrees. Preferably the wide-angle lens has a FOV of between 90 degrees and 160 degrees. More preferably, the wide-angle lens has a FOV of 120 degrees. The lens system may comprise or consist of a fisheye lens.
- The lens system may comprise a plurality of lens elements. The lens system may comprise any number and/or type of lenses required to achieve the desired FOV and/or to achieve achromatism across the visible spectrum.
- The apparent point source may be located within any one of the plurality of lens elements. Preferably, the apparent point source is located in the outermost lens element facing the illumination transfer device.
- The illumination transfer device may comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system. In the case where the illumination transfer device comprises a lens system, the lens system is arranged to provide two foci.
- The apparatus may further comprise an illumination relay device. The illumination relay device may comprise two foci. One foci of the illumination relay device may be coincident with one foci of the illumination transfer device and the other foci of the illumination relay device may be coincident with the apparent point source of the illumination device and the lens system. In this arrangement, the illumination relay device is placed between the illumination transfer device and the lens system. The illumination device and the lens system again combine to provide incident illumination from an apparent point source located within the lens system, the apparent point source is located at the first focus point of the illumination relay device and the second focus of the illumination relay device is coincident with the first focus of the illumination transfer device. The retina of the eye is again illuminated by the illumination transfer device transferring the illumination from its first focus point to the pupillary point of the eye at its second focus.
- The illumination relay device may comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system. In the case where the illumination transfer device comprises a lens system, the lens system is arranged to provide two foci.
- The illumination relay device may have the same geometry as the illumination transfer device.
- The illumination relay device has a major axis, which lies on a line joining the two foci. The illumination transfer device also has a major axis, which lies on a line joining the two foci. The illumination transfer device and the illumination relay device may be arranged such that the major axis of each device are parallel and/or collinear. This arrangement corrects for distortions introduced by the illumination transfer device. Since the geometry of the illumination relay device is the same as the geometry of the illumination transfer device, the distortions can be cancelled out, or at least partially corrected for.
- The illumination device may include a light source. The light source may provide collimated light.
- The light source may include a laser, a light emitting diode (LED), a Vertical Cavity Surface Emitting Laser (VCSEL), a super luminescent diode (SLD), a diode laser, a collimated incandescent lamp, a flash or illumination device or a digital light processing (DLP) projection device.
- The light source may provide illumination at one or more differing wavelengths. The light source may provide red light illumination (approximately 650 nm) and/or green light illumination (approximately 510 nm).
- The light source may be adapted to provide light at a wavelength between 450 nm and 1000 nm. Preferably, the light source may be adapted to provide light at a wavelength between 488 nm and 700 nm. More preferably, the light source provides light at a wavelength of between 515 nm and 650 nm.
- The light source may be adapted to provide light at a power of between 500 nWatt and 1 W.
- The light source may include one or more light sources of differing wavelengths.
- The light source may be configured such that the wavelength of light provided is variable.
- The light source may be configured such that the power of light provided is variable.
- The illumination device may include a two-dimensional scanning device for scanning the retina of the eye with collimated light. In this configuration, the illumination device and the lens system combine to provide a two-dimensional collimated light scan from the apparent point source located within the lens system.
- The two-dimensional scanning device may comprise a first scanning element and a second scanning element.
- The first and second scanning elements may comprise an oscillating mechanism. The oscillating mechanism may be a resonant scanner.
- The first and second scanning elements may comprise an oscillating plane mirror. The oscillating plane mirror may be a galvanometer mirror.
- The first and second scanning elements may comprise a rotating mechanism. The rotating mechanism may be a rotating polygon mirror.
- The first and second scanning elements may comprise a line scanning element. The line scanning element may comprise a laser line scanner. The laser line may be generated by a diffractive optical element, cylindrical lens, or other known means of creating a laser line.
- The first and second scanning elements may comprise a combination of oscillating mechanisms, rotating mechanisms or line scanning elements, as described above.
- The two-dimensional scanning device may be a microelectromechanical system (MEMS) scanning element having two axes of rotation. However, it should be appreciated that the two-dimensional scanning device may be any suitable device which is capable of rotating in at least two axes, which are preferably orthogonal. The scanning device should preferably be capable of operating at high speed (i.e. above 5 kHz) and provide a high amplitude of scan (i.e. up to 180 degrees or more).
- The illumination device may further comprise one or more detectors for detecting the reflected light from the retina. The reflected light from the retina may be used to form an image of the retina.
- The light detector may include fast photo detectors, such as avalanche photo diodes (APDs), PIN diodes, photomultiplier tubes (PMT), silicon photo multipliers (SPM), or similar single point detectors.
- The apparatus may further comprise one or more data processing devices for displaying, storing and/or combining the obtained images of the retina.
- The apparatus may be pivotable between a first position, in which the apparatus may be used to illuminate the first retina of a first eye, and a second position, in which the apparatus may be used to illuminate the second retina of a second eye.
- According to a second aspect of the invention, there is provided a system for illuminating the retina of each eye of a patient comprising two apparatuses according to the first aspect of the invention, wherein each apparatus may be capable of illuminating the retina of one eye.
- According to a third aspect of the present invention there is provided a method of illuminating the retina of an eye comprising the steps of:
-
- providing an illumination device;
- providing a lens system;
- using the illumination device and the lens system in combination to provide incident illumination from an apparent point source located within the lens system;
- providing an illumination transfer device having two foci;
- providing the apparent point source at the first focus point of the illumination transfer device and an eye at the second focus point of the illumination transfer device; and
- using the illumination transfer device to transfer the incident illumination from the apparent point source into the eye.
- The lens system may include an apparent focus point located within the lens system. The lens system may comprise a plurality of lens elements. The apparent focus point may be located within an outermost lens element of the lens system. The apparent focus point and the apparent point source are coincident.
- The illumination device and the lens system combine to illuminate an area of the retina. That is, the illumination device and the lens system are capable of illuminating a two-dimensional portion of the retina.
- The pupillary point of the eye may be accommodated at the second focus of the illumination transfer device.
- The front nodal point of the eye may be accommodated at the second focus of the illumination transfer device.
- The illumination device and the lens system are arranged such that the apparent point source is stationary. This ensures that the maximum incident illumination is transferred into the eye at the pupillary point.
- The lens system may include a wide-angle lens. The wide-angle lens may have a field of view (FOV) of between 30 degrees and 180 degrees. Preferably the wide-angle lens has a FOV of between 90 degrees and 160 degrees. More preferably, the wide-angle lens has a FOV of 120 degrees. The lens system may comprise or consist of a fisheye lens.
- The lens system may comprise a plurality of lens elements.
- The apparent point source may be located within any one of the plurality of lens elements. Preferably, the apparent point source is located in the outermost lens element facing the illumination transfer device.
- The illumination transfer device may comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system. In the case where the illumination transfer device comprises a lens system, the lens system is arranged to provide two foci.
- The method may comprise the further step of providing an illumination relay device comprising two foci. One foci of the illumination relay device may be coincident with one foci of the illumination transfer device and the other foci of the illumination relay device may be coincident with the apparent point source of the illumination device and the lens system. In this arrangement, the illumination relay device is placed between the illumination transfer device and the lens system. The illumination device and the lens system again combine to provide incident illumination from an apparent point source located within the lens system, the apparent point source is located at the first focus point of the illumination relay device and the second focus of the illumination relay device is coincident with the first focus of the illumination transfer device. The retina of the eye is again illuminated by the illumination transfer device transferring the illumination from its first focus point to the pupillary point of the eye at its second focus.
- The illumination relay device may comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system. In the case where the illumination transfer device comprises a lens system, the lens system is arranged to provide two foci.
- The illumination relay device may have the same geometry as the illumination transfer device.
- The illumination relay device has a major axis, which lies on a line joining the two foci. The illumination transfer device also has a major axis, which lies on a line joining the two foci. The illumination transfer device and the illumination relay device may be arranged such that the major axes of each device are parallel and/or collinear. This arrangement corrects for distortions introduced by the illumination transfer device. Since the geometry of the illumination relay device is the same as the geometry of the illumination transfer device, the distortions can be cancelled out, or at least partially corrected for.
- The illumination device may include a light source. The light source may provide collimated light.
- The light source may include a laser, a light emitting diode (LED), a Vertical Cavity Surface Emitting Laser (VCSEL), a super luminescent diode (SLD), a diode laser, a collimated incandescent lamp, a flash or illumination device or a digital light processing (DLP) projection device.
- The light source may provide illumination at one or more differing wavelengths. The light source may provide red light illumination (approximately 650 nm) and/or green light illumination (approximately 510 nm).
- The light source may be adapted to provide light at a wavelength between 450 nm and 1000 nm. Preferably, the light source may be adapted to provide light at a wavelength between 488 nm and 700 nm. More preferably, the light source provides light at a wavelength of between 515 nm and 650 nm.
- The light source may be adapted to provide light at a power of between 500 nWatt and 1 W.
- The light source may include one or more light sources of differing wavelengths.
- The light source may be configured such that the wavelength of light provided is variable.
- The light source may be configured such that the power of light provided is variable.
- The illumination device may include a two-dimensional scanning device for scanning the retina of the eye with collimated light. In this configuration, the illumination device and the lens system combine to provide a two-dimensional collimated light scan from the apparent point source located within the lens system.
- The two-dimensional scanning device may comprise a first scanning element and a second scanning element.
- The first and second scanning elements may comprise an oscillating mechanism. The oscillating mechanism may be a resonant scanner.
- The first and second scanning elements may comprise an oscillating plane mirror. The oscillating plane mirror may be a galvanometer mirror.
- The first and second scanning elements may comprise a rotating mechanism. The rotating mechanism may be a rotating polygon mirror.
- The first and second scanning elements may comprise a line scanning element. The line scanning element may comprise a laser line scanner. The laser line may be generated by a diffractive optical element, cylindrical lens, or other known means of creating a laser line.
- The first and second scanning elements may comprise a combination of oscillating mechanisms, rotating mechanisms or line scanning elements, as described above.
- The two-dimensional scanning device may be a microelectromechanical system (MEMS) scanning element having two axes of rotation. However, it should be appreciated that the two-dimensional scanning device may be any suitable device which is capable of rotating in at least two axes, which are preferably orthogonal. The scanning device should preferably be capable of operating at high speed (i.e. above 5 kHz) and provide a high amplitude of scan (i.e. up to 180 degrees or more).
- The method may comprise the further step of providing one or more light detectors and using the one or more light detectors to detect reflected light from the retina to form an image of the retina. In this arrangement the method performs the steps of illuminating the retina and obtaining an image of the retina.
- The light detector may include fast photo detectors, such as avalanche photo diodes (APDs), PIN diodes, photomultiplier tubes (PMT), silicon photo multipliers (SPM), or similar single point detectors.
- The method may comprise the further step of pivoting the illumination device, lens system and illumination transfer device between a first position, in which illumination of the first retina of a first eye is performed, and a second position, in which illumination of the second retina of a second eye is performed.
- According to a fourth aspect of the present invention there is provided an apparatus for imaging the retina of an eye comprising:
-
- an illumination device;
- a lens system,
wherein the illumination device and the lens system combine to provide incident illumination from an apparent point source located within the lens system; - a light detector; and
- an illumination transfer device, wherein the illumination transfer device has two foci and the apparent point source of the lens system is provided at a first focus point of the illumination transfer device and an eye is accommodated at a second focus point of the illumination transfer device, and wherein the illumination transfer device transfers the incident illumination from the apparent point source into the eye to illuminate the retina and the light detector detects light reflected from the retina to obtain an image of the retina.
- According to a fifth aspect of the present invention there is provided a method of imaging the retina of an eye comprising the steps of:
-
- providing an illumination device;
- providing a lens system;
- using the illumination device and the lens system in combination to provide incident illumination from an apparent point source located within the lens system;
- providing a light detector;
- providing an illumination transfer device having two foci;
- providing the apparent point source at the first focus point of the illumination transfer device and an eye at the second focus point of the illumination transfer device;
- using the illumination transfer device to transfer the incident illumination from the apparent point source into the eye; and
- using the light detector to detect light reflected from the retina to produce an image of the retina.
- According to a sixth aspect of the present invention there is provided an apparatus for treating the retina of an eye with collimated light comprising:
-
- a collimated light illumination device;
- a lens system,
wherein the illumination device and the lens system combine to provide incident collimated light illumination from an apparent point source located within the lens system; and - an illumination transfer device, wherein the illumination transfer device has two foci and the apparent point source of the lens system is provided at a first focus point of the illumination transfer device and an eye is accommodated at a second focus point of the illumination transfer device, and wherein the illumination transfer device transfers the incident collimated light illumination from the apparent point source into the eye.
- Treatment of the retina is interpreted here to include photodynamic therapy, photo-ablation, photoporation, photoactivation or other methods where the interaction of the light is used to alter the state or structure of the retina or to alter the state of chemicals within the retinal structure.
- According to a seventh aspect of the present invention there is provided a method of treating the retina of an eye with collimated light comprising the steps of:
-
- providing a collimated light illumination device;
- providing a lens system;
- using the illumination device and the lens system in combination to provide incident collimated light illumination from an apparent point source located within the lens system;
- providing an illumination transfer device having two foci;
- providing the apparent point source at the first focus point of the illumination transfer device and an eye at the second focus point of the illumination transfer device; and
- using the illumination transfer device to transfer the incident collimated light illumination from the apparent point source into the eye.
- Treatment of the retina is interpreted here to include photodynamic therapy, photo-ablation, photoporation, photoactivation or other methods where the interaction of the light is used to alter the state or structure of the retina or to alter the state of chemicals within the retinal structure.
- Embodiments of the present invention will now be described, by way of example only, with reference to the accompanying drawings, in which:—
-
FIG. 1 is a schematic side view of an apparatus for illuminating, imaging and treating the retina of an eye according to the present invention; -
FIG. 2 is a schematic side view of an alternative apparatus for illuminating, imaging and treating the retina of an eye; and -
FIG. 3 is a flowchart diagram detailing a method of illuminating, imaging and treating the retina of an eye according to the present invention. -
FIG. 1 illustrates anapparatus 10 for illuminating theretina 12 of aneye 14. Theapparatus 10 includes anillumination device 16, alens system 18 and anillumination transfer device 20. - The
lens system 18 is arranged to include anapparent focus point 23 located within thelens system 18. Theillumination device 16 and thelens system 18 are arranged such that they combine to provide incident illumination 22 from anapparent point source 24 located within thelens system 18. Theapparent focus point 23 of thelens system 18 is coincident with theapparent point source 24 of thelens system 18. Thefocus point 23 andpoint source 24 are termed “apparent” because when theillumination device 16 illuminates thelens system 18 it appears that the incident illumination 22 emanates from an actual, or “real”, point located within the system. That is, if the incident illumination 22 were traced back into thelens system 18 without any refraction, it would appear as if it were emanating from a single point. This is, of course, not true with a wide-angle lens, hence the term “apparent” for both focus point and point source is used. Importantly, theapparent point source 24 is stationary with respect to thelens system 18. This ensures that the incident illumination 22 emanates from theapparent point source 24 without translation. - The incident illumination 22 generated by the
illumination device 16 and thelens system 18 is two-dimensional and therefore illuminates an area of the retina 12 (see below). The incident illumination 22 in the embodiment illustrated and described here provides a “flood illumination”, i.e. theillumination device 16 simultaneously illuminates the area of the retina. - The
illumination device 16 includes alight source 26. Thelight source 26 may provide collimated light. Thelight source 26 may include a laser, a light emitting diode (LED), a Vertical Cavity Surface Emitting Laser (VCSEL), a super luminescent diode (SLD), a diode laser, a collimated incandescent lamp, a flash or illumination device or a digital light processing (DLP) projection device. - The
light source 26 is capable of providing illumination at one or more differing wavelengths. In this arrangement, thelight source 26 may provide red light illumination (approximately 650 nm) and/or green light illumination (approximately 510 nm). Thelight source 26 is capable of providing light at a power of between 500 nWatt and 1 W. The wavelength and power of the light from thelight source 26 may both be variable. - As illustrated in
FIG. 1 , thelens system 18 includes an incidentoptical path 28 and a returnoptical path 30. The incidentoptical path 28 and a returnoptical path 30 are split by abeam splitter 32. Thebeam splitter 32 illustrated and described here is 80:20 transmission/reflection. However, it should be appreciated that other types of beam splitters could be used if required. - The incident
optical path 28 includes afirst focussing lens 34 and the returnoptical path 30 includes second and third focussing lenses 38, 40 and a combined focussing lens andaperture 46. In the embodiment illustrated and described here the returnoptical path 30 also includes a second (dichroic) beam splitter 48 which splits the returned reflected light from theretina 12 to afirst detector 50 and asecond detector 52. As described below, thefirst detector 50 detects red light and thesecond detector 52 detects green light. It should, however, be appreciated that theapparatus 10 may not necessarily need to include two separate colour detectors and that theapparatus 10 may function equally well with a single detector. - In the embodiment described and illustrated here the
lens system 18 is a wide-angle lens system which may consist or comprise a fisheye lens. Thelens system 18 is a wide-angle lens comprising a plurality of meniscus lens elements 18 a to 18 e. The wide-angle lens may have a field of view (FOV) of between 30 degrees and 180 degrees. Preferably, the FOV is around 120 degrees. However, it should be appreciated that the wide-angle lens may have a FOV at any suitable angle between the above-referenced range depending on the specific requirements of theapparatus 10. - The
illumination device 16 and thelens system 18 are arranged such the incident illumination 22 emanates from theapparent point source 24 at an angle α. Angle α is around 120 degrees (seeFIG. 1 ). Theillumination transfer device 20 has two foci 20 a, 20 b. In the embodiment illustrated and described here theillumination transfer device 20 is an ellipsoidal mirror. However, it should be appreciated that theillumination transfer device 20 may alternatively comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system. In the case where the illumination transfer device comprises a lens system, the lens system is arranged to provide two foci. - As illustrated in
FIG. 1 , theillumination transfer device 20 and thelens system 18 are arranged such that theapparent point source 24 is provided at the first focus point 20 a of theillumination transfer device 20 and theeye 14 is accommodated at the second focus point 20 b of theillumination transfer device 20. More specifically, thepupillary point 14 a of theeye 14 is positioned at the second focus point 20 b of theillumination transfer device 20. - The incident illumination 22 is conveyed to the subject's
eye 14 via theillumination transfer device 20. The incident illumination 22 provided at theapparent point source 24 by theillumination device 16 and thelens system 18 is coupled by theillumination transfer device 20 through thepupillary point 14 a of the subject'seye 14, and thus onto theretina 12. Thus, theapparatus 10 provides illumination of an area of theretina 12. - As stated above, the incident illumination 22 emanates from the
apparent point source 24 without translation, i.e. theapparent point source 24 is stationary during operation. The result of this is that the incident illumination 22 emerging at the second focus point 20 b of theillumination transfer device 20 is also stationary. Theillumination transfer device 20 therefore provides “point-to-point” transfer of the incident illumination 22 without translation, or clipping, thereof. Since theillumination transfer device 20 provides point-to-point transfer of the incident illumination 22, the incident illumination 22 emerging at the second focus point 20 b of theillumination transfer device 20 emanates therefrom with the same angle α that the incident illumination 22 emanates from the first focus point 20 a of theillumination transfer device 20, i.e. at an angle of around 120 degrees. - The result of this is that the incident illumination 22 enters the eye without being “clipped” by the iris, for example. This maximises the area of the
retina 12 that can be illuminated by theapparatus 10 and allows ultra-wide illumination of theretina 12 to be performed. As described above, the incident illumination 22 enters thepupillary point 14 a of the subject'seye 14 at an angle of around 120 degrees. An angle of around 120 degrees at thepupillary point 14 a of theeye 14 equates to an angle of around 200 degrees when measured at the centre of theeye 14. Therefore, theapparatus 10 can be considered as providing a 120 degree “external” angle of illumination and a 200 degree “internal” angle of illumination. - The above-described properties of the
illumination device 16, thelens system 18 and theillumination transfer device 20 also ensures that reflected light from the retina is conveyed back through the same optical path of theapparatus 10. - The process of illuminating the
retina 12 of theeye 14 is illustrated inFIG. 3 . With reference toFIG. 3 , theretina 12 of theeye 14 may be illuminated by (a) providing theillumination device 16, (b) providing thelens system 18, (c) using theillumination device 16 and thelens system 18 in combination to provide incident illumination from theapparent point source 24 located within thelens system 18, (d) providing theillumination transfer device 20 having two foci 20 a, 20 b, (e) providing theapparent point source 24 at the first focus point 20 a of theillumination transfer device 20 and aneye 14 at the second focus point 20 b of theillumination transfer device 20 and (f) using theillumination transfer device 20 to transfer the incident illumination 22 from theapparent point source 24 into theeye 14. - As described above, the reflected light returned from the
retina 12 is detected at the first andsecond detectors retina 12 is used to produce an image of the subject'sretina 12 in the known manner. - The
detectors - The
apparatus 10 also comprises a data processing device for displaying, processing, storing, and/or combining the obtained images of theretina 12. Theapparatus 10 may also comprise a distortion correction device, which may be part of the data processing device, for correcting distortions introduced by theillumination transfer device 20. Theapparatus 10 may also include on or more filed flattener elements which correct for focal aberrations in the system. -
FIG. 2 illustrates an alternative embodiment of theapparatus 10. The only difference between theapparatus 10 ofFIG. 1 and theapparatus 100 ofFIG. 2 is that anillumination relay device 200 has been placed between thelens system 18 and theillumination transfer device 20. Theillumination relay device 200 has the same geometry as theillumination transfer device 20. - The
illumination relay device 200 has two foci 200 a, 200 b. In the embodiment illustrated and described here theillumination relay device 200 is an ellipsoidal mirror. However, it should be appreciated that theillumination relay device 200 may alternatively comprise a tilted spherical mirror, an aspherical mirror, an elliptical mirror, an ellipsoidal mirror, a pair of parabola mirrors, a pair of paraboloidal mirrors or a lens system. In the case where the illumination transfer device comprises a lens system, the lens system is arranged to provide two foci. - As illustrated in
FIG. 2 , theillumination relay device 200, theillumination transfer device 20 and thelens system 18 are arranged such that theapparent point source 24 is provided at the first focus point 200 a of theillumination relay device 200 and the second focus point 200 b of theillumination relay device 200 is coincident with the first focus point 20 a of theillumination transfer device 20. The subject'seye 14 is accommodated at the second focus point 20 b of theillumination transfer device 20 as before. - The incident illumination 22 is conveyed to the subject's
eye 14 via theillumination relay device 200 and theillumination transfer device 20. The incident illumination 22 provided at theapparent point source 24 by theillumination device 16 and thelens system 18 is coupled by theillumination relay device 200 to theillumination transfer device 20, which, in turn, couples the incident illumination 22 through thepupillary point 14 a of the subject'seye 14 to theretina 12, as before. - Given that the
illumination relay device 200 has the same geometry as theillumination transfer device 20, theillumination relay device 200 therefore also provides point-to-point transfer of the incident illumination 22 without translation, or clipping, thereof. Therefore, the incident illumination 22 emerging at the second focus point 200 b of theillumination relay device 200 emanates therefrom with the same angle α that the incident illumination emanates from the first focus point 200 a of theillumination relay device 200. It therefore follows that the incident illumination 22 emanating from the first focus point 20 a of the illumination transfer device 20 (or second focus point 200 b of the illumination relay device 200) emanates with the same angle α as the incident illumination 22 emanating from the second focus point 20 b of theillumination transfer device 20 into theeye 14, as before. The incident illumination 22 therefore again enters theeye 14 without being clipped, thus maximising the area of theretina 12 that can be illuminated by theapparatus 10. Theapparatus 100 again provides a 120 degree external angle (200 degree internal angle) of illumination of the retina, as before. - The
illumination relay device 200 has a major axis, which lies on a line joining the two foci (200 a, 200 b). Theillumination transfer device 20 also has a major axis, which lies on a line joining the two foci (20 a, 20 b). Theillumination transfer device 20 and theillumination relay device 200 may be arranged such that the major axes of each device are parallel and/or collinear. - The purpose of the
illumination relay device 200 is to correct for distortions introduced by theillumination transfer device 20. Since the geometry of theillumination relay device 200 is the same as the geometry of theillumination transfer device 20 the distortions can be cancelled out, or at least partially corrected for. The arrangement of theillumination relay device 200 and theillumination transfer device 20 is such that the major axis (i.e. the line joining the two foci of the device) of theillumination relay device 200 is parallel and collinear to the major axis of theillumination transfer device 20. In this arrangement the distortions are cancelled by symmetry. - The
apparatus 10 may also comprise a distortion correction device, which may be part of the data processing device, for correcting distortions introduced by theillumination transfer device 20. - The reflected light returned from the
retina 12 is detected in the same manner as described above in relation to theapparatus 10 ofFIG. 1 . Theapparatus 100 is therefore capable of imaging theretina 12 of theeye 14 in the same manner as described above in relation toapparatus 10. - Although the
apparatus retina 12 of asingle eye 14 of a subject, it should be appreciated that theapparatus apparatus apparatus apparatus apparatuses apparatus - Although the
apparatus retina 12 of theeye 14, it should be appreciated that theapparatus retina 12. That is, theapparatus retina 12 without acquiring an image, i.e. not detecting the reflected light from theretina 12. Theapparatus retina 12 of theeye 14 by illuminating theretina 12 with light. - The
apparatus apparatus apparatus apparatus apparatus apparatus apparatus angle lens system 18 in combination with anillumination transfer device 20, as described above, allows the incident illumination 22 to be provided indirectly to thepupillary point 14 a of theeye 14. This allows use of a wide-angle lens system where the “apparent” point source of incident illumination is located within the lens system itself to provide wide-field illumination of the retina. Theapparatus eye 14. This is advantageous, as patients often find physical contact with retinal illumination apparatuses extremely difficult. - Modifications and improvements may be made to the above without departing from the scope of the present invention. For example, although the
illumination device 16 has been described above as including alight source 26 which provides a “flood illumination” to the retina, i.e. theillumination device 16 simultaneously illuminates the area of theretina 12, it should be appreciated that alternatively, or additionally, theillumination device 16 may include a two-dimensional scanning device for scanning theretina 12 of theeye 14 with collimated light. In such a configuration theillumination device 16 and thelens system 18 combine to provide a two-dimensional collimated light scan from theapparent point source 24 located within thelens system 18. The two-dimensional scanning device may comprise a first scanning element and a second scanning element. The first and second scanning elements may comprise an oscillating mechanism. The oscillating mechanism may be a resonant scanner. The first and second scanning elements may comprise an oscillating plane mirror. The oscillating plane mirror may be a galvanometer mirror. The first and second scanning elements may comprise a rotating mechanism. The rotating mechanism may be a rotating polygon mirror. The first and second scanning elements may comprise a line scanning element. The line scanning element may comprise a laser line scanner. The laser line may be generated by a diffractive optical element, cylindrical lens, or other known means of creating a laser line. The first and second scanning elements may comprise a combination of oscillating mechanisms, rotating mechanisms or line scanning elements, as described above. Alternatively, the two-dimensional scanning device may be a microelectromechanical system (MEMS) scanning element having two axes of rotation. However, it should be appreciated that the two-dimensional scanning device may be any suitable device which is capable of rotating in at least two axes, which are preferably orthogonal. The scanning device should preferably be capable of operating at high speed (i.e. above 5 kHz) and provide a high amplitude of scan (i.e. up to 180 degrees or more). In this arrangement theapparatus retina 12 of theeye 14 by scanning the collimated light across the retina. In this arrangement the wavelength and power levels and variability of the collimated light from the scanning device may be the same as described for the flood illumination device. The reflected collimated light may be detected in the manner described above to produce an image of theretina 12. - Furthermore, although the
apparatus illumination device 16, it should be appreciated that theapparatus - Also, although the
apparent focus point 23 andapparent point source 24 have been illustrated and described above as being located within the outermost lens element 18 a of thelens system 18, it should be appreciated that, depending on the arrangement of thelens system 18, theapparent focus point 23 andapparent point source 24 could be located in one of the other lens elements 18 b to 18 e. - Furthermore, although the FOV of the
lens system 18 has been described above as being around 120 degrees, it should be appreciated that the FOV of thelens system 18 could be any suitable angle between 30 and 180 degrees, for example: 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160 or 170, or any value in between these angles. - Also, although the
apparatus 100 has been illustrated and described above with theillumination relay device 200 being positioned between thelens system 18 and theillumination transfer device 20, it should be appreciated that, since theillumination relay device 200 is essentially identical to theillumination transfer device 20, theapparatus 100 may be considered has having anillumination relay device 200 being positioned between theillumination transfer device 20 and theeye 14. - Furthermore, although the
apparatus retina 12 of theeye 14, it should be appreciated that theapparatus illumination device 16 would include a source of collimated light which may be operated to produce a laser beam of variable wavelength and/or power. Furthermore, the source of collimated light may be operated to produce a number of differing wavelengths, if required. This allows theapparatus - Also, although not illustrated or described above, it should be appreciated that, in order to minimise back reflections from the
lens system 18, thelight source 26 would be polarised and the returnoptical path 30 would include a polariser either before or after theaperture 46, or alternatively, two separate polarisers before the first andsecond detectors lens system 18 that is not randomly polarised. - Furthermore, although not illustrated or described above, it should be appreciated that the
lens system 18 and/or theillumination transfer device lens system 18 and/or theillumination transfer device apparent focus point 23 andapparent point source 24 in thelens system 18 when illuminating and/or imaging theretina 12 at different FOV angles. When illuminating and/or imaging theretina 12 at different FOV angles, for example when illuminating and/or imaging the fundus area of theretina 12 and then illuminating and/or imaging the peripheral of theretina 12, theapparent focus point 23 andapparent point source 24 in thelens system 18 may move slightly depending on the FOV angle. Arranging thelens system 18 and/or theillumination transfer device apparent focus point 23 andapparent point source 24 of thelens system 18 are always accommodated at the first focus point 20 a, 200 a of theillumination transfer device
Claims (24)
1. An apparatus for illuminating a retina of an eye, the apparatus comprising:
an illumination device;
a lens system;
wherein the illumination device and the lens system combine to provide incident illumination from an apparent point source located within the lens system;
an illumination transfer device, wherein the illumination transfer device has a first focus point and a second focus point and the apparent point source of the lens system is provided at the first focus point of the illumination transfer device and the eye is accommodated at the second focus point of the illumination transfer device; and
wherein the illumination transfer device transfers the incident illumination from the apparent point source into the eye to illuminate the retina.
2. The apparatus according to claim 1 , comprising an apparent focus point located within the lens system, wherein and the apparent focus point and the apparent point source are coincident.
3. The apparatus according to claim 1 , wherein the illumination device and the lens system are arranged to illuminate an area of the retina.
4. The apparatus according to claim 1 , wherein the lens system includes a wide-angle lens having a field of view (FOV) of between approximately 30 degrees and approximately 180 degrees.
5. The apparatus according to claim 1 , wherein the illumination transfer device comprises one of the group consisting of a tilted spherical mirror, an aspherical minor, an elliptical mirror, an ellipsoidal mirror, a pair of parabola minors, a pair of paraboloidal mirrors, and a second lens system comprising two foci.
6. The apparatus according to claim 1 , comprising an illumination relay device having a first focus point and a second focus point, wherein the first focus point of the illumination relay device is coincident with the first focus point of the illumination transfer device and the second focus point of the illumination relay device is coincident with the apparent point source of the illumination device and the lens system; and
wherein the illumination relay device transfers incident illumination from the apparent point source to the illumination transfer device and the illumination transfer device transfers incident illumination from the illumination relay device into the eye to illuminate the retina.
7. The apparatus according to claim 6 , wherein the illumination transfer device and the illumination relay device each comprise a major axis which major axis lies on a line joining the focus points of the illumination transfer device and the illumination relay device, and the illumination transfer device and the illumination relay device are arranged such that the major axis of the illumination transfer device and the illumination relay device are at least one of substantially parallel and collinear.
8. The apparatus according to claim 6 , wherein the illumination relay device has substantially the same geometry as the illumination transfer device.
9. The apparatus according to claim 1 , wherein the illumination device comprises a light source comprising one of the group consisting of a laser, a light emitting diode (LED), a Vertical Cavity Surface Emitting Laser (VCSEL), a super luminescent diode (SLD), a diode laser, a collimated incandescent lamp, a flash or illumination device, or a digital light processing (DLP) projection device.
10. The apparatus according to claim 1 , wherein the illumination device comprises a two-dimensional scanning device for scanning the retina of the eye with collimated light such that the illumination device and the lens system are arranged to provide a two-dimensional collimated light scan from the apparent point source located within the lens system.
11. The apparatus according to claim 10 , wherein the two-dimensional scanning device comprises at least one of a single scanning element capable of rotating in at least two axes and two separate scanning elements each having a single axis of rotation.
12. The apparatus according to claim 11 , wherein the single scanning element is a microelectromechanical (MEMS) scanning element.
13. The apparatus according to claim 1 , comprising one or more detectors for detecting the reflected light from the retina.
14. A method of illuminating a retina of an eye, the method comprising:
providing an illumination device;
providing a lens system;
using the illumination device and the lens system in combination to provide incident illumination from an apparent point source located within the lens system;
providing an illumination transfer device having a first focus point and a second focus point;
providing the apparent point source at the first focus point of the illumination transfer device and the eye at the second focus point of the illumination transfer device; and
using the illumination transfer device to transfer the incident illumination from the apparent point source into the eye.
15. The method according to claim 14 , wherein:
an apparent focus point is located within the lens system; and
the apparent focus point and the apparent point source are coincident.
16. The method according to claim 14 , wherein the illumination device and the lens system are arranged to illuminate an area of the retina.
17. The method according to claim 14 , comprising:
providing an illumination relay device having a first focus point and a second focus point; and
wherein the first focus point of the illumination relay device is coincident with the first focus point of the illumination transfer device and the second focus point of the illumination relay device is coincident with the apparent point source of the illumination device and the lens system; and
wherein the illumination relay device transfers incident illumination from the apparent point source to the illumination transfer device and the illumination transfer device transfers incident illumination from the illumination relay device into the eye to illuminate the retina.
18. The method according to claim 17 , wherein the illumination transfer device and the illumination relay device each comprise a major axis which major axis lies on a line joining the focus points of the illumination transfer device and the illumination relay device and the illumination transfer device and the illumination relay device are arranged such that the major axis of the illumination transfer device and the major axis of the illumination relay device are at least one of substantially parallel and collinear.
19. The method according to claim 17 , wherein the illumination relay device has substantially the same geometry as the illumination transfer device.
20. The method according to claim 14 , comprising providing one or more detectors to detect reflected light from the retina to form an image of the retina.
21. An apparatus for imaging a retina of an eye, the apparatus comprising:
an illumination device;
a lens system;
wherein the illumination device and the lens system combine to provide incident illumination from an apparent point source located within the lens system;
a light detector; and
an illumination transfer device, wherein the illumination transfer device has a first focus point and a second focus point and the apparent point source of the lens system is provided at the first focus point of the illumination transfer device and the eye is accommodated at the second focus point of the illumination transfer device; and
wherein the illumination transfer device transfers incident illumination from the apparent point source into the eye to illuminate the retina and the light detector detects light reflected from the retina to obtain an image of the retina.
22. A method of imaging a retina of an eye, the method comprising:
providing an illumination device;
providing a lens system;
using the illumination device and the lens system in combination to provide incident illumination from an apparent point source located within the lens system;
providing a light detector;
providing an illumination transfer device having a first focus point and a second focus point;
providing the apparent point source at the first focus point of the illumination transfer device and the eye at the second focus point of the illumination transfer device;
using the illumination transfer device to transfer incident illumination from the apparent point source into the eye; and
using the light detector to detect light reflected from the retina to produce an image of the retina.
23. An apparatus for treating a retina of an eye with collimated light, the apparatus comprising:
a collimated light illumination device;
a lens system;
wherein the illumination device and the lens system combine to provide incident collimated light illumination from an apparent point source located within the lens system; and
an illumination transfer device, wherein the illumination transfer device has a first focus point and a second focus point and the apparent point source of the lens system is provided at the first focus point of the illumination transfer device and the eye is accommodated at the second focus point of the illumination transfer device; and
wherein the illumination transfer device transfers incident collimated light illumination from the apparent point source into the eye.
24. A method of treating a retina of an eye with collimated light, the method comprising:
providing a collimated light illumination device;
providing a lens system;
using the illumination device and the lens system in combination to provide incident collimated light illumination from an apparent point source located within the lens system;
providing an illumination transfer device having a first focus point and a second focus point;
providing the apparent point source at the first focus point of the illumination transfer device and the eye at the second focus point of the illumination transfer device; and
using the illumination transfer device to transfer incident collimated light illumination from the apparent point source into the eye.
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Also Published As
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EP2663221B1 (en) | 2017-02-08 |
US20160128570A1 (en) | 2016-05-12 |
US9949638B2 (en) | 2018-04-24 |
GB201100555D0 (en) | 2011-03-02 |
JP2017221706A (en) | 2017-12-21 |
ES2741381T3 (en) | 2020-02-10 |
CN103298394B (en) | 2017-12-08 |
EP3195793B1 (en) | 2019-07-03 |
CN103298394A (en) | 2013-09-11 |
DK3195793T3 (en) | 2019-08-12 |
EP2663221A1 (en) | 2013-11-20 |
US10335028B2 (en) | 2019-07-02 |
JP6228847B2 (en) | 2017-11-08 |
JP6532064B2 (en) | 2019-06-19 |
WO2012095620A1 (en) | 2012-07-19 |
JP2014502552A (en) | 2014-02-03 |
US20180199811A1 (en) | 2018-07-19 |
EP3195793A1 (en) | 2017-07-26 |
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