US20080183016A1 - Process for the synthesis of O-desmethylvenlafaxine - Google Patents
Process for the synthesis of O-desmethylvenlafaxine Download PDFInfo
- Publication number
- US20080183016A1 US20080183016A1 US11/881,826 US88182607A US2008183016A1 US 20080183016 A1 US20080183016 A1 US 20080183016A1 US 88182607 A US88182607 A US 88182607A US 2008183016 A1 US2008183016 A1 US 2008183016A1
- Authority
- US
- United States
- Prior art keywords
- oba
- acid
- preparing
- coba
- odv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- KYYIDSXMWOZKMP-UHFFFAOYSA-N O-desmethylvenlafaxine Chemical compound C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 KYYIDSXMWOZKMP-UHFFFAOYSA-N 0.000 title claims abstract description 61
- 238000000034 method Methods 0.000 title claims abstract description 50
- 238000003786 synthesis reaction Methods 0.000 title abstract description 11
- 230000015572 biosynthetic process Effects 0.000 title abstract description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 33
- 239000002253 acid Substances 0.000 claims description 33
- 239000002904 solvent Substances 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 27
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims description 26
- 238000004519 manufacturing process Methods 0.000 claims description 24
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 230000003213 activating effect Effects 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 16
- -1 amine salt Chemical class 0.000 claims description 15
- 150000001412 amines Chemical class 0.000 claims description 13
- 239000003054 catalyst Substances 0.000 claims description 13
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 12
- 239000003638 chemical reducing agent Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 11
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 10
- 238000011084 recovery Methods 0.000 claims description 10
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical group ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims description 10
- 238000010791 quenching Methods 0.000 claims description 9
- 230000000171 quenching effect Effects 0.000 claims description 9
- XQXPVVBIMDBYFF-UHFFFAOYSA-N 4-hydroxyphenylacetic acid Chemical class OC(=O)CC1=CC=C(O)C=C1 XQXPVVBIMDBYFF-UHFFFAOYSA-N 0.000 claims description 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- RTRVJYTVTCOSIA-UHFFFAOYSA-N methylamino(phenyl)methanol Chemical compound CNC(O)C1=CC=CC=C1 RTRVJYTVTCOSIA-UHFFFAOYSA-N 0.000 claims description 6
- 239000003223 protective agent Substances 0.000 claims description 6
- FOBXCIWPAJUIQC-UHFFFAOYSA-N 2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)-n,n-dimethylacetamide Chemical compound C1CCCCC1(O)C(C(=O)N(C)C)C1=CC=C(O)C=C1 FOBXCIWPAJUIQC-UHFFFAOYSA-N 0.000 claims description 5
- BLUITXBEAKYQKE-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-n,n-dimethylacetamide Chemical compound CN(C)C(=O)CC1=CC=C(O)C=C1 BLUITXBEAKYQKE-UHFFFAOYSA-N 0.000 claims description 5
- 229910006124 SOCl2 Inorganic materials 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 125000006239 protecting group Chemical group 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 claims description 4
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims description 3
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical group Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 claims description 3
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 claims description 3
- YEDUAINPPJYDJZ-UHFFFAOYSA-N 2-hydroxybenzothiazole Chemical compound C1=CC=C2SC(O)=NC2=C1 YEDUAINPPJYDJZ-UHFFFAOYSA-N 0.000 claims description 2
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims description 2
- 150000008282 halocarbons Chemical class 0.000 claims description 2
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical group CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 claims 3
- 229910021580 Cobalt(II) chloride Inorganic materials 0.000 claims 1
- GRKCZMCXXJZFCI-UHFFFAOYSA-N OC1=CC=C(C=C1)CC(=O)O.OC1=CC=C(C=C1)CC(=O)O Chemical class OC1=CC=C(C=C1)CC(=O)O.OC1=CC=C(C=C1)CC(=O)O GRKCZMCXXJZFCI-UHFFFAOYSA-N 0.000 claims 1
- 229940043279 diisopropylamine Drugs 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
- 239000000543 intermediate Substances 0.000 abstract description 8
- 239000002585 base Substances 0.000 description 25
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 14
- 229960004688 venlafaxine Drugs 0.000 description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
- 239000012267 brine Substances 0.000 description 8
- 239000010410 layer Substances 0.000 description 8
- 239000003960 organic solvent Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 8
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 7
- 239000012047 saturated solution Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000007832 Na2SO4 Substances 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 description 6
- 239000007858 starting material Substances 0.000 description 6
- BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 description 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 5
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 4
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 4
- 239000012298 atmosphere Substances 0.000 description 4
- 230000017858 demethylation Effects 0.000 description 4
- 238000010520 demethylation reaction Methods 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 239000012044 organic layer Substances 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- NPRLKAVPQVFVSH-UHFFFAOYSA-N C.CN(C)C(=O)C(C1=CC=C(O)C=C1)C1(O)CCCCC1 Chemical compound C.CN(C)C(=O)C(C1=CC=C(O)C=C1)C1(O)CCCCC1 NPRLKAVPQVFVSH-UHFFFAOYSA-N 0.000 description 3
- NIWXRUCHFDRRBN-UHFFFAOYSA-N C.CN(C)C(=O)CC1=CC=C(O)C=C1 Chemical compound C.CN(C)C(=O)CC1=CC=C(O)C=C1 NIWXRUCHFDRRBN-UHFFFAOYSA-N 0.000 description 3
- IPLPZJDDTHGBGT-UHFFFAOYSA-N CC1=CC=C(C(C(=O)N(C)C)C2(O)CCCCC2)C=C1 Chemical compound CC1=CC=C(C(C(=O)N(C)C)C2(O)CCCCC2)C=C1 IPLPZJDDTHGBGT-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 229910010084 LiAlH4 Inorganic materials 0.000 description 3
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 150000001340 alkali metals Chemical class 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- 239000012280 lithium aluminium hydride Substances 0.000 description 3
- 229910052987 metal hydride Inorganic materials 0.000 description 3
- 150000004681 metal hydrides Chemical group 0.000 description 3
- FGTJJHCZWOVVNH-UHFFFAOYSA-N tert-butyl-[tert-butyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)O[Si](C)(C)C(C)(C)C FGTJJHCZWOVVNH-UHFFFAOYSA-N 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- BUPWIEJFVYWBHO-UHFFFAOYSA-N CC1=CC=C(CC(=O)N(C)C)C=C1 Chemical compound CC1=CC=C(CC(=O)N(C)C)C=C1 BUPWIEJFVYWBHO-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 150000001342 alkaline earth metals Chemical class 0.000 description 2
- IGUWWWKFCOSBCN-UHFFFAOYSA-N cyclohexyl-(methylamino)-phenylmethanol Chemical compound C=1C=CC=CC=1C(O)(NC)C1CCCCC1 IGUWWWKFCOSBCN-UHFFFAOYSA-N 0.000 description 2
- 235000019439 ethyl acetate Nutrition 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 239000003586 protic polar solvent Substances 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 229910000104 sodium hydride Inorganic materials 0.000 description 2
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical group CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- 0 *Cc1ccc(*)cc1 Chemical compound *Cc1ccc(*)cc1 0.000 description 1
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 1
- MOHIYTLRUDZQDP-UHFFFAOYSA-N 2-cyclohexyl-2-phenylpropanenitrile Chemical compound C=1C=CC=CC=1C(C#N)(C)C1CCCCC1 MOHIYTLRUDZQDP-UHFFFAOYSA-N 0.000 description 1
- SDTMFDGELKWGFT-UHFFFAOYSA-N 2-methylpropan-2-olate Chemical compound CC(C)(C)[O-] SDTMFDGELKWGFT-UHFFFAOYSA-N 0.000 description 1
- NVAOLENBKNECGF-UHFFFAOYSA-N 2-phenylpropanenitrile Chemical compound N#CC(C)C1=CC=CC=C1 NVAOLENBKNECGF-UHFFFAOYSA-N 0.000 description 1
- IMWPSXHIEURNKZ-UHFFFAOYSA-N 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol;hydrochloride Chemical class Cl.C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 IMWPSXHIEURNKZ-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- UTWMGMUMLVWXQC-UHFFFAOYSA-N C.CC1=CC=C(CC(=O)N(C)C)C=C1 Chemical compound C.CC1=CC=C(CC(=O)N(C)C)C=C1 UTWMGMUMLVWXQC-UHFFFAOYSA-N 0.000 description 1
- DYXYXWWWONQTTJ-DYCDLGHISA-M CC1=CC=C(C(C(=O)N(C)C)C2(O)CCCCC2)C=C1.CC1=CC=C(C(N(C)C)C2(O)CCCCC2)C=C1.CN(C)C(=O)C(C1=CC=C(O)C=C1)C1(O)CCCCC1.CN(C)C(=O)C(C1=CC=C(O)C=C1)C1(O)CCCCC1.CN(C)C(C1=CC=C(O)C=C1)C1(O)CCCCC1.O=C(O)CC1=CC=C(O)C=C1.O=C1CCCCC1.O=C1CCCCC1.[2H]O[V] Chemical compound CC1=CC=C(C(C(=O)N(C)C)C2(O)CCCCC2)C=C1.CC1=CC=C(C(N(C)C)C2(O)CCCCC2)C=C1.CN(C)C(=O)C(C1=CC=C(O)C=C1)C1(O)CCCCC1.CN(C)C(=O)C(C1=CC=C(O)C=C1)C1(O)CCCCC1.CN(C)C(C1=CC=C(O)C=C1)C1(O)CCCCC1.O=C(O)CC1=CC=C(O)C=C1.O=C1CCCCC1.O=C1CCCCC1.[2H]O[V] DYXYXWWWONQTTJ-DYCDLGHISA-M 0.000 description 1
- QALCRWBCHXIJRH-FNASUAHHSA-N CN(C)CC(C1=CC=C(O)C=C1)C1(O)CCCCC1.COC1=CC=C(C(C#N)C2(O)CCCCC2)C=C1.COC1=CC=C(C(CN(C)C)C2(O)CCCCC2)C=C1.COC1=CC=C(C(CN)C2(O)CCCCC2)C=C1.COC1=CC=C(CC#N)C=C1.O=C1CCCCC1.[2H][2H].[V] Chemical compound CN(C)CC(C1=CC=C(O)C=C1)C1(O)CCCCC1.COC1=CC=C(C(C#N)C2(O)CCCCC2)C=C1.COC1=CC=C(C(CN(C)C)C2(O)CCCCC2)C=C1.COC1=CC=C(C(CN)C2(O)CCCCC2)C=C1.COC1=CC=C(CC#N)C=C1.O=C1CCCCC1.[2H][2H].[V] QALCRWBCHXIJRH-FNASUAHHSA-N 0.000 description 1
- DCERHCFNWRGHLK-UHFFFAOYSA-N C[Si](C)C Chemical compound C[Si](C)C DCERHCFNWRGHLK-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 1
- KOOADCGQJDGAGA-UHFFFAOYSA-N [amino(dimethyl)silyl]methane Chemical compound C[Si](C)(C)N KOOADCGQJDGAGA-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 150000001805 chlorine compounds Chemical group 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- PBGGNZZGJIKBMJ-UHFFFAOYSA-N di(propan-2-yl)azanide Chemical compound CC(C)[N-]C(C)C PBGGNZZGJIKBMJ-UHFFFAOYSA-N 0.000 description 1
- 229960004132 diethyl ether Drugs 0.000 description 1
- 150000004656 dimethylamines Chemical class 0.000 description 1
- UXGNZZKBCMGWAZ-UHFFFAOYSA-N dimethylformamide dmf Chemical group CN(C)C=O.CN(C)C=O UXGNZZKBCMGWAZ-UHFFFAOYSA-N 0.000 description 1
- HPYNZHMRTTWQTB-UHFFFAOYSA-N dimethylpyridine Natural products CC1=CC=CN=C1C HPYNZHMRTTWQTB-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000011874 heated mixture Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 150000002641 lithium Chemical class 0.000 description 1
- DLEDOFVPSDKWEF-UHFFFAOYSA-N lithium butane Chemical compound [Li+].CCC[CH2-] DLEDOFVPSDKWEF-UHFFFAOYSA-N 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 230000013275 serotonin uptake Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Definitions
- the invention encompasses a process for the synthesis of O-desmethylvenlafaxine.
- Venlafaxine acts by inhibiting re-uptake of norepinephrine and serotonin, and is an alternative to the tricyclic anti-depressants and selective re-uptake inhibitors.
- O-desmethylvenlafaxine 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, of the following formula,
- MCC methyl benzyl cyanide
- CMBC cyclohexyl methylbenzyl cyanide
- DDMV didesmethyl venlafaxine
- ODV O-desmethylvenlafaxine
- U.S. Pat. No. 6,689,912 describes demethylation process performed by using a salt of high molecular weight alkane, arene, or arylalkyl thiolate anion in the presence of protic or aprotic solvent.
- the salt can be prepared separately and then react with venlafaxine, or can react in-situ with venlafaxine.
- the solvent, methanol should be removed. This operation is very complicated because the mixture containing the salt is highly viscous, hence the operation necessitate long time even under high vacuum.
- the reaction is performed in-situ via removal of methanol in situ, this operation is still tedious and only partially successful, since it is difficult to reach the high temperature that the reaction necessitate to advance.
- the described ODV synthesis processes are all indirect, i.e; performed via Venlafaxine.
- the present invention provides a direct synthesis of O-desmethylvenlafaxine; i.e.; without passing through venlafaxine as an intermediate.
- the invention encompasses hydroxyphenyl dimethylamide (OBA), having the following formula,
- the present invention provides a process for preparing hydroxyphenyl dimethylamide (OBA) comprising combining hydroxybenzyl carboxy (OBCarboxy), a catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid, and combining it with a dimethylamine to obtain OBA.
- OBA hydroxyphenyl dimethylamide
- the process for preparing OBA is done in the presence of an organic solvent.
- the present invention provides a process for preparing ODV by preparing OBA as described above, and converting it to ODV.
- OBA can be transformed to ODV via another intermediated such as COBA.
- the present invention encompasses hydroxy protected OBA (POBA), having the following formula,
- the present invention encompasses a process for preparing POBA comprising; combining OBA with a hydroxyl protecting agent and a base.
- the present invention provides a process for preparing ODV by preparing POBA as described above, and converting it to ODV.
- POBA can be transformed to ODV via another intermediated such as PCOBA.
- the present invention encompasses cyclohexylOBA (COBA), having the following formula,
- the process for the preparation of cyclohexylOBA comprising: reacting OBA with cyclohexanone and a base able to form a carbanion; and recovering the obtained COBA.
- the present invention provides a process for preparing ODV by preparing COBA as described above, and converting it to ODV, by any method known in the art, i.e: the method described above.
- the present invention encompasses a hydroxyl protected COBA (PCOBA), having the following formula,
- the process for preparing PCOBA comprising; combining POBA with cyclohexanone and a base able to form a carbanion; and recovering the obtained PCOBA.
- the present invention provides a process for preparing ODV by preparing PCOBA as described above and converting it to ODV, by any method known in the art, i.e: the method described above.
- the present invention encompasses a process for preparing ODV from COBA comprising: reacting COBA and a reducing agent to obtain ODV, where optionally, PCOBA can be used as a starting material.
- the present invention encompasses a process for preparing ODV comprising the steps of: combining OBCarboxy, a catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid and combining it with an amine to obtain OBA; reacting the obtained OBA with cyclohexanone and a base able to form a carbanion; recovering the obtained COBA and reacting the obtained COBA; a reducing agent; and recovering the obtained ODV, wherein, optionally, a protected derivative of OBA (POBA) can be used as a starting material and PCOBA is obtained, which is then reacted with the reducing agent to obtain ODV.
- POBA protected derivative of OBA
- ambient temperature refers to a temperature of about 18° C. to about 25° C.
- OAA hydroxyphenyl dimethylamide
- POBA refers to protected hydroxyphenyl dimethylamide (IUPAC name: protected 2-(4-hydroxyphenyl)-N,N-dimethylacetamide) of the following structure:
- x is a hydroxy protecting group
- COBA refers to cyclohexyl hydroxyphenyl dimethylamide (IUPAC name 2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide) of the following structure;
- PCOBA refers to protected cyclohexyl hydroxyphenyl dimethylamide (IUPAC name: protected: 2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide) of the following structure;
- x is a hydroxy protecting group
- ODV O-desmethylvenlafaxine
- the present invention provides a direct synthesis of ODV via novel intermediates. This process produces ODV and its intermediates in high yields and purity.
- ODV is synthesized without going through venlafaxine, leading to elimination of a demethylation step.
- the intermediate OBA is condensed with cyclohexanone to form the intermediate COBA. Further, the carboxylic group of COBA is reduced, and the reduced product is converted to ODV.
- the process can be performed via the protected intermediates POBA and PCOBA, in order to increase the yield, due to avoidance of side-reactions. The process is described in the following scheme.
- the invention encompasses hydroxyphenyl dimethylamide (OBA) (IUPAC name 2-(4-hydroxyphenyl)-N,N-dimethylacetamide).
- OBA hydroxyphenyl dimethylamide
- DMSO-d6 DMSO-d6
- ⁇ 2.80 (s, CH 3 —N), 2.96 (s, CH 3 N), 3.53 (s, CH 2 ), 6.70 (m, H atom), 6.98 (m, H atom), 9.24 (s, OH).
- the present invention provides isolated or purified OBA.
- Isolated refers to being separated from the reaction mixture in which it forms.
- OBA is at least about 50% pure as measured by HPLC.
- OBA is prepared by a process comprising combining hydroxybenzyl carboxy OBCarboxy (IUPAC name: (4-hydroxyphenyl)acetic acid)) catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid, and combining it with an amine to obtain OBA.
- OBCarboxy IUPAC name: (4-hydroxyphenyl)acetic acid
- the catalyst is an organic catalyst.
- the catalyst is dimethyl formamide DMF or Pyridinium p-toluene sulfonate (PPTS).
- PPTS Pyridinium p-toluene sulfonate
- the reaction is done in the presence of a solvent.
- the solvent is an organic solvent that does not react with the acid activating agent. More preferably, the solvent is selected from a group consisting of C 6-12 aromatic hydrocarbon, preferably C 6 to C 8 , a C 1-4 halogenated hydrocarbon, preferably chloroform, dichloromethane, a C 4-8 ether preferably C 4 to C 6 ether, more preferably tetrahydrofuran, diethylether, methyltert-butyl ether and mixtures thereof. Even more preferably, the solvent is selected from a group consisting of toluene, CH 2 Cl 2 and THF. Most preferably, the solvent is CH 2 Cl 2 .
- the reaction with the acid activating agent is exothermic; hence the mixture is cooled prior to combining it with the acid activating agent.
- the mixture is cooled to a temperature of about ⁇ 10° C. to about 10° C., preferably ⁇ 5° C. to about 5° C., more preferably, to a temperature of about 0° C.
- the acid activating agent is added dropwise, preferably during 30 minutes to about 3 hours.
- the acid activating agent is an agent that activates carboxylic acids, i.e., converts the “OH” to a suitable leaving group.
- the activating agent may be SOCl 2 , COCl 2 , DCC (N′-dicyclohexyl carbodiimide) or analogs, HOBT (N-Hydroxybenzotriazole), FMOC (fluorenylmethoxycarbonyl) or analogs (and other analogs used in peptide chemistry) or PC15 or (COCl) 2 .
- the activating agent is SOCl 2 .
- the obtained mixture is heated, preferably to a temperature of about 0° C. to about 30° C., preferably about 15° C. to about 28°. More preferably the heating is to a temperature of about ambient temperature.
- the heated mixture is stirred for a sufficient time to obtain the activated acid, preferably for a period of time of about 0.5 to about 3 hours, preferably for about 1 to about 2.5 hours. More preferably, the stirring is for about 2 hours.
- the activated acid is optionally recovered by any method known in the art. Preferably, it is recovered by removing the solvent and providing a residue comprising of the activated acid.
- One of ordinary skill of art can also devise a one pot process which skips recovery of the intermediate in the synthetic scheme.
- the solvent is removed by evaporation under reduced pressure (pressure of below one atmosphere).
- the residue is optionally dissolved in another organic solvent; wherein the solvent is described above.
- the solution is combined with dimethylamine to provide a mixture.
- the amine salt is dimethylamine-HCl and the second amine is a C 3 -C 9 trialkylamine, where each alkyl chain is independently selected from C 1 -C 7 carbons.
- Example of such amine includes diisopropylethylamine.
- a gaseous amine can also be used.
- the second amine is added dropwise, more preferably, during about 1 hour.
- the mixture is then stirred for a sufficient time to obtain OBA.
- the stirring is done over a period of time of about 1 hour to about 24 hours more preferably about 4 hours to about 16 hours. More preferably, the stirring is performed overnight.
- OBA can be recovered.
- the recovery is preferably done by quenching the new mixture providing a precipitate; washing, filtering, and drying.
- the quenching is done by adding a saturated solution of a base.
- the base is an inorganic base, such as an alkali metal or alkaline earth metal carbonate/bicarbonate.
- the base is NaHCO 3 .
- the precipitate is filtered under a reduced pressure.
- the washing is done with methylene chloride, and the drying, under vacuum (pressure of less than about 100 mmHg).
- the drying is at a temperature of about 20° C. to about 80° C. More preferably, the drying is done at room temperature.
- the process for preparing OBA can further comprise a process for converting OBA to ODV.
- OBA can be transformed to ODV via another intermediated such as COBA.
- the present invention encompasses hydroxy protected OBA (POBA).
- POBA hydroxy protected OBA
- Suitable hydroxy protected groups are listed in T. W. Greene, Protective Groups in Organic Synthesis, (2 nd ed.), which is incorporated herein by reference.
- POBA is a silyl-protected POBA, such as a tri(C 1-6 alkyl)silyl-protected POBA, wherein the alkyl groups can be the same or different, preferably t-butyldimethylsilyl ether (TBDMS)-protected OBA, or trimethylsilyl (TMS), with TBDMS being preferred, or DHP-protected OBA.
- TDMS t-butyldimethylsilyl ether
- TMS trimethylsilyl
- the present invention provides isolated or purified POBA, including TBDMS-OBA.
- Isolated refers to being separated from the reaction mixture in which it forms.
- the POBA is at least about 50% pure as measured by HPLC.
- TBDMS-OBA is characterized by 1 HNMR (Bruker DPX-300 (DMSO-d6)) with ⁇ : 0.20 (s, Me2Si), 0.99 (s, tBuSi), 2.85 (s, CH 3 —N), 2.99 (s, CH 3 N), 3.62 (s, CH 2 ), 6.77 (m, H atom), 7.10 (m, H atom).
- POBA including TBDMS-OBA
- TBDMS-OBA can be prepared by combining OBA with a suitable hydroxyl protecting agent and a base.
- An acid may also be used instead of a base.
- the reaction is done in the presence of a solvent.
- the solvent is an organic solvent.
- the solvent is a non-protic solvent.
- the organic solvent can be a C 6 to C 12 aromatic hydrocarbon or a C 1 -C 6 chlorinated hydrocarbon or C 4-6 ether. More preferably, the solvent is selected from the group consisting of toluene, CH 2 Cl 2 and THF. Most preferably, the solvent is CH 2 Cl 2 .
- the hydroxyl protecting agent is a trialkylsilyl halide, preferably a tri(C 1-6 alkyl)silyl halide, wherein the alkyl may be the same or different, preferably the trialkylsilyl halide is a trimethylsilyl halide or a tert-butyldimethylsilyl halide, wherein the halide is chloride or bromide or DHP (dihydropyran).
- the hydroxyl protecting agent is a silyl protecting group or DHP (dihydropyran). More preferably, the hydroxyl protecting agent is TBDMS-Cl, acetylchloride or acetic anhydride.
- the base is imidazole.
- Other bases such as pyridine, triethylamine, lutidine, dimethylaminopyridine may also be used.
- the obtained combination is stirred at a temperature of about 0° C. to about 100° C., preferably about 40° C. to about 70° C. Preferably, the stirring is done at a temperature of about 55° C.
- the above combination is maintained, while stirring, for about 0.5 hour to about 24 hours, preferably about 1 hour to about 4 hours, more preferably for about two hours, during which POBA is formed.
- the process for preparing POBA can further comprise a recovery process.
- the recovery is, preferably done by quenching the combination providing a two-phase system; separating the obtained two phases, washing and drying the organic phase, followed by filtering and solvent evaporation under reduced pressure (pressure of less than one atmosphere).
- the combination is quenched with brine and 10% aqueous solution of citric acid.
- the process for preparing POBA can further comprise a process for converting POBA to ODV.
- POBA can be converted to ODV via COBA or PCOBA.
- the present invention encompasses cyclohexylOBA (COBA).
- COBA cyclohexylOBA
- isolated or purified COBA refers to being separated from the reaction mixture in which it forms.
- the COBA is at least about 50% pure as measured by HPLC.
- COBA can be prepared by reacting OBA with cyclohexanone and a base able to form a carbanion; and recovering the obtained COBA.
- a protected derivative of OBA can be used as a starting material, to obtain PCOBA.
- the reaction is done in the presence of a solvent.
- the solvent is as described above. More preferably, the solvent is THF.
- OBA or POBA is combined with the solvent to obtain a mixture.
- a base able to form a carbanion is added, providing a new mixture.
- the base is able to form a carbanion. More preferably, the base is LDA; or alkali metal or alkaline earth metal (such as lithium) diisopropylamide; or BuLi.
- the base may also be Sodium hydride (NaH); or alkali metal or alkaline earth metal (such as sodium or potassium or lithium) salts of bis trimethylsilylamide ⁇ MN(SiMe 3 ) 2 ⁇ ; or metal salt of tert-butoxide (MOtBu)
- the reaction of the base with the reagent is exothermic.
- the base is added at a temperature of about 80° C. to about 25° C.
- the addition can be done at ambient temperature, and when the base is BuLi, the addition can be done at a temperature of about ⁇ 80° C.
- the base is added dropwise.
- the dropwise addition is done during a period of time of about 30 minutes.
- the new mixture is then stirred.
- the stirring is for about 10 minutes to about 2 hours. More preferably, the new mixture is stirred for about 30 minutes.
- Cyclohexanone is then added to the mixture.
- cyclohexanone is added dropwise, more preferably, during a period of time of 30 minutes.
- the obtained mixture is maintained, while being stirred, for about 30 minutes to about 24 hours, more preferably, the stirring is done overnight.
- the reaction mixture can then be quenched, by reacting the reaction mixture with a proton donor, such as NH 4 Cl.
- a proton donor such as NH 4 Cl.
- the recovery provides COBA or PCOBA, depending on the starting material.
- the recovery stage includes: separating the layers obtained after quenching, washing the organic layer obtained after quenching with brine, and further evaporating the residual organic solvent under reduced pressure (pressure of less than one atmosphere) to obtain COBA or PCOBA.
- the present invention encompasses a hydroxyl protected cyclohexylOBA (PCOBA).
- PCOBA is TBDMS-protected COBA.
- the process for preparing COBA or PCOBA can further comprise a process for converting COBA or PCOBA to ODV.
- COBA and PCOBA can be converted to ODV by reacting COBA or PCOBA with a reducing agent, and recovering to obtain ODV.
- COBA or PCOBA are combined with a solvent to obtain a solution.
- Solvents that are inert to the reducing agent can be used.
- the solvent is THF.
- a reducing agent is added, preferably, the reducing agent is a metal hydride complex.
- the metal hydride complex is selected from a group consisting of BH 3 derivatives or aluminum hydride derivatives.
- the reducing agent is LiAlH 4 , NaBH 4 , NaBH3CN: sodium cyanoborohydride
- the hydrogenation may be performed under H 2 pressure in presence of catalyst such Ni or Co.
- the reducing agent is added dropwise to avoid heat accumulation.
- the addition can be done during a period of time of about 30 min.
- the addition can preferably be done at a temperature of about ⁇ 50° C. to about RT.
- the temperature is ambient temperature.
- the addition of the reducing agent provides a mixture.
- the mixture is stirred for about 1 hour to about 24 hours. More preferably, the stirring is stirred for over night.
- the recovery of ODV is done by quenching. More preferably the quenching is done by acidification of the mixture. Acidification is done for example by adding aqueous solution of HCl or NH 4 Cl.
- the quenching typically, provides a two-phase system, comprising of an aqueous phase and of an organic phase. The phases are separated, and the aqueous phase is neutralized preferably, by adding a base.
- the neutralization is done by adding a base such as an alkali or alkaline earth metal carbonate/bicarbonate.
- the base is a saturated solution of NaHCO 3 .
- the process for preparing ODV can further comprise a recovery process.
- the recovery can be done by extracting ODV from the aqueous layer, such as by adding a water immiscible organic solvent.
- the water immiscible organic solvent is CH 2 Cl 2 , EtOAc, hexanes or toluene
- the extract may then be dried, filtered and evaporated under reduced pressure (pressure of less than one atmosphere).
- the drying is preferably over Na 2 SO 4 .
- ODV can be synthesized by combining OBCarboxy, a catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid, combining it with an amine to obtain OBA; reacting the obtained OBA with cyclohexanone and a base able to form a carbanion; recovering the obtained COBA; reacting the obtained COBA, and a reducing agent; and recovering the obtained ODV.
- a protected derivative of OBA can be used as a starting material for the process for preparing PCOBA, and wherein, optionally, a protected derivative of COBA (PCOBA) can be used as a starting material for the preparation of ODV.
- POBA protected derivative of OBA
- PCOBA protected derivative of COBA
- OBA (1.45 g, 8.09 mmol) was dissolved at room temperature in DHP (8 ml) under nitrogen.
- Pyridinium p-toluene sulfonate PPTS, catalytic amount
- PPTS Pyridinium p-toluene sulfonate
- the reaction was monitored by HPLC.
- EtOAc was added and the organic layer was washed with brine, dried over MgSO 4 and filtered under reduced pressure to get OBA-DHP.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Abstract
Provided are processes and intermediates for the synthesis of O-desmethylvenlafaxine.
Description
- The present application claims the benefit of the following U.S. Provisional Patent Application Nos. 60/833,616, filed Jul. 26, 2006; 60/837,879, filed Aug. 14, 2006; 60/849,216, filed Oct. 3, 2006; 60/843,998, filed Sep. 11, 2006; 60/849,255, filed Oct. 3, 2006; 60/906,639, filed Mar. 12, 2007; and 60/906,879, filed Mar. 13, 2007. The contents of these applications are incorporated herein by reference.
- The invention encompasses a process for the synthesis of O-desmethylvenlafaxine.
- Venlafaxine, (±)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol, of the following formula,
- is the first of a class of anti-depressants. Venlafaxine acts by inhibiting re-uptake of norepinephrine and serotonin, and is an alternative to the tricyclic anti-depressants and selective re-uptake inhibitors.
- O-desmethylvenlafaxine, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, of the following formula,
- is reported to be a metabolite of venlafaxine, which is known also as an inhibitor of norepiniphrine and serotonin uptake, See Klamerus, K. J. et al., “Introduction of the Composite Parameter to the Pharmacokinetics of Venlafaxine and its Active O-Desmethyl Metabolite,” and J. Clin. Pharmacol. 32:716-724 (1992).
- Processes for the synthesis of O-desmethylvenlafaxine by demethylation of the methoxy group of venlafaxine are described in U.S. Pat. Nos. 7,026,508 and in 6,689,912.
- The synthesis disclosed in the above patents is performed according to the following scheme:
- wherein “MBC” refers to methyl benzyl cyanide, “CMBC” refers to cyclohexyl methylbenzyl cyanide, “DDMV” refers to didesmethyl venlafaxine, and “ODV” refers to O-desmethylvenlafaxine.
- The demethylation process disclosed in U.S. Pat. No. 7,026,508 provides ODV succinate salt by using L-selectride, which is an alkali metal salt of trialkyl borohydride; where hydrogen gas is formed during the reaction. Hence, the process isn't suitable for industrial scale manufacture.
- US application No. 2005/0197392 describes a method for preparing (±)O-desmethylvenlafaxine hydrochloride salt by reacting venlafaxine with lithium diphenyl phosphide.
- U.S. Pat. No. 6,689,912 describes demethylation process performed by using a salt of high molecular weight alkane, arene, or arylalkyl thiolate anion in the presence of protic or aprotic solvent. The salt can be prepared separately and then react with venlafaxine, or can react in-situ with venlafaxine. When prepared separately, the solvent, methanol should be removed. This operation is very complicated because the mixture containing the salt is highly viscous, hence the operation necessitate long time even under high vacuum. When the reaction is performed in-situ via removal of methanol in situ, this operation is still tedious and only partially successful, since it is difficult to reach the high temperature that the reaction necessitate to advance.
- The described ODV synthesis processes are all indirect, i.e; performed via Venlafaxine. The present invention provides a direct synthesis of O-desmethylvenlafaxine; i.e.; without passing through venlafaxine as an intermediate.
- In one embodiment, the invention encompasses hydroxyphenyl dimethylamide (OBA), having the following formula,
- In another embodiment, the present invention provides a process for preparing hydroxyphenyl dimethylamide (OBA) comprising combining hydroxybenzyl carboxy (OBCarboxy), a catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid, and combining it with a dimethylamine to obtain OBA.
- Preferably, the process for preparing OBA is done in the presence of an organic solvent.
- In yet another embodiment, the present invention provides a process for preparing ODV by preparing OBA as described above, and converting it to ODV. OBA can be transformed to ODV via another intermediated such as COBA.
- In yet another embodiment, the present invention encompasses hydroxy protected OBA (POBA), having the following formula,
- In another embodiment, the present invention encompasses a process for preparing POBA comprising; combining OBA with a hydroxyl protecting agent and a base.
- In yet another embodiment, the present invention provides a process for preparing ODV by preparing POBA as described above, and converting it to ODV. POBA can be transformed to ODV via another intermediated such as PCOBA.
- In yet another embodiment, the present invention encompasses cyclohexylOBA (COBA), having the following formula,
- In one embodiment the process for the preparation of cyclohexylOBA (COBA) comprising: reacting OBA with cyclohexanone and a base able to form a carbanion; and recovering the obtained COBA.
- In yet another embodiment, the present invention provides a process for preparing ODV by preparing COBA as described above, and converting it to ODV, by any method known in the art, i.e: the method described above.
- In yet another embodiment, the present invention encompasses a hydroxyl protected COBA (PCOBA), having the following formula,
- In another embodiment the process for preparing PCOBA comprising; combining POBA with cyclohexanone and a base able to form a carbanion; and recovering the obtained PCOBA.
- In yet another embodiment, the present invention provides a process for preparing ODV by preparing PCOBA as described above and converting it to ODV, by any method known in the art, i.e: the method described above.
- In another embodiment, the present invention encompasses a process for preparing ODV from COBA comprising: reacting COBA and a reducing agent to obtain ODV, where optionally, PCOBA can be used as a starting material.
- In another embodiment, the present invention encompasses a process for preparing ODV comprising the steps of: combining OBCarboxy, a catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid and combining it with an amine to obtain OBA; reacting the obtained OBA with cyclohexanone and a base able to form a carbanion; recovering the obtained COBA and reacting the obtained COBA; a reducing agent; and recovering the obtained ODV, wherein, optionally, a protected derivative of OBA (POBA) can be used as a starting material and PCOBA is obtained, which is then reacted with the reducing agent to obtain ODV.
- As used herein, the term “ambient temperature” refers to a temperature of about 18° C. to about 25° C.
- As used herein, the term “OBA” refers to hydroxyphenyl dimethylamide (IUPAC name 2-(4-hydroxyphenyl)-N,N-dimethylacetamide) of the following structure:
- As used herein, the term “POBA” refers to protected hydroxyphenyl dimethylamide (IUPAC name: protected 2-(4-hydroxyphenyl)-N,N-dimethylacetamide) of the following structure:
- wherein x is a hydroxy protecting group.
- As used herein, the term “COBA” refers to cyclohexyl hydroxyphenyl dimethylamide (IUPAC name 2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide) of the following structure;
- As used herein, the term “PCOBA” refers to protected cyclohexyl hydroxyphenyl dimethylamide (IUPAC name: protected: 2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide) of the following structure;
- wherein x is a hydroxy protecting group.
- As used herein, the term “ODV” refers to O-desmethylvenlafaxine.
- The present invention provides a direct synthesis of ODV via novel intermediates. This process produces ODV and its intermediates in high yields and purity. In the process of the present invention ODV is synthesized without going through venlafaxine, leading to elimination of a demethylation step.
- In the process of the invention, the intermediate OBA is condensed with cyclohexanone to form the intermediate COBA. Further, the carboxylic group of COBA is reduced, and the reduced product is converted to ODV. The process can be performed via the protected intermediates POBA and PCOBA, in order to increase the yield, due to avoidance of side-reactions. The process is described in the following scheme.
- In one embodiment, the invention encompasses hydroxyphenyl dimethylamide (OBA) (IUPAC name 2-(4-hydroxyphenyl)-N,N-dimethylacetamide). OBA is characterized by 1HNMR (Bruker DPX-300 (DMSO-d6)) with δ: 2.80 (s, CH3—N), 2.96 (s, CH3N), 3.53 (s, CH2), 6.70 (m, H atom), 6.98 (m, H atom), 9.24 (s, OH). OBA has a mass of 180 (MS (CI+)=180).
- In one embodiment the present invention provides isolated or purified OBA. Isolated refers to being separated from the reaction mixture in which it forms. Preferably the OBA is at least about 50% pure as measured by HPLC.
- OBA is prepared by a process comprising combining hydroxybenzyl carboxy OBCarboxy (IUPAC name: (4-hydroxyphenyl)acetic acid)) catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid, and combining it with an amine to obtain OBA.
- Preferably, the catalyst is an organic catalyst. Most preferably, the catalyst is dimethyl formamide DMF or Pyridinium p-toluene sulfonate (PPTS). Typically, the reaction is done in the presence of a solvent. The solvent is an organic solvent that does not react with the acid activating agent. More preferably, the solvent is selected from a group consisting of C6-12 aromatic hydrocarbon, preferably C6 to C8, a C1-4 halogenated hydrocarbon, preferably chloroform, dichloromethane, a C4-8 ether preferably C4 to C6 ether, more preferably tetrahydrofuran, diethylether, methyltert-butyl ether and mixtures thereof. Even more preferably, the solvent is selected from a group consisting of toluene, CH2Cl2 and THF. Most preferably, the solvent is CH2Cl2.
- Usually, the reaction with the acid activating agent is exothermic; hence the mixture is cooled prior to combining it with the acid activating agent. Preferably, the mixture is cooled to a temperature of about −10° C. to about 10° C., preferably −5° C. to about 5° C., more preferably, to a temperature of about 0° C.
- In order to decrease the exothermic effect of the reaction, the acid activating agent is added dropwise, preferably during 30 minutes to about 3 hours. Preferably, the acid activating agent is an agent that activates carboxylic acids, i.e., converts the “OH” to a suitable leaving group. The activating agent may be SOCl2, COCl2, DCC (N′-dicyclohexyl carbodiimide) or analogs, HOBT (N-Hydroxybenzotriazole), FMOC (fluorenylmethoxycarbonyl) or analogs (and other analogs used in peptide chemistry) or PC15 or (COCl)2. Most preferably, the activating agent is SOCl2.
- Following to the addition of the activating agent, the obtained mixture is heated, preferably to a temperature of about 0° C. to about 30° C., preferably about 15° C. to about 28°. More preferably the heating is to a temperature of about ambient temperature.
- The heated mixture is stirred for a sufficient time to obtain the activated acid, preferably for a period of time of about 0.5 to about 3 hours, preferably for about 1 to about 2.5 hours. More preferably, the stirring is for about 2 hours.
- The activated acid is optionally recovered by any method known in the art. Preferably, it is recovered by removing the solvent and providing a residue comprising of the activated acid. One of ordinary skill of art can also devise a one pot process which skips recovery of the intermediate in the synthetic scheme.
- Preferably the solvent is removed by evaporation under reduced pressure (pressure of below one atmosphere).
- Then, the residue is optionally dissolved in another organic solvent; wherein the solvent is described above. Subsequently, the solution is combined with dimethylamine to provide a mixture. This reaction is more facile if a dimethylamine salt is used, and then the salt is removed with another amine. Preferably the amine salt is dimethylamine-HCl and the second amine is a C3-C9 trialkylamine, where each alkyl chain is independently selected from C1-C7 carbons. Example of such amine includes diisopropylethylamine. A gaseous amine can also be used. Preferably, the second amine is added dropwise, more preferably, during about 1 hour.
- The mixture is then stirred for a sufficient time to obtain OBA. Preferably, the stirring is done over a period of time of about 1 hour to about 24 hours more preferably about 4 hours to about 16 hours. More preferably, the stirring is performed overnight.
- OBA can be recovered. The recovery is preferably done by quenching the new mixture providing a precipitate; washing, filtering, and drying. Preferably, the quenching is done by adding a saturated solution of a base. More preferably, the base is an inorganic base, such as an alkali metal or alkaline earth metal carbonate/bicarbonate. Most preferably, the base is NaHCO3.
- Preferably, the precipitate is filtered under a reduced pressure. Preferably, the washing is done with methylene chloride, and the drying, under vacuum (pressure of less than about 100 mmHg). Preferably, the drying is at a temperature of about 20° C. to about 80° C. More preferably, the drying is done at room temperature.
- The process for preparing OBA can further comprise a process for converting OBA to ODV. OBA can be transformed to ODV via another intermediated such as COBA.
- In another embodiment, the present invention encompasses hydroxy protected OBA (POBA). Suitable hydroxy protected groups are listed in T. W. Greene, Protective Groups in Organic Synthesis, (2nd ed.), which is incorporated herein by reference. Most preferably, POBA is a silyl-protected POBA, such as a tri(C1-6 alkyl)silyl-protected POBA, wherein the alkyl groups can be the same or different, preferably t-butyldimethylsilyl ether (TBDMS)-protected OBA, or trimethylsilyl (TMS), with TBDMS being preferred, or DHP-protected OBA.
- In one embodiment the present invention provides isolated or purified POBA, including TBDMS-OBA. Isolated refers to being separated from the reaction mixture in which it forms. Preferably the POBA is at least about 50% pure as measured by HPLC.
- TBDMS-OBA is characterized by 1HNMR (Bruker DPX-300 (DMSO-d6)) with δ: 0.20 (s, Me2Si), 0.99 (s, tBuSi), 2.85 (s, CH3—N), 2.99 (s, CH3N), 3.62 (s, CH2), 6.77 (m, H atom), 7.10 (m, H atom).
- POBA, including TBDMS-OBA, can be prepared by combining OBA with a suitable hydroxyl protecting agent and a base. An acid may also be used instead of a base.
- Usually, the reaction is done in the presence of a solvent. Preferably, the solvent is an organic solvent. Preferably the solvent is a non-protic solvent. The organic solvent can be a C6 to C12 aromatic hydrocarbon or a C1-C6 chlorinated hydrocarbon or C4-6 ether. More preferably, the solvent is selected from the group consisting of toluene, CH2Cl2 and THF. Most preferably, the solvent is CH2Cl2.
- Preferably, the hydroxyl protecting agent is a trialkylsilyl halide, preferably a tri(C1-6 alkyl)silyl halide, wherein the alkyl may be the same or different, preferably the trialkylsilyl halide is a trimethylsilyl halide or a tert-butyldimethylsilyl halide, wherein the halide is chloride or bromide or DHP (dihydropyran). Preferably, the hydroxyl protecting agent is a silyl protecting group or DHP (dihydropyran). More preferably, the hydroxyl protecting agent is TBDMS-Cl, acetylchloride or acetic anhydride.
- Preferably, the base is imidazole. Other bases such as pyridine, triethylamine, lutidine, dimethylaminopyridine may also be used.
- The obtained combination is stirred at a temperature of about 0° C. to about 100° C., preferably about 40° C. to about 70° C. Preferably, the stirring is done at a temperature of about 55° C.
- Preferably the above combination is maintained, while stirring, for about 0.5 hour to about 24 hours, preferably about 1 hour to about 4 hours, more preferably for about two hours, during which POBA is formed.
- The process for preparing POBA can further comprise a recovery process. The recovery is, preferably done by quenching the combination providing a two-phase system; separating the obtained two phases, washing and drying the organic phase, followed by filtering and solvent evaporation under reduced pressure (pressure of less than one atmosphere). Preferably, the combination is quenched with brine and 10% aqueous solution of citric acid.
- The process for preparing POBA can further comprise a process for converting POBA to ODV. POBA can be converted to ODV via COBA or PCOBA.
- In another embodiment, the present invention encompasses cyclohexylOBA (COBA). Also provided is isolated or purified COBA. Isolated refers to being separated from the reaction mixture in which it forms. Preferably the COBA is at least about 50% pure as measured by HPLC.
- COBA can be prepared by reacting OBA with cyclohexanone and a base able to form a carbanion; and recovering the obtained COBA. Optionally, a protected derivative of OBA can be used as a starting material, to obtain PCOBA.
- Usually, the reaction is done in the presence of a solvent. Preferably, the solvent is as described above. More preferably, the solvent is THF.
- Initially, OBA or POBA is combined with the solvent to obtain a mixture. Then a base able to form a carbanion is added, providing a new mixture.
- Preferably, the base is able to form a carbanion. More preferably, the base is LDA; or alkali metal or alkaline earth metal (such as lithium) diisopropylamide; or BuLi. The base may also be Sodium hydride (NaH); or alkali metal or alkaline earth metal (such as sodium or potassium or lithium) salts of bis trimethylsilylamide {MN(SiMe3)2}; or metal salt of tert-butoxide (MOtBu)
- The reaction of the base with the reagent is exothermic. Preferably, the base is added at a temperature of about 80° C. to about 25° C. For example, when the base is LDA, the addition can be done at ambient temperature, and when the base is BuLi, the addition can be done at a temperature of about −80° C.
- Usually, the base is added dropwise. Preferably, the dropwise addition is done during a period of time of about 30 minutes. The new mixture is then stirred. Preferably, the stirring is for about 10 minutes to about 2 hours. More preferably, the new mixture is stirred for about 30 minutes.
- Cyclohexanone is then added to the mixture. Preferably cyclohexanone is added dropwise, more preferably, during a period of time of 30 minutes.
- Preferably, the obtained mixture is maintained, while being stirred, for about 30 minutes to about 24 hours, more preferably, the stirring is done overnight.
- The reaction mixture can then be quenched, by reacting the reaction mixture with a proton donor, such as NH4Cl. The recovery provides COBA or PCOBA, depending on the starting material.
- PCOBA and COBA can then be recovered. Preferably, the recovery stage includes: separating the layers obtained after quenching, washing the organic layer obtained after quenching with brine, and further evaporating the residual organic solvent under reduced pressure (pressure of less than one atmosphere) to obtain COBA or PCOBA.
- In another embodiment, the present invention encompasses a hydroxyl protected cyclohexylOBA (PCOBA). Preferably, PCOBA is TBDMS-protected COBA.
- The process for preparing COBA or PCOBA can further comprise a process for converting COBA or PCOBA to ODV. COBA and PCOBA can be converted to ODV by reacting COBA or PCOBA with a reducing agent, and recovering to obtain ODV.
- Usually, COBA or PCOBA are combined with a solvent to obtain a solution. Solvents that are inert to the reducing agent can be used. Preferably the solvent is THF. Subsequently, a reducing agent is added, preferably, the reducing agent is a metal hydride complex. More preferably, the metal hydride complex is selected from a group consisting of BH3 derivatives or aluminum hydride derivatives. Most preferably, the reducing agent is LiAlH4, NaBH4, NaBH3CN: sodium cyanoborohydride Instead of using metal hydride complex, the hydrogenation may be performed under H2 pressure in presence of catalyst such Ni or Co.
- Usually, the reducing agent is added dropwise to avoid heat accumulation. The addition can be done during a period of time of about 30 min. The addition can preferably be done at a temperature of about −50° C. to about RT. Preferably, the temperature is ambient temperature.
- The addition of the reducing agent provides a mixture. Preferably, the mixture is stirred for about 1 hour to about 24 hours. More preferably, the stirring is stirred for over night.
- Preferably, the recovery of ODV is done by quenching. More preferably the quenching is done by acidification of the mixture. Acidification is done for example by adding aqueous solution of HCl or NH4Cl. The quenching, typically, provides a two-phase system, comprising of an aqueous phase and of an organic phase. The phases are separated, and the aqueous phase is neutralized preferably, by adding a base. The neutralization is done by adding a base such as an alkali or alkaline earth metal carbonate/bicarbonate. Preferably, the base is a saturated solution of NaHCO3.
- The process for preparing ODV can further comprise a recovery process. The recovery can be done by extracting ODV from the aqueous layer, such as by adding a water immiscible organic solvent. Preferably, the water immiscible organic solvent is CH2Cl2, EtOAc, hexanes or toluene
- The extract may then be dried, filtered and evaporated under reduced pressure (pressure of less than one atmosphere). The drying is preferably over Na2SO4.
- One of ordinary skill of art would appreciate that each above described process can be combined into one continuous process for synthesis of ODV. In such process ODV can be synthesized by combining OBCarboxy, a catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid, combining it with an amine to obtain OBA; reacting the obtained OBA with cyclohexanone and a base able to form a carbanion; recovering the obtained COBA; reacting the obtained COBA, and a reducing agent; and recovering the obtained ODV. Optionally, a protected derivative of OBA (POBA) can be used as a starting material for the process for preparing PCOBA, and wherein, optionally, a protected derivative of COBA (PCOBA) can be used as a starting material for the preparation of ODV.
- Having described the invention with reference to certain preferred embodiments, other embodiments will become apparent to one skilled in the art from consideration of the specification. The invention is further defined by reference to the following examples describing in detail the synthesis of the compound OBA, COBA, their protected forms and further their conversion to O-desmethylvenlafaxine. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the scope of the invention.
- A 500 ml three-neck flask equipped with nitrogen inlet, thermometer and mechanical stirrer was charged with OBcarboxy (10 g, 65.72 mmol), DMF (1 ml) and CH2Cl2 (50 ml). The reaction mixture was stirred at 0° C. and SOCl2 was added dropwise.
- The reaction was stirred at ambient temperature for 2 hours and then the solvent was evaporated under reduced pressure. The residue was dissolved in CH2Cl2 (50 ml) and dimethylamine-HCl (100 g, 1.22 mol) was added. Then diisopropylethylamine (150 ml, 0.882 mol) was added dropwise. The mixture was stirred at ambient temperature overnight and then washed with a saturated solution of NaHCO3; a precipitate appeared. The precipitate was filtered under reduced pressure and washed with methylene chloride. The solid so-obtained was dried in a vacuum oven at room temperature to get 5.55 g of OBA (purity 99.45%).
- The organic layer was washed with brine and evaporated to dryness yielding crystals 5.84 g OBA (purity 96.57%). Total yield=97.85%.
- A 100 ml three-neck flask equipped with nitrogen inlet, thermometer and mechanical stirrer was charged with OBA (2.4 g, 13.39 mmol) TBDMS-Cl (4.5 g, 29.9 mmol), imidazole (5.5 g, 80.78 mmol) and CH2Cl2 (20 ml). The reaction mixture was stirred at ambient temperature for 2 hours. The reaction was quenched with brine and a 10% aqueous solution of citric acid The organic phase was then washed with brine and dried over Na2SO4. After filtration the solvent was evaporated under reduced pressure to get 3.82 g OBA-P (purity: 99.34%, yield: 97.45%).
- In a 50 ml flask equipped with a mechanical stirrer, OBA (1.45 g, 8.09 mmol) was dissolved at room temperature in DHP (8 ml) under nitrogen. Pyridinium p-toluene sulfonate (PPTS, catalytic amount) was added and the reaction mixture was heated to 55° C. for 5 hours. The reaction was monitored by HPLC. EtOAc was added and the organic layer was washed with brine, dried over MgSO4 and filtered under reduced pressure to get OBA-DHP.
- A 100 ml three-neck flask equipped with nitrogen inlet, thermometer and mechanical stirrer was charged with OBA-TBDMS (3.8 g 12.95 mmol) and THF (50 ml). The solution was cooled to −80° C. and n-BuLi (1M in Hexane 8.5 ml 13.6 mmol) was added dropwise. The reaction was stirred at −80° C. for 45 min and cyclohexanone (1.7 g, 17.32 mmol) was added dropwise. This mixture was stirred for 3 hours at this temperature and poured into a saturated solution of NH4Cl. The layers were separated.
- The organic layer was washed with brine and dried over Na2SO4. After filtration the solvent was evaporated under reduced pressure to get 4.85 g of COBA-P (purity: 79.63%, yield: 95.65%)
- A 100 ml three-neck flask equipped with nitrogen inlet, thermometer and mechanical stirrer was charged with OBA (1.2 g, 6.69 mmol) and THF (10 ml). The mixture was stirred at ambient temperature and LDA (2M in THF 7 ml, 14.02 mmol) was added dropwise. The mixture was stirred at this temperature for 30 min and cyclohexanone (1.4 g, 14.26 mmol) was added dropwise. This mixture was stirred overnight at ambient temperature and then poured into a NH4Cl aqueous saturated solution. The layers were separated and the organic phase was washed with brine dried over Na2SO4 and evaporated under reduced pressure to get COBA.
- A 100 ml three-neck flask equipped with nitrogen inlet, thermometer and mechanical stirrer was charged with PCOBA-TBDMS (2.2 g, 5.6 mmol) and THF (30 ml). This solution was stirred at ambient temperature and LiAlH4 (1M in THF10 ml, 10 mmol) was added dropwise. The mixture was stirred at ambient temperature overnight. This mixture was then acidified with a 10% aqueous solution of HCl. The layers were separated and the aqueous phase was basified with a NaHCO3 saturated solution. The aqueous layer was extracted with CH2Cl2, dried over Na2SO4, filtered and evaporated under reduced pressure to get 0.43 g of ODV (purity=100%).
- A 100 ml three-neck flask equipped with nitrogen inlet, thermometer and mechanical stirrer is charged with COBA-TBDMS (2.2 g, 5.6 mmol) and THF (30 ml). This solution is stirred at ambient temperature and LiAlH4 (1M in THF10 ml, 10 mmol) is added dropwise. The mixture is stirred at ambient temperature overnight. This mixture is then acidified with a 10% aqueous solution of HCl. The layers are separated and the aqueous phase is basified with a NaHCO3 saturated solution. The aqueous layer is extracted with CH2Cl2, dried over Na2SO4, filtered and evaporated under reduced pressure to obtain ODV.
Claims (39)
2-3. (canceled)
4. A process for preparing the 2-(4-hydroxyphenyl)-N,N-dimethylacetamide of claim 1 comprising forming an acid-activated derivative of 4-hydroxyphenylacetic acid (4-hydroxyphenyl)acetic acid), and reacting the activated acid with dimethylamine.
5. A process according to claim 4 wherein the acid-activated derivative of 4-hydroxyphenylacetic acid is prepared by combining 4-hydroxyphenylacetic acid with an acid activating agent and a catalyst, and optionally recovering the activated acid.
6. A process according to claim 4 wherein the activated acid is combined with an amine to obtain OBA, and optionally recovering the OBA.
7. The process of claim 5 , wherein the catalyst is an organic catalyst.
8. The process of claim 5 , wherein the catalyst is dimethyl formamide (DMF) or Pyridinium p-toluene sulfonate (PPTS).
9. The process of claim 4 , wherein the acid is activated in the presence of a solvent.
10. The process of claim 9 , wherein the solvent is selected from a group consisting of C6-12 aromatic hydrocarbon, a C1-4 halogenated hydrocarbon, a C4-8 ether and mixtures thereof.
11. The process of claim 9 , wherein the solvent is selected from a group consisting of toluene, CH2Cl2 and THF.
12. The process of claim 9 , wherein the solvent is CH2Cl2.
13. The process of claim 9 , wherein the solvent is cooled to a temperature of about −40° C. to about 70° C.
14. The process of claim 13 , wherein the solvent is cooled to a temperature of about −10° C. to about 10° C.
15. The process of claim 5 , wherein the activating agent is SOCl2, CoCl2, DCC(N′-dicyclohexyl carbodiimide) or analogs, HOBT or analogs, or FMOC or analogs.
16. The process of claim 15 , wherein the activating agent is SOCl2.
17. The process of claim 5 , wherein the activated acid is recovered by removing the solvent.
18. The process of claim 5 , wherein the dimethylamine is a salt, and subsequent to its reaction with the activated acid, a second amine is added.
19. The process of claim 18 , wherein the amine salt is dimethylamine HCl.
20. The process of claim 19 , wherein the second amine is a C3-C9 tertiary amine.
21. The process of claim 20 , wherein the second amine is diisopropylamine.
22. The process of claim 17 , wherein recovery is done by quenching; washing, filtering, and drying.
23. The process of claim 5 , further comprising converting OBA to O-desmethylvenlafaxine or a salt thereof.
25-30. (canceled)
31. A process for preparing compound of claim 24 comprising combining OBA with a suitable hydroxyl protecting agent and optionally a base.
32-39. (canceled)
41. (canceled)
42. A process for preparing the compound of claim 40 comprising reacting OBA with cyclohexanone and a base able to form a carbanion and recovering the obtained COBA.
45-53. (canceled)
55. (canceled)
56. A process for preparing the hydroxyl protected 2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide of claim 54 comprising reacting a hydroxy protected OBA (POBA) with cyclohexanone and a base able to form a carbanion and recovering the obtained PCOBA.
57. A process for preparing ODV (O-desmethylvenlafaxine) comprising converting the COBA of claim 40 or the PCOBA of claim 54 to ODV or a salt thereof.
58-66. (canceled)
67. A process for preparing ODV (O-desmethylvenlafaxine) or salts thereof comprising the steps of: combining OBCarboxy, a catalyst and an acid activating agent to obtain an activated acid; recovering the activated acid, combining it with dimethylamine or a salt thereof and an amine to obtain OBA; reacting the obtained OBA with cyclohexanone and a base able to form a carbanion; recovering the obtained COBA; reacting the obtained COBA, and a reducing agent; and recovering the obtained ODV or a salt thereof.
68. (canceled)
69. A process for preparing ODV (O-desmethylvenlafaxine) or salts thereof comprising the steps of:
(i) preparing OBA from 4-hydroxyphenylacetic acid by a process according to claim 4 ;
(ii) optionally preparing POBA from OBA by a process according to claim 31 ;
(iii) preparing COBA from OBA by a process according to claim 42 ;
(iv) optionally preparing PCOBA from POBA according to claim 56 ;
(v) converting the COBA or PCOBA to ODV by a process according to claim 57 .
70-71. (canceled)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/881,826 US20080183016A1 (en) | 2006-07-26 | 2007-07-26 | Process for the synthesis of O-desmethylvenlafaxine |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83361606P | 2006-07-26 | 2006-07-26 | |
US83787906P | 2006-08-14 | 2006-08-14 | |
US84399806P | 2006-09-11 | 2006-09-11 | |
US84925506P | 2006-10-03 | 2006-10-03 | |
US84921606P | 2006-10-03 | 2006-10-03 | |
US90663907P | 2007-03-12 | 2007-03-12 | |
US90687907P | 2007-03-13 | 2007-03-13 | |
US11/881,826 US20080183016A1 (en) | 2006-07-26 | 2007-07-26 | Process for the synthesis of O-desmethylvenlafaxine |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080183016A1 true US20080183016A1 (en) | 2008-07-31 |
Family
ID=38924359
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/881,731 Expired - Fee Related US7605290B2 (en) | 2006-07-26 | 2007-07-26 | Processes for the synthesis of O-desmethylvenlafaxine |
US11/881,825 Abandoned US20080177110A1 (en) | 2006-07-26 | 2007-07-26 | Processes for the synthesis of O-desmethylvenlafaxine |
US11/881,799 Abandoned US20090062572A1 (en) | 2006-07-26 | 2007-07-26 | Processes for the synthesis of O-desmethylvenlafaxine |
US11/881,826 Abandoned US20080183016A1 (en) | 2006-07-26 | 2007-07-26 | Process for the synthesis of O-desmethylvenlafaxine |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/881,731 Expired - Fee Related US7605290B2 (en) | 2006-07-26 | 2007-07-26 | Processes for the synthesis of O-desmethylvenlafaxine |
US11/881,825 Abandoned US20080177110A1 (en) | 2006-07-26 | 2007-07-26 | Processes for the synthesis of O-desmethylvenlafaxine |
US11/881,799 Abandoned US20090062572A1 (en) | 2006-07-26 | 2007-07-26 | Processes for the synthesis of O-desmethylvenlafaxine |
Country Status (7)
Country | Link |
---|---|
US (4) | US7605290B2 (en) |
EP (4) | EP1934168A2 (en) |
JP (3) | JP2008546850A (en) |
KR (3) | KR101019455B1 (en) |
CA (1) | CA2656161A1 (en) |
IL (1) | IL196403A0 (en) |
WO (1) | WO2008013990A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100076086A1 (en) * | 2007-01-31 | 2010-03-25 | Merck Development Centre Private Limited Plot 1 A/2 | Process for the preparation of o-desmethyl venlafaxine |
CN101781221A (en) * | 2010-02-11 | 2010-07-21 | 上海凯米侬医药科技有限公司 | Preparation method of O-desmethylvenlafaxine |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007016179A (en) * | 2006-04-17 | 2008-03-11 | Teva Pharma | Polymorphic forms of tegaserod maleate. |
EP1934168A2 (en) * | 2006-07-26 | 2008-06-25 | Teva Pharmaceutical Industries Ltd | Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine |
US20080221356A1 (en) * | 2006-07-26 | 2008-09-11 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
US20090137846A1 (en) * | 2006-07-26 | 2009-05-28 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-Desmethylvenlafaxine |
US20090069601A1 (en) * | 2006-07-26 | 2009-03-12 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
EP2061750A2 (en) * | 2006-08-04 | 2009-05-27 | Medichem, S.A. | Improved process for synthesizing desvenlafaxine free base and salts or solvates thereof |
WO2010008735A2 (en) * | 2008-06-16 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Solid states of o-desmethylvenlaf axine salts |
EP2539313A2 (en) * | 2010-03-29 | 2013-01-02 | Pliva Hrvatska D.O.O. | Crystal forms of o-desmethylvenlafaxine fumarate |
JP5858581B2 (en) * | 2012-09-27 | 2016-02-10 | 国立大学法人 東京大学 | Method for producing indole 3-carboxylic acids |
CN108499614B (en) * | 2018-04-28 | 2021-06-04 | 西南医科大学附属医院 | Method for preparing drug intermediate for central nervous system from modified nickel catalytic material |
Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4283418A (en) * | 1979-03-01 | 1981-08-11 | Ono Pharmaceutical Co., Ltd. | Guanidinobenzoic acid derivatives and process for their preparation |
US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
US6197828B1 (en) * | 1998-12-01 | 2001-03-06 | Sepracor, Inc. | Derivatives of (+)-venlafaxine and methods of preparing and using the same |
US20020022662A1 (en) * | 1999-06-15 | 2002-02-21 | American Home Products Corporation | Enantiomers of O-desmethyl venlafaxine |
US6350912B1 (en) * | 2001-02-28 | 2002-02-26 | Council Of Scientific And Industrial Research | One pot process for the preparation of 1-[2-dimethylamino-(4-methoxyphenyl)-ethyl]cyclohexanol |
US20020120164A1 (en) * | 2001-02-28 | 2002-08-29 | Council Of Scientific And Industrial Research | Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol |
US6673838B2 (en) * | 2001-02-12 | 2004-01-06 | Wyeth | Succinate salt of O-desmethyl-venlafaxine |
US6689912B2 (en) * | 2001-12-04 | 2004-02-10 | Wyeth | Methods for preparing O-desmethylvenlafaxine |
US20040106818A1 (en) * | 2002-11-29 | 2004-06-03 | Lan Zhiyin | Process for the preparation of cyclohexanol derivatives |
US20040181093A1 (en) * | 2003-03-11 | 2004-09-16 | Wyeth | Process for preparation of phenethylamine derivatives |
US20050009870A1 (en) * | 2003-07-11 | 2005-01-13 | Sher Philip M. | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
US20050197392A1 (en) * | 1999-04-06 | 2005-09-08 | Sepracor Inc. | O-desmethylvenlafaxine and methods of preparing and using the same |
US7026513B2 (en) * | 2002-03-26 | 2006-04-11 | Nicholas Piramal India Limited | Manufacture of phenyl ethylamine compounds, in particular venlafaxine |
US20070135449A1 (en) * | 2005-12-05 | 2007-06-14 | Wyeth | Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols |
US20080221356A1 (en) * | 2006-07-26 | 2008-09-11 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
US20090069601A1 (en) * | 2006-07-26 | 2009-03-12 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
US20090137846A1 (en) * | 2006-07-26 | 2009-05-28 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-Desmethylvenlafaxine |
US7605290B2 (en) * | 2006-07-26 | 2009-10-20 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of O-desmethylvenlafaxine |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3494954A (en) * | 1967-06-19 | 1970-02-10 | Cutter Lab | 3,3-bis(phenyl)-2-(4-hydroxyphenyl)acrylonitriles |
JPS5331642A (en) * | 1976-09-02 | 1978-03-25 | Sumitomo Chem Co Ltd | Preparation of benzyl cyanides |
JPS55115863A (en) * | 1979-03-01 | 1980-09-06 | Ono Pharmaceut Co Ltd | Guanidinobenzoic acid derivative and its preparation |
IE56324B1 (en) | 1982-12-13 | 1991-06-19 | American Home Prod | Phenethylamine derivatives and intermediates therefor |
ZA839073B (en) * | 1982-12-13 | 1984-09-26 | American Home Prod | Phenethylamine derivatives and intermediates therefor |
JP4201916B2 (en) * | 1999-05-10 | 2008-12-24 | 日本化学工業株式会社 | Optically active 1,2-bis (dialkylphosphino) benzene derivative, process for producing the same, and rhodium metal complex having the compound as a ligand |
CN1240206A (en) * | 1999-06-17 | 2000-01-05 | 华东理工大学 | Process for preparing 1[2-(dimethyamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloridumi |
DE10065442A1 (en) | 2000-12-27 | 2002-07-04 | Bayer Ag | Improved process for the preparation of 2- (4-trifluoromethoxyphenyl) ethylamine and 4-bromomethyl and 4-chloromethyl-1-trifluoromethoxy-benzene |
KR20030000217A (en) * | 2001-06-22 | 2003-01-06 | 와이어쓰 | Process for the preparation of cyclohexanol derivatives |
WO2005049560A2 (en) | 2003-09-29 | 2005-06-02 | Sun Pharmaceutical Industries Limited | Process for the preparation of anti-depressant compound |
CN101238094A (en) | 2005-06-29 | 2008-08-06 | Wyeth公司 | Process for the preparation of 1-[cyano(4-hydroxyphenyl)methyl]cyclohexanol compounds |
MX2008000249A (en) | 2005-07-06 | 2008-03-18 | Sepracor Inc | Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders. |
MX2008000680A (en) * | 2005-07-15 | 2008-03-14 | Wyeth Corp | Highly selective serotonin and norepinephrine dual reuptake inhibitor and use thereof. |
WO2007071404A1 (en) | 2005-12-20 | 2007-06-28 | Synthon B.V. | Process for making desvenlafaxine |
JP2008546718A (en) | 2006-04-17 | 2008-12-25 | テバ ファーマシューティカル インダストリーズ リミティド | Substantially pure O-desmethylvenlafaxine and method for its preparation. |
EP1870395A1 (en) * | 2006-06-19 | 2007-12-26 | KRKA, D.D., Novo Mesto | Process for preparation of o-desmethylvenlafaxine and its analogue |
EP2061750A2 (en) | 2006-08-04 | 2009-05-27 | Medichem, S.A. | Improved process for synthesizing desvenlafaxine free base and salts or solvates thereof |
-
2007
- 2007-07-26 EP EP07836330A patent/EP1934168A2/en not_active Withdrawn
- 2007-07-26 EP EP07836329A patent/EP1917237A2/en not_active Withdrawn
- 2007-07-26 US US11/881,731 patent/US7605290B2/en not_active Expired - Fee Related
- 2007-07-26 JP JP2008527228A patent/JP2008546850A/en active Pending
- 2007-07-26 JP JP2007194720A patent/JP2008044936A/en active Pending
- 2007-07-26 KR KR1020087006360A patent/KR101019455B1/en not_active IP Right Cessation
- 2007-07-26 WO PCT/US2007/017005 patent/WO2008013990A2/en active Application Filing
- 2007-07-26 KR KR1020087006359A patent/KR101019454B1/en not_active IP Right Cessation
- 2007-07-26 EP EP07836325A patent/EP2046725A2/en not_active Withdrawn
- 2007-07-26 US US11/881,825 patent/US20080177110A1/en not_active Abandoned
- 2007-07-26 KR KR1020087006356A patent/KR101019453B1/en not_active IP Right Cessation
- 2007-07-26 CA CA002656161A patent/CA2656161A1/en not_active Abandoned
- 2007-07-26 US US11/881,799 patent/US20090062572A1/en not_active Abandoned
- 2007-07-26 JP JP2007194774A patent/JP2008088159A/en active Pending
- 2007-07-26 EP EP07810899A patent/EP1934167A2/en not_active Withdrawn
- 2007-07-26 US US11/881,826 patent/US20080183016A1/en not_active Abandoned
-
2009
- 2009-01-08 IL IL196403A patent/IL196403A0/en unknown
Patent Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4283418A (en) * | 1979-03-01 | 1981-08-11 | Ono Pharmaceutical Co., Ltd. | Guanidinobenzoic acid derivatives and process for their preparation |
US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
US6197828B1 (en) * | 1998-12-01 | 2001-03-06 | Sepracor, Inc. | Derivatives of (+)-venlafaxine and methods of preparing and using the same |
US20050197392A1 (en) * | 1999-04-06 | 2005-09-08 | Sepracor Inc. | O-desmethylvenlafaxine and methods of preparing and using the same |
US20020022662A1 (en) * | 1999-06-15 | 2002-02-21 | American Home Products Corporation | Enantiomers of O-desmethyl venlafaxine |
US6673838B2 (en) * | 2001-02-12 | 2004-01-06 | Wyeth | Succinate salt of O-desmethyl-venlafaxine |
US7026508B2 (en) * | 2001-02-12 | 2006-04-11 | Wyeth | Succinate salt of O-desmethyl-venlafaxine |
US6350912B1 (en) * | 2001-02-28 | 2002-02-26 | Council Of Scientific And Industrial Research | One pot process for the preparation of 1-[2-dimethylamino-(4-methoxyphenyl)-ethyl]cyclohexanol |
US20020120164A1 (en) * | 2001-02-28 | 2002-08-29 | Council Of Scientific And Industrial Research | Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol |
US6689912B2 (en) * | 2001-12-04 | 2004-02-10 | Wyeth | Methods for preparing O-desmethylvenlafaxine |
US7026513B2 (en) * | 2002-03-26 | 2006-04-11 | Nicholas Piramal India Limited | Manufacture of phenyl ethylamine compounds, in particular venlafaxine |
US20040106818A1 (en) * | 2002-11-29 | 2004-06-03 | Lan Zhiyin | Process for the preparation of cyclohexanol derivatives |
US20040181093A1 (en) * | 2003-03-11 | 2004-09-16 | Wyeth | Process for preparation of phenethylamine derivatives |
US20050009870A1 (en) * | 2003-07-11 | 2005-01-13 | Sher Philip M. | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
US20070135449A1 (en) * | 2005-12-05 | 2007-06-14 | Wyeth | Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols |
US20080221356A1 (en) * | 2006-07-26 | 2008-09-11 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
US20090069601A1 (en) * | 2006-07-26 | 2009-03-12 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
US20090137846A1 (en) * | 2006-07-26 | 2009-05-28 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-Desmethylvenlafaxine |
US7605290B2 (en) * | 2006-07-26 | 2009-10-20 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of O-desmethylvenlafaxine |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100076086A1 (en) * | 2007-01-31 | 2010-03-25 | Merck Development Centre Private Limited Plot 1 A/2 | Process for the preparation of o-desmethyl venlafaxine |
CN101781221A (en) * | 2010-02-11 | 2010-07-21 | 上海凯米侬医药科技有限公司 | Preparation method of O-desmethylvenlafaxine |
Also Published As
Publication number | Publication date |
---|---|
KR20080037713A (en) | 2008-04-30 |
KR20080037714A (en) | 2008-04-30 |
EP2046725A2 (en) | 2009-04-15 |
EP1934168A2 (en) | 2008-06-25 |
EP1934167A2 (en) | 2008-06-25 |
WO2008013990A3 (en) | 2008-03-27 |
JP2008546850A (en) | 2008-12-25 |
KR20080037715A (en) | 2008-04-30 |
US20080139849A1 (en) | 2008-06-12 |
JP2008088159A (en) | 2008-04-17 |
JP2008044936A (en) | 2008-02-28 |
EP1917237A2 (en) | 2008-05-07 |
IL196403A0 (en) | 2009-11-18 |
KR101019453B1 (en) | 2011-03-07 |
KR101019455B1 (en) | 2011-03-07 |
WO2008013990A2 (en) | 2008-01-31 |
CA2656161A1 (en) | 2008-01-31 |
US20080177110A1 (en) | 2008-07-24 |
US20090062572A1 (en) | 2009-03-05 |
US7605290B2 (en) | 2009-10-20 |
KR101019454B1 (en) | 2011-03-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20080183016A1 (en) | Process for the synthesis of O-desmethylvenlafaxine | |
NZ260857A (en) | Alkyl n-(3-alkoxycarbonyloxy-3-phenyl-propyl)- n-methyl-carbamates | |
US20100113778A1 (en) | Process for preparing o-chloromethylphenylglyoxylic esters, improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters, and novel intermediates for their preparation | |
EP2349976B1 (en) | A process for producing (s)-3-[(1-dimethylamino)ethyl]phenyl-n-ethyl-n-methyl-carbamate via novel intermediates | |
US6506941B1 (en) | Venlafaxine production process | |
WO2009084037A2 (en) | Novel process for preparation of o-desmethylvenlafaxine | |
US9321712B2 (en) | Process for the preparation of ospemifene | |
MX2008004089A (en) | Processes for the synthesis of o-desmethylvenlafaxine | |
TW200405809A (en) | Process for preparing (S)-(+)-2-(substituted phenyl)-2-hydroxy-ethyl carbamates | |
JP4763788B2 (en) | Method for synthesizing O-desmethylvenlafaxine | |
US20150105567A1 (en) | Optically active axially chiral alpha-allenic alcohol, synthesis method and use thereof | |
US20120253074A1 (en) | Process for the preparation of o-desmethyl-venlafaxine and salts thereof | |
JP4829418B2 (en) | Optically active halohydrin derivative and method of using the same | |
ES2288376A1 (en) | Process for obtaining valine derivatives useful for obtaining a pharmaceutically active compound | |
CA2656167A1 (en) | Processes for the synthesis of o-desmethylvenlafaxine | |
KR100647068B1 (en) | Process for preparing racemic n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine | |
JP4039026B2 (en) | Method for producing 3-amino-2-thiophenecarboxylic acid ester | |
JP4000278B2 (en) | Process for producing ω-bromoalkylmalonic acid and ω-bromoalkylcarboxylic acid | |
WO2000050379A1 (en) | Process for the preparation of (1r, 2s, 4r) -(-) -2 - (2 -dimethylaminoethoxy) -2 -phenyl -1,7,7 - trimethylbicyclo [2.2.1] heptane | |
US20050137416A1 (en) | Process and intermediates for preparing a cyclohexylnitrile | |
JP2004500372A (en) | Methods and intermediates for preparing cyclohexylnitrile | |
EP1319646A1 (en) | Process for preparation of 3,5-bisalkylphenols | |
AU2004205303A1 (en) | Process and intermediates for preparing a cyclohexylnitrile | |
JP2003226676A (en) | Alfa-alkyl-fluoro, trifluoromethyl or trifluoromethoxy- substituted benzylamine, n-alkyl alfa-alkyl-fluoro, trifluoro- or trifluoromethoxy-substituted benzylamine | |
JPH09249641A (en) | Fluorinated vitamin d derivative and its production |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: TEVA PHARMACEUTICAL INDUSTRIES LTD., ISRAEL Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:NIDDAM-HILDESHEIM, VALERIE;NIDAM, TAMAR;REEL/FRAME:020649/0342;SIGNING DATES FROM 20070924 TO 20070925 Owner name: TEVA PHARMACEUTICALS USA, INC., PENNSYLVANIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:TEVA PHARMACEUTICAL INDUSTRIES LTD.;REEL/FRAME:020649/0359 Effective date: 20071015 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |