US20130158649A1 - Biological stent-graft - Google Patents
Biological stent-graft Download PDFInfo
- Publication number
- US20130158649A1 US20130158649A1 US13/672,686 US201213672686A US2013158649A1 US 20130158649 A1 US20130158649 A1 US 20130158649A1 US 201213672686 A US201213672686 A US 201213672686A US 2013158649 A1 US2013158649 A1 US 2013158649A1
- Authority
- US
- United States
- Prior art keywords
- stent
- graft
- biological
- fixed
- vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/062—Apparatus for the production of blood vessels made from natural tissue or with layers of living cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
Definitions
- a stent-graft is the combination of a flexible, compressible conduit, or graft, and a structural framework, or stent.
- the graft is a continuous sealed walled conduit surrounding a central plenum opened at opposing ends for the transport of blood or other body fluids.
- the graft is used to bridge diseased or weakened portions of vessels, or other corporeal lumen.
- a stent and graft are difficult to incorporate into a single integral unit, because each has a different function and each requires different material properties. Hence, the use of two distinct components.
- the connection of one component to another has been problematic.
- the stent-graft is introduced in a collapsed state into the vessel. After the stent-graft is positioned in the vessel it is then expanded within the target lumen area of the vessel. The change in diameter may cause separation of the one from the other.
- the current art has many examples of ways to bind the stent to the graft, including sewing the stent and graft together, sandwiching the stent between an inner and outer grafts, or sandwiching the graft between inner and outer stents. But none achieve full integration. The resulting problems from the lack of full integration include micro-movement, poor contact with surrounding lumen, and restriction of the lumen, and the like.
- Micromovement between the stent and graft can lead to graft erosion. Lack of contact between the stent and graft can lead to perigraft leakage, i.e. leakage of body fluids around the outer wall of the graft, especially when the stent is on the outside of the graft. Conversely, when the stent is on the inside of the graft, i.e. in the graft lumen, it can snag catheters and guidewires during re-instrumentation.
- the size of the stent-graft profile and the delivery system for the stent-graft can increase with the additional layers of stent or graft used in the sandwich method of attachment. In addition redundant folds of graft which is a problem with dual layer sandwich graft-stents, can fold into the lumen, occluding or impeding blood flow or other bodily fluid flow.
- stents Once implanted in a vascular lumen, most stents become rapidly incorporated into the wall of the surrounding vessel by smooth muscle invasion, followed by collagen deposition and intimal migration. The process of ingrowth varies according to the type of stent and the type of artery. Balloon-expanded stents incorporate more rapidly than self-expanding stents, and healthy canine arteries infiltrate the stent structure more rapidly than aging human arteries. It is believed that age is or would be a factor in the ingrowth of a stent in any mammal. The ingrowth of skeletal structures or frames for grafts in other biological vessels, such as the urethra or esophagus, is not well under stood as this point.
- the invention is a biologic stent-graft, in which the graft is derived from an animal blood vessel and the attachment between the stent and graft is a product of the natural process by which stents become incorporated into blood vessel walls through ingrowth.
- the biological stent graft of the present invention comprises the integration of a non-biological stent made from a biologically acceptable material, such as medicinally accepted metals and/or polymers, with the tissue of a vessel (the graft) by the natural ingrowth occurring when the stent is implanted in a vessel, such as an arterial vessel, of an animal for a period of time sufficient to permit ingrowth.
- a metal or polymeric stent is surgically implanted in the lumen of a vessel, such as the artery, of a living animal.
- the stent is left in place for a sufficient time for the arterial wall to incorporate the stent through tissue ingrowth to yield a stented vessel.
- the stented vessel is surgically harvested to yield a biological stent-graft precursor.
- the biological stent-graft precursor i.e. harvested stented vessel, is washed and cleaned.
- the washed and cleaned biological stent-graft precursor is fixed by one of the known methods used to fix pig valves, animal arterial vessels, animal arterial patches, and the like, to yield the biological stent-graft of the present invention.
- the fixation insures sterilization of the of the biological stent-graft, and makes the tissue inert to tissue rejection processes within a body.
- Canine, bovine and porcine arterial vessels at the present appear to be the most attractive source of vessels for biological stent-grafts. However other vessels, such as veins, and vessels from other animals, such as rabbit, may be equally suitable.
- the selection of vessel and the animal for implantation of the stent may depend on the size requirements as well as ingrowth rates. Cattle and pigs (including swine) might be the most convenient source because of the anatomical similarity of cattle and pig vessels and human vessels, and because cattle and pigs are raised for slaughter.
- the stents can be surgically implanted, i.e. intravascularly inserted, into the arterial vessels of young calves and pigs four to six moths prior to their scheduled slaughter.
- the formed stented graft i.e. biological stent-graft precursors, can be harvested from the steer and pigs under appropriate conditions to ensure cleanliness of the harvested stented vessel.
- the type of stent, metal, plastic, expandable, and the like, the animal species, the implantation site in the animal, the type of vessel, and the fixation method can all be varied to alter the properties of the resulting biological stent-graft.
- the external diameter of the stent is only slightly less than the internal diameter of the vessel wall.
- the stent can be expanded partially when implanted to contact the vessel wall to secure the stent in the vessel and to speed up tissue incorporation of the stent into the vessel.
- the stents are made of biologically acceptable materials that are suitable for implantation, such as medicinally acceptable metals and/or polymers.
- a small diameter, low profile biological stent-graft can be made by implanting a coronary stent in the thoracic aorta of a rabbit, allowing the ingrowth of smooth muscle and collagen into the stent to completely encapsulate the stent into the vessel wall to create a stented vessel, harvesting the stented vessel, washing and cleaning the harvested stented vessel, and fixing the washed and cleaned harvested stented vessel or biological stent-graft precursor to form the biological stent-graft.
- the surgical implantation is done endoscopically and/or endovascularly.
- the stented vessel is removed from the sacrificed animal and immersed in a sterile saline solution, preferably cold.
- the harvested stented vessel i.e. biological stent-graft precursor
- the biological stent-graft precursor is preferably washed and cleaned at a chilled temperature to minimize biological degradation.
- the biological stent-graft precursor is cut to length and excess connective tissue adhering to the biological stent-graft precursor is cut away. Unwanted branches, such as arterial branches, extending from the biological stent-graft precursor are ligated in accordance with standard medical practice.
- the biological stent-graft precursor can be given a final washing with sterile saline solutions and if stored, it is preferably stored in sterile saline solution, preferably at a cold temperature such as just above freezing.
- Fixation is a general name for the process by which the proteins of a biologic tissue are denatured.
- the most important effects of fixation include: cross-linking of collagen; strengthening the collagen and rendering it resistant to enzymatic degradation; alteration of the surface proteins on collagen and tissue; rendering the collagen and tissue non-immunogenic; destroying cellular DNA and enzymes, and eliminating infectivity of tissue.
- Animal tissues, that have been treated by fixation, are widely used as prosthetic valves, arterial conduits, and arterial patches. There are numerous well known methods for fixing and denaturing proteinaceous tissue.
- glutaraldehyde solutions (0.25 to 1.0% solutions at a pH of around 7.4, and glycerol triglycidyl ether solutions (1.0 to 2.5% solutions at a pH of around 10.0) are suitable.
- Glutaraldehyde fixation is relatively fast but renders the fixed tissue rather tough and less pliable, whereas glycerol triglycidyl ether fixation is relatively slow but renders the fixed tissue less tough and more pliable.
- the biological stent-graft After fixation, the biological stent-graft is thoroughly washed with a sterile solution to remove substantially all, or all, the fixation agent and stored in sterile solution, such as ethanol.
- a sterile solution such as ethanol.
- the biological stent-graft can be stored in a moist state.
- the biological stent-graft can optionally be stored at low temperatures such as near, but above, freezing.
- the biological stent graft is employed in a patient in the same manner as existing non-biological surgical stent-grafts.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
A biological stent-graft and a method of making the same wherein a stent is surgically implanted in the lumen of an artery of a mammal, harvesting the stent-graft precursor after the stent has been incorporated into artery wall, fixing the harvested stent-graft precursor, and washing the same to yield a biological stent-graft.
Description
- This application claims the benefit of U.S. Provisional Application No. 60/382,097, filed on May 21, 2002.
- As the name implies, a stent-graft is the combination of a flexible, compressible conduit, or graft, and a structural framework, or stent. The graft is a continuous sealed walled conduit surrounding a central plenum opened at opposing ends for the transport of blood or other body fluids. The graft is used to bridge diseased or weakened portions of vessels, or other corporeal lumen.
- Problems with the Current Supported Grafts
- The structural functions of a stent and graft are difficult to incorporate into a single integral unit, because each has a different function and each requires different material properties. Hence, the use of two distinct components. The connection of one component to another has been problematic. In most applications, the stent-graft is introduced in a collapsed state into the vessel. After the stent-graft is positioned in the vessel it is then expanded within the target lumen area of the vessel. The change in diameter may cause separation of the one from the other. The current art has many examples of ways to bind the stent to the graft, including sewing the stent and graft together, sandwiching the stent between an inner and outer grafts, or sandwiching the graft between inner and outer stents. But none achieve full integration. The resulting problems from the lack of full integration include micro-movement, poor contact with surrounding lumen, and restriction of the lumen, and the like.
- Micromovement between the stent and graft can lead to graft erosion. Lack of contact between the stent and graft can lead to perigraft leakage, i.e. leakage of body fluids around the outer wall of the graft, especially when the stent is on the outside of the graft. Conversely, when the stent is on the inside of the graft, i.e. in the graft lumen, it can snag catheters and guidewires during re-instrumentation. The size of the stent-graft profile and the delivery system for the stent-graft can increase with the additional layers of stent or graft used in the sandwich method of attachment. In addition redundant folds of graft which is a problem with dual layer sandwich graft-stents, can fold into the lumen, occluding or impeding blood flow or other bodily fluid flow.
- The Biology of Stent Ingrowth
- Once implanted in a vascular lumen, most stents become rapidly incorporated into the wall of the surrounding vessel by smooth muscle invasion, followed by collagen deposition and intimal migration. The process of ingrowth varies according to the type of stent and the type of artery. Balloon-expanded stents incorporate more rapidly than self-expanding stents, and healthy canine arteries infiltrate the stent structure more rapidly than aging human arteries. It is believed that age is or would be a factor in the ingrowth of a stent in any mammal. The ingrowth of skeletal structures or frames for grafts in other biological vessels, such as the urethra or esophagus, is not well under stood as this point.
- The invention is a biologic stent-graft, in which the graft is derived from an animal blood vessel and the attachment between the stent and graft is a product of the natural process by which stents become incorporated into blood vessel walls through ingrowth. Thus the biological stent graft of the present invention comprises the integration of a non-biological stent made from a biologically acceptable material, such as medicinally accepted metals and/or polymers, with the tissue of a vessel (the graft) by the natural ingrowth occurring when the stent is implanted in a vessel, such as an arterial vessel, of an animal for a period of time sufficient to permit ingrowth.
- The steps in biological stent-graft manufacture are as follows:
- 1. A metal or polymeric stent is surgically implanted in the lumen of a vessel, such as the artery, of a living animal.
- 2. The stent is left in place for a sufficient time for the arterial wall to incorporate the stent through tissue ingrowth to yield a stented vessel.
- 3. The stented vessel is surgically harvested to yield a biological stent-graft precursor.
- 4. The biological stent-graft precursor, i.e. harvested stented vessel, is washed and cleaned.
- 5. The washed and cleaned biological stent-graft precursor is fixed by one of the known methods used to fix pig valves, animal arterial vessels, animal arterial patches, and the like, to yield the biological stent-graft of the present invention. The fixation insures sterilization of the of the biological stent-graft, and makes the tissue inert to tissue rejection processes within a body.
- Implantation
- Canine, bovine and porcine arterial vessels at the present appear to be the most attractive source of vessels for biological stent-grafts. However other vessels, such as veins, and vessels from other animals, such as rabbit, may be equally suitable. The selection of vessel and the animal for implantation of the stent may depend on the size requirements as well as ingrowth rates. Cattle and pigs (including swine) might be the most convenient source because of the anatomical similarity of cattle and pig vessels and human vessels, and because cattle and pigs are raised for slaughter. The stents can be surgically implanted, i.e. intravascularly inserted, into the arterial vessels of young calves and pigs four to six moths prior to their scheduled slaughter. At slaughter the formed stented graft, i.e. biological stent-graft precursors, can be harvested from the steer and pigs under appropriate conditions to ensure cleanliness of the harvested stented vessel.
- The type of stent, metal, plastic, expandable, and the like, the animal species, the implantation site in the animal, the type of vessel, and the fixation method can all be varied to alter the properties of the resulting biological stent-graft. Preferably the external diameter of the stent is only slightly less than the internal diameter of the vessel wall. The stent can be expanded partially when implanted to contact the vessel wall to secure the stent in the vessel and to speed up tissue incorporation of the stent into the vessel. The stents are made of biologically acceptable materials that are suitable for implantation, such as medicinally acceptable metals and/or polymers. For example, a small diameter, low profile biological stent-graft can be made by implanting a coronary stent in the thoracic aorta of a rabbit, allowing the ingrowth of smooth muscle and collagen into the stent to completely encapsulate the stent into the vessel wall to create a stented vessel, harvesting the stented vessel, washing and cleaning the harvested stented vessel, and fixing the washed and cleaned harvested stented vessel or biological stent-graft precursor to form the biological stent-graft. Preferably the surgical implantation is done endoscopically and/or endovascularly.
- Harvesting
- The stented vessel is removed from the sacrificed animal and immersed in a sterile saline solution, preferably cold. The harvested stented vessel, i.e. biological stent-graft precursor, is preferably washed and cleaned at a chilled temperature to minimize biological degradation. The biological stent-graft precursor is cut to length and excess connective tissue adhering to the biological stent-graft precursor is cut away. Unwanted branches, such as arterial branches, extending from the biological stent-graft precursor are ligated in accordance with standard medical practice. The biological stent-graft precursor can be given a final washing with sterile saline solutions and if stored, it is preferably stored in sterile saline solution, preferably at a cold temperature such as just above freezing.
- Fixation of Biological Prosthesis
- Fixation is a general name for the process by which the proteins of a biologic tissue are denatured. The most important effects of fixation include: cross-linking of collagen; strengthening the collagen and rendering it resistant to enzymatic degradation; alteration of the surface proteins on collagen and tissue; rendering the collagen and tissue non-immunogenic; destroying cellular DNA and enzymes, and eliminating infectivity of tissue. Animal tissues, that have been treated by fixation, are widely used as prosthetic valves, arterial conduits, and arterial patches. There are numerous well known methods for fixing and denaturing proteinaceous tissue. For example glutaraldehyde solutions (0.25 to 1.0% solutions at a pH of around 7.4, and glycerol triglycidyl ether solutions (1.0 to 2.5% solutions at a pH of around 10.0) are suitable. Further information can be found in U.S. Pat. Nos. 4,388,735; 5,375,110; and 5,961,549; and the patents and references cited therein; the total disclosures of which are incorporated by reference herein. Glutaraldehyde fixation is relatively fast but renders the fixed tissue rather tough and less pliable, whereas glycerol triglycidyl ether fixation is relatively slow but renders the fixed tissue less tough and more pliable.
- After fixation, the biological stent-graft is thoroughly washed with a sterile solution to remove substantially all, or all, the fixation agent and stored in sterile solution, such as ethanol. The biological stent-graft can be stored in a moist state. The biological stent-graft can optionally be stored at low temperatures such as near, but above, freezing.
- The biological stent graft is employed in a patient in the same manner as existing non-biological surgical stent-grafts.
Claims (21)
1-40. (canceled)
41. A biological stent-graft comprising a stent made from a biologically acceptable material and a non-laminate wall of a fixed animal blood vessel subject to fixation, the stent fully incorporated and encapsulated into the wall of the fixed animal blood vessel, and the non-laminated wall of a fixed animal blood vessel an ingrowth of smooth muscle and collagen into the stent.
42. The stent-graft according to claim 41 wherein the stent is a metal stent.
43. The stent-graft according to claim 41 wherein the stent is a polymeric stent.
44. The biological stent-graft of claim 41 wherein the fixed animal blood vessel is a fixed animal arterial vessel.
45. The biological stent-graft of claim 44 wherein the fixed animal arterial vessel is a fixed canine arterial vessel.
46. The biological stent-graft of claim 44 wherein the fixed animal arterial vessel is a fixed bovine arterial vessel.
47. The biological stent-graft of claim 44 wherein the fixed animal arterial vessel is a fixed porcine arterial vessel.
48. The biological stent-graft of claim 41 wherein the stent is a self-expanding stent.
49. The biological stent-graft of claim 41 wherein the stent is an expandable stent.
50. The biological stent-graft of claim 41 wherein the fixed animal blood vessel is a glutaraldehyde fixed animal blood vessel.
51. The biological stent-graft of claim 41 wherein the fixed animal blood vessel is glycerol triglycidy ether fixed animal blood vessel.
52. A biological stent-graft comprising a stent made from a biologically acceptable material and a non-laminate wall of a fixed animal blood vessel, the stent in grown in and encapsulated in the walls of the animal blood vessel, and the non-laminated wall of a fixed animal blood vessel an ingrowth of smooth muscle and collagen into the stent.
53. The stent-graft according to claim 52 wherein the stent is a metal stent.
54. The stent-graft according to claim 52 wherein the stent is a polymeric stent.
55. The biological stent-graft of claim 52 wherein the fixed animal blood vessel is a fixed animal arterial vessel.
56. The biological stent-graft of claim 55 wherein the fixed animal arterial vessel is a fixed canine arterial vessel.
57. The biological stent-graft of claim 55 wherein the fixed animal arterial vessel is a fixed bovine arterial vessel.
58. The biological stent-graft of claim 55 wherein the fixed animal arterial vessel is a fixed porcine arterial vessel.
59. The biological stent-graft of claim 52 wherein the stent is an expandable stent.
60. A biological stent-graft comprising a stent made from a biological acceptable material and a non-laminate wall of a fixed and denatured animal blood vessel, the stent fully integrated into the wall of the fixed animal blood vessel.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/672,686 US20130158649A1 (en) | 2002-05-21 | 2012-11-08 | Biological stent-graft |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38209702P | 2002-05-21 | 2002-05-21 | |
US10/441,956 US6926743B1 (en) | 2002-05-21 | 2003-05-20 | Biological stent-graft |
US15392805A | 2005-06-15 | 2005-06-15 | |
US201113018760A | 2011-02-01 | 2011-02-01 | |
US13/672,686 US20130158649A1 (en) | 2002-05-21 | 2012-11-08 | Biological stent-graft |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US201113018760A Continuation | 2002-05-21 | 2011-02-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
US20130158649A1 true US20130158649A1 (en) | 2013-06-20 |
Family
ID=34811089
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/441,956 Expired - Fee Related US6926743B1 (en) | 2002-05-21 | 2003-05-20 | Biological stent-graft |
US13/672,686 Abandoned US20130158649A1 (en) | 2002-05-21 | 2012-11-08 | Biological stent-graft |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/441,956 Expired - Fee Related US6926743B1 (en) | 2002-05-21 | 2003-05-20 | Biological stent-graft |
Country Status (1)
Country | Link |
---|---|
US (2) | US6926743B1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1796597B1 (en) | 2004-09-14 | 2013-01-09 | Edwards Lifesciences AG | Device for treatment of heart valve regurgitation |
US11883273B2 (en) | 2017-04-28 | 2024-01-30 | Regents Of The University Of Minnesota | Compliant aortic stent grafts and related systems and methods |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5693085A (en) * | 1994-04-29 | 1997-12-02 | Scimed Life Systems, Inc. | Stent with collagen |
US20020123789A1 (en) * | 1998-12-04 | 2002-09-05 | Francis Ralph T. | Stent cover |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4388735A (en) | 1980-11-03 | 1983-06-21 | Shiley Inc. | Low profile prosthetic xenograft heart valve |
WO1992014419A1 (en) | 1991-02-14 | 1992-09-03 | Baxter International Inc. | Pliable biological graft materials and their methods of manufacture |
US6060640A (en) * | 1995-05-19 | 2000-05-09 | Baxter International Inc. | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue |
US5961549A (en) | 1997-04-03 | 1999-10-05 | Baxter International Inc. | Multi-leaflet bioprosthetic heart valve |
US6129757A (en) * | 1998-05-18 | 2000-10-10 | Scimed Life Systems | Implantable members for receiving therapeutically useful compositions |
LV12702B (en) * | 2000-02-16 | 2001-10-20 | Viktorija Kancevica | Artery Prosthesis |
-
2003
- 2003-05-20 US US10/441,956 patent/US6926743B1/en not_active Expired - Fee Related
-
2012
- 2012-11-08 US US13/672,686 patent/US20130158649A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5693085A (en) * | 1994-04-29 | 1997-12-02 | Scimed Life Systems, Inc. | Stent with collagen |
US20020123789A1 (en) * | 1998-12-04 | 2002-09-05 | Francis Ralph T. | Stent cover |
Also Published As
Publication number | Publication date |
---|---|
US6926743B1 (en) | 2005-08-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WILSON et al. | Acellular matrix allograft small caliber vascular prostheses | |
AU739684B2 (en) | Luminal graft, stent or conduit | |
Conklin et al. | Development and evaluation of a novel decellularized vascular xenograft | |
US20100204775A1 (en) | Tissue Synthetic- Biomaterial Hybrid Medical Devices | |
EP3281608B1 (en) | Medical product comprising a frame and visceral pleura | |
US4082507A (en) | Prosthesis and method for making the same | |
CN101128225B (en) | An implantable biomaterial and a method of producing same | |
AU743779B2 (en) | Tubular grafts from purified submucosa | |
US5131908A (en) | Tubular prosthesis for vascular reconstructive surgery and process for preparing same | |
US20160067031A1 (en) | Methods and uses of mediastinal pleura tissue for various stent and other medical applications | |
US20060136047A1 (en) | Tissue graft prosthesis devices containing juvenile or small diameter submucosa | |
EP0055250B1 (en) | Vascular prostheses | |
WO1998025545A1 (en) | Stent grafts containing purified submucosa | |
He et al. | Arterial replacement with compliant hierarchic hybrid vascular graft: biomechanical adaptation and failure | |
Ketharnathan et al. | Glutaraldehyde-tanned ovine collagen conduits as vascular xenografts in dogs: a preliminary report | |
US20130158649A1 (en) | Biological stent-graft | |
JP4735111B2 (en) | Stent with artificial valve | |
EP1123122B1 (en) | Implant material | |
Noishiki et al. | Development and evaluation of a pliable biological valved conduit. Part I: preparation, biochemical properties, and histological findings | |
RU2202991C2 (en) | Extracardiac valve-containing conduit and method for producing it | |
JPH04288165A (en) | Organ implant and manufacture thereof | |
Sullivan et al. | Small-diameter vascular grafts | |
Noishiki et al. | Development of a growable vascular graft | |
EP4046602A1 (en) | Self-extendable stent for pulmonary artery | |
CN105477680A (en) | Preparation method of in-vivo artificial blood vessel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |